{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:46:32Z","timestamp":1788965192182,"version":"build-2803163510"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies on the association between thyroid function and non\u2010alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQI<jats:sub>FT4<\/jats:sub>) was calculated. Also, we substituted free triiodothyronine (FT<jats:sub>3<\/jats:sub>) into the TFQI formulas to get the TFQI<jats:sub>FT3<\/jats:sub> index. NAFLD was defined using abdominal ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study results showed that FT<jats:sub>3<\/jats:sub>\/FT<jats:sub>4<\/jats:sub> and TFQI<jats:sub>FT3<\/jats:sub> were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (<jats:italic>P<\/jats:italic>&amp;lt;0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (<jats:italic>P<\/jats:italic>&amp;lt;0.05). In contrast, TFQI<jats:sub>FT4<\/jats:sub> was positively correlated with HDL-C level (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). After adjustment for multiple confounders, FT<jats:sub>3<\/jats:sub>, FT<jats:sub>3<\/jats:sub>\/FT<jats:sub>4<\/jats:sub>, and TFQI<jats:sub>FT3<\/jats:sub> were positively associated with the risks of dyslipidemia and NAFLD (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). TFQI<jats:sub>FT3<\/jats:sub> and FT<jats:sub>3<\/jats:sub>\/FT<jats:sub>4<\/jats:sub> performed better than TFQI<jats:sub>FT4<\/jats:sub> on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQI<jats:sub>FT4<\/jats:sub> with the risks of dyslipidemia and NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TFQI<jats:sub>FT3<\/jats:sub> and FT<jats:sub>3<\/jats:sub>\/FT<jats:sub>4<\/jats:sub> can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQI<jats:sub>FT4<\/jats:sub> has insufficient evidence in predicting dyslipidemia and NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2021.766419","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T14:51:45Z","timestamp":1636123905000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":69,"title":["Sensitivity to Thyroid Hormone Indices Are Closely Associated With 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