{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:26:43Z","timestamp":1773271603648,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Although research suggests a close association between maternal thyroid function and birth outcomes, no clear conclusion has been reached. We aimed to explore this potential association in a retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 8985 mother\u2013child dyads. The maternal serum free tetraiodothyronine (FT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPO Ab) concentrations and birth outcome data were reviewed from medical records. Subjects with TPO Ab concentrations of &amp;gt;34 and \u226434 IU\/ml were classified into the TPO Ab positivity (+) and TPO Ab negativity (\u2212) groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with subjects in the normal group (0.1 \u2264 TSH &amp;lt; 2.5 mIU\/L and TPO Ab\u2212), those with TSH concentrations of 2.5\u20134.0 mIU\/L and TPO Ab\u2212 had a 0.65-fold lower risk of low birth weight (LBW). In contrast, those with TSH concentrations of &amp;gt;4.0 mIU\/L, regardless of the TPO Ab status, had a 2.01-fold increased risk of LBW. Subclinical hypothyroidism, regardless of the TPO Ab status, was associated with a 1.94-fold higher risk of LBW when compared with that in subjects with euthyroidism and TPO Ab\u2212. No other significant associations were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A maternal TSH concentration of 2.5\u20134.0 mIU\/L was associated with a lower risk of LBW when combined with TPO Ab\u2212, whereas subjects with a TSH concentration of &amp;gt;4.0 mIU\/L had an increased risk of LBW. Subclinical hypothyroidism appears to be associated with a higher risk of LBW.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2020.611071","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T18:22:11Z","timestamp":1612549331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Associations Between Maternal Thyroid Function and Birth Outcomes in Chinese Mother-Child Dyads: A Retrospective Cohort 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