{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:17:49Z","timestamp":1790201869819,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1150359"],"award-info":[{"award-number":["1150359"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1190756"],"award-info":[{"award-number":["1190756"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00546","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T11:29:17Z","timestamp":1597836557000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Moderate Exercise in Spontaneously Hypertensive Rats Is Unable to Activate the Expression of Genes Linked to Mitochondrial Dynamics and Biogenesis in Cardiomyocytes"],"prefix":"10.3389","volume":"11","author":[{"given":"Clara","family":"Quiroga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georthan","family":"Mancilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Oyarzun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi A.","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Valladares-Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo F.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo E.","family":"Verdejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1161\/CIRCRESAHA.118.312669","article-title":"Sedentary behavior, exercise, and cardiovascular health","volume":"124","author":"Lavie","year":"2019","journal-title":"Circ Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1113\/JP273040","article-title":"Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle","volume":"595","author":"Nielsen","year":"2017","journal-title":"J Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2007.08.015","article-title":"Systemic and mitochondrial adaptive responses to moderate exercise in rodents","volume":"44","author":"Boveris","year":"2008","journal-title":"Free Radic Biol Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: a report from the american heart association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1253\/jcj.27.282","article-title":"Development of a strain of spontaneously hypertensive rats","volume":"27","author":"Okamoto","year":"1963","journal-title":"Jpn Circ J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e262","DOI":"10.1161\/CIR.0000000000000440","article-title":"Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the american heart association","volume":"134","author":"Young","year":"2016","journal-title":"Circulation."},{"key":"B7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1152\/jappl.1983.55.2.518","article-title":"Metabolism of rats running up and down an incline","volume":"55","author":"Armstrong","year":"1983","journal-title":"J Appl Physiol Respir Environ Exerc Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"45e","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/1756-0500-5-124","article-title":"Selection of reference genes in different myocardial regions of an in vivo ischemia\/reperfusion rat model for normalization of antioxidant gene expression","volume":"5","author":"Vesentini","year":"2012","journal-title":"BMC Res Notes."},{"key":"B10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3390\/cells9010242","article-title":"Cellular and molecular differences between HFpEF and HFrEF: a step ahead in an improved pathological understanding","volume":"9","author":"Simmonds","year":"2020","journal-title":"Cells."},{"key":"B11","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1146\/annurev-physiol-021317-121234","article-title":"Titin gene and protein functions in passive and active muscle","volume":"80","author":"Linke","year":"2018","journal-title":"Annu Rev Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.tcm.2012.07.003","article-title":"PGC-1 proteins and heart failure","volume":"22","author":"Riehle","year":"2012","journal-title":"Trends Cardiovasc Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1113\/jphysiol.2002.034850","article-title":"Exercise induces transient transcriptional activation of the PGC-1\u03b1 gene in human skeletal muscle","volume":"546","author":"Pilegaard","year":"2003","journal-title":"J Physiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00395-011-0213-9","article-title":"Mitochondrial biogenesis and PGC-1\u03b1 deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle","volume":"106","author":"Li","year":"2011","journal-title":"Basic Res Cardiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s11906-012-0305-4","article-title":"Mitochondria, myocardial remodeling, and cardiovascular disease","volume":"14","author":"Verdejo","year":"2012","journal-title":"Curr Hypertens Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1242\/jcs.159186","article-title":"OPA1 processing in cell death and disease - the long and short of it","volume":"129","author":"MacVicar","year":"2016","journal-title":"J Cell Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2337\/db13-0340","article-title":"Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway","volume":"63","author":"Parra","year":"2014","journal-title":"Diabetes."},{"key":"B18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.4161\/15384101.2014.991572","article-title":"MTOR coordinates protein synthesis, mitochondrial activity","volume":"14","author":"Morita","year":"2015","journal-title":"Cell Cycle."},{"key":"B19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: Guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1152\/jappl.1983.55.4.1305","article-title":"Influences of exercise intensity, age, and medication on resting systolic blood pressure of SHR populations","volume":"55","author":"Tipton","year":"1983","journal-title":"J Appl Physiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1038\/hr.2010.155","article-title":"Interaction between exercise and hypertension in spontaneously hypertensive rats: a meta-analysis of experimental studies","volume":"33","author":"Schl\u00fcter","year":"2010","journal-title":"Hypertens Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1161\/HYPERTENSIONAHA.106.086371","article-title":"Effects of excessive long-term exercise on cardiac function and myocyte remodeling in hypertensive heart failure rats","volume":"50","author":"Schultz","year":"2007","journal-title":"Hypertension."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1097\/HJH.0b013e32834d2532","article-title":"Cardiac benefits of exercise training in aging spontaneously hypertensive rats","volume":"29","author":"Rossoni","year":"2011","journal-title":"J. Hypertens."},{"key":"B24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00421-006-0161-5","article-title":"Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis","volume":"97","author":"Lee","year":"2006","journal-title":"Eur J Appl Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2016.00076","article-title":"Titin, a central mediator for hypertrophic signaling, exercise-induced mechanosignaling and skeletal muscle remodeling","volume":"7","author":"Kr\u00fcger","year":"2016","journal-title":"Front Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0008-6363(03)00328-6","article-title":"Titin isoform expression in normal and hypertensive myocardium","volume":"59","author":"Warren","year":"2003","journal-title":"Cardiovasc Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1161\/01.HYP.33.1.60","article-title":"Direct effects of colchicine on myocardial function: studies in hypertrophied and failing spontaneously hypertensive rats","volume":"33","author":"Cicogna","year":"1999","journal-title":"Hypertension."},{"key":"B28","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1748-1716.2010.02132.x","article-title":"Mechanisms of exercise-induced improvements in the contractile apparatus of the mammalian myocardium","volume":"199","author":"Kemi","year":"2010","journal-title":"Acta Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1161\/CIRCULATIONAHA.118.035116","article-title":"Impact of lifelong exercise training dose on ventricular-arterial coupling","volume":"138","author":"Hieda","year":"2018","journal-title":"Circulation."},{"key":"B30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mce.2013.05.008","article-title":"Mitochondrial and skeletal muscle health with advancing age","volume":"379","author":"Konopka","year":"2013","journal-title":"Mol Cell Endocrinol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00424-010-0834-0","article-title":"PGC-1\u03b1-mediated adaptations in skeletal muscle","volume":"460","author":"Olesen","year":"2010","journal-title":"Pfl\u00fcgers Arch Eur J Physiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10522-012-9408-1","article-title":"PGC-1\u03b1 transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males","volume":"13","author":"Cobley","year":"2012","journal-title":"Biogerontology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e12905","DOI":"10.1111\/apha.12905","article-title":"Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis","volume":"222","author":"Meinild Lundby","year":"2018","journal-title":"Acta Physiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1111\/apha.12690","article-title":"Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice","volume":"218","author":"Kang","year":"2016","journal-title":"Acta Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e465","DOI":"10.1371\/journal.pone.0000465","article-title":"Resistance exercise reverses aging in human skeletal muscle","volume":"2","author":"Melov","year":"2007","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1006\/bbrc.1996.1839","article-title":"Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle","volume":"229","author":"Barrientos","year":"1996","journal-title":"Biochem Biophys Res Commun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/gerona\/glp066","article-title":"Impact of lifelong sedentary behavior on mitochondrial function of mice skeletal muscle","volume":"64","author":"Figueiredo","year":"2009","journal-title":"J Gerontol - Ser A Biol Sci Med Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","article-title":"Transcriptional coactivator PGC-1\u03b1 controls the energy state and contractile function of cardiac muscle","volume":"1","author":"Arany","year":"2005","journal-title":"Cell Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/CIRCHEARTFAILURE.118.005529","article-title":"Recruitment of RNA polymerase II to metabolic gene promoters is inhibited in the failing heart possibly through PGC-1\u03b1 (Peroxisome Proliferator-Activated Receptor-\u03b3 Coactivator-1\u03b1) dysregulation","volume":"12","author":"Bhat","year":"2019","journal-title":"Circ Hear Fail."},{"key":"B40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1096\/fj.15-276337","article-title":"Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle","volume":"30","author":"Drake","year":"2016","journal-title":"FASEB J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/nature05861","article-title":"Akt\/PKB regulates hepatic metabolism by directly inhibiting PGC-1\u03b1 transcription coactivator","volume":"447","author":"Li","year":"2007","journal-title":"Nature."},{"key":"B42","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.1128\/mcb.00175-10","article-title":"Inactivation of foxo3a and subsequent downregulation of PGC-1\u03b1 mediate nitric oxide-induced endothelial cell migration","volume":"30","author":"Borniquel","year":"2010","journal-title":"Mol Cell Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"642","DOI":"10.2337\/diabetes.52.3.642","article-title":"Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR","volume":"52","author":"Daitoku","year":"2003","journal-title":"Diabetes."},{"key":"B44","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1128\/mcb.01109-14","article-title":"Enhanced cardiac Akt\/protein kinase b signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes","volume":"35","author":"Wende","year":"2015","journal-title":"Mol Cell Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2019.00889","article-title":"Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model","volume":"10","author":"Ol\u00e1h","year":"2019","journal-title":"Front Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1007\/s00018-018-2857-1","article-title":"Histones and heart failure in diabetes","volume":"75","author":"Yerra","year":"2018","journal-title":"Cell Mol Life Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep39752","article-title":"The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure","volume":"7","author":"Ono","year":"2017","journal-title":"Sci Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"aad0116","DOI":"10.1126\/science.aad0116","article-title":"Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice","volume":"350","author":"Wai","year":"2015","journal-title":"Science."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00546\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T11:29:21Z","timestamp":1597836561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00546\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":48,"alternative-id":["10.3389\/fendo.2020.00546"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00546","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]},"article-number":"546"}}