{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:21:33Z","timestamp":1790767293762,"version":"4.1.0"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.545638","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T01:08:31Z","timestamp":1603760911000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Possible New Strategies for the Treatment of Congenital Hyperinsulinism"],"prefix":"10.3389","volume":"11","author":[{"given":"Jelena","family":"Sikimic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Hoffmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gresch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Barthlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Wolke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Lendeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Krippeit-Drews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"D\u00fcfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Drews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2003","article-title":"Hyperinsulinism in infancy: from basic science to clinical disease","volume":"84","author":"Dunne","year":"2004","journal-title":"Physiol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/dme.13823","article-title":"Therapies and outcomes of congenital hyperinsulinism-induced hypoglycaemia","volume":"36","author":"Banerjee","year":"2019","journal-title":"Diabetes Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13633-017-0048-8","article-title":"Diagnosis and treatment of hyperinsulinaemic hypoglycaemia and its implications for paediatric endocrinology","volume":"2017","author":"Demirbilek","year":"2017","journal-title":"Int J Pediatr Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000645","article-title":"Genetic characteristics of patients with congenital hyperinsulinism","volume":"30","author":"Vajravelu","year":"2018","journal-title":"Curr Opin Pediatr"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00111","article-title":"The Genetic and Molecular Mechanisms of Congenital Hyperinsulinism","volume":"10","author":"Galcheva","year":"2019","journal-title":"Front Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.sempedsurg.2010.10.010","article-title":"Morphologic analysis of focal and diffuse forms of congenital hyperinsulinism","volume":"20","author":"Rahier","year":"2011","journal-title":"Semin Pediatr Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-3032","article-title":"Morphological mosaicism of the pancreatic islets: a novel anatomopathological form of persistent hyperinsulinemic hypoglycemia of infancy","volume":"96","author":"Sempoux","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.148171","article-title":"Hyperinsulinaemic hypoglycaemia","volume":"94","author":"Kapoor","year":"2009","journal-title":"Arch Dis Child"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.26.127","article-title":"Clinical practice guidelines for congenital hyperinsulinism","volume":"26","author":"Yorifuji","year":"2017","journal-title":"Clin Pediatr Endocrinol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"F98","DOI":"10.1136\/fn.82.2.F98","article-title":"Practical management of hyperinsulinism in infancy","volume":"82","author":"Aynsley-Green","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30323-0","article-title":"Hyperinsulinaemic hypoglycaemia in children and adults","volume":"5","author":"Shah","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13023-015-0367-x","article-title":"Long-term medical treatment in congenital hyperinsulinism: a descriptive analysis in a large cohort of patients from different clinical centers","volume":"10","author":"Welters","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2007.20.8.939","article-title":"Development of pulmonary hypertension in an infant treated with diazoxide","volume":"20","author":"Nebesio","year":"2007","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-008-0049-3","article-title":"Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy","volume":"25","author":"Yildizdas","year":"2008","journal-title":"Adv Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2011.238","article-title":"Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide","volume":"24","author":"Demirel","year":"2011","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1652-3","article-title":"Development of Pulmonary Hypertension During Treatment with Diazoxide: A Case Series and Literature Review","volume":"38","author":"Timlin","year":"2017","journal-title":"Pediatr Cardiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000129680","article-title":"Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon","volume":"70","author":"Mohnike","year":"2008","journal-title":"Horm Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0115","article-title":"Successful subcutaneous glucagon use for persistent hypoglycaemia in congenital hyperinsulinism","volume":"26","author":"Neylon","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051049","article-title":"Treatment of hyperinsulinaemic hypoglycaemia with nifedipine","volume":"158","author":"Eichmann","year":"1999","journal-title":"Eur J Pediatr"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0605","article-title":"Treatment of congenital hyperinsulinism with lanreotide acetate (Somatuline Autogel)","volume":"96","author":"Modan-Moses","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0874","article-title":"Successful treatment of congenital hyperinsulinism with long-acting release octreotide","volume":"166","author":"Le Quan Sang","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1404716","article-title":"Sirolimus in severe hyperinsulinemic hypoglycemia","volume":"370","author":"Senniappan","year":"2014","journal-title":"N Engl J Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1999.12.6.873","article-title":"Successful therapy with calcium channel blocker (nifedipine) in persistent neonatal hyperinsulinemic hypoglycemia of infancy","volume":"12","author":"Ba\u015f","year":"1999","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00207.2012","article-title":"SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells","volume":"303","author":"Kailey","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2004.t01-1-pto950502.x","article-title":"Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential","volume":"95","author":"Gromada","year":"2004","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1159\/000443959","article-title":"Late Presentation of Fulminant Necrotizing Enterocolitis in a Child with Hyperinsulinism on Octreotide Therapy","volume":"86","author":"Hawkes","year":"2016","journal-title":"Horm Res Paediatr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/pds.4144","article-title":"Octreotide use and safety in infants with hyperinsulinism","volume":"26","author":"McMahon","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1866","article-title":"Long-term follow-up of children with congenital hyperinsulinism on octreotide therapy","volume":"99","author":"Demirbilek","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.1230","article-title":"A combination of nifedipine and octreotide treatment in an hyperinsulinemic hypoglycemic infant","volume":"6","author":"Durmaz","year":"2014","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2711","article-title":"mTOR Inhibitors for the Treatment of Severe Congenital Hyperinsulinism: Perspectives on Limited Therapeutic Success","volume":"101","author":"Szymanowski","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13023-017-0621-5","article-title":"Extreme caution on the use of sirolimus for the congenital hyperinsulinism in infancy patient","volume":"12","author":"Banerjee","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088684","article-title":"Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity","volume":"9","author":"Corbin","year":"2014","journal-title":"PloS One"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.26871","article-title":"Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia","volume":"6","author":"Corbin","year":"2014","journal-title":"MAbs"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814529886","article-title":"Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders","volume":"8","author":"Issafras","year":"2014","journal-title":"J Diabetes Sci Technol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1080\/19420862.2018.1457599","article-title":"A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1(-\/-) mouse model of KATP hyperinsulinism","volume":"10","author":"Patel","year":"2018","journal-title":"MAbs"},{"key":"B36","article-title":"Activity of Xoma 358, an Inhibitor of Insulin Action Following Short-Term Administration to Congenital Hyperinsulinism Patients","volume":"38","author":"Johnson","year":"2017","journal-title":"Endocrine Rev June"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.17458\/PER.2016.BVE.Surgeryinfocal","article-title":"Surgery in Focal Congenital Hyperinsulinism (CHI) - The \u201cHyperinsulinism Germany International\u201d Experience in 30 Children","volume":"14","author":"Barthlen","year":"2016","journal-title":"Pediatr Endocrinol Rev"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.019","article-title":"A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy","volume":"39","author":"Adzick","year":"2004","journal-title":"J Pediatr Surg"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000321902","article-title":"Techniques in pediatric surgery: congenital hyperinsulinism","volume":"74","author":"Barthlen","year":"2010","journal-title":"Horm Res Paediatr"},{"key":"B40","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jpedsurg.2018.10.030","article-title":"Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children","volume":"54","author":"Adzick","year":"2019","journal-title":"J Pediatr Surg"},{"key":"B41","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/S0022-3468(99)90374-3","article-title":"Congenital hyperinsulinism and the surgeon: lessons learned over 35 years","volume":"34","author":"Lovvorn","year":"1999","journal-title":"J Pediatr Surg"},{"key":"B42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1530\/eje.0.1490043","article-title":"Long-term follow-up of 114 patients with congenital hyperinsulinism","volume":"149","author":"Meissner","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2010.10.002","article-title":"Surgery in congenital hyperinsulinism-tips and tricks not only for surgeons. A practical guide","volume":"20","author":"Barthlen","year":"2011","journal-title":"Semin Pediatr Surg"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5269.1785","article-title":"Adenosine diphosphate as an intracellular regulator of insulin secretion","volume":"272","author":"Nichols","year":"1996","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35414","article-title":"Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations","volume":"118","author":"Pinney","year":"2008","journal-title":"J Clin Invest"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01152.x","article-title":"The spectrum of ABCC8 mutations in Norwegian patients with congenital hyperinsulinism of infancy","volume":"75","author":"Sandal","year":"2009","journal-title":"Clin Genet"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2207-4","article-title":"Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8\/KCNJ11 mutations","volume":"54","author":"Kapoor","year":"2011","journal-title":"Diabetologia"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2169","article-title":"Genotype and phenotype correlations in 417 children with congenital hyperinsulinism","volume":"98","author":"Snider","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.11.1813","article-title":"Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews","volume":"5","author":"Nestorowicz","year":"1996","journal-title":"Hum Mol Genet"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.7.1119","article-title":"Genetic heterogeneity in familial hyperinsulinism","volume":"7","author":"Nestorowicz","year":"1998","journal-title":"Hum Mol Genet"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0353","article-title":"Clinical and histological heterogeneity of congenital hyperinsulinism due to paternally inherited heterozygous ABCC8\/KCNJ11 mutations","volume":"171","author":"Arya","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/humu.23995","article-title":"Update of variants identified in the pancreatic \u03b2-cell KATP channel genes KCNJ11 and ABCC8 in individuals with congenital hyperinsulinism and diabetes","volume":"41","author":"De Franco","year":"2020","journal-title":"Hum Mutat"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00619","article-title":"Clinical Diversity in Focal Congenital Hyperinsulinism in Infancy Correlates With Histological Heterogeneity of Islet Cell Lesions","volume":"9","author":"Craigie","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1530\/eje-11-0160","article-title":"Characterization of ABCC8 and KCNJ11 gene mutations and phenotypes in Korean patients with congenital hyperinsulinism","volume":"164","author":"Park","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0673","article-title":"Clinical and molecular characterisation of 300 patients with congenital hyperinsulinism","volume":"168","author":"Kapoor","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0072","article-title":"Congenital hyperinsulinism in a newborn with a novel homozygous mutation (p.Q392H) in the ABCC8 gene","volume":"27","author":"Ince","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B57","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13023-017-0653-x","article-title":"Treatment with long-acting lanreotide autogel in early infancy in patients with severe noenatal hyperinuslinism","volume":"12","author":"Corda","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38817","article-title":"Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress","volume":"119","author":"Gier","year":"2009","journal-title":"J Clin Invest"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3577-9","article-title":"Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells","volume":"58","author":"Edalat","year":"2015","journal-title":"Diabetologia"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005236","article-title":"ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels","volume":"294","author":"Sikimic","year":"2019","journal-title":"J Biol Chem"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0991","article-title":"Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion","volume":"57","author":"Braun","year":"2008","journal-title":"Diabetes"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1198-1","article-title":"Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues","volume":"46","author":"Dabrowski","year":"2003","journal-title":"Diabetologia."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9270","article-title":"Sur1 knockout mice. A model for KATP channel-independent regulation of insulin secretion","volume":"275","author":"Seghers","year":"2000","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0997-0","article-title":"Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression\u2013possible involvement of the mitochondrial membrane potential","volume":"46","author":"Kullin","year":"2003","journal-title":"Diabetologia."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-015-1707-3","article-title":"Evidence against a Ca(2+)-induced potentiation of dehydrogenase activity in pancreatic beta-cells","volume":"467","author":"Drews","year":"2015","journal-title":"Pflugers Arch"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1921","article-title":"Parallel oscillations of intracellular calcium activity and mitochondrial membrane potential in mouse pancreatic B-cells","volume":"267","author":"Krippeit-Drews","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1530\/EDM-18-0120","article-title":"Partial diazoxide responsiveness in a neonate with hyperinsulinism due to homozygous ABCC8 mutation","volume":"2019","author":"Kiff","year":"2019","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1628","article-title":"The heterogeneity of focal forms of congenital hyperinsulinism","volume":"97","author":"Ismail","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B69","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1172\/JCI9804","article-title":"Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1","volume":"106","author":"Huopio","year":"2000","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.091884","article-title":"Direct activation of beta-cell KATP channels with a novel xanthine derivative","volume":"85","author":"Raphemot","year":"2014","journal-title":"Mol Pharmacol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1941","article-title":"The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism","volume":"158","author":"Maczewsky","year":"2017","journal-title":"Endocrinology"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-3271-3_7","article-title":"Electrophysiology of islet cells","volume":"654","author":"Drews","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.2000","article-title":"Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses","volume":"52","author":"Tamarina","year":"2003","journal-title":"Diabetes"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1324","article-title":"Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells","volume":"58","author":"D\u00fcfer","year":"2009","journal-title":"Diabetes."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.190207","article-title":"Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses","volume":"588","author":"Jacobson","year":"2010","journal-title":"J Physiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1936-0","article-title":"BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells","volume":"54","author":"D\u00fcfer","year":"2011","journal-title":"Diabetologia"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.20028581","article-title":"Calcium-activated K+Channels of Mouse \u03b2-cells are Controlled by Both Store and Cytoplasmic Ca2+","volume":"120","author":"Goforth","year":"2002","journal-title":"J Gen Physiol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.114.6.759","article-title":"Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells","volume":"114","author":"G\u00f6pel","year":"1999","journal-title":"J Gen Physiol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.031344","article-title":"Glucose-dependent regulation of rhythmic action potential firing in pancreatic \u03b2-cells by kATP-channel modulation","volume":"545","author":"Kanno","year":"2002","journal-title":"J Physiol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/nn1449","article-title":"SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines","volume":"8","author":"Ngo-Anh","year":"2005","journal-title":"Nat Neurosci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3822","article-title":"Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment","volume":"21","author":"Marquard","year":"2015","journal-title":"Nat Med"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91497-7","article-title":"Dextromethorphan and dextrorphan as calcium channel antagonists","volume":"439","author":"Carpenter","year":"1988","journal-title":"Brain Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60991-9","article-title":"Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials","volume":"375","author":"Sattar","year":"2010","journal-title":"Lancet"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702397","article-title":"Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells","volume":"126","author":"Yada","year":"1999","journal-title":"Br J Pharmacol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142902","article-title":"Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells","volume":"10","author":"Yaluri","year":"2015","journal-title":"PloS One"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2916","article-title":"Assessment of Nifedipine Therapy in Hyperinsulinemic Hypoglycemia due to Mutations in the ABCC8 Gene","volume":"102","author":"G\u00fcemes","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12400","article-title":"Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening","volume":"81","author":"Maiorana","year":"2014","journal-title":"Clin Endocrinol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1177\/000992280204100310","article-title":"Compound heterozygosity for the common sulfonylurea receptor mutations can cause mild diazoxide-sensitive hyperinsulinism","volume":"41","author":"Dekel","year":"2002","journal-title":"Clin Pediatr (Phila)"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.06.007","article-title":"Multiplicity of effectors of the cardioprotective agent, diazoxide","volume":"140","author":"Coetzee","year":"2013","journal-title":"Pharmacol Ther"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.12162","article-title":"Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP","volume":"96","author":"D\u2019Hahan","year":"1999","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23643.x","article-title":"Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles","volume":"124","author":"Davies","year":"2005","journal-title":"J Invest Dermatol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb05123.x","article-title":"Hypertrichosis due to diazoxide","volume":"93","author":"Burton","year":"1975","journal-title":"Br J Dermatol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365026","article-title":"Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders","volume":"11","author":"Hansen","year":"2004","journal-title":"Curr Med Chem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1210\/jc.2003-031120","article-title":"Induction of beta-cell rest by a Kir6.2\/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose","volume":"89","author":"Ritzel","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1021\/jm0208121","article-title":"6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells","volume":"45","author":"Nielsen","year":"2002","journal-title":"J Med Chem"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.10.027","article-title":"Attenuation of hyperinsulinemia by NN414, a SUR1\/Kir6.2 selective K+-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats","volume":"53","author":"Alemzadeh","year":"2004","journal-title":"Metabolism."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005276947","article-title":"The effects of NN414, a SUR1\/Kir6.2 selective potassium channel opener, in healthy male subjects","volume":"45","author":"Zdravkovic","year":"2005","journal-title":"J Clin Pharmacol"},{"key":"B98","article-title":"NN-414. Novo Nordisk","volume":"4","author":"Choi","year":"2003","journal-title":"Curr Opin Invest Drugs"},{"key":"B99","article-title":"Recent advances in therapeutic approaches to type 2 diabetes","volume-title":"Annual Reports in Medicinal Chemistry","author":"Sarabu","year":"2005"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973062","article-title":"The effects of NN414, a SUR1\/Kir6.2 selective potassium channel opener in subjects with type 2 diabetes","volume":"115","author":"Zdravkovic","year":"2007","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0372","article-title":"Hepatitis in an infant treated with octreotide for congenital hyperinsulinism","volume":"26","author":"Koren","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0349","article-title":"Octreotide-induced hepatitis in a child with persistent hyperinsulinemia hypoglycemia of infancy","volume":"26","author":"Ben-Ari","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.2.F79","article-title":"Genetics of neonatal hyperinsulinism","volume":"82","author":"Glaser","year":"2000","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B104","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1053\/j.sempedsurg.2010.10.012","article-title":"KATP channel mutations in congenital hyperinsulinism","volume":"20","author":"Saint-Martin","year":"2011","journal-title":"Semin Pediatr Surg"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1631","article-title":"Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the beta-cell sulfonylurea receptor SUR1","volume":"60","author":"Macmullen","year":"2011","journal-title":"Diabetes"},{"key":"B106","article-title":"Octreotide, a new somatostatin analogue","volume":"8","author":"Katz","year":"1989","journal-title":"Clin Pharm"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.7","article-title":"Pharmacological agents that directly modulate insulin secretion","volume":"55","author":"Doyle","year":"2003","journal-title":"Pharmacol Rev"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800174-5.00007-7","article-title":"The somatostatin receptor in human pancreatic beta-cells","volume":"95","author":"Braun","year":"2014","journal-title":"Vitam Horm"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1159\/000439131","article-title":"Use of Long-Acting Somatostatin Analogue (Lanreotide) in an Adolescent with Diazoxide-Responsive Congenital Hyperinsulinism and Its Psychological Impact","volume":"84","author":"Shah","year":"2015","journal-title":"Horm Res Paediatr"},{"key":"B110","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000491101","article-title":"The Use of a Long-Acting Somatostatin Analogue (Lanreotide) in Three Children with Focal Forms of Congenital Hyperinsulinaemic Hypoglycaemia","volume":"91","author":"Dastamani","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1159\/000485184","article-title":"A Multicenter Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism","volume":"89","author":"van der Steen","year":"2018","journal-title":"Horm Res Paediatr"},{"key":"B112","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1530\/ey.16.2.4","article-title":"Sirolimus: Efficacy and Complications in Children With Hyperinsulinemic Hypoglycemia: A 5-Year Follow-Up Study","volume":"3","author":"G\u00fcemes","year":"2019","journal-title":"J Endocr Soc"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1324","article-title":"Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue","volume":"59","author":"Houde","year":"2010","journal-title":"Diabetes"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1232342100","article-title":"The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells","volume":"100","author":"Hoffman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409627200","article-title":"Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4","volume":"279","author":"Begenisich","year":"2004","journal-title":"J Biol Chem"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.275.3.C848","article-title":"Characterization of the cloned human intermediate-conductance Ca2+-activated K+ channel","volume":"275","author":"Jensen","year":"1998","journal-title":"Am J Physiol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90042-6","article-title":"Antagonist drug selectivity for radioligand binding sites on voltage-gated and N-methyl-D-aspartate receptor-gated Ca2+ channels","volume":"105","author":"Jaffe","year":"1989","journal-title":"Neurosci Lett"},{"key":"B119","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1124\/jpet.120.265835","article-title":"Dextromethorphan and dextrorphan influence insulin secretion by interacting with KATP and L-type Ca(2+) channels in pancreatic beta-cells","volume":"375","author":"Gresch","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.071","article-title":"Statin-Associated Side Effects","volume":"67","author":"Thompson","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/srep14076","article-title":"Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis","volume":"5","author":"Gotoh","year":"2015","journal-title":"Sci Rep"},{"key":"B122","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12933-018-0738-4","article-title":"Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy","volume":"17","author":"van Stee","year":"2018","journal-title":"Cardiovasc Diabetol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.545638\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T01:08:35Z","timestamp":1603760915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.545638\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":122,"alternative-id":["10.3389\/fendo.2020.545638"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.545638","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"article-number":"545638"}}