{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:16Z","timestamp":1753890676474,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Several attempts have been done to capture damaged hypothalamus (HT) using volumetric measurements to predict the development of hypothalamic obesity in patients with craniopharyngioma (CP). This study was to develop a novel method of HT volume measurement and examine the associations between postoperative HT volume and clinical parameters in patients with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 78 patients with adult-onset CP who underwent surgical resection. Postoperative HT volume was measured using T1- and T2-weighted magnetic resonance imaging (MRI) with a slice thickness of 3 mm, and corrected for temporal lobe volume. We collected data on pre- and postoperative body weights, which were measured at the time of HT volume measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The corrected postoperative HT volume measured using T1- and T2-weighted images was significantly correlated (<jats:italic>r<\/jats:italic>=0.51 [95% confidence interval (CI) 0.32 to 0.67], <jats:italic>P<\/jats:italic>&amp;lt;0.01). However, HT volume was overestimated using T1-weighted images owing to obscured MR signal of the thalamus in patients with severe HT damage. Therefore, we used T2-weighted images to evaluate its clinical implications in 72 patients with available medical data. Postoperative HT volume was negatively associated with preoperative body weight and preoperative tumor volume (<jats:italic>r<\/jats:italic>=\u20130.25 [95% CI -0.45 to -0.04], <jats:italic>P<\/jats:italic>=0.04 and <jats:italic>r<\/jats:italic>=\u20130.26 [95% CI -0.40 to -0.15], <jats:italic>P<\/jats:italic>=0.03, respectively). In the subgroup analysis of CP patients who underwent primary surgery (<jats:italic>n<\/jats:italic>=56), pre- and postoperative body weights were negatively associated with HT volume (<jats:italic>r<\/jats:italic>=\u20130.30 [95% CI -0.53 to -0.03], <jats:italic>P<\/jats:italic>=0.03 and <jats:italic>r<\/jats:italic>=\u20130.29 [95% CI -0.53 to -0.02], <jats:italic>P<\/jats:italic>=0.03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult-onset CP patients showed negative associations between postoperative HT volume and preoperative\/postoperative body weight using a new method of HT volume measurement based on T2-weighted images.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.763523","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T06:08:01Z","timestamp":1639980481000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Implication of Individually Tailored Segmentation Method for Distorted Hypothalamus in Craniopharyngioma"],"prefix":"10.3389","volume":"12","author":[{"given":"A Ram","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hwy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung 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