{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:19:19Z","timestamp":1787937559181,"version":"build-2784847793"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001004, 2016YFC1000205"],"award-info":[{"award-number":["2017YFC1001004, 2016YFC1000205"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The present study aimed to assess whether women with polycystic ovarian syndrome (PCOS) \u226535 years age undergoing <jats:italic>in vitro<\/jats:italic> fertilization (IVF)\/intracytoplasmic sperm injection (ICSI) cycles experienced a higher cumulative live birth rate (CLBR) over a two-year period compared with age- and body mass index (BMI)-matched patients with tubal factor infertility. Through propensity score matching (PSM) approach, the authors retrospectively analyzed the IVF\/ICSI outcomes of 263 PCOS patients (35-46 years of age [mean, 37 years]) and 526 age- and BMI-matched tubal factor controls two years after oocyte retrieval. Multivariate regression analysis was performed to explore factors influencing cumulative live birth. Women with PCOS exhibited better ovarian reserve and response, and higher CLBR in two years compared with age- and BMI-matched controls (CLBR: 55.51% in PCOS <jats:italic>vs<\/jats:italic>. 38.02% in control, p&amp;lt;0.001). Multivariate logistic regression analysis revealed that the number of transferable embryos and antral follicle counts were both significant independent factors predicting cumulative live birth after adjusting for female age, female body mass index, percentage of transferred blastocysts, number of embryos transferred per embryo-transfer cycle, diagnosis of PCOS and freeze-all cycles (p&amp;lt;0.001, p=0.045). Women with PCOS \u2265 35 years of age demonstrated a higher CLBR over two years compared with age- and BMI-matched controls. This could be explained by favorable oocyte reserve and more available embryos compared with controls, which overcome the compromised oocyte quality in aged PCOS patients.<\/jats:p>","DOI":"10.3389\/fendo.2021.724333","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T06:13:09Z","timestamp":1632809589000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of Cumulative Live Birth Rate Between Aged PCOS Women and Controls in IVF\/ICSI Cycles"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhuoyao","family":"Mai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218","article-title":"The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.035","article-title":"Effect of Body Mass Index on In Vitro Fertilization Outcomes in Women With Polycystic Ovary Syndrome","volume":"211","author":"Bailey","year":"2014","journal-title":"Am J Obstetrics Gynecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mam.2013.06.001","article-title":"The Root of Reduced Fertility in Aged Women and Possible Therapentic Options: Current Status and Future Perspects","volume":"38","author":"Qiao","year":"2014","journal-title":"Mol Aspects Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations From the International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew066","article-title":"Age-Related Infertility and Unexplained Infertility: An Intricate Clinical Dilemma","volume":"31","author":"Somigliana","year":"2016","journal-title":"Hum Reprod"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14410-8","article-title":"Formation and Early Development of Follicles in the Polycystic Ovary","volume":"362","author":"Webber","year":"2003","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat024","article-title":"Which Follicles Make the Most Anti-Mullerian Hormone in Humans? 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