{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:52Z","timestamp":1753890712244,"version":"3.41.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to verify that hypothalamus-pituitary dysfunction is one of the risk factors for postoperative central nervous system infections (PCNSIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a retrospective analysis of all patients with sellar region lesions who underwent surgery between January 2016 and November 2019 at Peking Union Medical College Hospital. In total, 44 age\u2212 and sex-matched controls were enrolled. Univariate and multivariate analyses were performed to identify risk factors for PCNSIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>We enrolled 88 patients, 44 of whom had PCNSIs. Surgical approach (TCS) (P&amp;lt;0.001), previous surgery on the same site (P=0.001), intraoperative cerebral spinal fluid (CSF) leakage (P&amp;lt;0.001), postoperative adrenal insufficiency (P=0.017), postoperative DI (P=0.004) and the maximum Na<jats:sup>+<\/jats:sup> levels(&amp;lt;0.001) correlated significantly with PCNSIs. Multivariate analysis showed that Surgery approach (TCS)(OR: 77.588; 95%CI: 7.981-754.263; P&amp;lt;0.001), intraoperative CSF leakage (OR: 12.906; 95%CI: 3.499-47.602; P&amp;lt;0.001), postoperative DI (OR: 6.999; 95%CI:1.371-35.723; P=0.019) and postoperative adrenal insufficiency (OR: 6.115; 95%CI: 1.025-36.469; P=0.047) were independent influencing factors for PCNSIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TCS, intraoperative CSF leakage, postoperative DI and postoperative adrenal insufficiency are risk factors for PCNSIs in patients with sellar region tumors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.661305","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T17:01:32Z","timestamp":1619802092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypothalamus-Pituitary Dysfunction as an Independent Risk Factor for Postoperative Central 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