{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:09:38Z","timestamp":1793315378143,"version":"4.5.0"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases.<\/jats:p>","DOI":"10.3389\/fendo.2022.1012508","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:28:36Z","timestamp":1666934916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":92,"title":["Osteopontin, a bridge links osteoarthritis and osteoporosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Rui-Jun","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7542.639","article-title":"Osteoarthritis","volume":"332","author":"Hunter","year":"2006","journal-title":"BMJ"},{"key":"B2","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull World Health Organ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.berh.2005.09.007","article-title":"Osteoarthritis: Epidemiology","volume":"20","author":"Arden","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-e","article-title":"Diagnosis, prophylaxis, and treatment of\u00a0osteoporosis","volume":"94","year":"1993","journal-title":"Am J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06376-0","article-title":"Prevalence of osteoporosis in osteoarthritis: A systematic review and meta-analysis","volume":"33","author":"Kim","year":"2022","journal-title":"Osteoporos Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/rheumatology\/kev377","article-title":"The relationships between bone mineral density and radiographic features of hand or knee osteoarthritis in older adults: Data from the dong-gu study","volume":"55","author":"Wen","year":"2016","journal-title":"Rheumatol (Oxford)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05504-y","article-title":"An in-depth study of the associations between osteoarthritis- and osteoporosis-related phenotypes at different skeletal locations","volume":"31","author":"Kasher","year":"2020","journal-title":"Osteoporos Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11657-020-00793-6","article-title":"Association of bone mineral density with the development of knee osteoarthritis in men and women: A cross-sectional study using the fourth and fifth Korea national health and nutrition examination surveys","volume":"15","author":"Jeon","year":"2020","journal-title":"Arch Osteoporos"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053x(00)00068-8","article-title":"Osteopontin is expressed by adult human osteoarthritic chondrocytes: Protein and mrna analysis of normal and osteoarthritic cartilage","volume":"19","author":"Pullig","year":"2000","journal-title":"Matrix Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.07.009","article-title":"Elevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patients","volume":"18","author":"Gao","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.02.002","article-title":"Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis","volume":"42","author":"Honsawek","year":"2009","journal-title":"Clin Biochem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1107-7","article-title":"Increased serum osteopontin is a risk factor for osteoporosis in menopausal women","volume":"21","author":"Chang","year":"2010","journal-title":"Osteoporos Int"},{"key":"B13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31+<92::AID-JCB13>3.0.CO;2-A","article-title":"Osteopontin expression and function: Role in bone remodeling","author":"Denhardt DT","year":"1998","journal-title":"J Cell Biochem Suppl"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19190","article-title":"Osteopontin: A bridge between bone and the immune system","volume":"112","author":"Gravallese","year":"2003","journal-title":"J Clin Invest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00296-011-2339-3","article-title":"The effect of hyaluronic acid on osteopontin and Cd44 mrna of fibroblast-like synoviocytes in patients with osteoarthritis of the knee","volume":"33","author":"Zhang","year":"2013","journal-title":"Rheumatol Int"},{"key":"B16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/jcm5040039","article-title":"Osteopontin-a master regulator of epithelial-mesenchymal transition","volume":"5","author":"Kothari","year":"2016","journal-title":"J Clin Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4045238","article-title":"Osteopontin: Relation between adipose tissue and bone homeostasis","volume":"2017","author":"De Fusco","year":"2017","journal-title":"Stem Cells Int"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.16445","article-title":"Role of osteopontin in liver diseases","volume":"12","author":"Wen","year":"2016","journal-title":"Int J Biol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049014","article-title":"Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture","volume":"7","author":"Yamaga","year":"2012","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3390\/biomedicines9081006","article-title":"Both full-length and protease-cleaved products of osteopontin are elevated in infectious diseases","volume":"9","author":"Hattori","year":"2021","journal-title":"Biomedicines"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-5699(00)01715-1","article-title":"Osteopontin (Eta-1) in cell-mediated immunity: Teaching an old dog new tricks","volume":"21","author":"O'Regan","year":"2000","journal-title":"Immunol Today"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960201)33:2<141::AID-JEMT5>3.0.CO;2-W","article-title":"Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair","volume":"33","author":"McKee MD","year":"1996","journal-title":"Microsc Res Tech"},{"key":"B23","article-title":"Role of osteopontin in adhesion, migration, cell survival and bone remodeling","author":"Standal T","year":"2004","journal-title":"Exp Oncol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00223-002-1025-6","article-title":"The integrin Alpha(V)Beta(3) and Cd44 regulate the actions of osteopontin on osteoclast motility","volume":"72","author":"Chellaiah","year":"2003","journal-title":"Calcif Tissue Int"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.8.1486","article-title":"Colocalization of intracellular osteopontin with Cd44 is associated with migration, cell fusion, and resorption in osteoclasts","volume":"17","author":"Suzuki","year":"2002","journal-title":"J Bone Miner Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/s0934-8832(11)80070-3","article-title":"Developmental expression of osteopontin (Opn) mrna in rat tissues: Evidence for a role for opn in bone formation and resorption","volume":"13","author":"Chen J","year":"1993","journal-title":"Matrix"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3428587","article-title":"Opn deficiency increases the severity of osteoarthritis associated with aberrant chondrocyte senescence and apoptosis and upregulates the expression of osteoarthritis-associated genes","volume":"2020","author":"Tian","year":"2020","journal-title":"Pain Res Manag"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2905634","article-title":"Mechanistic insight on the interaction between opn and integrin Alphanubeta3 in osteoarthritis","volume":"2020","author":"Yuan","year":"2020","journal-title":"BioMed Res Int"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28968","article-title":"Xist\/Mir-376c-5p\/Opn axis modulates the influence of proinflammatory M1 macrophages on osteoarthritis chondrocyte apoptosis","volume":"235","author":"Li","year":"2020","journal-title":"J Cell Physiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.919159","article-title":"Osteopontin in bone metabolism and bone diseases","volume":"26","author":"Si","year":"2020","journal-title":"Med Sci Monit"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1327-x","article-title":"Osteopontin regulates anabolic effect in human menopausal osteoporosis with intermittent parathyroid hormone treatment","volume":"22","author":"Chiang","year":"2011","journal-title":"Osteoporos Int"},{"key":"B32","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2310\/JIM.0b013e3182761264","article-title":"The value of osteopontin in the assessment of bone mineral density status in postmenopausal women","volume":"61","author":"Fodor","year":"2013","journal-title":"J Investig Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.10.1496","article-title":"High serum osteopontin levels are associated with low bone mineral density in postmenopausal women","volume":"28","author":"Cho","year":"2013","journal-title":"J Korean Med Sci"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2021.509","article-title":"Relationship between osteopontin and bone mineral density","volume":"17","author":"Vancea","year":"2021","journal-title":"Acta Endocrinol (Buchar)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2015.1087045","article-title":"Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women","volume":"76","author":"Wei","year":"2016","journal-title":"Scand J Clin Lab Invest"},{"key":"B36","article-title":"Obesity, osteoporosis and bone metabolism","volume":"20","author":"Gkastaris","year":"2020","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"B37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: Cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1038\/s41467-022-29191-x","article-title":"Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"B39","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41467-021-27683-w","article-title":"Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis","volume":"13","author":"Dai","year":"2022","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1312","article-title":"Osteopontin expression in human and murine obesity: Extensive local up-regulation in adipose tissue but minimal systemic alterations","volume":"149","author":"Kiefer","year":"2008","journal-title":"Endocrinology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05150-z","article-title":"Serum levels of leptin, osteopontin, and sclerostin in patients with and without knee osteoarthritis","volume":"40","author":"Min","year":"2021","journal-title":"Clin Rheumatol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(13)60042-5","article-title":"Expression of nf-Kb and osteopontin of synovial fluid of patients with knee osteoarthritis","volume":"6","author":"Qin LF","year":"2013","journal-title":"Asian Pac J Trop Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"BSR20182023","DOI":"10.1042\/BSR20182023","article-title":"Opn gene locus is associated with the risk of knee osteoarthritis: A case-control study","volume":"39","author":"Shang","year":"2019","journal-title":"Biosci Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.14670\/HH-29.925","article-title":"Osteopontin expression and localization of ca++ deposits in early stages of osteoarthritis in a rat model","volume":"29","author":"Martinez-Calleja","year":"2014","journal-title":"Histol Histopathol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203707","article-title":"Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of oa in a mouse model","volume":"14","author":"Lin","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2020.06.006","article-title":"Osteopontin inhibits osteoarthritis progression Via the Opn\/Cd44\/Pi3k signal axis","volume":"9","author":"Liu","year":"2022","journal-title":"Genes Dis"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.09.009","article-title":"Cd44: More than a mere stem cell marker","volume":"81","author":"Morath","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"B48","article-title":"Cd44 variants but not Cd44s cooperate with beta 1-containing integrins to permit cells to bind to osteopontin independently of arginine-Glycine-Aspartic acid, thereby stimulating cell motility and chemotaxis","volume":"59","author":"Katagiri","year":"1999","journal-title":"Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1177\/1076029620964864","article-title":"Interrelationship of osteopontin, mmp-9 and Adamts4 in patients with osteoarthritis undergoing total joint arthroplasty","volume":"26","author":"Slovacek","year":"2020","journal-title":"Clin Appl Thromb Hemost"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26025","article-title":"Neat1\/Mir-181c regulates osteopontin (Opn)-mediated synoviocyte proliferation in osteoarthritis","volume":"118","author":"Wang","year":"2017","journal-title":"J Cell Biochem"},{"key":"B51","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12951-021-01086-x","article-title":"Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis","volume":"19","author":"Li","year":"2021","journal-title":"J Nanobiotechno"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2019.1641723","article-title":"Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis","volume":"41","author":"Tsai","year":"2019","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bone.2017.11.004","article-title":"The key role of proinflammatory cytokines, matrix proteins, Rankl\/Opg and Wnt\/Beta-catenin in bone healing of hip arthroplasty patients","volume":"107","author":"Cassuto","year":"2018","journal-title":"Bone"},{"key":"B54","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1038\/s41598-021-84582-2","article-title":"Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion","volume":"11","author":"Garcia-Manrique","year":"2021","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/art.24705","article-title":"Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice","volume":"60","author":"Matsui","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1874904","article-title":"Perk activator Cct020312 prevents inflammation-mediated osteoporosis in the ovariectomized rats","volume":"37","author":"Tang","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S303412","article-title":"Nanohydroxyapatite (Nhap) doped with iron oxide nanoparticles (Io), mir-21 and mir-124 under magnetic field conditions modulates osteoblast viability, reduces inflammation and inhibits the growth of osteoclast - a novel concept for osteoporosis treatment: Part 1","volume":"16","author":"Marycz","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.710169","article-title":"Salvianolate ameliorates osteopenia and improves bone quality in prednisone-treated rheumatoid arthritis rats by regulating Rankl\/Rank\/Opg signaling","volume":"12","author":"Gao","year":"2021","journal-title":"Front Pharmacol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.065","article-title":"Angptl2 deletion inhibits osteoclast generation by modulating nf-Kappab\/Mapks\/Cyclin pathways","volume":"503","author":"Li","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.007","article-title":"Mln64 deletion suppresses rankl-induced osteoclastic differentiation and attenuates diabetic osteoporosis in streptozotocin (Stz)-induced mice","volume":"505","author":"Lei","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.06.015","article-title":"Monotropein attenuates ovariectomy and lps-induced bone loss in mice and decreases inflammatory impairment on osteoblast through blocking activation of nf-kappab pathway","volume":"291","author":"He","year":"2018","journal-title":"Chem Biol Interact"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/art.24814","article-title":"Thrombin-activatable carboxypeptidase b cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis","volume":"60","author":"Sharif","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100637","article-title":"Thrombin-cleaved osteopontin levels in synovial fluid correlate with disease severity of knee osteoarthritis","volume":"38","author":"Hasegawa","year":"2011","journal-title":"J Rheumatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.4238\/2015.December.29.32","article-title":"Meta-analysis of association between il-6 -634c\/G polymorphism and osteoporosis","volume":"14","author":"Yan","year":"2015","journal-title":"Genet Mol Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.3390\/ijms20236008","article-title":"Cytokines in inflammatory disease","volume":"20","author":"Kany","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401850","article-title":"Tlr signaling","volume":"13","author":"Kawai","year":"2006","journal-title":"Cell Death Differ"},{"key":"B67","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1089\/gtmb.2013.0223","article-title":"Association between interleukin-6 gene polymorphisms and bone mineral density: A meta-analysis","volume":"17","author":"Wang","year":"2013","journal-title":"Genet Test Mol Biomarkers"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2548-4","article-title":"Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13","volume":"33","author":"Xu","year":"2013","journal-title":"Rheumatol Int"},{"key":"B69","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.clinbiochem.2018.07.003","article-title":"The multiple functions and mechanisms of osteopontin","volume":"59","author":"Icer","year":"2018","journal-title":"Clin Biochem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202003_20647","article-title":"Osteopontin accelerates chondrocyte proliferation in osteoarthritis rats through the nf-kappab signaling pathway","volume":"24","author":"Sun","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1526-y","article-title":"Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis","volume":"20","author":"Qian","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2021-0004","article-title":"S-allylcysteine inhibits chondrocyte inflammation to reduce human osteoarthritis Via targeting rage, Tlr4, jnk, and Nrf2 signaling: Comparison with colchicine","volume":"99","author":"Elmazoglu","year":"2021","journal-title":"Biochem Cell Biol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.3390\/molecules26071831","article-title":"The effects of andrographolide on the enhancement of chondrogenesis and osteogenesis in human suprapatellar fat pad derived mesenchymal stem cells","volume":"26","author":"Kulsirirat","year":"2021","journal-title":"Molecules"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200036","article-title":"Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis","volume":"477","author":"Tang","year":"2020","journal-title":"Biochem J"},{"key":"B75","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s13075-018-1701-1","article-title":"Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice","volume":"20","author":"Xiao","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102742","article-title":"Aucubin exerts anti-osteoporotic effects by promoting osteoblast differentiation","volume":"12","author":"Li","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"B77","article-title":"An experimental research into the potential therapeutic effects of anti-osteoporosis decoction and yougui pill on ovariectomy-induced osteoporosis","volume":"11","author":"Gu F","year":"2019","journal-title":"Am J Transl Res"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2020.151601","article-title":"Artesunate promotes osteoblast differentiation through mir-34a\/Dkk1 axis","volume":"122","author":"Zeng","year":"2020","journal-title":"Acta Histochem"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109796","article-title":"Anagliptin stimulates osteoblastic cell differentiation and mineralization","volume":"129","author":"Dong","year":"2020","journal-title":"BioMed Pharmacother"},{"key":"B80","doi-asserted-by":"publisher","first-page":"5859641","DOI":"10.1155\/2019\/5859641","article-title":"Preventive effects of evodiamine on dexamethasone-induced osteoporosis in zebrafish","volume":"2019","author":"Yin","year":"2019","journal-title":"Biomed Res Int"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.06.006","article-title":"Myricetin ameliorates glucocorticoid-induced osteoporosis through the erk signaling pathway","volume":"207","author":"Fan","year":"2018","journal-title":"Life Sci"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155166","article-title":"Protein array test detected three osteoporosis related plasma inflammatory cytokines in Chinese postmenopausal women","volume":"133","author":"Wu","year":"2020","journal-title":"Cytokine"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113590","article-title":"Ameliorative effects of osteo-f, a newly developed herbal formula, on osteoporosis Via activation of bone formation","volume":"268","author":"Lee","year":"2021","journal-title":"J\u00a0Ethnopharmacol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.3390\/ma15113990","article-title":"Impact of polyrhodanine manganese ferrite binary nanohybrids (PRHD@MnFe2O4) on osteoblasts and osteoclasts activities-A key factor in osteoporosis treatment","volume":"15","author":"Marycz","year":"2022","journal-title":"Materials (Basel)"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1900633","article-title":"Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (Runx2): A therapeutic implication in osteoporosis","volume":"12","author":"Shao","year":"2021","journal-title":"Bioengineered"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.06.004","article-title":"Osteoporosis in older adults","volume":"104","author":"Johnston","year":"2020","journal-title":"Med Clin North Am"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.8156","article-title":"Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption","volume":"96","author":"Yoshitake","year":"1999","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.3.8006","article-title":"Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone","volume":"142","author":"Asou","year":"2001","journal-title":"Endocrinology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/cells8090985","article-title":"Osteopontin is an important regulative component of the fetal bone marrow hematopoietic stem cell niche","volume":"8","author":"Cao","year":"2019","journal-title":"Cells"},{"key":"B91","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3892\/etm.2021.10372","article-title":"Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the tgf-Beta\/Smad3 pathway","volume":"22","author":"Huang","year":"2021","journal-title":"Exp Ther Med"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0170-6","article-title":"Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells Via increasing osteopontin expression","volume":"50","author":"Lee","year":"2018","journal-title":"Exp Mol Med"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-012-9449-8","article-title":"Osteopontin promotes mesenchymal stem cell migration and lessens cell stiffness Via integrin Beta1, fak, and erk pathways","volume":"65","author":"Zou","year":"2013","journal-title":"Cell Biochem Biophys"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.04.004","article-title":"Decreased nuclear stiffness Via fak-Erk1\/2 signaling is necessary for osteopontin-promoted migration of bone marrow-derived mesenchymal stem cells","volume":"355","author":"Liu","year":"2017","journal-title":"Exp Cell Res"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19-0561","article-title":"Strontium ranelate improves alveolar bone healing in estrogen-deficient rats","volume":"91","author":"Miranda","year":"2020","journal-title":"J\u00a0Periodontol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.643482","article-title":"Palmul-tang, a Korean medicine, promotes bone formation Via bmp-2 pathway in osteoporosis","volume":"12","author":"Choi","year":"2021","journal-title":"Front Pharmacol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071665","article-title":"Effects of multi-Deficiencies-Diet on bone parameters of peripheral bone in ovariectomized mature rat","volume":"8","author":"El Khassawna","year":"2013","journal-title":"PLoS One"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1012508\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:28:46Z","timestamp":1666934926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1012508\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,28]]},"references-count":97,"alternative-id":["10.3389\/fendo.2022.1012508"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1012508","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,28]]},"article-number":"1012508"}}