{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:14Z","timestamp":1783948814499,"version":"3.55.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00551","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T04:21:53Z","timestamp":1598329313000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Predictive Factors of Lymph Node Metastasis in Patients With Papillary Microcarcinoma of the Thyroid: Retrospective Analysis on 293 Cases"],"prefix":"10.3389","volume":"11","author":[{"given":"Fabio","family":"Medas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Canu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Cappellacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Erdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Giorgio","family":"Cal\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"965212","DOI":"10.1155\/2013\/965212","article-title":"Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors","volume":"2013","author":"Pellegriti","year":"2013","journal-title":"J Cancer Epidemiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2217\/fon.09.161","article-title":"Increasing incidence of thyroid cancer: is diagnostic scrutiny the sole explanation?","volume":"6","author":"Ward","year":"2010","journal-title":"Future Oncol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.surg.2010.10.016","article-title":"Analysis of the rising incidence of thyroid cancer using the surveillance, epidemiology and end results national cancer data registry","volume":"148","author":"Cramer","year":"2010","journal-title":"Surgery."},{"key":"B4","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1002\/1097-0142(19890301)63:5<908::aid-cncr2820630520>3.0.co;2-i","article-title":"The WHO histological classification of thyroid tumors: a commentary on the second edition","volume":"63","author":"Hedinger","year":"1989","journal-title":"Cancer."},{"key":"B5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1160\/nukmed-0059","article-title":"Papillary microcarcinoma and papillary cancer of the thyroid \u2264 1 cm: modified definition of the WHO and the therapeutic dilemma","volume":"46","author":"Sch\u00f6nberger","year":"2007","journal-title":"Nuklearmedizin."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1007\/s00268-009-0359-x","article-title":"Three distinctly different kinds of papillary thyroid microcarcinoma should be recognized: our treatment strategies and outcomes","volume":"34","author":"Sugitani","year":"2010","journal-title":"World J Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/01.SLA.0000055273.58908.19","article-title":"Lymph node metastasis from 259 papillary thyroid microcarcinomas","volume":"237","author":"Wada","year":"2003","journal-title":"Ann Surg."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1245\/s10434-011-1600-z","article-title":"Central lymph node metastasis of unilateral papillary thyroid carcinoma: patterns and factors predictive of nodal metastasis, morbidity, and recurrence","volume":"18","author":"Roh","year":"2011","journal-title":"Ann Surg Oncol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.surg.2010.01.003","article-title":"Subclinical lymph node metastasis in papillary thyroid microcarcinoma: a study of 551 resections","volume":"148","author":"So","year":"2010","journal-title":"Surgery."},{"key":"B11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejso.2016.09.017","article-title":"Total thyroidectomy alone versus ipsilateral versus bilateral prophylactic central neck dissection in clinically node-negative differentiated thyroid carcinoma. A retrospective multicenter study","volume":"43","author":"Cal\u00f2","year":"2017","journal-title":"Eur J Surg Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.amjsurg.2019.11.032","article-title":"Predicting factors for central or lateral lymph node metastasis in conventional papillary thyroid microcarcinoma","volume":"220","author":"Sheng","year":"2019","journal-title":"Am J Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12902-019-0450-8","article-title":"Analysis of risk factors for cervical lymph node metastasis of papillary thyroid microcarcinoma: a study of 268 patients","volume":"19","author":"Gu","year":"2019","journal-title":"BMC Endocr Disord."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.3390\/cancers11091230","article-title":"Predictive factors of recurrence in patients with differentiated thyroid carcinoma: a retrospective analysis on 579 patients","volume":"11","author":"Medas","year":"2019","journal-title":"Cancers (Basel)."},{"key":"B15","doi-asserted-by":"publisher","first-page":"S140","DOI":"10.1016\/j.ijsu.2014.08.362","article-title":"Differentiated thyroid cancer in the elderly: our experience","volume":"12","author":"Cal\u00f2","year":"2014","journal-title":"Int J Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/cncr.11442","article-title":"Papillary microcarcinoma of the thyroid? Prognostic significance of lymph node metastasis and multifocality","volume":"98","author":"Chow","year":"2003","journal-title":"Cancer."},{"key":"B17","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s00268-004-7192-z","article-title":"Preoperative ultrasonographic examination for lymph node metastasis: usefulness when designing lymph node dissection for papillary microcarcinoma of the thyroid","volume":"28","author":"Ito","year":"2004","journal-title":"World J Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.20892\/j.issn.2095-3941.2018.0125","article-title":"Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients","volume":"16","author":"Xiangqian","year":"2019","journal-title":"Cancer Biol Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8579828","article-title":"Risk factors for cervical lymph node metastasis of papillary thyroid microcarcinoma: a single-center retrospective study","volume":"2019","author":"Cheng","year":"2019","journal-title":"Int J Endocrinol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1245\/s10434-016-5225-0","article-title":"Predictive factors for lymph node metastasis in papillary thyroid microcarcinoma","volume":"23","author":"Kim","year":"2016","journal-title":"Ann Surg Oncol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1007\/s00268-009-0375-x","article-title":"Papillary thyroid microcarcinoma: extrathyroidal extension, lymph node metastases, and risk factors for recurrence in a high prevalence of goiter area","volume":"34","author":"Lombardi","year":"2010","journal-title":"World J Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.amjsurg.2013.10.032","article-title":"Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma","volume":"208","author":"Park","year":"2014","journal-title":"Am J Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jss.2017.08.007","article-title":"Clinical predictors of lymph node metastasis and survival rate in papillary thyroid microcarcinoma: analysis of 3607 patients at a single institution","volume":"221","author":"Xu","year":"2018","journal-title":"J Surg Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"8625","DOI":"10.7314\/apjcp.2015.16.18.8625","article-title":"Could tumor size be a predictor for papillary thyroid microcarcinoma: a retrospective cohort study","volume":"16","author":"Wang","year":"2015","journal-title":"Asian Pac J Cancer Prev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2147\/CMAR.S154135","article-title":"A favorable tumor size to define papillary thyroid microcarcinoma: an analysis of 1176 consecutive cases","volume":"10","author":"Gong","year":"2018","journal-title":"Cancer Manag Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.2147\/CMAR.S173853","article-title":"Long-term oncologic outcomes of papillary thyroid microcarcinoma according to the presence of clinically apparent lymph node metastasis: a large retrospective analysis of 5,348 patients","volume":"10","author":"Choi","year":"2018","journal-title":"Cancer Manag Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1089\/thy.2018.0263","article-title":"Active surveillance of low-risk papillary thyroid microcarcinoma: a multi-center cohort study in Korea","volume":"28","author":"Oh","year":"2018","journal-title":"Thyroid."},{"key":"B28","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ejrad.2019.01.006","article-title":"Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: diagnosis of central and lateral compartment nodal metastases","volume":"112","author":"Zhao","year":"2019","journal-title":"Eur J Radiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3389\/fendo.2018.00736","article-title":"Active surveillance for papillary thyroid microcarcinoma: challenges and prospects","volume":"9","author":"Xue","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1245\/s10434-019-07256-4","article-title":"Thyroid antibody status is associated with central lymph node metastases in papillary thyroid carcinoma patients with Hashimoto's thyroiditis","volume":"26","author":"Wen","year":"2019","journal-title":"Ann Surg Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1245\/s10434-014-3593-x","article-title":"Thyroglobulin antibodies could be a potential predictive marker for papillary thyroid carcinoma","volume":"21","author":"Vasileiadis","year":"2014","journal-title":"Ann Surg Oncol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.amjsurg.2015.12.030","article-title":"Thyroglobulin antibodies as a potential predictive marker of papillary thyroid carcinoma in patients with indeterminate cytology","volume":"212","author":"Karatzas","year":"2016","journal-title":"Am J Surg."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1089\/thy.2013.0588","article-title":"Hashimoto's thyroiditis pathology and risk for thyroid cancer","volume":"24","author":"Paparodis","year":"2014","journal-title":"Thyroid."}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00551\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T04:21:54Z","timestamp":1598329314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00551\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,25]]},"references-count":33,"alternative-id":["10.3389\/fendo.2020.00551"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00551","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,25]]},"article-number":"551"}}