{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:39:49Z","timestamp":1780922389288,"version":"3.54.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"DOI":"10.3389\/fendo.2020.601956","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T08:31:20Z","timestamp":1605169880000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Does Maternal Normal Range Thyroid Function Play a Role in Offspring Birth Weight? Evidence From a Mendelian Randomization Analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Xinghao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.18","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0067","article-title":"Mendelian randomization supports a causative effect of TSH on thyroid carcinoma","volume":"27","author":"Fussey","year":"2020","journal-title":"Endocr Relat Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa239","article-title":"Thyroid Function Affects the Risk of Stroke via Atrial Fibrillation: A Mendelian Randomization Study","volume":"105","author":"Marouli","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32988","article-title":"Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer: A two-sample Mendelian randomization study","volume":"147","author":"Yuan","year":"2020","journal-title":"Int J Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0167","article-title":"Hypothyroidism and Kidney Function: A Mendelian Randomization Study","volume":"30","author":"Ellervik","year":"2020","journal-title":"Thyroid"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e002468","DOI":"10.1161\/CIRCGEN.118.002468","article-title":"Thyroid Function and Dysfunction in Relation to 16 Cardiovascular Diseases","volume":"12","author":"Larsson","year":"2019","journal-title":"Circ Genom Precis Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3426","article-title":"Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study","volume":"33","author":"van Vliet","year":"2018","journal-title":"J Bone Miner Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3343\/alm.2021.41.1.77","article-title":"Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population","volume":"41","author":"Zou","year":"2021","journal-title":"Ann Lab Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2019.09.005","article-title":"Hypothyroidism and isolated hypothyroxinemia in pregnancy, from physiology to the clinic","volume":"58","author":"Lopez-Munoz","year":"2019","journal-title":"Taiwan J Obstet Gynecol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15107","article-title":"The impact of isolated maternal hypothyroxinaemia on the incidence of large-for-gestational-age infants: the Ma\u2019anshan Birth Cohort study","volume":"125","author":"Zhu","year":"2018","journal-title":"BJOG"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00390","article-title":"Association Between Maternal Thyroid Hormones and Birth Weight at Early and Late Pregnancy","volume":"104","author":"Zhang","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0199","article-title":"The Impact of Thyroid Disorders on Clinical Pregnancy Outcomes in a Real-World Study Setting","volume":"30","author":"Sitoris","year":"2020","journal-title":"Thyroid"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12578","article-title":"Maternal thyrotropin is independently related to small for gestational age neonates at term","volume":"82","author":"Monen","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz275","article-title":"Associations Between Maternal Thyroid Function in Pregnancy and Obstetric and Perinatal Outcomes","volume":"105","author":"Lee","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3533-9","article-title":"Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population","volume":"291","author":"Kumru","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30145-7","article-title":"The importance of high-quality mendelian randomisation studies for clinical thyroidology","volume":"7","author":"Medici","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz160","article-title":"Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight","volume":"48","author":"Hwang","year":"2019","journal-title":"Int J Epidemiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0403-1","article-title":"Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors","volume":"51","author":"Warrington","year":"2019","journal-title":"Nat Genet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"Teumer","year":"2018","journal-title":"Nat Commun"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00157","article-title":"LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations","volume":"11","author":"Myers","year":"2020","journal-title":"Front Genet"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965","article-title":"Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt179","article-title":"Calculating statistical power in Mendelian randomization studies","volume":"42","author":"Brion","year":"2013","journal-title":"Int J Epidemiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.6.1235","article-title":"Fetal origins of adult disease: strength of effects and biological basis","volume":"31","author":"Barker","year":"2002","journal-title":"Int J Epidemiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00479","article-title":"Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets","volume":"14","author":"Wang","year":"2020","journal-title":"Front Neurosci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00618","article-title":"Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis","volume":"10","author":"Zeng","year":"2019","journal-title":"Front Genet"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30061-9","article-title":"Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis","volume":"8","author":"Derakhshan","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00432","article-title":"Gestational TSH and FT4 Reference Intervals in Chinese Women: A Systematic Review and Meta-Analysis","volume":"9","author":"Gao","year":"2018","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.601956\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T08:31:21Z","timestamp":1605169881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2020.601956\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":30,"alternative-id":["10.3389\/fendo.2020.601956"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2020.601956","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]},"article-number":"601956"}}