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Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diminished ovarian reserve (DOR) is one of the most intractable clinical issues in human reproduction and is reported to be associated with raised risk of recurrent pregnancy loss and aneuploid blastocysts. In this study, we aimed to explore whether DOR was also associated with maternal and neonatal complications in <jats:italic>in-vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection cycles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study including women below 40 years of age who achieved singleton live birth after fresh embryo transfer in <jats:italic>in-vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection cycles in a single center from January 2012 to June 2019 was conducted. Participants with DOR, defined as basal follicle-stimulating hormone (FSH) \u2265 10IU\/L and antimullerian hormone (AMH) &amp;lt; 1.2ng\/ml, were enrolled as the study group. The controls were 1:2 matched by age and body mass index with FSH &amp;lt; 10IU\/L and AMH \u2265 1.2ng\/ml. Maternal and neonatal complications were compared between the DOR group and the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 579 women, 193 in the DOR group and 386 matched as controls, were included in this study. Compared to controls, the incidence of hypertensive disorders of pregnancy was significantly increased in the DOR group (5.7% <jats:italic>vs<\/jats:italic>. 2.1%, <jats:italic>P<\/jats:italic> = 0.021). DOR patients also presented slightly higher incidences of preterm birth (10.9% <jats:italic>vs<\/jats:italic>. 7.5%, <jats:italic>P<\/jats:italic> = 0.174) and low birthweight (6.2% <jats:italic>vs<\/jats:italic>. 5.4%, <jats:italic>P<\/jats:italic> = 0.704) yet without statistical significances. The incidences of gestational diabetes mellitus and placenta previa were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to women with normal ovarian reserve, women with diminished ovarian reserve might have elevated incidence of hypertensive disorders of pregnancy. Patients with diminished ovarian reserve might need more strict antenatal care.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.648287","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:54:27Z","timestamp":1619693667000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal and Neonatal Complications in Patients With Diminished Ovarian Reserve in In-Vitro Fertilization\/Intracytoplasmic Sperm Injection Cycles"],"prefix":"10.3389","volume":"12","author":[{"given":"Shuang","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.fertnstert.2014.12.093","article-title":"Testing and Interpreting Measures of Ovarian Reserve: A Committee Opinion","volume":"103","year":"2015","journal-title":"Fertil Steril"},{"key":"B2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.fertnstert.2015.05.017","article-title":"Diminished Ovarian Reserve in the United States Assisted Reproductive Technology Population: Diagnostic Trends Among 181,536 Cycles From the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System","volume":"104","author":"Devine","year":"2015","journal-title":"Fertil Steril"},{"key":"B3","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.fertnstert.2019.11.014","article-title":"Diminished Ovarian Reserve in Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis","volume":"113","author":"Bunnewell","year":"2020","journal-title":"Fertil Steril"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.016","article-title":"Higher Rates of Aneuploidy in Blastocysts and Higher Risk of No Embryo Transfer in Recurrent Pregnancy Loss Patients With Diminished Ovarian Reserve Undergoing in Vitro Fertilization","volume":"106","author":"Shahine","year":"2016","journal-title":"Fertil Steril"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.128","article-title":"Current Clinical Irrelevance of Luteal Phase Deficiency: A Committee Opinion","volume":"103","year":"2015","journal-title":"Fertil Steril"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12046","article-title":"Absent or Excessive Corpus Luteum Number is Associated With Altered Maternal Vascular Health in Early Pregnancy","volume":"73","author":"von Versen-Hoynck","year":"2019","journal-title":"Hypertension"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased Preeclampsia Risk and Reduced Aortic Compliance With in Vitro Fertilization Cycles in the Absence of a Corpus Luteum","volume":"73","author":"von Versen-Hoynck","year":"2019","journal-title":"Hypertension"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3","article-title":"Appropriate Body-Mass Index for Asian Populations and Its Implications for Policy and Intervention Strategies","volume":"363","year":"2004","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The Classification, Diagnosis and Management of the Hypertensive Disorders of Pregnancy: A Revised Statement From the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.10.012","article-title":"Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy: A World Health Organization Guideline","volume":"103","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/1471-0528.15306","article-title":"Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green-Top Guideline No","volume":"126","author":"Jauniaux","year":"2019","journal-title":"27a. 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