{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:00:29Z","timestamp":1767855629223,"version":"3.49.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Our goal is to investigate the connection between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED).Serum 25(OH)D and CIMT were measured in 124 participants with erectile dysfunction and 39 healthy controls. The relationship between them and different patient-related parameters and disease-related parameters was studied. Compared with the control group and mild ED group, the level of serum 25(OH)D in moderate ED group and severe ED group decreased significantly(<jats:italic>P<\/jats:italic>&amp;lt;0.05). The CIMT values of moderate ED group and severe ED group were higher than those of the control group(<jats:italic>P<\/jats:italic>&amp;lt;0.05). The CIMT value of severe ED group was significantly higher than that of mild ED group(<jats:italic>P<\/jats:italic>&amp;lt;0.05). IIEF-5 score was positively correlated with serum 25(OH)D level, but negatively correlated with CIMT value(<jats:italic>P<\/jats:italic>&amp;lt;0.05). After adjusting for the influence of confounding factors, The CIMT values, 25(OH)D and IIEF-5 score were substantially associated(<jats:italic>P<\/jats:italic>&amp;lt;0.05). The serum level of 25(OH)D and IIEF-5 score were positively correlated, while the CIMT values and IIEF-5 score were negatively correlated. The level of serum 25(OH)D should be analyzed in men with ED, especially in patients with vasculogenic ED, and supplementation is recommended for those who were with vitamin D deficiency.<\/jats:p>","DOI":"10.3389\/fendo.2022.1027430","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T04:50:55Z","timestamp":1665031855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlation analysis of carotid artery intima-media thickness, serum 25(OH)D and men with erectile dysfunction"],"prefix":"10.3389","volume":"13","author":[{"given":"Jun-hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-ni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-zhong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-duo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-fa","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-hui","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001367","article-title":"Erectile dysfunction in a sample of sexually active young adult men from a U.S. cohort: Demographic, metabolic and mental health correlates","volume":"2","author":"Calzo","year":"2021","journal-title":"J Urol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","article-title":"Erectile dysfunction","author":"Yafi","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.173609","article-title":"Correlation between carotid intimal\/medial thickness and atherosclerosis: a point of view from pathology","volume":"2","author":"Finn","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2147\/DMSO.S8540","article-title":"Carotid intima-media thickness as a surrogate marker of cardiovascular disease in diabetes","author":"Sibal","year":"2011","journal-title":"Diabetes Metab Syndr Obes"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2015.11.011","article-title":"Peripheral atherosclerosis in patients with erectile dysfunction: A population-based study","volume":"13","author":"Carlos","year":"2016","journal-title":"J Sex Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_73_17","article-title":"Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors","volume":"4","author":"Yao","year":"2018","journal-title":"Asian J Androl"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12661","article-title":"Vitamin d and erectile dysfunction","volume":"11","author":"Barassi","year":"2014","journal-title":"J Sex Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020575","article-title":"Vitamin D and Endothelial Function","volume":"12","author":"Kim","year":"2020","journal-title":"Nutrients"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.12.025","article-title":"Vitamin D and cardiovascular health","volume":"40","author":"de la Gu\u00eda-Galipienso","year":"2021","journal-title":"Clin Nutr"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20177185","article-title":"Correlation between serum 25-hydroxyvitamin d levels and carotid intima-media thickness in a Brazilian population descended from African slaves","volume":"4","author":"Monteiro J\u00fanior","year":"2018","journal-title":"Braz J Med Biol Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged, 5-item version of the international index of erectile function (IIEF-5) as a diagnostic tool for erectile dysfunction","volume":"6","author":"Rosen","year":"1999","journal-title":"Int J Impot Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1285-3","article-title":"IOF position statement: vitamin d recommendations for older adults","volume":"21","author":"Dawson-Hughes","year":"2010","journal-title":"Osteoporos Int"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0851-z","article-title":"Hypovitaminosis d is associated with erectile dysfunction in type 2 diabetes","volume":"3","author":"Caretta","year":"2016","journal-title":"Endocrine"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.07.921","article-title":"Vitamin d deficiency is independently associated with greater prevalence of erectile dysfunction: The national health and nutrition examination survey (NHANES) 2001\u20132004","volume":"252","author":"Farag","year":"2016","journal-title":"Atherosclerosis"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2018.1459544","article-title":"The relationship between erectile dysfunction severity, mean platelet volume and vitamin d levels","author":"Culha","year":"2020","journal-title":"Aging male"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051411","article-title":"Is there an association between vitamin d deficiency and erectile dysfunction? a systematic review and meta-analysis","volume":"12","author":"Crafa","year":"2020","journal-title":"Nutrients"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/and.13211","article-title":"Serum vitamin d levels and erectile dysfunction: A systematic review and meta-analysis","volume":"3","author":"Wei","year":"2019","journal-title":"Andrologia"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14494","article-title":"Association of serum vitamin d level and carotid atherosclerosis: A systematic review and meta-analysis","volume":"37","author":"Chen","year":"2018","journal-title":"J Ultrasound Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13705","article-title":"Carotid intima-media thickness as a biomarker of subclinical atherosclerosis","volume":"142","author":"Bauer","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/and.14127","article-title":"Serum lipocalin-2 and carotid artery intima-media thickness in relation to obesity in eugonadal males over forty with venogenic erectile dysfunction","volume":"53","author":"El Mulla","year":"2021","journal-title":"Andrologia"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-018-0103-x","article-title":"Carotid artery intima-media thickness can predict the response of patients with erectile dysfunction to phosphodiesterase 5 inhibitors","volume":"31","author":"Pelit","year":"2019","journal-title":"Int J impot Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.06.017","article-title":"Vitamin d deficiency may be an independent risk factor for arterial disease","volume":"44","author":"Van de Luijtgaarden","year":"2012","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00342","article-title":"Impact of vitamin d deficiency on subclinical carotid atherosclerosis: A pooled analysis of cohort studies","volume":"102","author":"Lupoli","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147719.27237.14","article-title":"Distribution and crosssectional age-related increases of carotid artery intima-media thickness in young adults: the bogalusa heart study","volume":"35","author":"Stein","year":"2004","journal-title":"Stroke"},{"key":"B25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ijcard.2013.11.091","article-title":"Low circulating level of IGF-1 is a distinct indicator for the development of cardiovascular disease caused by combined hyperglycemia and dyslipidemia","volume":"171","author":"Li","year":"2014","journal-title":"Int J Cardiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N Engl J Med"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44267-4","article-title":"Physiology of erection and pharmacological management of impotence","volume":"137","author":"Lue","year":"1987","journal-title":"J Urol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1027430\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T04:50:57Z","timestamp":1665031857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1027430\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":27,"alternative-id":["10.3389\/fendo.2022.1027430"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1027430","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"article-number":"1027430"}}