{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:29:59Z","timestamp":1783488599015,"version":"3.55.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ovarian stimulation and finished a follow-up for 3 years. A premature rise in LH was defined as an LH level &amp;gt;10 IU\/L or &amp;gt;50% rise from baseline during ovarian stimulation. The cumulative live birth rate was calculated as the number of women who achieved a live birth divided by the total number of women who had either delivered a baby or had used up all their embryos received from the first stimulated cycle. In the advanced patients (\u226537 years), the cumulative live birth rate was reduced in patients with a premature rise of LH (\u03b2: 0.20; 95% CI: 0.05\u20130.88; <jats:italic>p<\/jats:italic>=0.03), compared to patients (\u226537 years) without the premature LH rise. The incidence of premature LH rise is associated with decreased rates of cumulative live birth rate in patients of advanced age (\u226537 years) and aggravated the reduced potential of embryos produced by the advanced age, not the number of embryos.<\/jats:p>","DOI":"10.3389\/fendo.2021.722655","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T09:14:51Z","timestamp":1638522891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["A Premature Rise of Luteinizing Hormone Is Associated With a Reduced Cumulative Live Birth Rate in Patients \u226537 Years Old Undergoing GnRH Antagonist In Vitro Fertilization Cycles"],"prefix":"10.3389","volume":"12","author":[{"given":"Fumei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06797-6","article-title":"Gonadotropin-Releasing-Hormone-Receptor Antagonists","volume":"358","author":"Huirne","year":"2001","journal-title":"Lancet (Lond Engl)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1477-7827-11-20","article-title":"Optimal Usage of the GnRH Antagonists: A Review of the Literature","volume":"11","author":"Copperman","year":"2013","journal-title":"Reprod Biol Endocrinol RB&E"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.14.9.1085","article-title":"New Developments in the Use of Peptide Gonadotropin-Releasing Hormone Antagonists Versus Agonists","volume":"14","author":"Schultze-Mosgau","year":"2005","journal-title":"Expert Opin Invest Drugs"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.05.023","article-title":"The Impact of a Gonadotropin-Releasing Hormone Antagonist on Gonadotropin Ovulation Induction Cycles in Women With Polycystic Ovary Syndrome: A Prospective Randomized Study","volume":"95","author":"Stadtmauer","year":"2011","journal-title":"Fertil Steril"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-005-0021-2","article-title":"GnRH-Antagonists in Reproductive Medicine","volume":"273","author":"Griesinger","year":"2005","journal-title":"Arch Gynecol Obstet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-009-9299-5","article-title":"Does Premature Luteinization or Early Surge of LH Impair Cycle Outcome? 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