{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:35Z","timestamp":1791946115319,"version":"4.3.4"},"reference-count":189,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.563816","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T02:28:40Z","timestamp":1601951320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["The Impact of Adipose Tissue\u2013Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer"],"prefix":"10.3389","volume":"11","author":[{"given":"Gabriella Sim\u00f5es","family":"Heyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Henrique","family":"Corr\u00eaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly Grace","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.metabol.2018.10.011","article-title":"Obesity and cardiovascular disease: revisiting an old relationship","volume":"92","author":"Koliaki","year":"2019","journal-title":"Metabolism"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15046184","article-title":"Obesity and its metabolic complications: The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease","volume":"15","author":"Jung","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936.Rapid","article-title":"Rapid Publication Obesity and Insulin Resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J Clin Invest"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"De Pergola","year":"2013","journal-title":"J Obes"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2603","article-title":"Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer","volume":"19","author":"Howe","year":"2013","journal-title":"Clin Cancer Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, Inflammation, and Insulin Resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-4572.2008.00044.x.The","article-title":"The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus","volume":"4","author":"Ginsberg","year":"2009","journal-title":"J Cardiometab Syndr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0154003","article-title":"The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in modest obesity and early metabolic dysfunction","volume":"11","author":"Kang","year":"2016","journal-title":"PloS One"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/289645.123","article-title":"Inflammation and the Metabolic Syndrome","volume":"26","author":"Sharma","year":"2011","journal-title":"Indian J Biochem"},{"key":"B10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.trsl.2017.10.004","article-title":"Macrophage polarization and meta-inflammation","volume":"191","author":"Li","year":"2018","journal-title":"Transl Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070662","article-title":"The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression","volume":"8","author":"Corr\u00eaa","year":"2019","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0219-6","article-title":"Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells","volume":"43","author":"Ejarque","year":"2019","journal-title":"Int J Obes"},{"key":"B14","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/nature13477","article-title":"The different shades of fat","volume":"510","author":"Peirce","year":"2014","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0295","article-title":"New insights into the secretory functions of brown adipose tissue","volume":"243","author":"Villarroya","year":"2019","journal-title":"J Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.cmet.2019.10.001","article-title":"Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine","volume":"30","author":"Deshmukh","year":"2019","journal-title":"Cell Metab"},{"key":"B17","doi-asserted-by":"publisher","first-page":"13891","DOI":"10.1038\/s41598-019-50210-3","article-title":"MicroRNA-27a\/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis","volume":"9","author":"Kulyt\u00e9","year":"2019","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tem.2018.01.001","article-title":"The Common and Distinct Features of Brown and Beige Adipocytes","volume":"29","author":"Ikeda","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0945","article-title":"MECHANISMS IN ENDOCRINOLOGY: White, brown and pink adipocytes: the extraordinary plasticity of the adipose organ","volume":"170","author":"Giordano","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.05.007","article-title":"Pink Adipocytes","volume":"29","author":"Cinti","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"B21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.biochi.2004.10.019","article-title":"Positive and negative regulation of insulin signaling through IRS-1 phosphorylation","volume":"87","author":"Gual","year":"2005","journal-title":"Biochimie"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.371","article-title":"JNK Expression by Macrophages Promotes Obesity-induced Insulin Resistance and Inflammation","volume":"339","author":"Han","year":"2013","journal-title":"Sci (80- )"},{"key":"B23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1172\/JCI200319246.Introduction","article-title":"Obesity is associated with macrophage accumulation","volume":"12","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.11.001","article-title":"Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation","volume":"18","author":"Xu","year":"2013","journal-title":"Cell Metab"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2020.23.e35","article-title":"Obesity and breast cancer: The role of crown-like structures in breast adipose tissue in tumor progression, prognosis, and therapy","volume":"23","author":"Faria","year":"2020","journal-title":"J Breast Cancer"},{"key":"B26","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: Mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage Polarization in Inflammatory Diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int J Biol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01097","article-title":"Regulation of human Macrophage M1-M2 Polarization Balance by hypoxia and the Triggering receptor expressed on Myeloid cells-1","volume":"8","author":"Raggi","year":"2017","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0872","article-title":"Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes","volume":"57","author":"Lumeng","year":"2008","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3892\/ijmm.2013.1260","article-title":"Expression profiles of miRNAs in polarized macrophages","volume":"31","author":"Zhang","year":"2013","journal-title":"Int J Mol Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0114-1","article-title":"MicroRNA-30 modulates metabolic inflammation by regulating Notch signaling in adipose tissue macrophages","volume":"42","author":"Miranda","year":"2018","journal-title":"Int J Obes"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.739839","article-title":"MicroRNA-155 deficiency leads to decreased atherosclerosis, increased white adipose tissue obesity, and non-alcoholic fatty liver disease a novel mouse model of obesity paradox","volume":"292","author":"Virtue","year":"2017","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/scitranslmed.aav1892","article-title":"The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs","volume":"11","author":"Virtue","year":"2019","journal-title":"Sci Transl Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/484696","article-title":"MicroRNAs in insulin resistance and obesity","volume":"2012","author":"Williams","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-014-0315-9","article-title":"Differential Inflammatory MicroRNA and Cytokine Expression in Pulmonary Sarcoidosis","volume":"63","author":"Jazwa","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132514.111.22","article-title":"Impact of microRNA regulation on variation in human geneexpression","volume":"7","author":"Lu","year":"2012","journal-title":"Genome Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of microRNA biogenesis, mechanisms of actions, and circulation","volume":"9","author":"O\u2019Brien","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-25578-3","article-title":"Distinguishing mirtrons from canonical miRNAs with data exploration and machine learning methods","volume":"8","author":"Rorbach","year":"2018","journal-title":"Sci Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.08.028","article-title":"MRNA Destabilization Is the dominant effect of mammalian microRNAs by the time substantial repression ensues","volume":"56","author":"Eichhorn","year":"2014","journal-title":"Mol Cell"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2174\/156652411795677990","article-title":"microRNAs in the regulation of adipogenesis and obesity","volume":"11","author":"McGregor","year":"2011","journal-title":"Curr Mol Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73468","article-title":"Altered miRNA processing disrupts brown\/white adipocyte determination and associates with lipodystrophy","volume":"124","author":"Mori","year":"2014","journal-title":"J Clin Invest"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.199","article-title":"Lipodystrophy\u202f: Pathophysiology and advances intreatment","volume":"7","author":"Fiorenza","year":"2011","journal-title":"Nature Reviews Endocrinol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7372636","article-title":"Li Y. A New Insight into the Roles of MiRNAs in Metabolic Syndrome","volume":"2018","author":"Huang","year":"2018","journal-title":"BioMed Res Int"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2835761","article-title":"Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response","volume":"2018","author":"Zhong","year":"2018","journal-title":"J Immunol Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0260-0","article-title":"The clinical potential of circulating microRNAs in obesity","volume":"15","author":"Ji","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808855115","article-title":"Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice","volume":"115","author":"Casta\u00f1o","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2286.MiR-193b-365","article-title":"MiR-193b-365, a brown fat enriched microRNA cluster, is essential for brown fat differentiation","volume":"13","author":"Sun","year":"2012","journal-title":"Nat Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e1001314","DOI":"10.1371\/journal.pbio.1001314","article-title":"Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells","volume":"10","author":"Mori","year":"2012","journal-title":"PloS Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1517\/14728220903190707","article-title":"Targeting microRNAs in obesity","volume":"13","author":"Xie","year":"2009","journal-title":"Expert Opin Ther Targets"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.01.004.MicroRNA-133","article-title":"MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16","volume":"17","author":"Yin","year":"2014","journal-title":"Cell Metab"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e1003626","DOI":"10.1371\/journal.pgen.1003626","article-title":"miR-133a Regulates Adipocyte Browning In Vivo","volume":"9","author":"Liu","year":"2013","journal-title":"PloS Genet"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2011.07.004","article-title":"MiR-27 promotes human gastric cancer cell metastasis by inducing epithelial-to-mesenchymal transition","volume":"204","author":"Zhang","year":"2011","journal-title":"Cancer Genet"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.10.004","article-title":"MiR-27 orchestrates the transcriptional regulation of brown adipogenesis","volume":"63","author":"Sun","year":"2014","journal-title":"Metabolism"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1603","article-title":"MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes","volume":"32","author":"Karbiener","year":"2014","journal-title":"Stem Cells"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.95","article-title":"MiR-26b modulates insulin sensitivity in adipocytes by interrupting the PTEN\/PI3K\/AKT pathway","volume":"39","author":"Xu","year":"2015","journal-title":"Int J Obes"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2211","article-title":"Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism","volume":"13","author":"Jordan","year":"2011","journal-title":"Nat Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.1.14259","article-title":"MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1","volume":"8","author":"Cho","year":"2011","journal-title":"RNA Biol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00596-14","article-title":"MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function","volume":"34","author":"Fu","year":"2014","journal-title":"Mol Cell Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-012-0186-5","article-title":"MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1","volume":"13","author":"Li","year":"2013","journal-title":"Clin Exp Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540837","article-title":"MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1 signaling network","volume":"16","author":"Zhang","year":"2015","journal-title":"EMBO Rep"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/354517","article-title":"Human miR-221\/222 in physiological and atherosclerotic vascularremodeling","volume":"2015","author":"Chistiakov","year":"2015","journal-title":"BioMed Res Int"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gm272","article-title":"MicroRNAs miR-221 and miR-222: A new level of regulation inaggressive breast cancer","volume":"3","author":"Shah","year":"2011","journal-title":"Genome Med"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-697003","article-title":"MiR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics","volume":"128","author":"Duroux-Richard","year":"2016","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.06.005","article-title":"miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function","volume":"5","author":"Giroud","year":"2016","journal-title":"Mol Metab"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05207.x","article-title":"Changes in microrna (mir) profile and effects of mir-320 in insulin-resistant 3t3-l1 adipocytes","volume":"36","author":"Ling","year":"2009","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.12.007.Peroxiredoxin","article-title":"MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis","volume":"328","author":"Najafi-Shoushtari","year":"2010","journal-title":"Sci (80- )"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810550106","article-title":"miR-375 maintains normal pancreatic alpha- and beta-cell mass","volume":"106","author":"Poy","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19742","article-title":"MiR-377 promotes white adipose tissue inflammation and decreases insulin sensitivity in obesity via suppression of sirtuin-1 (SIRT1)","volume":"8","author":"Peng","year":"2017","journal-title":"Oncotarget"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1002\/stem.235","article-title":"MiR-21 regulates adipogenic differentiation through the modulation of TGF-\u03b2 signaling in mesenchymal stem cells derived from human adipose tissue","volume":"27","author":"Jeong Kim","year":"2009","journal-title":"Stem Cells"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1159\/000481648","article-title":"MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer","volume":"43","author":"Wu","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.01276-10","article-title":"MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 Activity during Prolonged Hypoxia","volume":"31","author":"Bruning","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.10.17681","article-title":"Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells","volume":"12","author":"Babar","year":"2011","journal-title":"Cancer Biol Ther"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2014.09.005","article-title":"MicroRNA functions in brite\/brown fat - Novel perspectives towards anti-obesity strategies","volume":"11","author":"Karbiener","year":"2014","journal-title":"Comput Struct Biotechnol J"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.05.011","article-title":"Adipose tissue plasticity from WAT to BAT and in between","volume":"1842","author":"Lee","year":"2014","journal-title":"Biochim Biophys Acta  Mol Basis Dis"},{"key":"B77","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.redox.2017.01.020","article-title":"Shortcuts to a functional adipose tissue: The role of small non-coding RNAs","volume":"12","author":"Brand\u00e3o","year":"2017","journal-title":"Redox Biol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0466","article-title":"MicroRNAs Are Required for the Feature Maintenance and Differentiation of Brown Adipocytes","volume":"63","author":"Kim","year":"2014","journal-title":"Diabetes"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328337a81f.Brown","article-title":"Brown fat as a therapy for obesity and diabetes","volume":"17","author":"Cypess","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00027","article-title":"Humans and Mice Display Opposing Patterns of \u201cBrowning\u201d Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots","volume":"4","author":"Zuriaga","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2014-0241","article-title":"miR-103 promotes 3T3-L1 cell adipogenesis through AKT\/mTOR signal pathway with its target being MEF2D","volume":"396","author":"Li","year":"2015","journal-title":"Biol Chem"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M082602","article-title":"miR-103\/107 promote ER stress-mediated apoptosis via targeting the Wnt3a\/\u03b2-catenin\/ATF6 pathway in preadipocytes","volume":"59","author":"Zhang","year":"2018","journal-title":"J Lipid Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2612","article-title":"MyomiR-133 regulates brown fat differentiation through Prdm16","volume":"14","author":"Trajkovski","year":"2012","journal-title":"Nat Cell Biol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1038\/ncomms2742","article-title":"miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit","volume":"4","author":"Chen","year":"2013","journal-title":"Nat Commun"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.06967.x","article-title":"A role of miR-27 in the regulation of adipogenesis","volume":"276","author":"Lin","year":"2009","journal-title":"FEBS J"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmu036","article-title":"miR-27 inhibits adipocyte differentiation via suppressing CREB expression","volume":"46","author":"Zhu","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21319","article-title":"miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase","volume":"23","author":"Chen","year":"2015","journal-title":"Obesity"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.514372","article-title":"MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells","volume":"288","author":"Kang","year":"2013","journal-title":"J Biol Chem"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.3712","article-title":"miR-26b Promotes 3T3-L1 Adipocyte Differentiation Through Targeting PTEN","volume":"36","author":"Li","year":"2017","journal-title":"DNA Cell Biol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00894-10","article-title":"miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor Expression","volume":"31","author":"Lee","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2365609","article-title":"Novel Browning Agents, Mechanisms, and Therapeutic Potentials ofBrown Adipose Tissue","volume":"2016","author":"Wankhade","year":"2016","journal-title":"BioMed Res Int"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21621","article-title":"Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes","volume":"218","author":"Walden","year":"2009","journal-title":"J Cell Physiol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-010-0226-0","article-title":"Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: A clinical study","volume":"48","author":"Kong","year":"2011","journal-title":"Acta Diabetol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00205","article-title":"MicroRNA regulation of brown adipogenesis and thermogenic energy expenditure","volume":"8","author":"Shamsi","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1508","article-title":"Adipose tissue MicroRNAs as regulators of CCL2 production in human obesity","volume":"61","author":"Arner","year":"2012","journal-title":"Diabetes"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2105","article-title":"Expression profiling of PPAR\u03b3-regulated MicroRNAs in human subcutaneous and visceral adipogenesis in both genders","volume":"155","author":"Yu","year":"2014","journal-title":"Endocrinology"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.195776","article-title":"Targeting the circulating microRNA signature of obesity","volume":"59","author":"Ortega","year":"2013","journal-title":"Clin Chem"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00251.2016","article-title":"Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women","volume":"312","author":"Dahlman","year":"2017","journal-title":"Am J Physiol  Endocrinol Metab"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080859","article-title":"MicroRNAs in Obesity and Related Metabolic Disorders","volume":"8","author":"Landrier","year":"2019","journal-title":"Cells"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.7638","article-title":"MicroRNAs and cancer: Key paradigms in molecular therapy (Review)","volume":"15","author":"Tan","year":"2018","journal-title":"Oncol Lett"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8","article-title":"The metabolic syndrome\u2014a new worldwide definition","volume":"366","author":"Alberti","year":"2005","journal-title":"Lancet"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and Management of the Metabolic Syndrome","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"B103","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ijo.2015.170","article-title":"MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics","volume":"40","author":"Deiuliis","year":"2016","journal-title":"Int J Obes"},{"key":"B104","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.intimp.2016.01.009","article-title":"MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages","volume":"32","author":"Huang","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.561317","article-title":"MicroRNAs in adipogenesis and as therapeutic targets forobesity","volume":"5","author":"Alexander","year":"2011","journal-title":"Expert Opin Ther Targets"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3862","article-title":"The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes","volume":"21","author":"Belgardt","year":"2015","journal-title":"Nat Med"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73066","article-title":"MicroRNA-7a regulates pancreatic \u03b2 cell function","volume":"124","author":"Latreille","year":"2014","journal-title":"J Clin Invest"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.087817","article-title":"A novel regulator of macrophage activation: MiR-223 in obesity-associated adipose tissue\u00a0inflammation","volume":"125","author":"Zhuang","year":"2012","journal-title":"Circulation"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1593\/neo.13998","article-title":"MicroRNA-130b Promotes Tumor Development and Is Associated with Poor Prognosis in Colorectal Cancer","volume":"15","author":"Colangelo","year":"2013","journal-title":"Neoplasia"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.094524","article-title":"A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition","volume":"285","author":"Lee","year":"2010","journal-title":"J Biol Chem"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.094524","article-title":"A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition","volume":"285","author":"Kemper","year":"2010","journal-title":"J Biol Chem"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12135","article-title":"Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT","volume":"12","author":"Choi","year":"2013","journal-title":"Aging Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.5.16153","article-title":"MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2","volume":"8","author":"Karbiener","year":"2011","journal-title":"RNA Biol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00472","article-title":"Regulation of IGF -1 signaling by microRNAs","volume":"5","author":"Jung","year":"2015","journal-title":"Front Genet"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7267910","article-title":"MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expressionand Translocation in Insulin Resistance","volume":"2017","author":"Esteves","year":"2017","journal-title":"J Diabetes Res"},{"key":"B116","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.06.020","article-title":"MicroRNAs as stress regulators in pancreatic beta cells and diabetes","volume":"6","author":"LaPierre","year":"2017","journal-title":"Mol Metab"},{"key":"B118","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1139\/bcb-2012-0053","article-title":"The physiological and pathophysiological roles of adipocyte miRNAs","volume":"91","author":"Ling","year":"2013","journal-title":"Biochem Cell Biol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0963","article-title":"Mirna-93 inhibits glut4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance","volume":"62","author":"Chen","year":"2013","journal-title":"Diabetes"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1614","article-title":"miR-375 targets 3\u2019-phosphoinositide-dependent protein kinase-1 and regulated glucose-induced biological responses in pancreatic beta-cells","volume":"57","author":"El Ouaamari","year":"2008","journal-title":"Diabetes"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3892\/br.2013.88","article-title":"Expression levels of microRNA-375 in pancreatic cancer","volume":"1","author":"Song","year":"2013","journal-title":"BioMed Rep"},{"key":"B122","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12986-017-0176-4","article-title":"Case-control study of metabolic syndrome and ovarian cancer in Chinese population","volume":"14","author":"Chen","year":"2017","journal-title":"Nutr Metab (Lond)"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0336","article-title":"Metabolic Syndrome and Risk of Cancer: A systematic review and meta-analysis","volume":"35","author":"Esposito","year":"2012","journal-title":"Diabetes Care"},{"key":"B124","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1186\/s12885-015-1769-9","article-title":"Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study","volume":"15","author":"Montella","year":"2015","journal-title":"BMC Cancer"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346748","article-title":"Effect of metabolic syndrome and its components on prostate cancer risk: Meta-analysis","volume":"36","author":"Esposito","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-014-0422-9","article-title":"Metabolic syndrome in hematologic malignancies survivors: a meta-analysis","volume":"32","author":"Li","year":"2015","journal-title":"Med Oncol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60892-8","article-title":"Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5\u00b724 million UK adults","volume":"384","author":"Bhaskaran","year":"2014","journal-title":"Lancet"},{"key":"B128","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The Hallmarks of Cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ncrna6010005","article-title":"MiRNAs as novel adipokines: Obesity-related circulating MiRNAsinfluence chemosensitivity in cancer patients","volume":"6","author":"Withers","year":"2020","journal-title":"Non Cod RNA"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds244","article-title":"A meta-analysis of body mass index and esophageal and gastric cardia adenocarcinoma","volume":"24","author":"Turati","year":"2013","journal-title":"Ann Oncol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.04.019","article-title":"Overweight, obesity and gastric cancer risk: Results from a meta-analysis of cohort studies","volume":"45","author":"Yang","year":"2009","journal-title":"Eur J Cancer"},{"key":"B133","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1001\/jamaoncol.2018.4280","article-title":"Association of Obesity with Risk of Early-Onset Colorectal Cancer among Women","volume":"5","author":"Liu","year":"2019","journal-title":"JAMA Oncol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603932","article-title":"Overweight, obesity and risk of liver cancer: A meta-analysis of cohort studies","volume":"97","author":"Larsson","year":"2007","journal-title":"Br J Cancer"},{"key":"B135","doi-asserted-by":"publisher","first-page":"S248","DOI":"10.1016\/j.respe.2018.05.040","article-title":"Abdominal obesity and prostate cancer risk: epidemiological evidence from the EPICAP study","volume":"66","author":"Lavalette","year":"2018","journal-title":"Rev Epidemiol Sante Publique"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.gmit.2015.03.003","article-title":"The association between obesity and gynecological cancer","volume":"4","author":"Feng","year":"2015","journal-title":"Gynecol Minim Invasive Ther"},{"key":"B137","doi-asserted-by":"publisher","first-page":"e12860","DOI":"10.1097\/md.0000000000012860","article-title":"The association between BMI and kidney cancer risk","volume":"97","author":"Liu","year":"2018","journal-title":"Med (Balt)"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0090167","article-title":"Overweight, obesity and meningioma risk: Ameta-analysis","volume":"9","author":"Shao","year":"2014","journal-title":"PloS One"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1177\/030006051204000601","article-title":"Overweight, obesity and thyroid cancer risk: A meta-analysis of cohort studies","volume":"40","author":"Zhao","year":"2012","journal-title":"J Int Med Res"},{"key":"B140","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.clml.2015.06.003","article-title":"Risk Factors for Multiple Myeloma: A Systematic Review of Meta-Analyses","volume":"15","author":"Sergentanis","year":"2015","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.07.008","article-title":"Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation","volume":"398","author":"Ogawa","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B143","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.1038\/sigtrans.2015.4","article-title":"The role of MicroRNAs in human cancer","volume":"1","author":"Peng","year":"2016","journal-title":"Signal Transduct Target Ther"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0359","article-title":"OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer","volume":"76","author":"Svoronos","year":"2016","journal-title":"Cancer Res"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3365","article-title":"The critical role of the class III histone deacetylase SIRT1 in cancer","volume":"69","author":"Liu","year":"2009","journal-title":"Cancer Res"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4274","article-title":"Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth","volume":"71","author":"Chen","year":"2011","journal-title":"Cancer Res"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/789174","article-title":"Insulin resistance and cancer risk: An overview of the pathogeneticmechanisms","volume":"2012","author":"Arcidiacono","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol Cell"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.99","article-title":"Emerging roles of p53 and other tumour-suppressor genes in immune regulation","volume":"16","author":"Mu\u00f1oz-Fontela","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703029115","article-title":"miR-34a directly targets tRNA i Met precursors and affects cellular proliferation, cell cycle, and apoptosis","volume":"115","author":"Wang","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41389-018-0106-y","article-title":"miR-100 maintains phenotype of tumor-associated macrophages bytargeting mTOR to promote tumor metastasis via Stat5a\/IL-1ra pathway in mouse breastcancer","volume":"7","author":"Wang","year":"2018","journal-title":"Oncogenesis"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1530","article-title":"MicroRNA-193b controls adiponectin production in human white adipose tissue","volume":"100","author":"Belarbi","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B153","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cca.2007.01.026.Adiponectin","article-title":"Adiponectin as an anti-inflammatory factor","volume":"380","author":"Ouchi","year":"2009","journal-title":"Clin Chim Acta"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e328364f293","article-title":"Circulating adiponectin levels and the risk of breast cancer: A meta-analysis","volume":"23","author":"Ye","year":"2014","journal-title":"Eur J Cancer Prev"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0129824","article-title":"Circulating adiponectin and risk of endometrial cancer","volume":"10","author":"Zheng","year":"2015","journal-title":"PloS One"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.02.003","article-title":"Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt\/\u03b2-catenin signaling pathway by targeting LRP6","volume":"26","author":"Chen","year":"2014","journal-title":"Cell Signal"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319269111","article-title":"TGF-\u03b2-inducible microRNA-183 silences tumor-associated natural killer cells","volume":"111","author":"Donatelli","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B158","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3892\/br.2016.747","article-title":"Emerging role of microRNA-21 in cancer (Review)","volume":"5","author":"Feng","year":"2016","journal-title":"BioMed Rep"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/genes8010021","article-title":"Targeting MicroRNAs in Cancer Gene Therapy","volume":"8","author":"Ji","year":"2017","journal-title":"Genes (Basel)"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506654102","article-title":"miR-15 and miR-16 induce apoptosis by targeting BCL2","volume":"102","author":"Cimmino","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0177","article-title":"Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31","volume":"5","author":"Kang","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.02.011.Mitochondria","article-title":"Mitochondria and Cancer Wei-Xing","volume":"61","author":"Zong","year":"2016","journal-title":"Mol Cell"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3215.267","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Warburg","year":"1956","journal-title":"Sci (80- )"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.928","article-title":"Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)","volume":"4","author":"Zheng","year":"2012","journal-title":"Oncol Lett"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5215","article-title":"MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with the Mitochondrial Function","volume":"21","author":"Tomasetti","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.123","article-title":"Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications","volume":"40","author":"Togliatto","year":"2016","journal-title":"Int J Obes"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3390\/genes5040865","article-title":"The Role of microRNAs in Mitochondria: Small Players Acting Wide","volume":"5","author":"Duarte","year":"2014","journal-title":"Genes (Basel)"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016611107","article-title":"MicroRNA miR-125b causes leukemia","volume":"107","author":"Bousquet","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.90","article-title":"MiR-125 in normal and malignant hematopoiesis","volume":"26","author":"Shaham","year":"2012","journal-title":"Leukemia"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-6-6","article-title":"Diverse functions of miR-125 family in different cell contexts","volume":"6","author":"Sun","year":"2013","journal-title":"J Hematol Oncol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"6956","DOI":"10.1038\/s41598-019-43355-8","article-title":"MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2","volume":"9","author":"Hirono","year":"2019","journal-title":"Sci Rep"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2293","article-title":"Chemopreventive effect of peroxisome proliferator-activated receptor \u03b3 on gastric carcinogenesis in mice","volume":"65","author":"Lu","year":"2005","journal-title":"Cancer Res"},{"key":"B173","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15761\/IMM.1000187","article-title":"Pharmacological regulation of bladder cancer by miR-130 familyseed-targeting LNA","volume":"3","author":"Egawa","year":"2016","journal-title":"Integr Mol Med"},{"key":"B174","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s12967-019-2093-y","article-title":"Prognostic values of microRNA-130 family expression in patients with cancer: a meta-analysis and database test","volume":"17","author":"Peng","year":"2019","journal-title":"J Transl Med"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14454-1","article-title":"MiR-193b regulates breast cancer cell migration and vasculogenic mimicry by targeting dimethylarginine dimethylaminohydrolase","volume":"7","author":"Hulin","year":"2017","journal-title":"Sci Rep"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12596","article-title":"MiR-193a-5p and -3p Play a Distinct Role in Gastric Cancer: miR-193a-3p Suppresses Gastric Cancer Cell Growth by Targeting ETS1 and CCND1","volume":"38","author":"Chou","year":"2018","journal-title":"Anticancer Res"},{"key":"B177","article-title":"MicroRNA-365 suppressed cell proliferation and migration viatargeting PAX6 in glioblastoma","volume":"11","author":"Yuan","year":"2019","journal-title":"Am J Transl Res"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5458","article-title":"MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3","volume":"37","author":"Zhu","year":"2017","journal-title":"Oncol Rep"},{"key":"B179","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3233\/CBM-150500","article-title":"MicroRNA-365 inhibits growth, invasion and metastasis of malignant melanoma by targeting NRP1 expression","volume":"15","author":"Bai","year":"2015","journal-title":"Cancer Biomarkers"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz015","article-title":"miR-145 improves metabolic inflammatory disease through multiple pathways","volume":"12","author":"He","year":"2020","journal-title":"J Mol Cell Biol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000356978","article-title":"miR-145 Inhibits Proliferation and Invasion of Esophageal Squamous Cell Carcinoma in Part by Targeting c-Myc","volume":"36","author":"Wang","year":"2013","journal-title":"Oncol Res Treat"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10015","article-title":"Effect of miR\u2212145 on gastric cancer cells","volume":"5","author":"Wang","year":"2019","journal-title":"Mol Med Rep"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3410","article-title":"Obesity-associated inflammation induces microRNA-155 expression in adipocytes and adipose tissue: Outcome on adipocyte function","volume":"101","author":"Karkeni","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B184","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10555-017-9724-7","article-title":"miR-155 in cancer drug resistance and as target for miRNA-based therapeutics","volume":"37","author":"Bayraktar","year":"2018","journal-title":"Cancer Metastasis Rev"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.95","article-title":"LNA-based oligonucleotide electrotransfer for miRNA inhibition","volume":"20","author":"Chabot","year":"2012","journal-title":"Mol Ther"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/nature04303","article-title":"Silencing of microRNAs in vivo with \u201cantagomirs","volume":"438","author":"Kr\u00fctzfeldt","year":"2005","journal-title":"Nature"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-016-0407-y","article-title":"Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors","volume":"35","author":"Beg","year":"2017","journal-title":"Invest New Drugs"},{"key":"B188","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2019.00478","article-title":"The potential for microRNA therapeutics and clinicalresearch","volume":"10","author":"Hanna","year":"2019","journal-title":"Front Genet"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.25","article-title":"Locked nucleic acid anti-MIR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line: LNA-anti-MIR as a novel approach","volume":"23","author":"Nedaeinia","year":"2016","journal-title":"Cancer Gene Ther"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.563816\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T02:28:44Z","timestamp":1601951324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fendo.2020.563816\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":189,"alternative-id":["10.3389\/fendo.2020.563816"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.563816","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]},"article-number":"563816"}}