{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:41:24Z","timestamp":1784288484913,"version":"3.55.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the influence of endometriosis activity on the pregnancy outcomes of patients with recurrent implantation failure (RIF) in <jats:italic>in-vitro<\/jats:italic> fertilization\/intra-cytoplasmic sperm injection (IVF\/ICSI) cycles. The pregnancy outcomes were compared between RIF patients with endometriosis who received treatment at different occasions to explore the appropriate treatment plan for these patients and to optimize the pregnancy-support strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Ambispective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 330 patients with endometriosis were enrolled from 2008 to 2018 and included 1043 IVF\/ICSI cycles. All patients were diagnosed with RIF after IVF\/ICSI. Patients were assigned to three subtypes according to different control states of endometriosis, including the untreated, early-treatment, and late-treatment groups. The clinical pregnancy rate, live birth rate, and cumulative live birth rate of endometriosis patients with RIF were the main outcomes; additionally, the fertilization rate, available embryonic rate, and high-quality embryonic rate were also compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The early-treatment and late-treatment groups showed higher cumulative live birth rate than the untreated group (early-treated 43.6% <jats:italic>vs<\/jats:italic>. late-treated 46.3% <jats:italic>vs<\/jats:italic>. untreated 27.7%, P&amp;lt;0.001), though patients in the two treatment groups had higher rates of adenomyosis and ovarian surgery. The two treatment group showed a better laboratory result than the untreated and especially, the early-treatment group. The untreated group (46.24%) had a lower IVF fertilization rate than the treated group (early-treated [64.40%] and late-treated [60.27%] (P&amp;lt;0.001). In addition, the rates of available embryos and high-quality embryos in the early-treated group were much higher those that in the untreated group (90.30% <jats:italic>vs<\/jats:italic>. 85.20%, 76.50% <jats:italic>vs<\/jats:italic>. 64.47%). Kaplan\u2013Meier curve showed that patients in the untreated group needed a mean of 23.126 months to achieve one live birth; whereas those in the treated group needed a comparatively shorter duration (early-treated: 18.479 \u00b1 0.882 months and late-treated: 14.183 \u00b1 1.102 months, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endometriosis has a negative influence on IVF\/ICSI outcome. The control of endometriosis activity can result in a higher cumulative live birth rate in patients. It is necessary for endometriosis patients to receive medical treatment to achieve a better prognosis especially for those with RIF.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.640288","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T08:40:42Z","timestamp":1627634442000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Analysis of IVF\/ICSI Outcomes in Endometriosis Patients With Recurrent Implantation Failure: Influence on Cumulative Live Birth Rate"],"prefix":"10.3389","volume":"12","author":[{"given":"Chenyi","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liusijie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and Infertility: Definition and Epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin Biochem"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082385","article-title":"Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies","volume":"19","author":"Lin","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12577","article-title":"Implications of Immune Dysfunction on Endometriosis Associated Infertility","volume":"8","author":"Miller","year":"2017","journal-title":"Oncotarget"},{"key":"B4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13048-017-0341-4","article-title":"Is the Oocyte Quality Affected by Endometriosis? 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