{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:34:11Z","timestamp":1783553651956,"version":"3.55.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effectiveness of high-concentration oxygen on the improvement of throat symptoms and voice changes after thyroid surgery and its protection of the parathyroid function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 600 patients undergoing thyroid surgery who met the inclusion criteria were randomly divided into the experimental group (n = 300) and the control group (n = 300) by using a random number generator. The patients in the experimental group underwent high-oxygen treatment [FiO<jats:sub>2<\/jats:sub>80 (8 L\/min)] for 6 continuous hours after returning to the ward after surgery. The patients in the control group underwent low-oxygen treatment [FiO<jats:sub>2<\/jats:sub>30 (2 L\/min)] for 6 continuous hours after returning to the ward after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The postoperative incision pain score of patients in the experimental group was significantly better than that in the control group at 6\u00a0h (1.07 \u00b1 0.80 <jats:italic>VS<\/jats:italic> 1.23 \u00b1 0.95, <jats:italic>P<\/jats:italic>=0.031) and 12\u00a0h (1.08 \u00b1 0.64 <jats:italic>VS<\/jats:italic> 1.20 \u00b1 0.73, <jats:italic>P<\/jats:italic>=0.041). The postoperative throat pain score of the patients in the experimental group was significantly better than that of the control group at 6\u00a0h (1.40 \u00b1 0.85 <jats:italic>VS<\/jats:italic> 1.59 \u00b1 0.97, <jats:italic>P<\/jats:italic>=0.011) and 12\u00a0h (1.40 \u00b1 0.85 <jats:italic>VS<\/jats:italic> 1.59 \u00b1 0.97, <jats:italic>P<\/jats:italic>=0.019). The PONV score of the patients in the experimental group was significantly better than that of the control group at 12\u00a0h (0.09 \u00b1 0.19 <jats:italic>VS<\/jats:italic> 0.14 \u00b1 0.37, <jats:italic>P<\/jats:italic>=0.024). The Voice Handicap Index score of the patients in the experimental group was significantly better than that of the control group at 24\u00a0h (2.89 \u00b1 5.92 <jats:italic>VS<\/jats:italic> 4.10 \u00b1 6.31, <jats:italic>P<\/jats:italic>=0.017), 36\u00a0h (2.46 \u00b1 5.06 <jats:italic>VS<\/jats:italic> 3.43 \u00b1 5.97, <jats:italic>P<\/jats:italic>=0.035), and 48\u00a0h (2.46 \u00b1 5.06 <jats:italic>VS<\/jats:italic> 3.43 \u00b1 5.97, <jats:italic>P<\/jats:italic>=0.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High-concentration oxygen can alleviate PONV and pain after thyroid surgery, with less severe voice changes potentially. However, its effects on swallowing function, and parathyroid function need to be further verified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration Number<\/jats:title><jats:p>ChiCTR-IOR-17012765 (China Clinical Trial Registry clinical trial registration center [<jats:uri>http:\/\/www.chictr.org.cn\/index.aspx<\/jats:uri>)<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.595571","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T08:25:40Z","timestamp":1625473540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Postoperative High-Concentration Oxygen on Recovery After Thyroid Surgery: A Prospective, Open, Randomized, Controlled 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