{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:00:16Z","timestamp":1794024016058,"version":"4.8.0"},"reference-count":93,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008119","name":"Norges Milj\u00f8- og Biovitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008119","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes\n                    <jats:italic>via<\/jats:italic>\n                    the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and comprehensive knowledge of the spatial distribution of those endocrine cell types is required to better understand their physiological functions. Using medaka as a model and several combinations of multi-color fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization, we present the first 3D atlas revealing the gland-wide distribution of seven endocrine cell populations: lactotropes, thyrotropes, Lh and Fsh gonadotropes, somatotropes, and\n                    <jats:italic>pomca<\/jats:italic>\n                    -expressing cells (corticotropes and melanotropes) in the anterior pituitary of a teleost fish. By combining\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization and immunofluorescence techniques, we deciphered the location of corticotropes and melanotropes within the\n                    <jats:italic>pomca<\/jats:italic>\n                    -expressing cell population. The 3D localization approach reveals sexual dimorphism of\n                    <jats:italic>tshba<\/jats:italic>\n                    -,\n                    <jats:italic>pomca<\/jats:italic>\n                    -, and\n                    <jats:italic>lhb<\/jats:italic>\n                    -expressing cells in the adult medaka pituitary. Finally, we show the existence of bi-hormonal cells co-expressing\n                    <jats:italic>lhb<\/jats:italic>\n                    -\n                    <jats:italic>fshb<\/jats:italic>\n                    ,\n                    <jats:italic>fshb<\/jats:italic>\n                    -\n                    <jats:italic>tshba<\/jats:italic>\n                    and\n                    <jats:italic>lhb<\/jats:italic>\n                    -\n                    <jats:italic>sl<\/jats:italic>\n                    using single-cell transcriptomics analysis and\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization. This study offers a solid basis for future comparative studies of the teleost pituitary and its functional plasticity.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2021.719843","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T02:47:06Z","timestamp":1629686826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":37,"title":["3D Atlas of the Pituitary Gland of the Model Fish Medaka (Oryzias latipes)"],"prefix":"10.3389","volume":"12","author":[{"given":"Muhammad Rahmad","family":"Royan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadeeja","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Csucs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja A.","family":"Puchades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Nourizadeh-Lillabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Bjaalie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan V.","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn-Arne","family":"Weltzien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.02.012","article-title":"Cells of the Anterior Pituitary","volume":"38","author":"Yeung","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2004.07.018","article-title":"Pituitary Cell Lines and Their Endocrine Applications","volume":"228","author":"Ooi","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2008.11.010","article-title":"Discovery of Transcriptional Regulators and Signaling Pathways in the Developing Pituitary Gland by Bioinformatic and Genomic Approaches","volume":"93","author":"Brinkmeier","year":"2009","journal-title":"Genomics"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.08.002","article-title":"Anterior Pituitary Cell Networks","volume":"33","author":"Le Tissier","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"B5","first-page":"1","article-title":"Cell Biology of Somatolactin","volume-title":"International Review of Cytology","author":"Kaneko","year":"1996"},{"key":"B6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.mce.2013.10.016","article-title":"Embryonic Development of Gonadotrope Cells and Gonadotropic Hormones \u2013 Lessons From Model Fish","volume":"385","author":"Weltzien","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0016-6480(02)00052-7","article-title":"Investigation Into the Duality of Gonadotropic Cells of Mediterranean Yellowtail (Seriola Dumerilii, Risso 1810): Immunocytochemical and Ultrastructural Studies","volume":"128","author":"Hern\u00e1ndez","year":"2002","journal-title":"Gen Comp Endocrinol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1530\/JOE-19-0405","article-title":"Plasticity in Medaka Gonadotropes via Cell Proliferation and Phenotypic Conversion","volume":"245","author":"Fontaine","year":"2020","journal-title":"J Endocrinol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1530\/REP-16-0377","article-title":"Gonadotropin Characterization, Localization and Expression in the European Hake (Merluccius Merluccius)","volume":"153","author":"Candelma","year":"2017","journal-title":"Reproduction"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00182","article-title":"A Novel Model for Development, Organization, and Function of Gonadotropes in Fish Pituitary","volume":"5","author":"Golan","year":"2014","journal-title":"Front Endocrinol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/13.3.719","article-title":"Functional Morphology of the Teleost Pituitary Gland","volume":"13","author":"Schreibman","year":"2015","journal-title":"Am Zoologist"},{"key":"B12","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1186\/2193-1801-2-460","article-title":"Immunohistochemical Study of Pituitary Cells in Wild and Captive Salminus Hilarii (Characiformes: Characidae) Females During the Annual Reproductive Cycle","volume":"2","author":"Honji","year":"2013","journal-title":"SpringerPlus"},{"key":"B13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1507\/endocrj1954.17.45","article-title":"Cell Types in the Pituitary of the Medaka (Oryzias Latipes)","volume":"17","author":"Aoki","year":"1970","journal-title":"Endocrinologia Japonica"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.12.91","article-title":"Histological Changes in the Pituitary, Thyroid Gland and Gonads of the Fourspine Sculpin (Cottus Kazika) During Downstream Migration","volume":"12","author":"Mukai","year":"1995","journal-title":"Zool Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1590\/1982-0224-2019-0092","article-title":"Morphological and Immunohistochemical Comparison of the Pituitary Gland Between a Tropical Paracheirodon Axelrodi and a Subtropical Aphyocharax Anisitsi Characids (Characiformes: Characidae)","volume":"18","author":"Camacho","year":"2020","journal-title":"J Neotropical Ichthyol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(03)00018-1","article-title":"Immunocytochemical Characterization of Adenohypophyseal Cells in the Greater Weever Fish (Trachinus Draco)","volume":"35","author":"S\u00e1nchez Cala","year":"2003","journal-title":"Tissue Cell"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1023\/A:1004101127461","article-title":"An Immunocytochemical Study of the Pituitary Gland of the White Seabream (Diplodus Sargus)","volume":"32","author":"Segura-Noguera","year":"2000","journal-title":"Histochemical J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.32604\/biocell.2009.33.001","article-title":"Studies on the Reproductive and Developmental Biology of Cichlasoma Dimerus (Percifomes, Cichlidae)","volume":"33","author":"Pandolfi","year":"2009","journal-title":"Biocell"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00266-0","article-title":"Identification and Localization of Eight Distinct Hormone-Producing Cell Types in the Pituitary of Male Atlantic Halibut (Hippoglossus Hippoglossus L.). Comparative Biochemistry and Physiology Part A","volume":"134","author":"Weltzien","year":"2003","journal-title":"Mol Integr Physiol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-005-0119-7","article-title":"A Systematic Immunohistochemical Survey of the Distribution Patterns of GH, Prolactin, Somatolactin, \u03b2\u2013TSH, \u03b2\u2013FSH, \u03b2\u2013LH, ACTH, and \u03b1\u2013MSH in the Adenohypophysis of Oreochromis Niloticus, the Nile Tilapia","volume":"325","author":"Kasper","year":"2006","journal-title":"Cell Tissue Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2108\/zsj.15.263","article-title":"Immunocytochemical and Ultrastructural Identification of Pituitary Cell Types in the Protogynous (Thalassoma Duperrey) During Adult Sexual Ontogeny","volume":"15","author":"Parhar","year":"1998","journal-title":"Zool Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1076\/apab.110.1.42.906","article-title":"Development of Gonadotropes may Involve Cyclic Transdifferentiation of Growth Hormone Cells","volume":"110","author":"Childs","year":"2002","journal-title":"Arch Physiol Biochem"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(05)80007-4","article-title":"Multipotential Pituitary Cells That Contain Adrenocorticotropin (ACTH) and Other Pituitary Hormones","volume":"2","author":"Childs","year":"1991","journal-title":"Trends Endocrinol Metab"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-4-337","article-title":"Mammosomatotropes: Presence and Functions in Normal and Neoplastic Pituitary Tissue","volume":"12","author":"Frawley","year":"1991","journal-title":"Endocrine Rev"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.44.819","article-title":"Bihormonal Cells Secreting Both Prolactin and Gonadotropins in Normal Rat Pituitary Cells","volume":"44","author":"Fukami","year":"1997","journal-title":"Endocrine J"},{"key":"B26","first-page":"21","article-title":"Chapter 2 - Hypothalamic Regulation of Anterior Pituitary Function","volume-title":"The Pituitary (Third Edition)","author":"Ben-Shlomo","year":"2011"},{"key":"B27","doi-asserted-by":"publisher","first-page":"113344","DOI":"10.1016\/j.ygcen.2019.113344","article-title":"Gonadotrope Plasticity at Cellular, Population and Structural Levels: A Comparison Between Fishes and Mammals","volume":"287","author":"Fontaine","year":"2020","journal-title":"Gen Comp Endocrinol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nrg704","article-title":"Medaka \u2014 a Model Organism From the Far East","volume":"3","author":"Wittbrodt","year":"2002","journal-title":"Nat Rev Genet"},{"key":"B29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-4-431-92691-7_1","article-title":"A Glance at the Past of Medaka Fish Biology","volume-title":"Medaka: A Model for Organogenesis, Human Disease, and Evolution","author":"Hori","year":"2011"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1101\/2020.12.14.422690","article-title":"Characterization of Hormone-Producing Cell Types in the Medaka Pituitary Gland Using Single-Cell RNA-Seq","author":"Siddique","year":"2020","journal-title":"bioRxiv"},{"key":"B31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/9781119575399.ch3","article-title":"Looking at Adult Medaka","volume-title":"Medaka: Biology, Management, and Experimental Protocols","author":"Murata","year":"2019"},{"key":"B32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ygcen.2018.12.006","article-title":"Medaka Follicle-Stimulating Hormone (Fsh) and Luteinizing Hormone (Lh): Developmental Profiles of Pituitary Protein and Gene Expression Levels","volume":"272","author":"Burow","year":"2019","journal-title":"Gen Comp Endocrinol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23860","article-title":"Developmental Tracing of Luteinizing Hormone \u03b2-Subunit Gene Expression Using Green Fluorescent Protein Transgenic Medaka (Oryzias Latipes) Reveals a Putative Novel Developmental Function","volume":"241","author":"Hildahl","year":"2012","journal-title":"Dev Dyn"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00595","article-title":"Gnrh1-Induced Responses Are Indirect in Female Medaka Fsh Cells, Generated Through Cellular Networks","volume":"160","author":"Hodne","year":"2019","journal-title":"Endocrinology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1759","article-title":"Dopamine Inhibits Reproduction in Female Zebrafish (Danio Rerio) via Three Pituitary D2 Receptor Subtypes","volume":"154","author":"Fontaine","year":"2013","journal-title":"Endocrinology"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00107","article-title":"Heterogeneity of Calcium Responses to Secretagogues in Corticotrophs From Male Rats","volume":"158","author":"Roman\u00f2","year":"2017","journal-title":"Endocrinology"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv159","article-title":"Progressive Postnatal Decline in Leptin Sensitivity of Arcuate Hypothalamic Neurons in the Magel2-Null Mouse Model of Prader\u2013Willi Syndrome","volume":"24","author":"Pravdivyi","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e59768","DOI":"10.3791\/59768","article-title":"Labeling of Blood Vessels in the Teleost Brain and Pituitary Using Cardiac Perfusion With a DiI-Fixative","author":"Fontaine","year":"2019","journal-title":"J Visualized Experiments"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2018.02.004","article-title":"Data Integration Through Brain Atlasing: Human Brain Project Tools and Strategies","volume":"50","author":"Bjerke","year":"2018","journal-title":"Eur Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2019.00075","article-title":"QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain","volume":"13","author":"Yates","year":"2019","journal-title":"Front Neuroinformatics"},{"key":"B41","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1530\/JOE-18-0412","article-title":"Plasticity of Lh Cells Caused by Cell Proliferation and Recruitment of Existing Cells","volume":"240","author":"Fontaine","year":"2019","journal-title":"J Endocrinol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20568","article-title":"A Three-Dimensional Atlas of Pituitary Gland Development in the Zebrafish","volume":"487","author":"Chapman","year":"2005","journal-title":"J Comp Neurol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(90)90066-U","article-title":"The Development of Monoclonal Antibodies Against Salmon (Oncorhynchus Kisutch and O. Keta) Pituitary Hormones and Their Immunohistochemical Identification","volume":"79","author":"Farbridge","year":"1990","journal-title":"Gen Comp Endocrinol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(83)90229-0","article-title":"Immunocytochemical Identification of the Prolactin-Secreting Cells in the Teleost Pituitary With an Antiserum to Chum Salmon Prolactin","volume":"50","author":"Naito","year":"1983","journal-title":"Gen Comp Endocrinol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218126","article-title":"The Immunocytochemical Localization of Pituitary Somatotrops in the Genus Oncorhynchus Using an Antiserum to Growth Hormone of Chum Salmon (Oncorhynchus Keta)","volume":"231","author":"Wagner","year":"1983","journal-title":"Cell Tissue Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(86)90222-4","article-title":"Immunocytochemical Identification and Localization of the Different Cell Types in the Pituitary of the Seabass (Dicentrarchus Labrax)","volume":"61","author":"Cambr\u00e9","year":"1986","journal-title":"Gen Comp Endocrinol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(88)90204-3","article-title":"Immunocytochemical and Ultrastructural Characterization of the Cell Types in the Adenohypophysis of Sparus Aurata L. (Teleost)","volume":"72","author":"Quesada","year":"1988","journal-title":"Gen Comp Endocrinol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0016-6480(91)90103-D","article-title":"Immunocytochemical Study of Cell Type Distribution in the Pituitary of Barbus Barbus (Teleostei, Cyprinidae)","volume":"83","author":"Toubeau","year":"1991","journal-title":"Gen Comp Endocrinol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1994.1079","article-title":"Growth Hormone- and Prolactin-Producing Cells in the Pituitary Gland of Striped Bass (Morone Saxatilis): Immunocytochemical Characterization at Different Life Stages","volume":"94","author":"Huang","year":"1994","journal-title":"Gen Comp Endocrinol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10695-008-9254-x","article-title":"Immunocytochemical Identification of Adenohypophyseal Cells in the Pirarucu (Arapaima Gigas), an Amazonian Basal Teleost","volume":"35","author":"Borella","year":"2009","journal-title":"Fish Physiol Biochem"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(83)90225-3","article-title":"Immunocytochemistry of Gonadotropic Cells in the Pituitary of Some Teleost Species","volume":"50","author":"Olivereau","year":"1983","journal-title":"Gen Comp Endocrinol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(85)90407-1","article-title":"Light and Electron Microscopic Identification of Gonadotrophic Cells in the Pituitary Gland of the Goldfish by Means of Immunocytochemistry","volume":"59","author":"Dubourg","year":"1985","journal-title":"Gen Comp Endocrinol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(90)90224-A","article-title":"Salmonid Pituitary Gonadotrophs I. Distinct Cellular Distributions of Two Gonadotropins, GTH I and GTH II","volume":"77","author":"Nozaki","year":"1990","journal-title":"Gen Comp Endocrinol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S0016-6480(02)00646-9","article-title":"Immunocytochemical Studies on the Pituitary Gland of Anguilla Anguilla L., in Relation to Early Growth Stages and Diet-Induced Sex Differentiation","volume":"131","author":"Grandi","year":"2003","journal-title":"Gen Comp Endocrinol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-8166(96)80060-7","article-title":"The Adenohypophysis of Mediterranean Yellowtail, Seriola Dumerilii (Risso, 1810): An Immunocytochemical Study","volume":"28","author":"Garc\u00eda-Hern\u00e1ndez","year":"1996","journal-title":"Tissue Cell"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-004-0402-5","article-title":"Early Development of the Pituitary Gland in Acipenser Naccarii (Chondrostei, Acipenseriformes): An Immunocytochemical Study","volume":"208","author":"Grandi","year":"2004","journal-title":"Anat Embryol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(86)90192-9","article-title":"Immunocytochemical Demonstration of Pituitary Cell Types in the Teleost Poecilia Latipinna, by Light and Electron Microscopy","volume":"63","author":"Batten","year":"1986","journal-title":"Gen Comp Endocrinol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.09.004","article-title":"The Hypothalamic Neuropeptide Oxytocin Is Required for Formation of the Neurovascular Interface of the Pituitary","volume":"21","author":"Gutnick","year":"2011","journal-title":"Dev Cell"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1150","article-title":"Architecture of GnRH-Gonadotrope-Vasculature Reveals a Dual Mode of Gonadotropin Regulation in Fish","volume":"156","author":"Golan","year":"2015","journal-title":"Endocrinology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"20200713","DOI":"10.1098\/rspb.2020.0713","article-title":"Androgen-Dependent Sexual Dimorphism in Pituitary Tryptophan Hydroxylase Expression: Relevance to Sex Differences in Pituitary Hormones","volume":"287","author":"Kawabata-Sakata","year":"2020","journal-title":"Proc R Soc B: Biol Sci"},{"key":"B61","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ygcen.2009.05.004","article-title":"Control of Puberty in Farmed Fish","volume":"165","author":"Taranger","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(94)00063-G","article-title":"Androgens in Teleost Fishes. Comparative Biochemistry and Physiology Part C: Pharmacology","volume":"109","author":"Borg","year":"1994","journal-title":"Toxicol Endocrinol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e62006","DOI":"10.3791\/62006","article-title":"Gonadectomy and Blood Sampling Procedures in the Small Size Teleost Model Japanese Medaka (Oryzias Latipes)","author":"Royan","year":"2020","journal-title":"JoVE"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/jez.485","article-title":"Sexually Dimorphic Expression of Pituitary Glycoprotein Hormones in a Sex-Changing Fish (Pseudolabrus Sieboldi)","author":"Ohta","year":"2008","journal-title":"J Exp Zool Part A: Ecol Genet Physiol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8649.1999.tb02031.x","article-title":"Differential Expression of Atlantic Salmon Thyrotropin \u03b2 Subunit mRNA and Its cDNA Sequence","volume":"54","author":"Martin","year":"1999","journal-title":"J Fish Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1530\/JOE-13-0488","article-title":"Zebrafish Pituitary Gene Expression Before and After Sexual Maturation","volume":"221","author":"He","year":"2014","journal-title":"J Endocrinol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF03346543","article-title":"cDNA Cloning of Blue Gourami (Trichogaster Trichopterus) Prolactin and Its Expression During the Gonadal Cycles of Males and Females","volume":"33","author":"Degani","year":"2010","journal-title":"J Endocrinological Invest"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.009209","article-title":"Quantification of Prolactin (PRL) and PRL Receptor Messenger RNA in Gilthead Seabream (Sparus Aurata) After Treatment With Estradiol-17\u03b21","volume":"68","author":"Cavaco","year":"2003","journal-title":"Biol Reprod"},{"key":"B69","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1677\/joe.0.1330393","article-title":"Somatolactin, a Novel Pituitary Protein: Purification and Plasma Levels During Reproductive Maturation of Coho Salmon","volume":"133","author":"Rand-Weaver","year":"1992","journal-title":"J Endocrinol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/gcen.1998.7200","article-title":"Immunocytochemical Study on the Localization and Distribution of the Somatolactin Cells in the Pituitary Gland and the Brain Oforeochromis Niloticus(Teleostei, Cichlidae)","volume":"113","author":"Mousa","year":"1999","journal-title":"Gen Comp Endocrinol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/1097-010X(20000615)287:1<62::AID-JEZ8>3.0.CO;2-0","article-title":"Implication of Somatolactin in the Regulation of Sexual Maturation and Spawning of Mugil Cephalus","volume":"287","author":"Mousa","year":"2000","journal-title":"J Exp Zool"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-6-42","article-title":"Cloning of Somatolactin Alpha, Beta Forms and the Somatolactin Receptor in Atlantic Salmon: Seasonal Expression Profile in Pituitary and Ovary of Maturing Female Broodstock","volume":"6","author":"Benedet","year":"2008","journal-title":"Reprod Biol Endocrinol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1385\/ENDO:20:1-2:23","article-title":"Changes in Expression of Genes Encoding Gonadotropin Subunits and Growth Hormone\/Prolactin\/Somatolactin Family Hormones During Final Maturation and Freshwater Adaptation in Prespawning Chum Salmon","volume":"20","author":"Onuma","year":"2003","journal-title":"Endocrine"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.605068","article-title":"Direct and Indirect Effects of Sex Steroids on Gonadotrope Cell Plasticity in the Teleost Fish Pituitary","volume":"11","author":"Fontaine","year":"2020","journal-title":"Front Endocrinol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00656","article-title":"Molecular Mechanisms of Pituitary Cell Plasticity","volume":"11","author":"Childs","year":"2020","journal-title":"Front Endocrinol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07524.x","article-title":"Adult Pituitary Progenitors\/Stem Cells: From In Vitro Characterization to In Vivo Function","volume":"32","author":"Rizzoti","year":"2010","journal-title":"Eur J Neurosci"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00705-x","article-title":"Single-Cell Transcriptomic Analysis of Adult Mouse Pituitary Reveals Sexual Dimorphism and Physiologic Demand-Induced Cellular Plasticity","volume":"11","author":"Ho","year":"2020","journal-title":"Protein Cell"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba4767","article-title":"Lineage Analysis Reveals an Endodermal Contribution to the Vertebrate Pituitary","volume":"370","author":"Fabian","year":"2020","journal-title":"Science"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/BF00220372","article-title":"Ultrastructure of the Adenohypophysis in the Teleost Poecilia Latipinna","volume":"161","author":"Batten","year":"1975","journal-title":"Cell Tissue Res"},{"key":"B80","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/jez.1402150112","article-title":"Ultrastructural Localization of Gonadotropin and Luteinizing Hormone Releasing Hormone in the Pituitary Gland of a Teleost Fish (the Platyfish)","volume":"215","author":"Margolis-Kazan","year":"1981","journal-title":"J Exp Zool"},{"key":"B81","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-41603-8_8","article-title":"Pituitary Stem Cells During Normal Physiology and Disease","volume-title":"Stem Cells in Neuroendocrinology","author":"Andoniadou","year":"2016"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1080\/01913120290104476","article-title":"Folliculo-Stellate Cells of the Human Pituitary: A Type of Adult Stem Cell","volume":"26","author":"Horvath","year":"2002","journal-title":"Ultrastructural Pathol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583585","article-title":"Mammosomatotroph Cell Adenoma of the Human Pituitary: A Morphologic Entity","volume":"398","author":"Horvath","year":"1983","journal-title":"Virchows Archiv A"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880252","article-title":"Reversible Transdifferentiation: Interconversion of Somatotrophs and Lactotrophs in Pituitary Hyperplasia","volume":"14","author":"Vidal","year":"2001","journal-title":"Modern Pathol: an Off J United States Can Acad Pathol Inc"},{"key":"B85","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/PL00008197","article-title":"Transdifferentiation of Somatotrophs to Thyrotrophs in the Pituitary of Patients With Protracted Primary Hypothyroidism","volume":"436","author":"Vidal","year":"2000","journal-title":"Virchows Archiv"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0378","article-title":"Pituitary-Specific Gata2 Knockout: Effects on Gonadotrope and Thyrotrope Function","volume":"20","author":"Charles","year":"2006","journal-title":"Mol Endocrinol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80770-9","article-title":"Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling Gradient\u2013Induced Determination of Pituitary Cell Types","volume":"97","author":"Dasen","year":"1999","journal-title":"Cell"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1065703","article-title":"Tpit Determines Alternate Fates During Pituitary Cell Differentiation","volume":"17","author":"Pulichino","year":"2003","journal-title":"Genes Dev"},{"key":"B89","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1210\/er.2009-0008","article-title":"Genetic Regulation of Pituitary Gland Development in Human and Mouse","volume":"30","author":"Kelberman","year":"2009","journal-title":"Endocrine Rev"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6336(00)80003-0","article-title":"Cytochemical and Molecular BiologicalAspects of the Pituitary and Pituitary Adenomas \u2014 Cell Differentiation and Transcription Factors","volume":"36","author":"Sanno","year":"2001","journal-title":"Prog Histochem Cytochem"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880204","article-title":"Expression of Pituitary Homeo Box 1 (Ptx1) in Human Non-Neoplastic Pituitaries and Pituitary Adenomas","volume":"13","author":"Tahara","year":"2000","journal-title":"Modern Pathol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16502","article-title":"Plurihormonal Cells of Normal Anterior Pituitary: Facts and Conclusions","volume":"8","author":"Mitrofanova","year":"2017","journal-title":"Oncotarget"},{"key":"B93","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0016-6480(91)90086-L","article-title":"Histochemical and Immunocytochemical Identification of the Pituitary Cell Types in Three Sciaenid Fishes: Atlantic Croaker (Micropogonias Undulatus), Spotted Seatrout (Cynoscion Nebulosus), and Red Drum (Sciaenops Ocellatus)","volume":"84","author":"Yan","year":"1991","journal-title":"Gen Comp Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.719843\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T02:47:20Z","timestamp":1629686840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.719843\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":93,"alternative-id":["10.3389\/fendo.2021.719843"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2021.719843","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.05.31.446412","asserted-by":"object"}]},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]},"article-number":"719843"}}