{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:48:59Z","timestamp":1759942139991,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The purpose of this study was to evaluate the usefulness of the sonographic characteristics of papillary thyroid carcinoma (PTC) with Hashimoto\u2019s thyroiditis (HT) for predicting central lymph node metastasis (CLNM). One hundred thirty-three patients who underwent thyroidectomy and central cervical lymph node dissection for PTC with coexistent HT were retrospectively analyzed. All PTCs with HT were preoperatively evaluated by ultrasound (US) regarding their nodular number, size, component, shape, margin, echogenicity, calcification, capsule contact with protrusion, vascularity and contrast enhanced ultrasound (CEUS) parameters. Univariate analysis demonstrated that patients with PTCs with HT and CLNM more frequently had age \u2264 45 years, size &amp;gt;\u00a010\u00a0mm, a wider than tall shape, microcalcification, hypo-enhancement and peak intensity index &amp;lt; 1 than those without CLNM (all <jats:italic>p<\/jats:italic>&amp;lt;0.05). Binary logistic regression analysis demonstrated that size &amp;gt; 10\u00a0mm and CEUS hypo-enhancement were independent characteristics for the presence of CLNM. Our study indicated that preoperative US characteristics could offer help in predicting CLNM in PTCs with coexistent HT.<\/jats:p>","DOI":"10.3389\/fendo.2021.556851","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T10:36:43Z","timestamp":1615891003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Sonographic Characteristics of Papillary Thyroid Carcinoma With Coexistent Hashimoto\u2019s Thyroiditis in the Preoperative Prediction of Central Lymph Node Metastasis"],"prefix":"10.3389","volume":"12","author":[{"given":"Sijie","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengcheng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghai","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1","article-title":"Current thyroid cancer trends in the United States","volume":"140","author":"Davies","year":"2014","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719","article-title":"Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013","volume":"317","author":"Lim","year":"2017","journal-title":"JAMA"},{"key":"B3","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1089\/thy.2012.0329","article-title":"Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades","volume":"23","author":"Cho","year":"2013","journal-title":"Thyroid"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.06.020","article-title":"Conventional Ultrasound, Immunohistochemical Factors and BRAF(V600E) Mutation in Predicting Central Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma","volume":"44","author":"Chen","year":"2018","journal-title":"Ultrasound Med Biol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej12-0086","article-title":"Prognosis and prognostic factors of papillary thyroid carcinoma in patients under 20 years","volume":"59","author":"Ito","year":"2012","journal-title":"Endocr J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0243","article-title":"Clinical risk factors associated with cervical lymph node recurrence in papillary thyroid carcinoma","volume":"20","author":"Baek","year":"2010","journal-title":"Thyroid"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328333ac97","article-title":"3rd and R. 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