{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:09:37Z","timestamp":1775592577303,"version":"3.50.1"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014220","name":"NSFC-Henan Joint Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Some studies have demonstrated that adenomyosis patients can achieve a comparable pregnancy outcome with women with normal uteruses, while there is no unanimous conclusion at present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We recruited 65 adenomyosis patients and 260 frequency-matched control women with endometriosis at a ratio of 1:4 according to age. Clinical pregnancy rate, spontaneous abortion rate, and live birth rate were compared between these two groups after controlling other factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with endometriosis patients, adenomyosis patients had a higher antral follicle count (AFC) (12.71 <jats:italic>vs<\/jats:italic> 11.65, <jats:italic>P<\/jats:italic>=0.027). Though the two groups had the same number of embryos transferred, adenomyosis patients had an obviously declined implantation rate (31.91% <jats:italic>vs<\/jats:italic> 46.74%, <jats:italic>P<\/jats:italic>=0.005), clinical pregnancy rate (47.06% <jats:italic>vs<\/jats:italic> 64.42%, P=0.028), live birth rate (31.37% <jats:italic>vs<\/jats:italic> 54.81%, P=0.004), and significantly increased spontaneous abortion rate (33.33% <jats:italic>vs<\/jats:italic> 13.43%, P=0.034). Multivariate logistic regression analysis showed that adenomyosis had adverse influences on pregnancy outcome when age and the number of embryo transfers were controlled (adjusted OR=0.361, P=0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even after being matched with age, adenomyosis still had adverse influences on the pregnancy outcome of IVF in patients undergoing the long protocol.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.655803","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T11:55:57Z","timestamp":1629287757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Uterine Adenomyosis on Pregnancy Outcomes in Women Undergoing In Vitro Fertilization Treated With a Long-Term Pituitary Downregulation 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