{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:11:26Z","timestamp":1785820286772,"version":"3.56.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to investigate the role of nerve conduction studies (NCS) and\u00a0sympathetic skin response (SSR) in evaluating diabetic cardiac autonomic neuropathy (DCAN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DCAN was diagnosed using the Ewing test combined with heart rate variability analysis. NCS and SSR were assessed by electrophysiological methods. The association between NCS\/SSR and DCAN was assessed <jats:italic>via<\/jats:italic> multivariate regression and receiver-operating characteristic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The amplitude and conduction velocity of the motor\/sensory nerve were found to be significantly lower in the DCAN+ group (all <jats:italic>P<\/jats:italic> &amp;lt; 0.05). A lower amplitude of peroneal nerve motor fiber was found to be associated with increased odds for DCAN (OR 2.77, <jats:italic>P<\/jats:italic>\u00a0&amp;lt; 0.05). The SSR amplitude was lower while the SSR latency was longer in the DCAN+ group than in the DCAN\u2013 group. The receiver-operating characteristic analysis revealed that the optimal cutoff points of upper\/lower limb amplitude of SSR to indicate DCAN were 1.40 mV (sensitivity, 61.9%; specificity, 66.3%, <jats:italic>P &amp;lt;<\/jats:italic> 0.001) and 0.85 mV (sensitivity, 66.7%; specificity, 68.5%, <jats:italic>P &amp;lt;<\/jats:italic> 0.001), respectively. The optimal cutoff points of upper\/lower limb latency to indicate DCAN were 1.40 s (sensitivity, 61.9%; specificity, 62%, <jats:italic>P &amp;lt;<\/jats:italic> 0.05) and 1.81 s (sensitivity, 69.0%; specificity, 52.2%, <jats:italic>P &amp;lt;<\/jats:italic> 0.05), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NCS and SSR are reliable methods to detect DCAN. Abnormality in the peroneal nerve (motor nerve) is crucial in predicting DCAN. SSR may help predict DCAN.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.709114","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T06:07:46Z","timestamp":1632204466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Peripheral Nerve Conduction And Sympathetic Skin Response Are Reliable Methods to Detect Diabetic Cardiac Autonomic 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