{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:22:06Z","timestamp":1790720526816,"version":"4.1.0"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin resistance, diabetes, hypertriglyceridemia, nonalcoholic fatty liver disease, dysfunctions of the gonadotropic axis and endocrine defects of adipose tissue with leptin and adiponectin deficiency. Diagnosis, based on clinical and metabolic investigations, and on genetic analyses, is of major importance to adapt medical care and genetic counseling. Molecular and cellular bases of these syndromes involve, among others, altered adipocyte differentiation, structure and\/or regulation of the adipocyte lipid droplet, and\/or premature cellular senescence. Lipodystrophy syndromes frequently present as systemic diseases with multi-tissue involvement. After an update on the main molecular bases and clinical forms of lipodystrophy, we will focus on topics that have recently emerged in the field. We will discuss the links between lipodystrophy and premature ageing and\/or immuno-inflammatory aggressions of adipose tissue, as well as the relationships between lipomatosis and lipodystrophy. Finally, the indications of substitutive therapy with metreleptin, an analog of leptin, which is approved in Europe and USA, will be discussed.<\/jats:p>","DOI":"10.3389\/fendo.2021.803189","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T07:10:27Z","timestamp":1641193827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":80,"title":["Molecular and Cellular Bases of Lipodystrophy Syndromes"],"prefix":"10.3389","volume":"12","author":[{"given":"Jamila","family":"Zammouri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Vatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Capel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Auclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Storey-London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Bismuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e9na","family":"Mosbah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Donadille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Janmaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"J\u00e9ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Vigouroux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000316893","article-title":"Human Lipodystrophies: Genetic and Acquired Diseases of Adipose Tissue","volume":"19","author":"Capeau","year":"2010","journal-title":"Endocr Dev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1159","article-title":"Clinical Review: Lipodystrophies: Genetic and Acquired Body Fat Disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s11892-018-1099-9","article-title":"Phenotypic and Genetic Characteristics of Lipodystrophy: Pathophysiology, Metabolic Abnormalities, and Comorbidities","volume":"18","author":"Akinci","year":"2018","journal-title":"Curr Diabetes Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41572-020-0181-1","article-title":"HIV and Antiretroviral Therapy-Related Fat Alterations","volume":"6","author":"Koethe","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2265.2012.04348.x","article-title":"Adipokine Profile in Glucocorticoid-Treated Patients: Baseline Plasma Leptin Level Predicts Occurrence of Lipodystrophy","volume":"78","author":"Fardet","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00032.2020","article-title":"Lipodistrophy: A Paradigm for Understanding the Consequences of \u201cOverloading\u201d Adipose Tissue","volume":"101","author":"Lim","year":"2021","journal-title":"Physiol Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2466","article-title":"The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline","volume":"101","author":"Brown","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.ando.2019.10.003","article-title":"Lipodystrophic Syndromes: From Diagnosis to Treatment","volume":"81","author":"Sollier","year":"2020","journal-title":"Ann Endocrinol (Paris)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S130810","article-title":"Estimating the Prevalence of Generalized and Partial Lipodystrophy: Findings and Challenges","volume":"10","author":"Chiquette","year":"2017","journal-title":"Diabetes Metab Syndr Obes"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0447","article-title":"Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort","volume":"69","author":"Gonzaga-Jauregui","year":"2020","journal-title":"Diabetes"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng585","article-title":"Identification of the Gene Altered in Berardinelli-Seip Congenital Lipodystrophy on Chromosome 11q13","volume":"28","author":"Magr\u00e9","year":"2001","journal-title":"Nat Genet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ng880","article-title":"AGPAT2 Is Mutated in Congenital Generalized Lipodystrophy Linked to Chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat Genet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.06.022","article-title":"Function of Seipin: New Insights From Bscl2\/seipin Knockout Mouse Models","volume":"96","author":"Dollet","year":"2014","journal-title":"Biochimie"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695170","article-title":"Seipin Regulates ER-Lipid Droplet Contacts and Cargo Delivery","volume":"35","author":"Salo","year":"2016","journal-title":"EMBO J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.devcel.2019.05.016","article-title":"Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact","volume":"50","author":"Salo","year":"2019","journal-title":"Dev Cell"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00039","article-title":"Congenital Generalized Lipoatrophy (Berardinelli-Seip Syndrome) Type 1: Description of Novel AGPAT2 Homozygous Variants Showing the Highly Heterogeneous Presentation of the Disease","volume":"11","author":"Ceccarini","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2008.10.008","article-title":"Filling Up Adipocytes With Lipids. Lessons From Caveolin-1 Deficiency","volume":"1791","author":"Le Lay","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"B18","doi-asserted-by":"publisher","first-page":"jcs241562","DOI":"10.1242\/jcs.241562","article-title":"Non-Caveolar Caveolins - Duties Outside the Caves","volume":"133","author":"Pol","year":"2020","journal-title":"J Cell Sci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng.3714","article-title":"Integrative Genomic Analysis Implicates Limited Peripheral Adipose Storage Capacity in the Pathogenesis of Human Insulin Resistance","volume":"49","author":"Lotta","year":"2017","journal-title":"Nat Genet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.plefa.2005.04.010","article-title":"The Adipose Organ","volume":"73","author":"Cinti","year":"2005","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What We Talk About When We Talk About Fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12015-011-9242-x","article-title":"Developmental Origins of the Adipocyte Lineage: New Insights From Genetics and Genomics Studies","volume":"8","author":"Billon","year":"2012","journal-title":"Stem Cell Rev Rep"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_7","article-title":"Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome","volume":"960","author":"Carobbio","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409229111","article-title":"Role of Diacylglycerol Activation of PKCtheta in Lipid-Induced Muscle Insulin Resistance in Humans","volume":"111","author":"Szendroedi","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210127","article-title":"Lipotoxicity: A Driver of Heart Failure With Preserved Ejection Fraction","volume":"135","author":"Leggat","year":"2021","journal-title":"Clin Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11154-012-9235-3","article-title":"Lipotoxicity Contributes to Endothelial Dysfunction: A Focus on the Contribution From Ceramide","volume":"14","author":"Symons","year":"2013","journal-title":"Rev Endocr Metab Disord"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.09.016","article-title":"Recent Insights Into Mechanisms of \u03b2-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes","volume":"432","author":"Lytrivi","year":"2020","journal-title":"J Mol Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0095-y","article-title":"Leptin and the Endocrine Control of Energy Balance","volume":"1","author":"Friedman","year":"2019","journal-title":"Nat Metab"},{"key":"B29","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2337\/dbi18-0035","article-title":"Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture","volume":"68","author":"Kahn","year":"2019","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cmet.2014.10.011","article-title":"A New Biology of Diabetes Revealed by Leptin","volume":"21","author":"Unger","year":"2015","journal-title":"Cell Metab"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1824","article-title":"Higher Adiponectin Levels in Patients With Berardinelli-Seip Congenital Lipodystrophy Due to Seipin as Compared With 1-Acylglycerol-3-Phosphate-O-Acyltransferase-2 Deficiency","volume":"95","author":"Antuna-Puente","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.metabol.2019.05.001","article-title":"Fatty Liver in Lipodystrophy: A Review With a Focus on Therapeutic Perspectives of Adiponectin and\/or Leptin Replacement","volume":"96","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1172\/JCI129187","article-title":"Altered Adipose Tissue and Adipocyte Function in the Pathogenesis of Metabolic Syndrome","volume":"129","author":"Kahn","year":"2019","journal-title":"J Clin Invest"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.12.8456","article-title":"Mechanism of Insulin Resistance in A-ZIP\/F-1 Fatless Mice","volume":"275","author":"Kim","year":"2000","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60408-4","article-title":"Lipid-Induced Insulin Resistance: Unravelling the Mechanism","volume":"375","author":"Samuel","year":"2010","journal-title":"Lancet"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2017.289","article-title":"Comparison of Regional Fat Measurements by Dual-Energy X-Ray Absorptiometry and Conventional Anthropometry and Their Association With Markers of Diabetes and Cardiovascular Disease Risk","volume":"42","author":"Vasan","year":"2018","journal-title":"Int J Obes"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30110-8","article-title":"Causes, Consequences, and Treatment of Metabolically Unhealthy Fat Distribution","volume":"8","author":"Stefan","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1042\/bst0290072","article-title":"Regional Differences in Protein Production by Human Adipose Tissue","volume":"29","author":"Arner","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22509","article-title":"Body Fat Distribution and Systolic Blood Pressure in 10,000 Adults With Whole-Body Imaging: UK Biobank and Oxford BioBank","volume":"27","author":"Malden","year":"2019","journal-title":"Obesity"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.12.012","article-title":"LMNA Mutations Resulting in Lipodystrophy and HIV Protease Inhibitors Trigger Vascular Smooth Muscle Cell Senescence and Calcification: Role of ZMPSTE24 Downregulation","volume":"245","author":"Afonso","year":"2016","journal-title":"Atherosclerosis"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.058","article-title":"Lamins as Mediators of Oxidative Stress","volume":"421","author":"Sieprath","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2013.12.015","article-title":"Nuclear Envelope-Related Lipodystrophies","volume":"29","author":"Gu\u00e9nantin","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00849","article-title":"PLIN1-Study Group, Et al. Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy","volume":"104","author":"J\u00e9ru","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.10.1545","article-title":"Skeletal Muscle Morphology and Exercise Response in Congenital Generalized Lipodystrophy","volume":"23","author":"Garg","year":"2000","journal-title":"Diabetes Care"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1297","article-title":"Increased Skeletal Muscle Volume in Women With Familial Partial Lipodystrophy, Dunnigan Variety","volume":"98","author":"Ji","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2012.04.010","article-title":"How to Diagnose a Lipodystrophy Syndrome","volume":"73","author":"Vantyghem","year":"2012","journal-title":"Ann Endocrinol (Paris)"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b44c","article-title":"Phenotypic Heterogeneity of the 8344A>G mtDNA \"MERRF\" Mutation","volume":"80","author":"Mancuso","year":"2013","journal-title":"Neurology"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.09.007","article-title":"A Novel LIPE Nonsense Mutation Found Using Exome Sequencing in Siblings With Late-Onset Familial Partial Lipodystrophy","volume":"30","author":"Farhan","year":"2014","journal-title":"Can J Cardiol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315496","article-title":"Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes","volume":"370","author":"Albert","year":"2014","journal-title":"N Engl J Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv229","article-title":"Homozygous Mutations in MFN2 Cause Multiple Symmetric Lipomatosis Associated With Neuropathy","volume":"24","author":"Sawyer","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e23813","DOI":"10.7554\/eLife.23813","article-title":"Human Biallelic MFN2 Mutations Induce Mitochondrial Dysfunction, Upper Body Adipose Hyperplasia, and Suppression of Leptin Expression","volume":"6","author":"Rocha","year":"2017","journal-title":"Elife"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37880","article-title":"Homozygous LIPE Mutation in Siblings With Multiple Symmetric Lipomatosis, Partial Lipodystrophy, and Myopathy","volume":"173","author":"Zolotov","year":"2017","journal-title":"Am J Med Genet A"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.07.009","article-title":"MFN2-Associated Lipomatosis: Clinical Spectrum and Impact on Adipose Tissue","volume":"12","author":"Capel","year":"2018","journal-title":"J Clin Lipidol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-1013","article-title":"LIPE-Related Lipodystrophic Syndrome: Clinical Features and Disease Modeling Using Adipose Stem Cells","volume":"184","author":"Sollier","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1873","article-title":"Type A Insulin Resistance Syndrome Revealing a Novel Lamin A Mutation","volume":"54","author":"Young","year":"2005","journal-title":"Diabetes"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2234","article-title":"A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights Into the Pathogenicity of Nonfarnesylated Prelamin-A","volume":"96","author":"Le Dour","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4158\/endp.19.1.v767575m65p5mr06","article-title":"The Clinical Approach to the Detection of Lipodystrophy - An AACE Consensus Statement","volume":"19","author":"Handelsman","year":"2013","journal-title":"Endocr Pract"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22382","article-title":"Unbuckling Lipodystrophy From Insulin Resistance and Hypertension","volume":"114","author":"Hegele","year":"2004","journal-title":"J Clin Invest"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300962","article-title":"Peroxisome Proliferator-Activated Receptor-Gamma Mutations Responsible for Lipodystrophy With Severe Hypertension Activate the Cellular Renin-Angiotensin System","volume":"33","author":"Auclair","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.684182","article-title":"Case Report: Metreleptin Treatment in a Patient With a Novel Mutation for Familial Partial Lipodystrophy Type 3, Presenting With Uncontrolled Diabetes and Insulin Resistance","volume":"12","author":"Lambadiari","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.18.2225","article-title":"Premature Atherosclerosis Associated With Monogenic Insulin Resistance","volume":"103","author":"Hegele","year":"2001","journal-title":"Circulation"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-Linked LMNA P.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy055","article-title":"The Lipodystrophic Hotspot Lamin A P.R482W Mutation Deregulates the Mesodermal Inducer T\/Brachyury and Early Vascular Differentiation Gene Networks","volume":"27","author":"Briand","year":"2018","journal-title":"Hum Mol Genet"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181e9442f","article-title":"Cardiomyopathy in Congenital and Acquired Generalized Lipodystrophy: A Clinical Assessment","volume":"89","author":"Lupsa","year":"2010","journal-title":"Med (Baltimore)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.036","article-title":"Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging","volume":"112","author":"Nelson","year":"2013","journal-title":"Am J Cardiol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(02)01070-7","article-title":"Multisystem Dystrophy Syndrome Due to Novel Missense Mutations in the Amino-Terminal Head and Alpha-Helical Rod Domains of the Lamin a\/C Gene","volume":"112","author":"Garg","year":"2002","journal-title":"Am J Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021506","article-title":"A New Clinical Condition Linked to a Novel Mutation in Lamins A and C With Generalized Lipoatrophy, Insulin-Resistant Diabetes, Disseminated Leukomelanodermic Papules, Liver Steatosis, and Cardiomyopathy","volume":"88","author":"Caux","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052632","article-title":"Primary Prevention of Sudden Death in Patients With Lamin a\/C Gene Mutations","volume":"354","author":"Meune","year":"2006","journal-title":"N Engl J Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2018.09.006","article-title":"Cardiometabolic Assessment of Lamin a\/C Gene Mutation Carriers: A Phenotype-Genotype Correlation","volume":"45","author":"Kwapich","year":"2019","journal-title":"Diabetes Metab"},{"key":"B71","doi-asserted-by":"publisher","first-page":"765","DOI":"10.3390\/cells9030765","article-title":"Looking at New Unexpected Disease Targets in LMNA-Linked Lipodystrophies in the Light of Complex Cardiovascular Phenotypes: Implications for Clinical Practice","volume":"9","author":"Mosbah","year":"2020","journal-title":"Cells"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0282","article-title":"A Recurrent Familial Partial Lipodystrophy Due to a Monoallelic or Biallelic LMNA Founder Variant Highlights the Multifaceted Cardiac Manifestations of Metabolic Laminopathies","volume":"185","author":"Treiber","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a Homozygous Nonsense Caveolin-1 Mutation With Berardinelli-Seip Congenital Lipodystrophy","volume":"93","author":"Kim","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38660","article-title":"Human PTRF Mutations Cause Secondary Deficiency of Caveolins Resulting in Muscular Dystrophy With Generalized Lipodystrophy","volume":"119","author":"Hayashi","year":"2009","journal-title":"J Clin Invest"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e1000874","DOI":"10.1371\/journal.pgen.1000874","article-title":"Fatal Cardiac Arrhythmia and Long-QT Syndrome in a New Form of Congenital Generalized Lipodystrophy With Muscle Rippling (CGL4) Due to PTRF-CAVIN Mutations","volume":"6","author":"Rajab","year":"2010","journal-title":"PLoS Genet"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-015-2556-y","article-title":"Berardinelli-Seip Syndrome and Achalasia: A Shared Pathomechanism","volume":"174","author":"van der Pol","year":"2015","journal-title":"Eur J Pediatr"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-21-0915","article-title":"Biallelic CAV1 Null Variants Induce Congenital Generalized Lipodystrophy With Achalasia","volume":"185","author":"Karhan","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2020.104028","article-title":"Pathophysiology of Premature Aging Characteristics in Mendelian Progeroid Disorders","volume":"63","author":"Hennekam","year":"2020","journal-title":"Eur J Med Genet"},{"key":"B79","doi-asserted-by":"publisher","first-page":"e68445","DOI":"10.7554\/eLife.68445","article-title":"EPHX1 Mutations Cause a Lipoatrophic Diabetes Syndrome Due to Impaired Epoxide Hydrolysis and Increased Cellular Senescence","volume":"10","author":"Gautheron","year":"2021","journal-title":"Elife"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2670","article-title":"An in-Frame Deletion at the Polymerase Active Site of POLD1 Causes a Multisystem Disorder With Lipodystrophy","volume":"45","author":"Weedon","year":"2013","journal-title":"Nat Genet"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-106","article-title":"Partial Lipodystrophy With Severe Insulin Resistance and Adult Progeria Werner Syndrome","volume":"8","author":"Donadille","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031658","article-title":"Patients With Familial Partial Lipodystrophy of the Dunnigan Type Due to a LMNA R482W Mutation Show Muscular and Cardiac Abnormalities","volume":"89","author":"Vantyghem","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0654","article-title":"New Metabolic Phenotypes in Laminopathies: LMNA Mutations in Patients With Severe Metabolic Syndrome","volume":"92","author":"Decaudain","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.10.031","article-title":"PSMB8 Encoding the Beta5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome","volume":"87","author":"Agarwal","year":"2010","journal-title":"Am J Hum Genet"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33578","article-title":"Congenital Generalized Lipodystrophy, Type 4 (CGL4) Associated With Myopathy Due to Novel PTRF Mutations","author":"Shastry","year":"2010","journal-title":"Am J Med Genet A"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81260","article-title":"Additive Loss-of-Function Proteasome Subunit Mutations in CANDLE\/PRAAS Patients Promote Type I IFN Production","volume":"125","author":"Brehm","year":"2015","journal-title":"J Clin Invest"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02142","article-title":"Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy","volume":"9","author":"Corvillo","year":"2018","journal-title":"Front Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-016-2457-9","article-title":"Bone Imaging Findings in Genetic and Acquired Lipodystrophic Syndromes: An Imaging Study of 24 Cases","volume":"45","author":"Teboul-Cor\u00e9","year":"2016","journal-title":"Skeletal Radiol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.683697","article-title":"Misdiagnosis of Paget's Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report","volume":"12","author":"Freire","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.111162","article-title":"How Does Adipose Tissue Contribute to Inflammageing","volume":"143","author":"Zamboni","year":"2021","journal-title":"Exp Gerontol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13059-020-02003-5","article-title":"Lamina-Associated Domains: Peripheral Matters and Internal Affairs","volume":"21","author":"Briand","year":"2020","journal-title":"Genome Biol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022188","article-title":"Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome","volume":"134","author":"Gordon","year":"2016","journal-title":"Circulation"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e9736","DOI":"10.15252\/emmm.201809736","article-title":"Progerin Accelerates Atherosclerosis by Inducing Endoplasmic Reticulum Stress in Vascular Smooth Muscle Cells","volume":"11","author":"Hamczyk","year":"2019","journal-title":"EMBO Mol Med"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.3390\/cells9051201","article-title":"Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells","volume":"9","author":"Bidault","year":"2020","journal-title":"Cells"},{"key":"B95","doi-asserted-by":"publisher","first-page":"335ra358","DOI":"10.1126\/scitranslmed.aad4991","article-title":"Laminopathies Disrupt Epigenomic Developmental Programs and Cell Fate","volume":"8","author":"Perovanovic","year":"2016","journal-title":"Sci Transl Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.stem.2020.12.016","article-title":"Pathogenic LMNA Variants Disrupt Cardiac Lamina-Chromatin Interactions and De-Repress Alternative Fate Genes","volume":"28","author":"Shah","year":"2021","journal-title":"Cell Stem Cell"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi480","article-title":"Nuclear Lamin A Inhibits Adipocyte Differentiation: Implications for Dunnigan-Type Familial Partial Lipodystrophy","volume":"15","author":"Boguslavsky","year":"2006","journal-title":"Hum Mol Genet"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201701043","article-title":"A Lipodystrophy-Causing Lamin A Mutant Alters Conformation and Epigenetic Regulation of the Anti-Adipogenic MIR335 Locus","volume":"216","author":"Oldenburg","year":"2017","journal-title":"J Cell Biol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.008","article-title":"FPLD2 LMNA Mutation R482W Dysregulates iPSC-Derived Adipocyte Function and Lipid Metabolism","volume":"495","author":"Friesen","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0289-0","article-title":"Altered Adipocyte Differentiation and Unbalanced Autophagy in Type 2 Familial Partial Lipodystrophy: An In Vitro and In Vivo Study of Adipose Tissue Browning","volume":"51","author":"Pellegrini","year":"2019","journal-title":"Exp Mol Med"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.3390\/cells10071598","article-title":"Impact of Progerin Expression on Adipogenesis in Hutchinson-Gilford Progeria Skin-Derived Precursor Cells","volume":"10","author":"Najdi","year":"2021","journal-title":"Cells"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4528","article-title":"Age-Related Lipid Metabolic Signature in Human LMNA-Lipodystrophic Stem Cell-Derived Adipocytes","volume":"100","author":"Sanchez","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101073","article-title":"Lamin A Involvement in Ageing Processes","volume":"62","author":"Cenni","year":"2020","journal-title":"Ageing Res Rev"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0419","article-title":"A Novel Syndrome of Mandibular Hypoplasia, Deafness, and Progeroid Features Associated With Lipodystrophy, Undescended Testes, and Male Hypogonadism","volume":"95","author":"Shastry","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.06.031","article-title":"POLD1: Central Mediator of DNA Replication and Repair, and Implication in Cancer and Other Pathologies","volume":"590","author":"Nicolas","year":"2016","journal-title":"Gene"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.08.011","article-title":"DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria","volume":"18","author":"Karakasilioti","year":"2013","journal-title":"Cell Metab"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202680","article-title":"Functional Analysis of POLD1 P.Ser605del Variant: The Aging Phenotype of MDPL Syndrome Is Associated With an Impaired DNA Repair Capacity","volume":"13","author":"Murdocca","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B108","doi-asserted-by":"publisher","first-page":"7490","DOI":"10.1038\/s41598-020-64136-8","article-title":"Human Pluripotent Stem Cell-Based Models Suggest Preadipocyte Senescence as a Possible Cause of Metabolic Complications of Werner and Bloom Syndromes","volume":"10","author":"Goh","year":"2020","journal-title":"Sci Rep"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73264","article-title":"Hypomorphism in Human NSMCE2 Linked to Primordial Dwarfism and Insulin Resistance","volume":"124","author":"Payne","year":"2014","journal-title":"J Clin Invest"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-021-00839-4","article-title":"MCM Complex Members MCM3 and MCM7 Are Associated With a Phenotypic Spectrum From Meier-Gorlin Syndrome to Lipodystrophy and Adrenal Insufficiency","volume":"29","author":"Knapp","year":"2021","journal-title":"Eur J Hum Genet"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58414","article-title":"A Mutation in the Immunoproteasome Subunit PSMB8 Causes Autoinflammation and Lipodystrophy in Humans","volume":"121","author":"Kitamura","year":"2011","journal-title":"J Clin Invest"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.631329","article-title":"Type I Interferonopathies in Children: An Overview","volume":"9","author":"D'Angelo","year":"2021","journal-title":"Front Pediatr"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3722","article-title":"Progressive Generalized Lipodystrophy as a Manifestation of Autoimmune Polyglandular Syndrome Type 1","volume":"101","author":"Sorkina","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200303000-00007","article-title":"Clinical Features and Metabolic Derangements in Acquired Generalized Lipodystrophy: Case Reports and Review of the Literature","volume":"82","author":"Misra","year":"2003","journal-title":"Med (Baltimore)"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1703","article-title":"Complement Abnormalities in Acquired Lipodystrophy Revisited","volume":"94","author":"Savage","year":"2009","journal-title":"J?Clin Endocrinol Metab"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2021.104073","article-title":"Autoimmunity in Lipodystrophy Syndromes","volume":"104073","author":"Ceccarini","year":"2021","journal-title":"Presse Med"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.05.011","article-title":"An Overview of Lipodystrophy and the Role of the Complement System","volume":"112","author":"Corvillo","year":"2019","journal-title":"Mol Immunol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13023-019-1292-1","article-title":"Immunological Features of Patients Affected by Barraquer-Simons Syndrome","volume":"15","author":"Corvillo","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2535","article-title":"Acquired Generalized Lipodystrophy: A New Cause of Anti-PD-1 Immune-Related Diabetes","volume":"42","author":"Jehl","year":"2019","journal-title":"Diabetes Care"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02221","article-title":"Acquired Lipodystrophy Associated With Nivolumab in a Patient With Advanced Renal Cell Carcinoma","volume":"104","author":"Falcao","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18124","article-title":"Acquired Generalized Lipodystrophy Under Immune Checkpoint Inhibition","volume":"182","author":"Haddad","year":"2020","journal-title":"Br J Dermatol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.7326\/L19-0635","article-title":"Lipodystrophic Nonalcoholic Fatty Liver Disease Induced by Immune Checkpoint Blockade","volume":"172","author":"Eigentler","year":"2020","journal-title":"Ann Intern Med"},{"key":"B123","doi-asserted-by":"publisher","first-page":"e150399","DOI":"10.1172\/jci.insight.150399","article-title":"Altered Pattern of Circulating miRNAs in HIV Lipodystrophy Perturbs Key Adipose Differentiation and Inflammation Pathways","volume":"6","author":"Srinivasa","year":"2021","journal-title":"JCI Insight"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201611194","article-title":"A New Mitofusin Topology Places the Redox-Regulated C Terminus in the Mitochondrial Intermembrane Space","volume":"217","author":"Mattie","year":"2018","journal-title":"J Cell Biol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8086-3","article-title":"Expanded Phenotypic Spectrum of the M.8344A>G \u201cMERRF\u201d Mutation: Data From the German mitoNET Registry","volume":"263","author":"Altmann","year":"2016","journal-title":"J Neurol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801867","article-title":"Multiple Symmetric Lipomatosis: Clinical Aspects and Outcome in a Long-Term Longitudinal Study","volume":"26","author":"Enzi","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"B127","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.3390\/ijms22062854","article-title":"Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan","volume":"22","author":"Kobayashi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012437","article-title":"Leptin-Replacement Therapy for Lipodystrophy","volume":"346","author":"Oral","year":"2002","journal-title":"N Engl J Med"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15001","article-title":"Leptin Reverses Insulin Resistance and Hepatic Steatosis in Patients With Severe Lipodystrophy","volume":"109","author":"Petersen","year":"2002","journal-title":"J Clin Invest"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95476","article-title":"Metreleptin-Mediated Improvements in Insulin Sensitivity Are Independent of Food Intake in Humans With Lipodystrophy","volume":"128","author":"Brown","year":"2018","journal-title":"J Clin Invest"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.137180","article-title":"Leptin Decreases De Novo Lipogenesis in Patients With Lipodystrophy","volume":"5","author":"Baykal","year":"2020","journal-title":"JCI Insight"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12606","article-title":"One-Year Metreleptin Improves Insulin Secretion in Patients With Diabetes Linked to Genetic Lipodystrophic Syndromes","volume":"18","author":"Vatier","year":"2016","journal-title":"Diabetes Obes Metab"},{"key":"B133","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s13023-019-1141-2","article-title":"Adherence With Metreleptin Therapy and Health Self-Perception in Patients With Lipodystrophic Syndromes","volume":"14","author":"Vatier","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab019","article-title":"Effects of Metreleptin on Patient Outcomes and Quality of Life in Generalized and Partial Lipodystrophy","volume":"5","author":"Cook","year":"2021","journal-title":"J Endocr Soc"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab499","article-title":"Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy","volume":"106","author":"Nguyen","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4491","article-title":"Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin","volume":"100","author":"Diker-Cohen","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2021.1976125","article-title":"Effects of Metreleptin in Patients With Lipodystrophy With and Without Baseline Concomitant Medication Use","volume":"37","author":"Adamski","year":"2021","journal-title":"Curr Med Res Opin"},{"key":"B138","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3109\/10428194.2015.1040015","article-title":"Lymphoma in Acquired Generalized Lipodystrophy","volume":"57","author":"Brown","year":"2016","journal-title":"Leuk Lymphoma"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.803189\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T07:10:33Z","timestamp":1641193833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2021.803189\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,3]]},"references-count":138,"alternative-id":["10.3389\/fendo.2021.803189"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2021.803189","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,3]]},"article-number":"803189"}}