{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T03:59:49Z","timestamp":1771991989370,"version":"3.50.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Somatic <jats:italic>KCNJ5<\/jats:italic> mutation occurs in half of unilateral primary aldosteronism (PA) and is associated with more severe phenotype. Mutation status can only be identified by tissue sample from adrenalectomy. NP-59 adrenal scintigraphy is a noninvasive functional study for disease activity assessment. This study aimed to evaluate the predictive value of NP-59 adrenal scintigraphy in somatic <jats:italic>KCNJ5<\/jats:italic> mutation among PA patients who received adrenalectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty-two PA patients who had NP-59 adrenal scintigraphy before adrenalectomy with available <jats:italic>KCNJ5<\/jats:italic> mutation status were included. Two semiquantitative parameters, adrenal to liver ratio (ALR) and lesion to contralateral ratio of bilateral adrenal glands (CON) derived from NP-59 adrenal scintigraphy, of mutated and wild-type patients were compared. Cutoff values calculated by receiver-operating characteristic (ROC) analysis were used as a predictor of <jats:italic>KCNJ5<\/jats:italic> mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients had <jats:italic>KCNJ5<\/jats:italic> mutation and 42 patients were wild type. Patients harboring <jats:italic>KCNJ5<\/jats:italic> mutation had both higher ALR and CON (p = 0.0031 and 0.0833, respectively) than wild-type patients. With ALR and CON cutoff of 2.10 and 1.95, the sensitivity and specificity to predict <jats:italic>KCNJ5<\/jats:italic> mutation were 85%, 57% and 45%, 93%, respectively. Among 20 patients with <jats:italic>KCNJ5<\/jats:italic> mutation, 16 showed G151R point mutation (<jats:italic>KCNJ5<\/jats:italic>- G151R) and 4 showed L168R point mutation (<jats:italic>KCNJ5<\/jats:italic>-L168R), which former one had significantly lower ALR (p=0.0471).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PA patients harboring somatic <jats:italic>KCNJ5<\/jats:italic> mutation had significantly higher NP-59 uptake regarding to ALR and CON than those without mutation. APAs with <jats:italic>KCNJ5-<\/jats:italic>L168R point mutation showed significantly higher ALR than those with <jats:italic>KCNJ5<\/jats:italic>-G151R point mutation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.644927","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T08:53:53Z","timestamp":1619600033000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["NP-59 Adrenal Scintigraphy as an Imaging Biomarker to Predict KCNJ5 Mutation in Primary Aldosteronism Patients"],"prefix":"10.3389","volume":"12","author":[{"given":"Ching-Chu","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoh-Fang","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-Yung","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jei-Yie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan-Dun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff S.","family":"Chueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1472","article-title":"Study Heterogeneity and Estimation of Prevalence of Primary Aldosteronism: A Systematic Review and Meta-Regression Analysis","volume":"101","author":"Kayser","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular Events and Target Organ Damage in Primary Aldosteronism Compared With Essential Hypertension: A Systematic Review and Meta-Analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jfma.2018.01.006","article-title":"Targeted Treatment of Primary Aldosteronism - The Consensus of Taiwan Society of Aldosteronism","volume":"118","author":"Huang","year":"2019","journal-title":"J Formos Med Assoc"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30272-8","article-title":"Primary Aldosteronism as a Public Health Issue","volume":"4","author":"Funder","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198785","article-title":"K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2149","article-title":"Rossi Gp. 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