{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:57:39Z","timestamp":1753891059316,"version":"3.41.2"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pancreas transplantation is a high-risk procedure in terms of cardiovascular complications. Therefore, identification of all cardiovascular risk factors is crucial to prevent cardiovascular complications after pancreas transplantation. Vitamin D deficiency (VDD) appears to be a potential risk factor for coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of VDD in pancreas transplant candidates, and further to examine the relationship between vitamin D and the prevalence of coronary artery disease and lipid profile parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a prospective cross-sectional study. We enrolled consecutive patients with type 1 diabetes eligible for simultaneous pancreas-kidney transplantation or pancreas transplant alone. The laboratory tests included HbA1c, lipid profile, creatinine, and total 25-hydroxyvitamin D (25(OH)D). The diagnosis of coronary artery disease was based on coronary angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 48 patients. VDD was revealed in 48% of patients and coronary artery disease in 35% of patients. The mean concentration of vitamin D in the entire cohort was 21.3 \u00b1 9.48 ng\/ml. The median value of 25(OH)D in patients with coronary artery disease was significantly lower than in patients without coronary artery disease (18.5 (11.6\u201321.5) <jats:italic>vs<\/jats:italic>. 24.8 (18.4\u201331.8) ng\/ml, p = 0.018). There was a significant relationship between VDD and coronary artery disease (OR = 4.36; 95% confidence interval (CI): 1.22\u201315.64, p = 0.034). A patient\u2019s odds of having coronary artery disease while having a sufficient level of vitamin D was 4.36 times lower than if the patient had VDD. There was a significant relationship between VDD and hypertension (OR = 5.91; 95% CI: 1.12\u201331.20, p = 0.039) and hemodialysis (OR = 4.25; 95% CI: 1.25\u201314.5, p = 0.023). There was no significant correlation between 25(OH)D and lipid profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>VDD is highly prevalent in pancreas transplant candidates with type 1 diabetes. There is a significant relationship between VDD and increased prevalence of coronary disease. The lack of any significant association between serum vitamin D and lipid profile suggests that the relationship between vitamin D and coronary artery disease results from other causes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.714728","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T05:36:41Z","timestamp":1628660201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D Deficiency as a Predictor of a High Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates With Type 1 Diabetes"],"prefix":"10.3389","volume":"12","author":[{"given":"Ma\u0142gorzata","family":"Buksi\u0144ska-Lisik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw J.","family":"Kwasiborski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ryczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Lisik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Mamcarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13177","article-title":"Successful Pancreas Transplantation Alone Is Associated With Excellent Self-Identified Health Score and Glucose Control: A Retrospective Study From a High-Volume Center in the United States","volume":"32","author":"Scalea","year":"2018","journal-title":"Clin Transplant"},{"key":"B2","article-title":"A Single Center 11 Year Experience With 202 Pancreas Transplants in the New Millennium: Evolving Trends","volume":"31","author":"Rogers","year":"2015","journal-title":"Clin Transpl"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2111","article-title":"Major Adverse Cardiovascular Events Following Simultaneous Pancreas and Kidney Transplantation in the United Kingdom","volume":"42","author":"Yiannoullou","year":"2019","journal-title":"Diabetes Care"},{"key":"B4","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/MOT.0000000000000146","article-title":"Simultaneous Pancreas and Kidney Transplantation: Current Trends and Future Directions","volume":"20","author":"Redfield","year":"2015","journal-title":"Curr Opin Organ Transplant"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108135","article-title":"Cardiovascular Risk Factors and Cardiovascular Disease in Patients With Type 1 Diabetes and End-Stage Renal Disease Candidates for Kidney-Pancreas Transplantation: Trends From 1999 to 2017","volume":"163","author":"Ruiz","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2017.07.009","article-title":"Role of Vitamin D in Cardiovascular Diseases","volume":"46","author":"Rai","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00373","article-title":"A. 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