{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:13:14Z","timestamp":1787026394379,"version":"build-2736575974"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epithelial-mesenchymal transition (EMT) is a complex event that drives polar epithelial cells transform from adherent cells to motile mesenchymal cells, in which are involved immune cells and stroma cells. EMT plays crucial roles in migration and invasion of endometriosis. The interaction of endometrial implants with the surrounding peritoneal micro-environment probably affects the development of peritoneal endometriosis. To date, very few studies have been carried out on peritoneal endometriosis sub-type classification and micro-environment analysis based on EMT. The purpose of this study is to investigate the potential application of EMT-based classification in precise diagnosis and treatment of peritoneal endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Based on EMT hallmark genes, 76 peritoneal endometriosis samples were classified into two clusters by consistent cluster classification. EMT scores, which calculated by Z score of 8 epithelial cell marker genes and 8 mesenchymal cell marker genes, were compared in two clusters. Then, immune scores and the abundances of corresponding immune cells, stroma scores and the abundances of corresponding stroma cells were analyzed by the \u201cxCell\u201d package. Futhermore, a diagnostic model was constructed based on 9 diagnostic markers which related to immune score and stroma score by Lasso-Logistic regression analysis. Finally, based on EMT classification, a total of 8 targeted drugs against two clusters were screened out by drug susceptibility analysis\n                      <jats:italic>via<\/jats:italic>\n                      \u201cpRRophetic\u201d package.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hallmark epithelial-mesenchymal transition was the mainly enriched pathway of differentially expressed genes between peritoneal endometriosis tissues and endometrium tissues. Compared with cluster 2, EMT score and the abundances of most infiltrating stroma cell were significantly higher, while the abundances of most infiltrating immune cells were dramatically less. The diagnostic model could accurately distinguish cluster 1 from cluster 2. Pathway analysis showed drug candidates targeting cluster 1 mainly act on the IGF-1 signaling pathway, and drug candidates targeting cluster 2 mainly block the EGFR signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In peritoneal endometriosis, EMT was probably promoted by stroma cell infiltration and inhibited by immune cell infiltration. Besides, our study highlighted the potential uses of the EMT classification in the precise diagnosis and treatment of peritoneal endometriosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.1035158","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:52:40Z","timestamp":1669686760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Immune micro-environment and drug analysis of peritoneal endometriosis based on epithelial-mesenchymal transition classification"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingli","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/humrep\/dey332","article-title":"Iatrogenic endometriosis harbors somatic cancer-driver mutations","volume":"34","author":"Lac","year":"2019","journal-title":"Hum Reprod"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910792","article-title":"The role of peritoneal macrophages in endometriosis","volume":"22","author":"Ram\u00edrez-Pavez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112438443","article-title":"Stress exacerbates endometriosis manifestations and inflammatory parameters in an animal model","volume":"19","author":"Cuevas","year":"2012","journal-title":"Reprod Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.09.025","article-title":"ASRM m\u00fcllerian anomalies classification","volume":"116","author":"Pfeifer","year":"2021","journal-title":"Fertil Steril"},{"key":"B6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.bpobgyn.2020.11.004","article-title":"Classification of deep endometriosis (DE) including bowel endometriosis: From r-ASRM to #Enzian-classification","volume":"71","author":"Keckstein","year":"2021","journal-title":"Best Pract Res Cl Ob"},{"key":"B7","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrm4045","article-title":"Cell migration: EMT promotes contact inhibition of locomotion","volume":"16","author":"Wrighton","year":"2015","journal-title":"Nat Rev Mol Cell Bio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","article-title":"New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer","volume":"20","author":"Dongre","year":"2019","journal-title":"Nat Rev Mol Cell Bio"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/1933719117718275","article-title":"Histological and immunohistochemical characterization of the similarity and difference between ovarian endometriomas and deep infiltrating endometriosis","volume":"25","author":"Liu","year":"2018","journal-title":"Reprod Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"44616","DOI":"10.1038\/srep44616","article-title":"Effects of matrix stiffness on epithelial to mesenchymal transition-like processes of endometrial epithelial cells: Implications for the pathogenesis of endometriosis","volume":"7","author":"Matsuzaki","year":"2017","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13179","article-title":"ZEB1 expression is a potential indicator of invasive endometriosis","volume":"96","author":"Furuya","year":"2017","journal-title":"Acta Obstet Gyn Scan"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.08.018","article-title":"A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma","volume":"24","author":"Caramel","year":"2013","journal-title":"Cancer Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1016\/j.devcel.2021.11.006","article-title":"Distinct contributions of partial and full EMT to breast cancer malignancy","volume":"56","author":"L\u00fc\u00f6nd","year":"2021","journal-title":"Dev Cell"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.07.003","article-title":"EMT MET plasticity and tumor metastasis","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"188564","DOI":"10.1016\/j.bbcan.2021.188564","article-title":"Epithelial-mesenchymal transition: When tumor cells meet myeloid-derived suppressor cells","volume":"1876","author":"Cai","year":"2021","journal-title":"Bba-Rev Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41416-020-01177-w","article-title":"TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms","volume":"124","author":"Peyre","year":"2021","journal-title":"Brit J Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2741\/e358","article-title":"Peritoneal endometriosis is an inflammatory disease","volume":"4","author":"Lousse","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1038\/s41598-022-07349-3","article-title":"Endometriosis pain and epithelial neutrophil activating peptide-78 levels","volume":"12","author":"Gardella","year":"2022","journal-title":"Sci Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s13046-018-0981-2","article-title":"The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer","volume":"37","author":"Kuwada","year":"2018","journal-title":"J Exp Clin Cancer Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaab036","article-title":"Endometrial epithelial-mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia","volume":"27","author":"Kusama","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4995-y","article-title":"Arrangement of myofibroblastic and smooth muscle-like cells in superficial peritoneal endometriosis and a possible role of transforming growth factor beta 1 (TGF\u03b21) in myofibroblastic metaplasia","volume":"299","author":"Ibrahim","year":"2019","journal-title":"Arch Gynecol Obstet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.3390\/cancers14153727","article-title":"A novel risk score model of lactate metabolism for predicting over survival and immune signature in lung adenocarcinoma","volume":"14","author":"Jiang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.769685","article-title":"Identification of molecular subtypes and a prognostic signature based on inflammation-related genes in colon adenocarcinoma","volume":"12","author":"Qiu","year":"2021","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an r package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B25","doi-asserted-by":"publisher","first-page":"100141","DOI":"10.1016\/j.xinn.2021.100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (N Y)"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00961-5","article-title":"Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues","volume":"24","author":"Tan","year":"2022","journal-title":"Nat Cell Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13578-021-00637-x","article-title":"Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity","volume":"11","author":"Ma","year":"2021","journal-title":"Cell Biosci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12916-022-02500-3","article-title":"Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis","volume":"20","author":"Shih","year":"2022","journal-title":"BMC Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3390\/jcm9061915","article-title":"Epithelial-mesenchymal transition in endometriosis-when does it happen","volume":"9","author":"Konrad","year":"2020","journal-title":"J Clin Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lungcan.2019.10.012","article-title":"Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy","volume":"139","author":"Thompson","year":"2020","journal-title":"Lung Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.56","article-title":"Application of ggplot2 to pharmacometric graphics","volume":"2","author":"Ito","year":"2013","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an r package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1214\/19-STS733","article-title":"Best subset forward stepwise or lasso? glmnet: Analysis and recommendations based on extensive comparisons","volume":"35","author":"Trevor","year":"2020","journal-title":"Stat Sc"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in r","volume":"21","author":"Sing","year":"2005","journal-title":"Bioinformatics"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107468","article-title":"pRRophetic: an r package for prediction of clinical chemotherapeutic response from tumor gene expression levels","volume":"9","author":"Geeleher","year":"2014","journal-title":"PloS One"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1198\/000313002533","article-title":"Corrgrams: Exploratory displays for correlation matrices","volume":"256","author":"Michael","year":"2002","journal-title":"Am Statistician"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew293","article-title":"World endometriosis society consensus on the classification of endometriosis","volume":"32","author":"Johnson","year":"2017","journal-title":"Hum Reprod"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14668","article-title":"E2 -mediated EMT by activation of \u03b2-catenin\/Snail signalling during the development of ovarian endometriosis","volume":"23","author":"Xiong","year":"2019","journal-title":"J Cell Mol Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1498477","article-title":"ILK enhances migration and invasion abilities of human endometrial stromal cells by facilitating the epithelial-mesenchymal transition","volume":"34","author":"Zheng","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"153214","DOI":"10.1016\/j.phymed.2020.153214","article-title":"The effects of isoliquiritigenin on endometriosis in vivo and in vitro study","volume":"77","author":"Hsu","year":"2020","journal-title":"Phytomedicine"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.29","article-title":"Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells","volume":"112","author":"Ricciardi","year":"2015","journal-title":"Brit J Cancer"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.25720","article-title":"Effect of stromal cells in tumor microenvironment on metastasis initiation","volume":"14","author":"Guo","year":"2018","journal-title":"Int J Biol Sci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1017\/erm.2021.13","article-title":"Tumour microenvironment: a non-negligible driver for epithelial-mesenchymal transition in colorectal cancer","volume":"23","author":"Han","year":"2021","journal-title":"Expert Rev Mol Med"},{"key":"B49","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12307-011-0087-2","article-title":"Adipocytes promote B16BL6 melanoma cell invasion and the epithelial-to-Mesenchymal transition","volume":"5","author":"Kushiro","year":"2012","journal-title":"Cancer Microenviron"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3550-9","article-title":"Adipocytes can induce epithelial-mesenchymal transition in breast cancer cells","volume":"153","author":"Lee","year":"2015","journal-title":"Breast Cancer Res Tr"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.133","article-title":"TGF-\u03b21-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7\/CCL21-mediated chemotaxis","volume":"35","author":"Pang","year":"2016","journal-title":"Oncogene"},{"key":"B52","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12931-021-01646-7","article-title":"Role of CXCL16 in BLM-induced epithelial-mesenchymal transition in human A549 cells","volume":"22","author":"Ma","year":"2021","journal-title":"Respir Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010060616","article-title":"Resolved: EMT produces fibroblasts in the kidney","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"9918379","DOI":"10.1155\/2021\/9918379","article-title":"Exploring the crosstalk between inflammation and epithelial-mesenchymal transition in cancer","volume":"2021","author":"Chattopadhyay","year":"2021","journal-title":"Mediat Inflamm"},{"key":"B55","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1530\/REP-17-0174","article-title":"Different macrophages equally induce EMT in endometria of adenomyosis and normal","volume":"154","author":"An","year":"2017","journal-title":"Reproduction"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444563","article-title":"Endothelial amine oxidase AOC3 transiently contributes to adaptive immune responses in the airways","volume":"44","author":"Dunkel","year":"2014","journal-title":"Eur J Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-020-09583-6","article-title":"Calsequestrin, a key protein in striated muscle health and disease","volume":"42","author":"Rossi","year":"2021","journal-title":"J Muscle Res Cell M"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-022-01345-3","article-title":"Transcriptional regulation of FRZB in chondrocytes by osterix and Msx2","volume":"40","author":"Yagi","year":"2022","journal-title":"J Bone Miner Metab"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180716104159","article-title":"The role of matrix gla protein (MGP) in vascular calcification","volume":"27","author":"Bj\u00f8rklund","year":"2020","journal-title":"Curr Med Chem"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003793","article-title":"Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization","volume":"10","author":"Sheng","year":"2022","journal-title":"J Immunother Cancer"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3890","DOI":"10.3390\/ijms23073890","article-title":"The human monocyte-a circulating sensor of infection and a potent and rapid inducer of inflammation","volume":"23","author":"Lara","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.01.065","article-title":"Porcine IFI30 inhibits PRRSV proliferation and host cell apoptosis in vitro","volume":"649","author":"Guo","year":"2018","journal-title":"Gene"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202204139","article-title":"Drug repurposing by siderophore conjugation: Synthesis and biological evaluation of siderophore-methotrexate conjugates as antibiotics","volume":"61","author":"Zhao","year":"2022","journal-title":"Angew Chem Int Edit"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909530","article-title":"Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR","volume":"362","author":"Maemondo","year":"2010","journal-title":"New Engl J Med"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2753","article-title":"Trapping of PARP1 and PARP2 by clinical PARP inhibitors","volume":"72","author":"Murai","year":"2012","journal-title":"Cancer Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27755","article-title":"Inhibition of wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin","volume":"61","author":"Zhang","year":"2015","journal-title":"Hepatology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0492","article-title":"Inducing hypermutability to promote anti-PD-1 therapy response","volume":"12","author":"Willis","year":"2022","journal-title":"Cancer Discovery"},{"key":"B68","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1186\/s12935-021-02159-5","article-title":"CMTM3 suppresses chordoma progress through EGFR\/STAT3 regulated EMT and TP53 signaling pathway","volume":"21","author":"Yuan","year":"2021","journal-title":"Cancer Cell Int"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.547","article-title":"Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin\/EGFR-ERK\/MAPK signaling pathway","volume":"8","author":"Sheng","year":"2017","journal-title":"Cell Death Dis"},{"key":"B70","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41392-020-0113-2","article-title":"IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct Tar"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1396-1","article-title":"IGF-I stimulates ER\u03b2 and aromatase expression via IGF1R\/PI3K\/AKT-mediated transcriptional activation in endometriosis","volume":"94","author":"Zhou","year":"2016","journal-title":"J Mol Med"},{"key":"B72","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s12905-021-01560-6","article-title":"Expression levels of MCP-1 HGF and IGF-1 in endometriotic patients compared with non-endometriotic controls","volume":"21","author":"Heidari","year":"2021","journal-title":"BMC Womens Health"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900797R","article-title":"Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis","volume":"33","author":"Forster","year":"2019","journal-title":"FASEB J"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-022-02209-w","article-title":"Role of IGF-1R in epithelial-mesenchymal trans differentiation of human peritoneal mesothelial cells","volume":"26","author":"Xia","year":"2022","journal-title":"Clin Exp Nephrol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1035158\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:52:43Z","timestamp":1669686763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1035158\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":74,"alternative-id":["10.3389\/fendo.2022.1035158"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1035158","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]},"article-number":"1035158"}}