{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:42Z","timestamp":1787026362918,"version":"build-2736575974"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged fasting (36 hours)\n                    <jats:italic>via<\/jats:italic>\n                    an intermittently-scanned continuous glucose monitoring system. Anthropometric data, metabolic and hormonal markers were compared between both trial arms. After each fasting period, a 75\u00a0g oral glucose tolerance test was performed and plasma glucose levels and hormones were assessed. Data were compared\n                    <jats:italic>via<\/jats:italic>\n                    paired t-tests and mixed-model regressions (p \u2264 0.05). Twenty individuals with type 1 diabetes (7 females) with a mean \u00b1 SD age of 35 \u00b1 11 years, body mass index (BMI) 24.8 \u00b1 2.8 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and HbA\n                    <jats:sub>1c<\/jats:sub>\n                    54 \u00b1 7 mmol\/mol were included. Hypoglycemia\/hour (70 mg\/dL; &amp;lt;3.9 mmol\/L) was similar in both trial arms (12 hrs: 0.07 \u00b1 0.06\n                    <jats:italic>vs.<\/jats:italic>\n                    36 hrs: 0.05 \u00b1 0.03, p=0.21). Glycemic excursions during the oral glucose tolerance test were not different after the two fasting periods. Beta-hydroxybutyrate levels were higher after prolonged fasting (p=0.0006). Our study showed that people with type 1 diabetes can safely perform a 36 hours fasting period with a low risk of hypoglycemia and ketoacidosis.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>DRKS.de, identifier DRKS00016148.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2021.656346","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T03:36:53Z","timestamp":1625542613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of a Single 36 Hours Prolonged Fasting Period in Adults With Type 1 Diabetes \u2013 A Cross-Over Controlled Trial"],"prefix":"10.3389","volume":"12","author":[{"given":"Othmar","family":"Moser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max 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