{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:36Z","timestamp":1790810916490,"version":"4.1.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["No. 2019YJ0038"],"award-info":[{"award-number":["No. 2019YJ0038"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>The thyroid is a rare site for distant metastases from breast carcinoma. The incidence of thyroid metastases in fine needle aspiration biopsy (FNAB) was less than 0.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient concerns<\/jats:title><jats:p>We report a case of 54-year-old woman with a history of breast carcinoma presented with diffuse scattered microcalcifications in thyroid and enlarged bilateral cervical lymph nodes detected on ultrasound (US). Physical examination of the patient revealed firm and enlarged thyroid lobes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnoses<\/jats:title><jats:p>FNAB and immunohistochemistry (IHC) of the thyroid lesion confirmed the thyroid metastases from breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions and Outcomes<\/jats:title><jats:p>Due to the comorbidities of breast carcinoma metastases to the right axillary, cervical lymph nodes and left chest wall, the patient received chemotherapy. After a follow-up of 19 months, the patient was alive without any new distant metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lessons<\/jats:title><jats:p>Our case highlights that thyroid metastases should be considered in a patient combined with thyroid lesions and a history of breast carcinoma. IHC played an important role in differentiating thyroid metastases from primary thyroid cancer.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.631894","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:28:59Z","timestamp":1615526939000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Case Report and Review of Literature: Thyroid Metastases From Breast Carcinoma"],"prefix":"10.3389","volume":"12","author":[{"given":"Yichao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v17i4.11","article-title":"Breast cancer metastasis to thyroid: a retrospective analysis","volume":"17","author":"Zhou","year":"2017","journal-title":"Afr Health Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23462","article-title":"Metastatic ductal carcinoma of the breast to the thyroid gland diagnosed with fine needle aspiration: A case report with emphasis on morphologic and immunophenotypic features","volume":"44","author":"Magers","year":"2016","journal-title":"Diagn Cytopathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02206.x","article-title":"Metastasis to the thyroid diagnosed by fine-needle aspiration biopsy","volume":"62","author":"Kim","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s12885-018-4054-x","article-title":"It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature","volume":"18","author":"Pensabene","year":"2018","journal-title":"BMC Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9890716","article-title":"Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions","volume":"2019","author":"Ghias","year":"2019","journal-title":"Case Rep Pathol"},{"key":"B6","article-title":"Thyroid metastases from a breast cancer diagnosed by fine-needle aspiration biopsy. Case report and overview of the literature","volume":"34","author":"Lacka","year":"2012","journal-title":"Exp Oncol"},{"key":"B7","first-page":"67","article-title":"Metastasis to the thyroid gland; unusual site of metastasis","volume":"18","author":"Gerges","year":"2006","journal-title":"J Egypt Natl Canc Inst"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31829d1d09","article-title":"Metastasis to the thyroid gland: report of a large series from the Mayo Clinic","volume":"38","author":"Hegerova","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.012","article-title":"Metastases to the thyroid gland: the Royal Marsden experience","volume":"30","author":"Wood","year":"2004","journal-title":"Eur J Surg Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20311","article-title":"Metastatic breast carcinoma involving the thyroid gland diagnosed by fine-needle aspiration: a case report","volume":"33","author":"Owens","year":"2005","journal-title":"Diagn Cytopathol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2011.09.009","article-title":"Met\u00e1stasis tiroidea de carcinoma lobulillar de mama","volume":"59","author":"Egana","year":"2012","journal-title":"Endocrinol Nutr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s12022-018-9532-9","article-title":"Immunohistochemical Biomarkers in Thyroid Pathology","volume":"29","author":"Baloch","year":"2018","journal-title":"Endocr Pathol"},{"key":"B13","first-page":"97","article-title":"Clinico-pathological and prognostic findings on 27 cases of medullary thyroid carcinoma","volume":"95","author":"Gabsi","year":"2017","journal-title":"Tunis Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1793","article-title":"Thyrotropin receptor\/thyroglobulin messenger ribonucleic acid in peripheral blood and fine-needle aspiration cytology: diagnostic synergy for detecting thyroid cancer","volume":"90","author":"Wagner","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.humpath.2015.09.015","article-title":"GATA-3 and FOXA1 expression is useful to differentiate breast carcinoma from other carcinomas","volume":"47","author":"Davis","year":"2016","journal-title":"Hum Pathol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000237","article-title":"Comparative Sensitivities and Specificities of Antibodies to Breast Markers GCDFP-15, Mammaglobin A","volume":"24","author":"Kandalaft","year":"2016","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10549-017-4645-2","article-title":"GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer","volume":"169","author":"Ni","year":"2018","journal-title":"Breast Cancer Res Treat"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1515\/pp-2017-0014","article-title":"Comparison of GATA-3, mammaglobin, GCDFP-15 expression in breast carcinoma in serous effusions: A cell-block micro-array study","volume":"2","author":"El Hag","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2018.21.e55","article-title":"Lobular Breast Carcinoma Metastasis to the Thyroid Gland: Case Report and Literature Review","volume":"2","author":"Bourcier","year":"2018","journal-title":"J Breast Cancer"},{"key":"B20","article-title":"Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study","volume":"28","author":"Calzolari","year":"2008","journal-title":"Anticancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0154","article-title":"Metastases to the thyroid: a review of the literature from the last decade","volume":"22","author":"Chung","year":"2012","journal-title":"Thyroid"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.631894\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T05:29:05Z","timestamp":1615526945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.631894\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":21,"alternative-id":["10.3389\/fendo.2021.631894"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2021.631894","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]},"article-number":"631894"}}