{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:35:23Z","timestamp":1793082923955,"version":"4.5.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK071320"],"award-info":[{"award-number":["DK071320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK119341"],"award-info":[{"award-number":["DK119341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK109408"],"award-info":[{"award-number":["DK109408"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.00606","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T16:20:16Z","timestamp":1599841216000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus"],"prefix":"10.3389","volume":"11","author":[{"given":"Kripa","family":"Shankar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath K.","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna G.","family":"Findley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Osborne-Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Berglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Zigman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e44089","DOI":"10.1371\/journal.pone.0044089","article-title":"Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose","volume":"7","author":"Scott","year":"2012","journal-title":"PLoS ONE"},{"key":"B2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000054680","article-title":"A role of ghrelin in neuroendocrine and behavioral responses to stress in mice","volume":"74","author":"Asakawa","year":"2001","journal-title":"Neuroendocrinology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/10253890701820257","article-title":"Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress","volume":"11","author":"Kawakami","year":"2008","journal-title":"Stress"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1007\/s00125-007-0599-y","article-title":"Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration","volume":"50","year":"2007","journal-title":"Diabetologia"},{"key":"B5","unstructured":"Physiologic response to hypoglycemia in normal subjects and patients with diabetes mellitus\n            CryerPE\n          2015"},{"key":"B6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1152\/physiol.00069.2013","article-title":"Peripheral and central glucose sensing in hypoglycemic detection","volume":"29","author":"Donovan","year":"2014","journal-title":"Physiology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1464-5491.2010.03203.x","article-title":"Frequency of symptomatic and asymptomatic hypoglycaemia in Type 1 diabetes: effect of impaired awareness of hypoglycaemia","volume":"28","author":"Schopman","year":"2011","journal-title":"Diabet Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2337\/diabetes.54.3.757","article-title":"Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans","volume":"54","author":"Raju","year":"2005","journal-title":"Diabetes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e12705","DOI":"10.1111\/jne.12705","article-title":"Ghrelin regulation of glucose metabolism","volume":"31","author":"Gray","year":"2019","journal-title":"J Neuroendocrinol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1210\/en.2019-00074","article-title":"Ghrelin's relationship to blood glucose","volume":"160","author":"Mani","year":"2019","journal-title":"Endocrinology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1210\/me.2011-1001","article-title":"Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells","volume":"25","author":"Chuang","year":"2011","journal-title":"Mol Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1530\/EJE-14-0183","article-title":"Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions","volume":"171","author":"Heppner","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.2337\/db18-0451","article-title":"Interaction of GLP-1 and ghrelin on glucose tolerance in healthy humans","volume":"67","author":"Page","year":"2018","journal-title":"Diabetes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molmet.2013.10.001","article-title":"Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin","volume":"3","author":"Wang","year":"2014","journal-title":"Mol Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.2337\/diabetes.53.12.3142","article-title":"Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents","volume":"53","author":"Dezaki","year":"2004","journal-title":"Diabetes"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.2337\/db07-0345","article-title":"Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin","volume":"56","author":"Dezaki","year":"2007","journal-title":"Diabetes"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1210\/jcem.86.10.8098","article-title":"Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans","volume":"86","author":"Broglio","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"B18","doi-asserted-by":"publisher","first-page":"E752","DOI":"10.1152\/ajpendo.00463.2007","article-title":"Mice with chronically increased circulating ghrelin develop age-related glucose intolerance","volume":"294","author":"Reed","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/00006676-200308000-00009","article-title":"Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets","volume":"27","author":"Colombo","year":"2003","journal-title":"Pancreas"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.2337\/db10-0504","article-title":"Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans","volume":"59","author":"Tong","year":"2010","journal-title":"Diabetes"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3486","DOI":"10.2337\/db06-0878","article-title":"Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance","volume":"55","author":"Dezaki","year":"2006","journal-title":"Diabetes"},{"key":"B22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.regpep.2008.03.011","article-title":"Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice","volume":"150","author":"Longo","year":"2008","journal-title":"Regul Pept"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1172\/JCI26003","article-title":"Absence of ghrelin protects against early-onset obesity","volume":"115","author":"Wortley","year":"2005","journal-title":"J Clin Invest"},{"key":"B24","doi-asserted-by":"publisher","first-page":"7467","DOI":"10.1073\/pnas.1002271107","article-title":"Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1111\/dom.13020","article-title":"Ghrelin receptor inverse agonists as a novel therapeutic approach against obesity-related metabolic disease","volume":"19","author":"Abegg","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"B26","doi-asserted-by":"publisher","first-page":"G610","DOI":"10.1152\/ajpgi.00321.2007","article-title":"Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure","volume":"294","author":"Pfluger","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"17942","DOI":"10.1074\/jbc.M112.358051","article-title":"Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids","volume":"287","author":"Li","year":"2012","journal-title":"J Biol Chem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cmet.2014.04.007","article-title":"Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet","volume":"20","author":"McFarlane","year":"2014","journal-title":"Cell Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.cmet.2017.10.016","article-title":"LEAP2 Is an endogenous antagonist of the ghrelin receptor","volume":"27","author":"Ge","year":"2018","journal-title":"Cell Metab"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1172\/JCI86270","article-title":"beta1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals","volume":"126","author":"Mani","year":"2016","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.cmet.2006.04.004","article-title":"Ablation of ghrelin improves the diabetic but not obese phenotype of ob\/ob mice","volume":"3","author":"Sun","year":"2006","journal-title":"Cell Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.2337\/db15-0124","article-title":"Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1\u03b1 (MODY3)-deficient mice","volume":"64","author":"Brial","year":"2015","journal-title":"Diabetes"},{"key":"B33","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s12020-015-0627-5","article-title":"Circulating ghrelin level is higher in HNF1A-MODY and GCK-MODY than in polygenic forms of diabetes mellitus","volume":"50","author":"Nowak","year":"2015","journal-title":"Endocrine"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1053\/j.gastro.2008.06.044","article-title":"Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice","volume":"135","author":"Verhulst","year":"2008","journal-title":"Gastroenterology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"R1807","DOI":"10.1152\/ajpregu.00785.2007","article-title":"Does ghrelin explain accelerated gastric emptying in the early stages of diabetes mellitus?","volume":"294","author":"Ariga","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1210\/en.2005-1335","article-title":"Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes","volume":"147","author":"Dong","year":"2006","journal-title":"Endocrinology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"R1703","DOI":"10.1152\/ajpregu.00773.2004","article-title":"Leptin downregulates ghrelin levels in streptozotocin-induced diabetic mice","volume":"289","author":"Tsubone","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4934","DOI":"10.1210\/en.2002-220612","article-title":"Role of ghrelin in streptozotocin-induced diabetic hyperphagia","volume":"143","author":"Ishii","year":"2002","journal-title":"Endocrinology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"4575","DOI":"10.1210\/en.2004-0605","article-title":"Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding","volume":"145","author":"Gelling","year":"2004","journal-title":"Endocrinology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0014-5793(03)00306-5","article-title":"Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes","volume":"541","author":"Masaoka","year":"2003","journal-title":"FEBS Lett"},{"key":"B41","doi-asserted-by":"publisher","first-page":"228","DOI":"10.2337\/db19-0438","article-title":"Acyl-ghrelin is permissive for the normal counterregulatory response to insulin-induced hypoglycemia","volume":"69","author":"Shankar","year":"2020","journal-title":"Diabetes"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2337\/db16-1303","article-title":"Hypoglycemic effect of combined ghrelin and glucagon receptor blockade","volume":"66","author":"Mani","year":"2017","journal-title":"Diabetes"},{"key":"B43","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1474-9726.2011.00740.x","article-title":"Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues","volume":"10","author":"Lin","year":"2011","journal-title":"Aging Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4006","DOI":"10.1210\/en.2018-00801","article-title":"Ghrelin receptor agonist rescues excess neonatal mortality in a prader-willi syndrome mouse model","volume":"159","author":"Rodriguez","year":"2018","journal-title":"Endocrinology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"9232","DOI":"10.1073\/pnas.0602956103","article-title":"Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice","volume":"103","author":"Le May","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3909","DOI":"10.1172\/JCI125332","article-title":"LEAP2 changes with body mass and food intake in humans and mice","volume":"129","author":"Mani","year":"2019","journal-title":"J Clin Invest"},{"key":"B47","doi-asserted-by":"publisher","first-page":"eaam6072","DOI":"10.1126\/scitranslmed.aam6072","article-title":"Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy","volume":"9","author":"Tsantoulas","year":"2017","journal-title":"Sci Transl Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1016\/j.cell.2015.08.018","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature21070","article-title":"Interspecies organogenesis generates autologous functional islets","volume":"542","author":"Yamaguchi","year":"2017","journal-title":"Nature."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1172\/JCI65268","article-title":"Diabetes increases mortality after myocardial infarction by oxidizing CaMKII","volume":"123","author":"Luo","year":"2013","journal-title":"J Clin Invest"},{"key":"B51","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1172\/JCI111487","article-title":"Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell line","volume":"74","author":"McEvoy","year":"1984","journal-title":"J Clin Invest"},{"key":"B52","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2010.02.010","article-title":"Antidiabetic effects of IGFBP2, a leptin-regulated gene","volume":"11","author":"Hedbacker","year":"2010","journal-title":"Cell Metab"},{"key":"B53","doi-asserted-by":"publisher","first-page":"E1300","DOI":"10.1152\/ajpendo.00041.2012","article-title":"Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells","volume":"302","author":"Sakata","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1210\/en.2012-1040","article-title":"Insulin and norepinephrine regulate ghrelin secretion from a rat primary stomach cell culture","volume":"153","author":"Gagnon","year":"2012","journal-title":"Endocrinology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.2337\/diabetes.51.10.2911","article-title":"Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia","volume":"51","author":"Lucidi","year":"2002","journal-title":"Diabetes"},{"key":"B56","doi-asserted-by":"publisher","first-page":"E313","DOI":"10.1152\/ajpendo.00569.2001","article-title":"The influence of insulin on circulating ghrelin","volume":"284","author":"Flanagan","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B57","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1530\/EJE-14-0880","article-title":"Circulating acylghrelin levels are suppressed by insulin and increase in response to hypoglycemia in healthy adult volunteers","volume":"172","author":"Lauritzen","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"E140","DOI":"10.1152\/ajpendo.00112.2013","article-title":"Overexpression of intraislet ghrelin enhances beta-cell proliferation after streptozotocin-induced beta-cell injury in mice","volume":"305","author":"Bando","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B59","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000066629","article-title":"The hypothalamic mechanisms of the hypophysiotropic action of ghrelin","volume":"76","author":"Wren","year":"2002","journal-title":"Neuroendocrinology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.psyneuen.2016.01.027","article-title":"Ghrelin activates hypophysiotropic corticotropin-releasing factor neurons independently of the arcuate nucleus","volume":"67","author":"Cabral","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1055\/s-2003-41801","article-title":"Ghrelin is released from rat hypothalamic explants and stimulates corticotrophin-releasing hormone and arginine-vasopressin","volume":"35","author":"Mozid","year":"2003","journal-title":"Horm Metab Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"5854","DOI":"10.1210\/jcem.86.12.8115","article-title":"Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure","volume":"86","author":"Nagaya","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"B63","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.lfs.2006.11.018","article-title":"The effect of centrally administered ghrelin on pituitary ACTH cells and circulating ACTH and corticosterone in rats","volume":"80","author":"Stevanovic","year":"2007","journal-title":"Life Sci"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/s41386-019-0334-7","article-title":"\u03b21-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress","volume":"44","author":"Gupta","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.2337\/diabetes.43.11.1378","article-title":"Banting lecture. Hypoglycemia: the limiting factor in the management of IDDM","volume":"43","author":"Cryer","year":"1994","journal-title":"Diabetes"},{"key":"B66","doi-asserted-by":"publisher","first-page":"E422","DOI":"10.1152\/ajpendo.00389.2004","article-title":"Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis","volume":"288","author":"Inouye","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B67","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0041-1345(97)01425-5","article-title":"Effects of high or low dose of streptozocin on pancreatic islets in C57BL\/6 and C.B17-SCID mice","volume":"30","author":"Lu","year":"1998","journal-title":"Transplant Proc"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1515\/JPEM.2005.18.12.1433","article-title":"Ghrelin, IGF-I and IGFBP-3 levels in children with type 1 diabetes mellitus","volume":"18","author":"Bideci","year":"2005","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B69","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1203\/01.PDR.0000120679.92416.70","article-title":"Response of circulating ghrelin levels to insulin therapy in children with newly diagnosed type 1 diabetes mellitus","volume":"55","author":"Soriano-Guillen","year":"2004","journal-title":"Pediatr Res"},{"key":"B70","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s00125-003-1258-6","article-title":"Abnormal ghrelin secretion in new onset childhood Type 1 diabetes","volume":"47","author":"Holdstock","year":"2004","journal-title":"Diabetologia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"E599","DOI":"10.1210\/jc.2013-3294","article-title":"Obestatin levels are associated with C-peptide and antiinsulin antibodies at the onset, whereas unacylated and acylated ghrelin levels are not predictive of long-term metabolic control in children with type 1 diabetes","volume":"99","author":"Prodam","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.2337\/diabetes.52.12.2923","article-title":"Insulin is required for prandial ghrelin suppression in humans","volume":"52","author":"Murdolo","year":"2003","journal-title":"Diabetes"},{"key":"B73","doi-asserted-by":"publisher","first-page":"647","DOI":"10.33549\/physiolres.931995","article-title":"Gut peptide hormones and pediatric type 1 diabetes mellitus","volume":"60","author":"Huml","year":"2011","journal-title":"Physiol Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"390","DOI":"10.2337\/diabetes.55.02.06.db05-0686","article-title":"Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse","volume":"55","author":"Ayala","year":"2006","journal-title":"Diabetes"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.2337\/db07-1615","article-title":"Glucose metabolism in vivo in four commonly used inbred mouse strains","volume":"57","author":"Berglund","year":"2008","journal-title":"Diabetes"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00606\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T16:20:19Z","timestamp":1599841219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.00606\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,11]]},"references-count":75,"alternative-id":["10.3389\/fendo.2020.00606"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.00606","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,11]]},"article-number":"606"}}