{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:01:35Z","timestamp":1768449695957,"version":"3.49.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.544658","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T06:39:11Z","timestamp":1603435151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Analysis of Polymorphisms rs7093069-IL-2RA, rs7138803-FAIM2, and rs1748033-PADI4 in the Group of Adolescents With Autoimmune Thyroid Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Beata","family":"Sawicka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Borysewicz-Sa\u0144czyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Wawrusiewicz-Kurylonek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Aversa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Corica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Go\u015bcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kr\u0119towski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Wa\u015bniewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Bossowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.02.007","article-title":"The etiology of autoimmune thyroid disease: a story of genes and environment","volume":"32","author":"Tomer","year":"2009","journal-title":"J Autoimmun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/1741-7015-11-73","article-title":"How do autoimmune diseases cluster in families","volume":"11","author":"Cardenas- Roldan","year":"2013","journal-title":"A Systemat Rev Meta Analys BMC Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13887","article-title":"Paediatric-onset and adult-onset Graves\u2019 disease share multiple genetic risk factors","volume":"90","author":"Ku\u015b","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3109\/08916934.2014.910767","article-title":"Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseaeses","volume":"47","author":"Bossowski","year":"2014","journal-title":"Autoimmunity"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2018.1486824","article-title":"Analysis of chosen polymorphisms rs2476601 a\/G- PTPN22, rs1990760 C\/T- IFIH1, rs179247 a\/G- TSHR in pathogenesis of autoimmune thyroid diseases in children","volume":"51","author":"Rydzewska","year":"2018","journal-title":"Autoimmunity"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000088875","article-title":"Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves\u2019 disease","volume":"64","author":"Bossowski","year":"2005","journal-title":"Horm Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0803","article-title":"Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic \u03b2-Cells","volume":"43","author":"Inshaw","year":"2020","journal-title":"Diabetes Care"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.036","article-title":"The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease","volume":"81","author":"Brunner","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2015.41","article-title":"Current Treatments for Alopecia Areata","volume":"17","author":"Hordinsky","year":"2015","journal-title":"J Invest Dermatol Symp Proc"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2018.33.2.175","article-title":"Genome-Wide Association Studies of Autoimmune Thyroid\u00a0Diseases,\u00a0Thyroid\u00a0Function, and\u00a0Thyroid\u00a0Cancer","volume":"33","author":"Hwangbo","year":"2018","journal-title":"Endocrinol Metab (Seoul)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00781","article-title":"Computational Intelligence Technique for Prediction of Multiple Sclerosis Based on Serum Cytokines","volume":"10","author":"Goyal","year":"2019","journal-title":"Front Neurol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a92c25","article-title":"Risk alleles for multiple\u00a0sclerosis\u00a0in\u00a0multiplex\u00a0families","volume":"72","author":"D\u2019Netto","year":"2009","journal-title":"Neurology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13681","article-title":"W\u00e5gs\u00e4ter D.Genetic Variants of the\u00a0IL2\u00a0Gene Related to Risk and Survival in Patients With Colorectal Cancer","volume":"39","author":"Dimberg","year":"2019","journal-title":"Anticancer Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12428","article-title":"Associations of genetic variants in\/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis","volume":"81","author":"Xi","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz161","article-title":"A Trans-ancestral Meta-Analysis of genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity","volume":"28","author":"Bradfield","year":"2019","journal-title":"Hum Mol Genet"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1039\/C7MB00104E","article-title":"Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age","volume":"13","author":"Krishnan","year":"2017","journal-title":"Mol Biosyst"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4764751","DOI":"10.1155\/2019\/4764751","article-title":"Polymorphisms in Adipokines in Mexican Children with Obesity","volume":"2019","author":"Jim\u00e9nez-Osorio","year":"2019","journal-title":"Int J Endocrinol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e007670","DOI":"10.1136\/bmjopen-2015-007670","article-title":"Influence of lifestyle on the FAIM2 promoter methylation between obese and lean children: a cohort study","volume":"5","author":"Wu","year":"2015","journal-title":"BMJ Open"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/1479164114565630","article-title":"Promoter methylation of fas apoptotic inhibitory molecule 2 gene is associated with obesity and dyslipidaemia in Chinese children","volume":"12","author":"Wu","year":"2015","journal-title":"Diabetes Vasc Dis Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/mps2030063","article-title":"One-Step ARMS-PCR for the Detection of SNPs-Using the Example of the PADI4 Gene","volume":"2","author":"Ehnert","year":"2019","journal-title":"Methods Protoc"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0080","article-title":"Five-Year Prospective Evaluation of Thyroid Function Test Evolution in Children with Hashimoto\u2019s Thyroiditis Presenting with Either Euthyroidism or Subclinical Hypothyroidism","volume":"26","author":"Aversa","year":"2016","journal-title":"Thyroid"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0484","article-title":"Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology","volume":"173","author":"Wasniewska","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3531","article-title":"Recommended tests for association in 2 x 2 tables","volume":"28","author":"Lydersen","year":"2009","journal-title":"Statist Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0751","article-title":"Peculiarities of Graves\u2019 disease in children and adolescents with Down\u2019s syndrome","volume":"162","author":"De Luca","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1159\/000357130","article-title":"Epidemiology, presentation and long-term evolution of Graves\u2019 disease in children, adolescents and young adults with Turner syndrome","volume":"81","author":"Valenzise","year":"2014","journal-title":"Horm Res Paediatr"},{"key":"B27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/genetics\/49.1.49","article-title":"The interaction of selection and linkage. I. General considerations; heterotic models","volume":"49","author":"Lewontin","year":"1964","journal-title":"Genetics"},{"key":"B28","volume-title":"A language and environment for statistical computing","year":"2012"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00024","article-title":"Protein arginine deiminases (pads): Biochemistry and chemical biology of protein citrullination","volume":"52","author":"Mondal","year":"2019","journal-title":"Acc Chem Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.06.002","article-title":"Peptidylarginine deiminase 4 and citrullination in health and disease","volume":"9","author":"Anzilotti","year":"2010","journal-title":"Autoimmun Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"20(12)","DOI":"10.3390\/ijms20123093","article-title":"Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans","volume":"25","author":"Mergaert","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13075-019-1896-9","article-title":"Increased peptidylarginine deiminases expression during the macrophage differentiation and participated inflammatory responses","volume":"21","author":"Lai","year":"2019","journal-title":"Arthritis Res Ther"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.544658\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T02:56:17Z","timestamp":1618023377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.544658\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":32,"alternative-id":["10.3389\/fendo.2020.544658"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.544658","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"article-number":"544658"}}