{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T15:29:54Z","timestamp":1767108594262,"version":"3.41.2"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00497","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T05:53:47Z","timestamp":1596088427000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Linear and Non-linear Correlations Between Serum Phosphate Level and Bone Mineral Density in Type 2 Diabetes"],"prefix":"10.3389","volume":"11","author":[{"given":"Yinqiu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangwang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.cjca.2018.03.002","article-title":"Evolving trends in the epidemiology, risk factors, and prevention of type 2 diabetes: a review","volume":"34","author":"Weisman","year":"2018","journal-title":"Can J Cardiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1477-7525-8-18","article-title":"Health-related quality of life in diabetes: the associations of complications with EQ-5D scores","volume":"8","author":"Solli","year":"2010","journal-title":"Health Qual Life Outcomes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/MED.0000000000000203","article-title":"Diabetes and bone: biological and environmental factors","volume":"22","author":"Piscitelli","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.2337\/diacare.27.10.2568","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Rathmann","year":"2004","journal-title":"Diabetes Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician's guide to prevention and treatment of osteoporosis","volume":"25","author":"Cosman","year":"2014","journal-title":"Osteoporos Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e39662","DOI":"10.5812\/ijem.39662","article-title":"Associated factors of bone mineral density and osteoporosis in elderly males","volume":"15","author":"Heidari","year":"2017","journal-title":"Int J Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5455\/medarh.2017.71.25-28","article-title":"Risk factors for osteoporosis in postmenopausal women","volume":"71","author":"Bijelic","year":"2017","journal-title":"Med Arch"},{"key":"B8","doi-asserted-by":"publisher","first-page":"502","DOI":"10.11817\/j.issn.1672-7347.2016.05.009","article-title":"[Level of serum phosphorus and adult type 2 diabetes mellitus]","volume":"41","author":"Fang","year":"2016","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"B9","doi-asserted-by":"publisher","first-page":"F1170","DOI":"10.1152\/ajprenal.00072.2005","article-title":"\u201cPhosphatonins\u201d and the regulation of phosphorus homeostasis","volume":"289","author":"Berndt","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4065\/79.1.91","article-title":"Phosphorus nutrition and the treatment of osteoporosis","volume":"79","author":"Heaney","year":"2004","journal-title":"Mayo Clin Proc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1002\/jbmr.5650111211","article-title":"An acute intake of phosphate increases parathyroid hormone secretion and inhibits bone formation in young women","volume":"11","author":"K\u00e4rkk\u00e4inen","year":"1996","journal-title":"J Bone Miner Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0003-9969(61)90007-3","article-title":"The main mineral constituent of bone and teeth","volume":"5","author":"Herman","year":"1961","journal-title":"Arch Oral Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrneph.2010.17","article-title":"Recent advances in renal phosphate handling","volume":"6","author":"Farrow","year":"2010","journal-title":"Nat Rev Nephrol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/eci.12769","article-title":"Serum phosphate is related to adiposity in healthy adults","volume":"47","author":"Billington","year":"2017","journal-title":"Eur J Clin Invest."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/jbmr.3094","article-title":"Serum phosphate is associated with fracture risk: the rotterdam study and MrOS","volume":"32","author":"Campos-Obando","year":"2017","journal-title":"J Bone Miner Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00223-001-1072-4","article-title":"Predictors of bone mineral density in aging healthy men varies by skeletal site","volume":"70","author":"Clarke","year":"2002","journal-title":"Calcif Tissue Int"},{"key":"B17","first-page":"1546","article-title":"[Analysis of clinical factors correlating with osteoporosis in patients with type 2 diabetes mellitus]","volume":"36","author":"Zhang","year":"2016","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"B18","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.2337\/dc12-s011","article-title":"Standards of medical care in diabetes\u22122012","volume":"35","year":"2012","journal-title":"Diabetes Care."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1210\/en.2005-0671","article-title":"Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts","volume":"147","author":"Koyama","year":"2006","journal-title":"Endocrinology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/ajcn\/58.4.537","article-title":"Intakes of calcium, phosphorus, and protein, and physical-activity level are related to radial bone mass in young adult women","volume":"58","author":"Metz","year":"1993","journal-title":"Am J Clin Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF02060281","article-title":"Bone growth in organ culture: effects of phosphate and other nutrients on bone and cartilage","volume":"14","author":"Bingham","year":"1974","journal-title":"Calcif Tissue Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/jbmr.294","article-title":"Unique roles of phosphorus in endochondral bone formation and osteocyte maturation","volume":"26","author":"Zhang","year":"2011","journal-title":"J Bone Miner Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/S8756-3282(03)00060-7","article-title":"Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency","volume":"32","author":"Shapiro","year":"2003","journal-title":"Bone"},{"key":"B24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/jn\/92.1.30","article-title":"The relationship of Ca and P nutrition during adult life and osteoporosis in aged mice","volume":"92","author":"Shah","year":"1967","journal-title":"J Nutr."},{"key":"B25","first-page":"185","article-title":"Acute effects of soft drink intake on calcium and phosphate metabolism in immature and adult rats","volume":"50","author":"Amato","year":"1998","journal-title":"Rev Invest Clin"},{"key":"B26","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bone.2014.10.013","article-title":"FGF23 gene variation and its association with phosphate homeostasis and bone mineral density in finnish children and adolescents","volume":"71","author":"Pekkinen","year":"2015","journal-title":"Bone"},{"key":"B27","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1172\/JCI200319687","article-title":"Evidence for a bone-kidney axis regulating phosphate homeostasis","volume":"112","author":"Quarles","year":"2003","journal-title":"J Clin Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1074\/jbc.M207872200","article-title":"Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production","volume":"278","author":"Saito","year":"2003","journal-title":"J Biol Chem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1210\/jcem.81.3.8772587","article-title":"Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. EPIDOS study group","volume":"81","author":"Chapuy","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3304","DOI":"10.1210\/jcem.80.11.7593443","article-title":"Role of parathyroid hormone in mediating nocturnal and age-related increases in bone resorption","volume":"80","author":"Ledger","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1210\/jcem.80.4.7714065","article-title":"Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial","volume":"80","author":"Ooms","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cca.2016.09.009","article-title":"A relationship between vitamin D, parathyroid hormone, calcium levels and lactose intolerance in type 2 diabetic patients and healthy subjects","volume":"462","author":"Rana","year":"2016","journal-title":"Clin Chim Acta"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.2169\/internalmedicine.48.2236","article-title":"Is this the worst outcome of metabolic syndrome? Hypophosphatemia and resulting cardiac arrest during the treatment of diabetic ketoacidosis with hypertriglyceridemia","volume":"48","author":"Osuka","year":"2009","journal-title":"Intern Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1093\/qjmed\/hcq039","article-title":"Medication-induced hypophosphatemia: a review","volume":"103","author":"Liamis","year":"2010","journal-title":"QJM"},{"key":"B35","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.nut.2013.12.010","article-title":"Bioavailable dietary phosphate, a mediator of cardiovascular disease, may be decreased with plant-based diets, phosphate binders, niacin, and avoidance of phosphate additives","volume":"30","author":"McCarty","year":"2014","journal-title":"Nutrition"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1056\/NEJM198011273032203","article-title":"Hypophosphatemia and glucose intolerance: evidence for tissue insensitivity to insulin","volume":"303","author":"DeFronzo","year":"1980","journal-title":"N Engl J Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1359\/JBMR.050304","article-title":"Predictive value of BMD for hip and other fractures","volume":"20","author":"Johnell","year":"2005","journal-title":"J Bone Miner Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1001\/archinte.1996.00440120051005","article-title":"Osteoporosis. Frequency, consequences, and risk factors","volume":"156","author":"Ross","year":"1996","journal-title":"Arch Intern Med"},{"key":"B39","first-page":"864","article-title":"Commentary: bone density can be used to assess fracture risk","volume":"318","author":"Eastell","year":"1999","journal-title":"BMJ"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00497\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T05:53:51Z","timestamp":1596088431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00497\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":39,"alternative-id":["10.3389\/fendo.2020.00497"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00497","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"article-number":"497"}}