{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:25:45Z","timestamp":1792074345849,"version":"4.4.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To retrospectively analyze the correlation between anti-M\u00fcllerian hormone (AMH) and the number of oocytes obtained by controlled ovarian hyperstimulation (COH) in women of different ages and explore the factors affecting <jats:italic>in vitro<\/jats:italic> fertilization and embryo transfer (IVF-ET) in clinical pregnancy of infertile women to provide evidence for infertile women to choose assisted reproduction strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infertile women who received IVF-ET or intracytoplasmic sperm injection and embryo transfer (ICSI-ET) treatment in the reproductive center of XX hospital between October 2018 and September 2019 were included. Patient data on medical records, age, body mass index (BMI), years of infertility, basic follicle-stimulating hormone (FSH), basic luteinizing hormone (LH), basic estradiol (E<jats:sub>2<\/jats:sub>), anti-M\u00fcllerian hormone level (AMH), antral follicle count (AFC), gonadotropins (Gn) medication days, Gn dosage, endometrial thickness on transplantation day, the number of retrieved oocytes, the number of mature oocytes obtained, the number of embryos transferred, clinical pregnancy status, etc., were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 314 patients were enrolled in this study, with an average age of 31.0 \u00b1 4.5 years. The infertility period ranged from 0\u201321 years. The AMH level showed a downward trend with increasing age. Overall, the AMH level of women of all ages was positively correlated with the number of retrieved oocytes (<jats:italic>r<\/jats:italic> = 0.335, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The AMH level of women between 22 and 28 years old was positively correlated with the number of retrieved oocytes (<jats:italic>r<\/jats:italic> = 0.164, <jats:italic>p<\/jats:italic> &amp;lt; 0.061) but it was not statistically significant. Similarly, the AMH level of women aged 29\u201335 and 36\u201343 was positively correlated with the number of retrieved oocytes (<jats:italic>r<\/jats:italic> = 0.356, <jats:italic>p<\/jats:italic> &amp;lt; 0.001; <jats:italic>r<\/jats:italic> = 0.461, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). The average age of the pregnant group (30.6 \u00b1 4.4 years) was lower than that of the non-pregnant group (32.2 \u00b1 4.6 years) (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). The number of oocytes obtained (9.8 \u00b1 4.5) and the number of embryos transferred (1.9 \u00b1 0.4) in the pregnant group was significantly higher than that in the non-pregnant group (9.2 \u00b1 4.5; 1.7 \u00b1 0.5); the difference was statistically significant. The multivariate logistic regression model showed that age (OR = 0.574 95% CI: 0.350\u20130.940), AMH (OR = 1.430 95% CI: 1.130\u20131.820) and the number of oocytes obtained (OR = 1.360 95% CI: 1.030\u20131.790) were factors affecting clinical pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that the level of AMH in infertile women decreased with age and the number of oocytes obtained in infertile women was positively correlated with AMH. Moreover, the number of oocytes and embryo transferred in the pregnant group was significantly higher than those in the non-pregnant group. Furthermore, age, AMH and the number of oocytes affected the clinical pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2020.595448","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T05:42:52Z","timestamp":1607060572000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Relationship Between Anti-M\u00fcllerian Hormone and In Vitro Fertilization-Embryo Transfer in Clinical Pregnancy"],"prefix":"10.3389","volume":"11","author":[{"given":"Xing Yu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Zhu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Ping","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi Guang","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu003","article-title":"The predictive accuracy of anti-M\u00fcllerian hormone for live birth after assisted conception: a systematic review and meta-analysis of the literature","volume":"20","author":"Iliodromiti","year":"2014","journal-title":"Hum Reprod Update"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13334","article-title":"The use of anti-Mullerian hormone for controlled ovarian stimulation in assisted reproductive technology, fertility assessment and -counseling","volume":"97","author":"Pilsgaard","year":"2018","journal-title":"Acta Obstet Gynecol Scand"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del291","article-title":"Serum anti-Mullerian hormone throughout the human menstrual cycle","volume":"21","author":"La Marca","year":"2006","journal-title":"Hum Reprod"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09513590.2020.1737668","article-title":"Influence of age on response to controlled ovarian stimulation in women with low levels of serum anti-M\u00fcllerian hormone","volume":"9","author":"Massarotti","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa013","article-title":"Does an association exist between menstrual cycle length within the normal range and ovarian reserve biomarkers during the reproductive years? 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