{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:45:04Z","timestamp":1790952304570,"version":"4.1.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Ependymomas are primary glial tumors arising from cells related to the ependymal lining of the ventricular system. They are classified into at least nine different molecular subtypes according to molecular phenotype, histological morphology, and tumor location. Primary sellar ependymoma is an extremely rare malignancy of the central nervous system, with only 12 known cases reported in humans. We herein report a case of ependymoma located at the pituitary region in a 44-year-old female patient and discuss the molecular subtype, natural history, clinical presentation, radiological findings, histological features, immunohistochemical characteristics, ultrastructural examinations, treatment, and prognosis of sellar ependymoma. This case report may serve as a helpful reference for clinicians and radiologists in clinical practice.<\/jats:p>","DOI":"10.3389\/fendo.2021.551493","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T14:01:29Z","timestamp":1623160889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Case Report: Sellar Ependymomas: A Clinic-Pathological Study and Literature Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Liyan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO Classification of Tumours of the Central Nervous System","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.12.Jns10846","article-title":"Cortical Ependymoma: An Unusual Epileptogenic Lesion","volume":"114","author":"Van Gompel","year":"2011","journal-title":"J Neurosurg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.wneu.2017.10.134","article-title":"Pituitary Ependymoma: A Case Report and Review of the Literature","volume":"110","author":"Wang","year":"2018","journal-title":"World Neurosurg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3171\/2008.9.Jns08117","article-title":"Incidence Patterns for Ependymoma: A Surveillance, Epidemiology, and End Results Study","volume":"110","author":"McGuire","year":"2009","journal-title":"J Neurosurg"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.12.1443","article-title":"An Ependymoma Involving the Pituitary Fossa","volume":"52","author":"Winer","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B6","article-title":"Pituitary Ependymoma","volume":"7","author":"Sarkisian","year":"1956","journal-title":"United States Armed Forces Med J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/026886901750353764","article-title":"Ependymoma of the Neurohypophysis","volume":"15","author":"Thomson","year":"2001","journal-title":"Br J Neurosurg"},{"key":"B8","article-title":"Chan Cjjohkcor","volume":"4","author":"Chiu","year":"2001","journal-title":"Suprasellar Ependymoma"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.4.616","article-title":"Ependymoma of the Pituitary Fossa. 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