{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:57:02Z","timestamp":1780581422836,"version":"3.54.1"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Single nucleotide variants (SNVs) <jats:italic>FSHB<\/jats:italic>:c.-211G&amp;gt;T, <jats:italic>FSHR<\/jats:italic>:c.919G&amp;gt;A, and <jats:italic>FSHR<\/jats:italic>:c.2039G&amp;gt;A were reported to be associated with the variability in FSH and LH levels, and <jats:italic>in vitro<\/jats:italic> fertilization (IVF) outcomes. In this study, we aimed to evaluate the effects of <jats:italic>FSHB<\/jats:italic>:c.-211G&amp;gt;T, <jats:italic>FSHR<\/jats:italic>:c.919G&amp;gt;A, and <jats:italic>FSHR:<\/jats:italic>c.2039G&amp;gt;A variants, alone and combined, on the hormonal profile and reproduction outcomes of women with endometriosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was performed comprising 213 infertile Brazilian women with endometriosis who underwent IVF treatment. Genotyping was performed using TaqMan real-time PCR. Variables were compared according to the genotypes of each variant and genetic models, and the combined effects of the SNVs were evaluated using the multifactorial dimensionality reduction method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>FSHB<\/jats:italic>:c.-211G&amp;gt;T affected LH levels in women with overall endometriosis and minimal\/mild disease. <jats:italic>FSHR<\/jats:italic>:c.919G&amp;gt;A affected FSH levels in women with overall endometriosis and the number of oocytes retrieved in those with moderate\/severe endometriosis. Moreover, the <jats:italic>FSHR<\/jats:italic>:c.2039G&amp;gt;A affected FSH levels in women with overall endometriosis, LH levels and total amount of rFSH in those with minimal\/mild disease, and number of follicles and number of oocytes retrieved in those with moderate\/severe endometriosis. No effect on hormone profile or reproductive outcomes was observed when the genotypes were combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Variants of the <jats:italic>FSHB<\/jats:italic> and <jats:italic>FSHR<\/jats:italic> genes separately interfered with the hormonal profiles and IVF outcomes of women with endometriosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.760616","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T18:09:05Z","timestamp":1633025345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Bianca","family":"Bianco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Altheman","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Martins","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Maria","family":"Christofolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Montagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Parente","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.3390\/ijms20225615","article-title":"The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights","volume":"20","author":"Lagan\u00e0","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4633-0","article-title":"Should We Consider Integrated Approach for Endometriosis-Associated Infertility as Gold Standard Management? 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