{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T08:56:50Z","timestamp":1774083410147,"version":"3.50.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00550","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T04:59:22Z","timestamp":1597121962000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs"],"prefix":"10.3389","volume":"11","author":[{"given":"Erin Vanessa LaRae","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca Maree","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Judith","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clint","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu9060549","article-title":"Chronic fructose ingestion as a major health concern: is a sedentary lifestyle making it worse?","volume":"9","author":"Bidwell","year":"2017","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/482027a","article-title":"The toxic truth about sugar","volume":"482","author":"Lustig","year":"2012","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"E685","DOI":"10.1152\/ajpendo.00283.2010","article-title":"Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome Mechanism of liponecrosis, a distinct mode of programmed cell death View project","volume":"299","author":"Dekker","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1743-7075-2-1","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr Metab"},{"key":"B5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1753-4887.2005.tb00132.x","article-title":"Dietary fructose: implications for dysregulation of energy homeostasis and lipid\/carbohydrate metabolism","volume":"63","author":"Havel","year":"2005","journal-title":"Nutr Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1749-6632.2009.05266.x","article-title":"Fructose consumption: recent results and their potential implications","volume":"1190","author":"Stanhope","year":"2010","journal-title":"Ann NY Acad Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu9090981","article-title":"Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease","volume":"9","author":"Ter Horst","year":"2017","journal-title":"Nutrients"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/682673","article-title":"Fructose: a key factor in the development of metabolic syndrome and hypertension","volume":"2013","author":"Khitan","year":"2013","journal-title":"J Nutr Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu9040335","article-title":"High dietary fructose: direct or indirect dangerous factors disturbing tissue and organ functions","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"},{"key":"B10","first-page":"34","volume-title":"WHO Guideline: Sugars Intake for Adults and Children","year":"2015"},{"key":"B11","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1017\/S0007114515004936","article-title":"Excess maternal salt or fructose intake programmes sex-specific, stress-and fructose-sensitive hypertension in the offspring","volume":"115","author":"Gray","year":"2016","journal-title":"Br J Nutr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/418975","article-title":"Maternal obesity, inflammation, and developmental programming","volume":"2014","author":"Segovia","year":"2014","journal-title":"BioMed Res Int"},{"key":"B13","first-page":"17","article-title":"Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments","volume":"60","author":"Guilloteau","year":"2009","journal-title":"J Physiol Pharmacol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s40572-016-0102-3","article-title":"A framework to address challenges in communicating the developmental origins of health and disease","volume":"3","author":"Winett","year":"2016","journal-title":"Curr Environ Health Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/1440-1681.12162","article-title":"Fructose, pregnancy and later life impacts","volume":"40","author":"Regnault","year":"2013","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1210\/en.2009-1192","article-title":"A maternal \u201cjunk food\u201d diet in pregnancy and lactation promotes nonalcoholic Fatty liver disease in rat offspring","volume":"151","author":"Bayol","year":"2010","journal-title":"Endocrinology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0141962","article-title":"Early life exposure to fructose alters maternal, fetal and neonatal hepatic gene expression and leads to sex-dependent changes in lipid metabolism in rat offspring","volume":"10","author":"Clayton","year":"2015","journal-title":"PLoS ONE"},{"key":"B19","first-page":"2158","article-title":"Low dose fructose ingestion during gestation and lactation affects carbohydrate metabolism in rat dams and their offspring","volume":"123","author":"Rawana","year":"1993","journal-title":"J Nutr"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1210\/en.2010-1093","article-title":"Maternal fructose intake during pregnancy and lactation alters placental growth and leads to sex-specific changes in fetal and neonatal endocrine function","volume":"152","author":"Vickers","year":"2011","journal-title":"Endocrinology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.tem.2016.06.005","article-title":"The sweet path to metabolic demise: fructose and lipid synthesis","volume":"27","author":"Herman","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"B22","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1172\/JCI96702","article-title":"Fructose metabolism and metabolic disease","volume":"128","author":"Hannou","year":"2018","journal-title":"J Clin Investig Am Soc Clin Investig"},{"key":"B23","volume-title":"Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"B26","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1210\/jc.2014-2299","article-title":"Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic finnish offspring of type 2 diabetic individuals","volume":"100","author":"Lorenzo","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.plefa.2014.09.009","article-title":"A method for long term stabilisation of long chain polyunsaturated fatty acids in dried blood spots and its clinical application","volume":"91","author":"Liu","year":"2014","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.plefa.2018.08.003","article-title":"Comparison of breast milk fatty acid composition from mothers of premature infants of three countries using novel dried milk spot technology","volume":"139","author":"Gao","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B29","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-2275(20)38861-1","article-title":"Direct transesterification of all classes of lipids in a one-step reaction","volume":"27","author":"Lepage","year":"1986","journal-title":"J Lipid Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1177\/0890334418772279","article-title":"Comparison of human milk fatty acid composition of women from Cambodia and Australia","volume":"34","author":"Gao","year":"2018","journal-title":"J Human Lactat"},{"key":"B31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.plefa.2010.04.001","article-title":"Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression","volume":"83","author":"Tu","year":"2010","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0233010","article-title":"Methamphetamine administration increases hepatic CYP1A2 but not CYP3A activity in female guinea pigs","volume":"15","author":"Soo","year":"2020","journal-title":"PLoS ONE"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep25091","article-title":"Maternal fructose drives placental uric acid production leading to adverse fetal outcomes","volume":"6","author":"Asghar","year":"2016","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.1113\/JP274948","article-title":"Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic","volume":"596","author":"Morrison","year":"2018","journal-title":"J Physiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1093\/ajcn\/20.2.108","article-title":"Evolutionary and historical changes in dietary carbohydrates","volume":"20","author":"Yudkin","year":"1967","journal-title":"Am J Clin Nutr"},{"key":"B36","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/ajcn\/86.4.899","article-title":"Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease1-3","volume":"86","author":"Johnson","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2011\/934659","article-title":"The relation between fructose-induced metabolic syndrome and altered renal haemodynamic and excretory function in the rat","volume":"2011","author":"Abdulla","year":"2011","journal-title":"Int J Nephrol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/203474","article-title":"Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis","volume":"10","author":"Sloboda","year":"2014","journal-title":"J Obesity"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1016\/j.jnutbio.2013.02.011","article-title":"Fructose during pregnancy affects maternal and fetal leptin signaling","volume":"24","author":"Rodr\u00edguez","year":"2013","journal-title":"J Nutr Biochem"},{"key":"B40","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bj.2018.02.006","article-title":"Translational insights on developmental origins of metabolic syndrome: focus on fructose consumption","volume":"41","author":"Lee","year":"2018","journal-title":"Biomed J"},{"key":"B41","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.ajog.2016.03.038","article-title":"High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring","volume":"215","author":"Saad","year":"2016","journal-title":"Am J Obstetr Gynecol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.ajog.2018.11.004","article-title":"3: Pregnancy high fructose diet: pathways involved in fetal programming of metabolic syndrome in adult offspring","volume":"220","author":"Saad","year":"2019","journal-title":"Am J Obstetr Gynecol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1152\/physrev.00019.2009","article-title":"Metabolic effects of fructose and the worldwide increase in obesity","volume":"90","author":"Tappy","year":"2010","journal-title":"Physiol Rev"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1590\/S0100-879X2001000900008","article-title":"A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats","volume":"34","author":"Bezerra","year":"2001","journal-title":"Braz J Med Biol Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1023\/B:MCBI.0000028734.77867.d2","article-title":"Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance","volume":"261","author":"Litherland","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12944-015-0123-1","article-title":"The role of fatty acids in insulin resistance","volume":"14","author":"Sears","year":"2015","journal-title":"Lipids Health Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.2337\/db11-0425","article-title":"Fatty acids, obesity, and insulin resistance: time for a reevaluation","volume":"60","author":"Karpe","year":"2011","journal-title":"Diabetes"},{"key":"B48","doi-asserted-by":"publisher","first-page":"327","DOI":"10.2337\/db14-0877","article-title":"New insights into gestational glucose metabolism: lessons learned from 21st century approaches","volume":"64","author":"Angueira","year":"2015","journal-title":"Diabetes"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu10060669","article-title":"High-fructose corn-syrup-sweetened beverage intake increases 5-hour breast milk fructose concentrations in lactating women","volume":"10","author":"Berger","year":"2018","journal-title":"Nutrients"},{"key":"B50","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/nrendo.2013.108","article-title":"The obesogenic effect of high fructose exposure during early development","volume":"9","author":"Goran","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/ajcn\/42.1.49","article-title":"Trans fatty acids in human milk lipids: Influence of maternal diet and weight loss","volume":"42","author":"Chappel","year":"1985","journal-title":"Am J Clin Nutr"},{"key":"B52","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jnutbio.2014.10.001","article-title":"Type of fatty acids in maternal diets during pregnancy and\/or lactation and metabolic consequences of the offspring","volume":"26","author":"Mennitti","year":"2015","journal-title":"J Nutr Biochem"},{"key":"B53","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.nutres.2012.06.012","article-title":"Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats","volume":"32","author":"Zou","year":"2012","journal-title":"Nutr Res"},{"key":"B54","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12020-008-9143-1","article-title":"Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats","volume":"35","author":"Alzamendi","year":"2009","journal-title":"Endocrine"},{"key":"B55","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1001\/jama.292.8.978","article-title":"Sugar-sweetened soft drinks, obesity, and type 2 diabetes","volume":"292","author":"Apovian","year":"2004","journal-title":"J Am Med Assoc"},{"key":"B56","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1136\/ard.42.2.123","article-title":"A controlled study of diet in patients with gout","volume":"42","author":"Gibson","year":"1983","journal-title":"Ann Rheumatic Dis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/0026-0495(72)90120-5","article-title":"Studies on the mechanism of fructose-induced hyperuricemia in man","volume":"21","author":"Fox","year":"1972","journal-title":"Metabolism"},{"key":"B58","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ecl.2008.06.007","article-title":"Obesity and free fatty acids","volume":"37","author":"Boden","year":"2008","journal-title":"Endocrinol Metab Clin North Am."},{"key":"B59","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.vph.2012.05.003","article-title":"From excess adiposity to insulin resistance: The role of free fatty acids","volume":"57","author":"Capurso","year":"2012","journal-title":"Vasc Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/MOL.0b013e3282f2b24a","article-title":"Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance","volume":"19","author":"Stanhope","year":"2008","journal-title":"Curr Opin Lipidol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/0026-0495(82)90155-X","article-title":"Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat","volume":"31","author":"Zavaroni","year":"1982","journal-title":"Metab Clin Exp"},{"key":"B62","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000175521","article-title":"Effect of dietary fructose on free fatty acid release from adipose tissue and serum free fatty acid concentration in the rat","volume":"17","author":"Vr\u00e1na","year":"1974","journal-title":"Ann Nutr Metab"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1113\/JP274066","article-title":"Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS-55) on adiposity and hepatic lipid composition in rat offspring","volume":"595","author":"Toop","year":"2017","journal-title":"J Physiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00550\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T04:33:33Z","timestamp":1616906013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00550\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":64,"alternative-id":["10.3389\/fendo.2020.00550"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00550","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"article-number":"550"}}