{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:39:07Z","timestamp":1792471147876,"version":"4.5.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been demonstrated that a thin endometrium is associated with a lower chance of pregnancy, but there is a paucity of research into whether a thin endometrium adversely affects perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study on 10098 frozen cycles with single blastocyst transfer, resulting in 5505 singleton clinical pregnancies, and 4314 singleton live births. Patients were divided into a thin endometrium group (&amp;lt;8\u00a0mm) and a normal endometrium group (\u22658 mm). Multivariable logistic regression with restricted cubic splines, receiver operating characteristic curve, and multivariable linear model were used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidences of preterm birth (15.65 vs. 9.80%, aOR=1.69 [1.19-2.42]), low birth weight (8.40 vs. 4.10%, aOR=2.05 [1.27-3.30]) and gestational diabetes (6.87 vs. 4.17%, aOR=1.74 [1.05-2.90]) were all higher in the endometrial thickness (EMT) &amp;lt;8\u00a0mm group. The miscarriage rate was higher in the EMT &amp;lt;8\u00a0mm group than the EMT \u22658 mm group (27.91 vs. 20.39%, aOR=1.40 [1.10-1.79]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A thin endometrium may be associated with a higher incidence of preterm birth, low birth weight, and miscarriage. Therefore, embryo transfer should be performed with caution in these patients, and postponing to a later cycle with a thicker endometrium should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.1040140","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T03:07:36Z","timestamp":1668049656000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Thin endometrium is associated with higher risks of preterm birth and low birth weight after frozen single blastocyst transfer"],"prefix":"10.3389","volume":"13","author":[{"given":"Yu","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoab011","article-title":"Endometrial receptivity analysis (ERA): Data versus opinions","volume":"2021","author":"Ruiz-Alonso","year":"2021","journal-title":"Hum Reprod Open"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: A systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum Reprod Update"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13309","article-title":"Endometrial vascularity is lower in pregnancies with pregnancy-induced hypertension or small-for-gestational-age fetus in live birth after in-vitro fertilization","volume":"44","author":"Lai","year":"2014","journal-title":"Ultrasound obstetrics gynecology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.005","article-title":"Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection (IVF\/ICSI) treatments? analysis of 100 prospectively recorded variables in 8,400 IVF\/ICSI single-embryo transfers","volume":"107","author":"Vaegter","year":"2017","journal-title":"Fertil Steril"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey281","article-title":"The impact of a thin endometrial lining on fresh and frozen-thaw IVF outcomes: An analysis of over 40 000 embryo transfers","volume":"33","author":"Liu","year":"2018","journal-title":"Hum Reprod"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa060","article-title":"Endometrial thickness on the day of the LH surge: An effective predictor of pregnancy outcomes after modified natural cycle-frozen blastocyst transfer","volume":"2020","author":"Onogi","year":"2020","journal-title":"Hum Reprod Open"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.05.036","article-title":"Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers","volume":"104","author":"Gingold","year":"2015","journal-title":"Fertil Steril"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.04.008","article-title":"The entire range of trigger-day endometrial thickness in fresh IVF cycles is independently correlated with live birth rate","volume":"41","author":"Simeonov","year":"2020","journal-title":"Reprod BioMed Online"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.02.041","article-title":"Endometrial thickness is not predictive for live birth after embryo transfer, even without a cutoff","volume":"116","author":"Shakerian","year":"2021","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu011","article-title":"Endometrial thickness and pregnancy rates after IVF: A systematic review and meta-analysis","volume":"20","author":"Kasius","year":"2014","journal-title":"Hum Reprod Update"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.12.119","article-title":"Perinatal outcomes associated with assisted reproductive technology: The Massachusetts outcomes study of assisted reproductive technologies (MOSART)","volume":"103","author":"Declercq","year":"2015","journal-title":"Fertil Steril"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.12.014","article-title":"Endometrial thickness is associated with incidence of small-for-gestational-age infants in fresh in vitro fertilization-intracytoplasmic sperm injection and embryo transfer cycles","volume":"113","author":"Guo","year":"2020","journal-title":"Fertil Steril"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez103","article-title":"Effect of endometrial thickness on birthweight in frozen embryo transfer cycles: An analysis including 6181 singleton newborns","volume":"34","author":"Zhang","year":"2019","journal-title":"Hum Reprod"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.04.014","article-title":"Endometrial thickness in the prediction of neonatal adverse outcomes in frozen cycles for singleton pregnancies","volume":"43","author":"Hu","year":"2021","journal-title":"Reprod BioMed Online"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.08.021","article-title":"Association between endometrial thickness and birth weight in fresh IVF\/ICSI embryo transfers: A retrospective cohort study of 9273 singleton births","volume":"43","author":"Liu","year":"2021","journal-title":"Reprod BioMed Online"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.12.016","article-title":"Should we continue to measure endometrial thickness in modern-day medicine? The effect on live birth rates and birth weight","volume":"36","author":"Ribeiro","year":"2018","journal-title":"Reprod BioMed Online"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14362","article-title":"Fibroids that do not distort the uterine cavity and IVF success rates: An observational study using extensive matching criteria","volume":"124","author":"Christopoulos","year":"2017","journal-title":"BJOG"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.621221","article-title":"The morphology of inner cell mass is the strongest predictor of live birth after a frozen-thawed single embryo transfer","volume":"12","author":"Ai","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.08.025","article-title":"Optimal endometrial thickness to maximize live births and minimize pregnancy losses: Analysis of 25,767 fresh embryo transfers","volume":"37","author":"Gallos","year":"2018","journal-title":"Reprod BioMed Online"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2021.04.002","article-title":"The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer","volume":"2","author":"Martel","year":"2021","journal-title":"F S Rep"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.05.013","article-title":"Endometrial thickness of less than 7.5 mm is associated with obstetric complications in fresh IVF cycles: a retrospective cohort study","volume":"37","author":"Oron","year":"2018","journal-title":"Reprod BioMed Online"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05295-6","article-title":"The risk of placenta previa and cesarean section associated with a thin endometrial thickness: A retrospective study of 5251 singleton births during frozen embryo transfer in China","volume":"300","author":"Jing","year":"2019","journal-title":"Arch Gynecol Obstet"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4411-z","article-title":"Endometrial thickness influences neonatal birth weight in pregnancies with obstetric complications achieved after fresh IVF-ICSI cycles","volume":"296","author":"Moffat","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513873","article-title":"Fresh versus frozen embryos for infertility in the polycystic ovary syndrome","volume":"375","author":"Chen","year":"2016","journal-title":"N Engl J Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1096","article-title":"It's time to pay attention to the endometrium","volume":"96","author":"Casper","year":"2011","journal-title":"Fertil Steril"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.958988","article-title":"The artificial cycle method improves the pregnancy outcome in frozen-thawed embryo transfer: a retrospective cohort study","volume":"31","author":"Zheng","year":"2015","journal-title":"Gynecol Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1040140\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T03:07:40Z","timestamp":1668049660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1040140\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":26,"alternative-id":["10.3389\/fendo.2022.1040140"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1040140","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"article-number":"1040140"}}