{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:43:25Z","timestamp":1770493405433,"version":"3.49.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the risk factors for erectile dysfunction (ED) in male patients with acromegaly and to prospectively investigate the short-term changes of erectile function after surgery or medical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty-three male patients were subjected to nocturnal penile tumescence and rigidity (NPTR) test for the evaluation of erectile function. The measurement of serum nitric oxide (NO) was also performed. Twenty-seven patients were re-evaluated by NPTR after surgery or long-term somatostatin analogues (SSA) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty-two patients (34.9%) had ED. Patients with ED showed higher random GH (17.89 [10.97-44.19] \u03bcg\/L <jats:italic>vs<\/jats:italic> 11.63 [4.31-28.80] \u03bcg\/L, <jats:italic>p<\/jats:italic> = 0.020) and GH nadir (GHn) (10.80 [6.69-38.30] \u03bcg\/L <jats:italic>vs<\/jats:italic> 8.76 [3.62-18.19] \u03bcg\/L, <jats:italic>p<\/jats:italic> = 0.044) during oral glucose tolerance test (OGTT). The NO levels of ED patients were lower than non-ED patients (9.15 [5.58-22.48] \u03bcmol\/L <jats:italic>vs<\/jats:italic> 16.50 [12.33-31.78] \u03bcmol\/L, <jats:italic>p<\/jats:italic> = 0.012). After treatment, patients who present improvement in erectile function showed lower post-GHn (0.07 [0.03-0.12] ng\/ml <jats:italic>vs<\/jats:italic> 1.32 [0.09-3.60] ng\/ml, <jats:italic>p<\/jats:italic> = 0.048) and post-IGF-1 index (1.03 \u00b1 0.38 <jats:italic>vs<\/jats:italic> 1.66 \u00b1 0.95, <jats:italic>p<\/jats:italic> = 0.049). The multivariate analysis indicated post-GHn was still associated with the improvement of erectile function after correction of other covariates (OR: 0.059, 95% CI: 0.003-1.043, <jats:italic>p<\/jats:italic> = 0.053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Excessive GH is related to ED in male patients with acromegaly. GH normalization after treatment is beneficial for short-term erectile function recovery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.633904","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T07:09:26Z","timestamp":1620112166000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Erectile Dysfunction Is Associated With Excessive Growth Hormone Levels in Male Patients With 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