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Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study included 2011 women who underwent <jats:italic>in vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Higher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21\u20132.08], quartile 3 OR 1.36 [1.04\u20131.77]), LDL-C (quartile 1 OR 1.41 [1.07\u20131.86]), and TG (quartile 2 OR 1.39 [1.06\u20131.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58\u20133.13], quartile 2 OR 1.78 [1.27\u20132.50], quartile 3 OR 1.51 [1.07\u20132.13]), TC (quartile 1 OR 1.39 [1.00\u20131.93]), TG (quartile 1 OR 1.44 [1.03\u20132.03], quartile 2 OR 1.46 [1.04\u20132.04], quartile 3 OR 1.44 [1.04\u20131.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51\u20130.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30\u20130.66], quartile 2 OR 0.49 [0.33\u20130.73], quartile 3 OR 0.63 [0.43\u20130.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07\u20132.39]) were independently associated with miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.633766","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T05:58:57Z","timestamp":1615183137000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Serum Lipid Levels and Treatment Outcomes in Women Undergoing Assisted Reproduction: A Retrospective Cohort 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