{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:31:05Z","timestamp":1782869465082,"version":"3.54.5"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Research on melatonin remains one of the major hot spots in the field of disease treatment, but relevant data are numerous. The purpose of this study was to quantitatively and qualitatively analyze the progress of melatonin research through the method of bibliometrics and to predict hot spots and trends in melatonin research. This study retrieved all the studies on melatonin from 2000 to 2019 in the Web of Science and PubMed and analysed the publishing trends in the literature on a bibliometric online analysis platform and CiteSpace software. The research results were also visually analysed to summarize melatonin research hot spots through gCLUTO and pubMR. The study retrieved a total of 20,351 publications, of which the number of US publications ranked first, accounting for 21.46%, with the greatest impact (centrality = 0.31). The University of Texas Health Science Center at San Antonio and Harvard University had the highest average number of citations at 43.19 and 33.96, respectively. <jats:italic>Journal of Pineal Research<\/jats:italic> had the highest average number of citations in 2,993 journals. Professor Reiter made the largest contribution to this area. We further analysed 100 highly cited articles for clinical applications and ongoing related clinical drug trials based on the first hot spot. We systematically analysed melatonin for nearly 20 years while predicting the main research trends in the future, which may provide new directions and ideas for melatonin research. The structure and normal physiological functions of melatonin have been intensively studied in the past few years. And clinical application research and target of melatonin treatment for different diseases and target-based drug design will certainly become the focus of melatonin research.<\/jats:p>","DOI":"10.3389\/fendo.2021.753923","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T18:06:55Z","timestamp":1638382015000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Research Hot Spots and Trends on Melatonin From 2000 to 2019"],"prefix":"10.3389","volume":"12","author":[{"given":"Yan","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbo","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wacili","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01543a060","article-title":"Isolation of Melatonin, the Pineal Gland Factor That Lightens Melanocytes","volume":"80","author":"Lerner","year":"1958","journal-title":"J Am Chem Soc"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01923947","article-title":"The Melatonin Rhythm: Both a Clock and a Calendar","volume":"49","author":"Reiter","year":"1993","journal-title":"Experientia"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"key":"B4","article-title":"[Phototransduction Mediated by Melanopsin in Intrinsically Photosensitive Retinal Ganglion Cells]","volume":"151","author":"Dom\u00ednguez-Sol\u00eds","year":"2015","journal-title":"Gac Med Mex"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1144-0","article-title":"XFEL Structures of the Human MT2 Melatonin Receptor Reveal the Basis of Subtype Selectivity","volume":"569","author":"Johansson","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1141-3","article-title":"Structural Basis of Ligand Recognition at the Human MT1 Melatonin Receptor","volume":"569","author":"Stauch","year":"2019","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF01953050","article-title":"Melatonin and Circadian Control in Mammals","volume":"45","author":"Armstrong","year":"1989","journal-title":"Experientia"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2178","article-title":"Elevated Rectal Temperature Produced by All-Night Bright Light Is Reversed by Melatonin Infusion in Men","volume":"71","author":"Strassman","year":"1991","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.004","article-title":"Melatonin: From Basic Research to Cancer Treatment Clinics","volume":"20","author":"Vijayalaxmi","year":"2002","journal-title":"J Clin Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.amjmed.2006.02.002","article-title":"Melatonin Reduces Night Blood Pressure in Patients With Nocturnal Hypertension","volume":"119","author":"Grossman","year":"2006","journal-title":"Am J Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00435.x","article-title":"Melatonin Influences the Proliferative and Differentiative Activity of Neural Stem Cells","volume":"42","author":"Moriya","year":"2007","journal-title":"J Pineal Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2008.04.001","article-title":"Physiological Effects of Melatonin: Role of Melatonin Receptors and Signal Transduction Pathways","volume":"85","author":"Pandi-Perumal","year":"2008","journal-title":"Prog Neurobiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2119\/molmed.2008.00117","article-title":"Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials","volume":"15","author":"Korkmaz","year":"2009","journal-title":"Mol Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i48.6087","article-title":"Hepatoprotective Actions of Melatonin: Possible Mediation by Melatonin Receptors","volume":"16","author":"Mathes","year":"2010","journal-title":"World J Gastroenterol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1503\/jpn.130009","article-title":"Unveiling the Role of Melatonin MT2 Receptors in Sleep, Anxiety and Other Neuropsychiatric Diseases: A Novel Target in Psychopharmacology","volume":"39","author":"Comai","year":"2014","journal-title":"J\u00a0Psychiatry Neurosci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13048-014-0098-y","article-title":"Melatonin: Shedding Light on Infertility?\u2013A Review of the Recent Literature","volume":"7","author":"Fernando","year":"2014","journal-title":"J Ovarian Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.12.031","article-title":"Melatonin, Bone Regulation and the Ubiquitin-Proteasome Connection: A Review","volume":"145","author":"Vriend","year":"2016","journal-title":"Life Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.lfs.2017.02.008","article-title":"Association Between Light at Night, Melatonin Secretion, Sleep Deprivation, and the Internal Clock: Health Impacts and Mechanisms of Circadian Disruption","volume":"173","author":"Touitou","year":"2017","journal-title":"Life Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01100","article-title":"The Top 100 Highly Cited Original Articles on Immunotherapy for Childhood Leukemia","volume":"10","author":"Zhong","year":"2019","journal-title":"Front Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003381","article-title":"Global Trends of Researches on Sacral Fracture Surgery: A Bibliometric Study Based on VOSviewer","volume":"45","author":"Huang","year":"2020","journal-title":"Spine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.7150\/ijbs.37496","article-title":"Publication Trends of Research on Sepsis and Host Immune Response During 1999-2019: A 20-Year Bibliometric Analysis","volume":"16","author":"Yao","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8145","article-title":"Mapping Theme Trends and Recognizing Hot Spots in Postmenopausal Osteoporosis Research: A Bibliometric Analysis","volume":"7","author":"Zhou","year":"2019","journal-title":"PeerJ"},{"key":"B23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.21037\/atm.2020.02.67","article-title":"The Publication Trends and Hot Spots of Scoliosis Research From 2009 to 2018: A 10-Year Bibliometric Analysis","volume":"8","author":"Tao L","year":"2020","journal-title":"Ann Transl Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1003-3513.2008.08.013","article-title":"Development of a Text Mining System Based on the Co-Occurrence of Bibliographic Items in Literature","volume":"8","author":"Cui L","year":"2008","journal-title":"New Technol Library Inf Service"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1996.tb00247.x","article-title":"Scientific Research on the Pineal Gland and Melatonin: A Bibliometric Study for the Period 1966-1994","volume":"20","author":"L\u00f3pez-Mu\u00f1oz","year":"1996","journal-title":"J Pineal Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.11.302","article-title":"Melatonin for Sleep Disorders: A Bibliometric Approach During the Last 20 Years","volume":"14","author":"Garc\u00eda-Garc\u00eda","year":"2013","journal-title":"Sleep Med"},{"key":"B27","article-title":"Bibliometric Study of Scientific Research on Melatonin During the Last 25 Years","volume-title":"Melatonin, Neuroprotective Agents and Antidepressant Therapy","author":"Francisco","year":"2016"},{"key":"B28","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3390\/molecules21020240","article-title":"The Impact of Melatonin in Research","volume":"21","author":"Varoni","year":"2016","journal-title":"Molecules"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.2196\/jmir.3326","article-title":"Mapping Publication Trends and Identifying Hot Spots of Research on Internet Health Information Seeking Behavior: A Quantitative and Co-Word Biclustering Analysis","volume":"17","author":"Li","year":"2015","journal-title":"J Med Internet Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2307\/2529310","article-title":"The Measurement of Observer Agreement for Categorical Data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"B31","first-page":"36","article-title":"[Time-Dependent Effects of Antihypertensive Agents and Chronocorrecting Action of Melatonin in Patients With Arterial Hypertension]","volume":"8","author":"Zaslavskaia","year":"2000","journal-title":"Vestn Ross Akad Med Nauk"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/09636410500292861","article-title":"Morning Melatonin has Limited Benefit as a Soporific for Daytime Sleep After Night Work","volume":"22","author":"Smith","year":"2005","journal-title":"Chronobiol Int"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.719962","article-title":"Melatonin Treatment Effects on Adolescent Students\u2019 Sleep Timing and Sleepiness in a Placebo-Controlled Crossover Study","volume":"29","author":"Eckerberg","year":"2012","journal-title":"Chronobiol Int"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12134","article-title":"Melatonin as a Potential Therapy for Sepsis: A Phase I Dose Escalation Study and an Ex Vivo Whole Blood Model Under Conditions of Sepsis","volume":"56","author":"Galley","year":"2014","journal-title":"J\u00a0Pineal Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.2174\/157015910792246209","article-title":"Clinical Aspects of Melatonin Intervention in Alzheimer\u2019s Disease Progression","volume":"8","author":"Cardinali","year":"2010","journal-title":"Curr Neuropharmacol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23884","article-title":"The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the Non-Motor Symptoms of Parkinson\u2019s Disease","volume":"26","author":"Seppi","year":"2011","journal-title":"Mov Disord"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523000205","article-title":"When Melatonin Gets on Your Nerves: Its Beneficial Actions in Experimental Models of Stroke","volume":"230","author":"Reiter","year":"2005","journal-title":"Exp Biol Med (Maywood)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/hup.964","article-title":"Circadian Rhythm Disturbances in Depression","volume":"23","author":"Germain","year":"2008","journal-title":"Hum Psychopharmacol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05347blu","article-title":"Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder: A Randomized, Double-Blind Comparison With Sertraline","volume":"71","author":"Kasper","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.02.006","article-title":"Melatonin as a Radioprotective Agent: A Review","volume":"59","author":"Vijayalaxmi","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B41","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/ijms18040843","article-title":"Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis","volume":"18","author":"Reiter","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/j.1600-079X.2006.00369.x","article-title":"Therapeutic Treatments Potentially Mediated by Melatonin Receptors: Potential Clinical Uses in the Prevention of Osteoporosis, Cancer and as an Adjuvant Therapy","volume":"41","author":"Witt-Enderby","year":"2006","journal-title":"J Pineal Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.5.609","article-title":"Sleep-Facilitating Effect of Exogenous Melatonin in Healthy Young Men and Women is Circadian-Phase Dependent","volume":"29","author":"Wyatt","year":"2006","journal-title":"Sleep"},{"key":"B44","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.chc.2008.06.006","article-title":"Assessment and Pharmacologic Treatment of Sleep Disturbance in Autism","volume":"17","author":"Johnson","year":"2008","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.regg.2009.03.015","article-title":"[Use of Combined Treatment With Melatonin and Clomethiazole in Circadian Rhythm Sleep Disorder in the Elderly With Dementia]","volume":"44","author":"Sim\u00f3n Padilla","year":"2009","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000522","article-title":"The Use and Misuse of Exogenous Melatonin in the Treatment of Sleep Disorders","volume":"24","author":"Riha","year":"2018","journal-title":"Curr Opin Pulm Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00932.x","article-title":"Evidence That Membrane-Bound G Protein-Coupled Melatonin Receptors MT1 and MT2 Are Not Involved in the Neuroprotective Effects of Melatonin in Focal Cerebral Ischemia","volume":"52","author":"Kilic","year":"2012","journal-title":"J Pineal Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.12.025","article-title":"Alterations of Melatonin Receptors MT1 and MT2 in the Hypothalamic Suprachiasmatic Nucleus During Depression","volume":"148","author":"Wu","year":"2013","journal-title":"J Affect Disord"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.09.003","article-title":"New Coumarin-Based Fluorescent Melatonin Ligands. Design, Synthesis and Pharmacological Characterization","volume":"103","author":"De La Fuente Revenga","year":"2015","journal-title":"Eur J Med Chem"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.229989","article-title":"Alternative Radioligands for Investigating the Molecular Pharmacology of Melatonin Receptors","volume":"356","author":"Legros","year":"2016","journal-title":"J Pharmacol Exp Ther"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00247-1","article-title":"Adaptation of the Circadian Rhythm of 6-Sulphatoxymelatonin to a Shift Schedule of Seven Nights Followed by Seven Days in Offshore Oil Installation Workers","volume":"325","author":"Gibbs","year":"2002","journal-title":"Neurosci Lett"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00385.2003","article-title":"Efficacy of a Single Sequence of Intermittent Bright Light Pulses for Delaying Circadian Phase in Humans","volume":"287","author":"Gronfier","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.43.193","article-title":"Changes in the Concentration of Urinary 6-Sulphatoxymelatonin During a Week of Simulated Night Work","volume":"43","author":"Roach","year":"2005","journal-title":"Ind Health"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.675257","article-title":"Photic Resetting in Night-Shift Work: Impact on Nurses\u2019 Sleep","volume":"29","author":"Boivin","year":"2012","journal-title":"Chronobiol Int"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.100098597","article-title":"Establishment and Persistence of Photoperiodic Memory in Hamsters","volume":"97","author":"Prendergast","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B56","article-title":"Melatonin and Seasonal Reproduction: Understanding the Neuroendocrine Mechanisms Using the Sheep as a Model","volume":"59","author":"Malpaux","year":"2002","journal-title":"Reprod Suppl"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1530\/biosciprocs.5.023","article-title":"Origin of Cerebrospinal Fluid Melatonin and Possible Function in the Integration of Photoperiod","volume":"61","author":"Tricoire","year":"2003","journal-title":"Reprod Suppl"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2006.11.002","article-title":"Effects of Ageing and Exogenous Melatonin on Pituitary Responsiveness to GnRH in Ewes During Anestrus and the Reproductive Season","volume":"67","author":"Forcada","year":"2007","journal-title":"Theriogenology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0006-8993(02)03603-X","article-title":"Pineal Melatonin and Brain Transmitter Monoamines in CBA Mice During Chronic Oral Nicotine Administration","volume":"957","author":"G\u00e4ddn\u00e4s","year":"2002","journal-title":"Brain Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345159","article-title":"Effect of a Synthetic Pineal Tetrapeptide (Ala-Glu-Asp-GLy) on Melatonin Secretion by the Pineal Gland of Young and Old Rats","volume":"26","author":"Djeridane","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-265678","article-title":"Amyloid \u03b2 Peptide Directly Impairs Pineal Gland Melatonin Synthesis and Melatonin Receptor Signaling Through the ERK Pathway","volume":"29","author":"Cecon","year":"2015","journal-title":"FASEB J"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02551-9","article-title":"Protective Effect of Melatonin in a Chronic Experimental Model of Parkinson\u2019s Disease","volume":"943","author":"Antol\u00edn","year":"2002","journal-title":"Brain Res"},{"key":"B63","article-title":"In Situ Demonstration of Improvement of Liver Mitochondria Function by Melatonin After Cold Ischemia","volume":"20","author":"Freitas","year":"2006","journal-title":"In Vivo"},{"key":"B64","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.etp.2009.10.002","article-title":"Effects of Melatonin on Lipid Peroxidation and Antioxidative Enzyme Activities in the Liver, Kidneys and Brain of Rats Administered With Benzo(a)Pyrene","volume":"63","author":"Murawska-Cia\u0142owicz","year":"2011","journal-title":"Exp Toxicol Pathol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"197","DOI":"10.33549\/physiolres.932295","article-title":"Changes in the Density of Nitrergic Neurons in the Hippocampus of Rats Following Kainic Acid and Melatonin Administration","volume":"62","author":"Jain","year":"2013","journal-title":"Physiol Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03627.x","article-title":"Free Radical-Mediated Molecular Damage. Mechanisms for the Protective Actions of Melatonin in the Central Nervous System","volume":"939","author":"Reiter","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.2174\/156802611794863517","article-title":"Melatonin-Mitochondria Interplay in Health and Disease","volume":"11","author":"Acu\u00f1a Castroviejo","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2011.623700","article-title":"Intracellular Redox State as Determinant for Melatonin Antiproliferative vs Cytotoxic Effects in Cancer Cells","volume":"45","author":"S\u00e1nchez-S\u00e1nchez","year":"2011","journal-title":"Free Radic Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-015-9855-0","article-title":"Synergic Effects of Doxorubicin and Melatonin on Apoptosis and Mitochondrial Oxidative Stress in MCF-7 Breast Cancer Cells: Involvement of TRPV1 Channels","volume":"249","author":"Ko\u015far","year":"2016","journal-title":"J Membr Biol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.753923\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T18:07:05Z","timestamp":1638382025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.753923\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":69,"alternative-id":["10.3389\/fendo.2021.753923"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2021.753923","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"article-number":"753923"}}