{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:47:00Z","timestamp":1788878820591,"version":"build-2803163510"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Long non-coding RNAs (lncRNAs) have been comprehensively implicated in various cellular functions by mediating transcriptional or post-transcriptional activities. MALAT1 is involved in the differentiation, proliferation, and apoptosis of multiple cell lines, including BMSCs, osteoblasts, osteoclasts, and chondrocytes. Interestingly, MALAT1 may interact with RNAs or proteins, regulating cellular processes. Recently, MALAT1 has been reported to be associated with the development of bone and cartilage diseases by orchestrating the signaling network. The involvement of MALAT1 in the pathological development of bone and cartilage diseases makes it available to be a potential biomarker for clinical diagnosis or prognosis. Although the potential mechanisms of MALAT1 in mediating the cellular processes of bone and cartilage diseases are still needed for further elucidation, MALAT1 shows great promise for drug development.<\/jats:p>","DOI":"10.3389\/fendo.2022.1054827","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T05:13:20Z","timestamp":1668402800000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The regulatory activities of MALAT1 in the development of bone and cartilage diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Di","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20149","article-title":"Local regulation of gene expression by lncRNA promoters, transcription and splicing","volume":"539","author":"Engreitz","year":"2016","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna6020022","article-title":"MALAT1 long non-coding RNA: Functional implications","volume":"6","author":"Arun","year":"2020","journal-title":"Noncoding RNA"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.10.035","article-title":"Evolutionary conservation of long non-coding RNAs; sequence, structure, function","volume":"1840","author":"Johnsson","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.199","article-title":"A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression","volume":"29","author":"Bernard","year":"2010","journal-title":"EMBO J"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/microarrays4040503","article-title":"Cancer-osteoblast interaction reduces sost expression in osteoblasts and up-regulates lncRNA MALAT1 in prostate cancer","volume":"4","author":"Sebastian","year":"2015","journal-title":"Microarrays (Basel)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19082343","article-title":"Mesenchymal stem cell migration during bone formation and bone diseases therapy","volume":"19","author":"Su","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4252\/wjsc.v14.i1.92","article-title":"Epigenetic regulation by long noncoding RNAs in osteo-\/adipogenic differentiation of mesenchymal stromal cells and degenerative bone diseases","volume":"14","author":"Xia","year":"2022","journal-title":"World J Stem Cells"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00277","article-title":"LncRNA functions as a new emerging epigenetic factor in determining the fate of stem cells","volume":"11","author":"Chen","year":"2020","journal-title":"Front Genet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/term.3279","article-title":"LncRNA metastasis-associated lung adenocarcinoma transcript-1 promotes osteogenic differentiation of bone marrow stem cells and inhibits osteoclastic differentiation of m\u00f8 in osteoporosis via the miR-124-3p\/IGF2BP1\/Wnt\/\u03b2-catenin axis","volume":"16","author":"Li","year":"2022","journal-title":"J Tissue Eng Regener Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11010034","article-title":"A whole-genome sequencing association study of low bone mineral density identifies new susceptibility loci in the phase I Qatar biobank cohort","volume":"11","author":"Younes","year":"2021","journal-title":"J Pers Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.06.019","article-title":"Long non-coding RNA MALAT1 functions as miR-1 sponge to regulate connexin 43-mediated ossification of the posterior longitudinal ligament","volume":"127","author":"Yuan","year":"2019","journal-title":"Bone"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20336","article-title":"Molecular anatomy of a speckle","volume":"288","author":"Hall","year":"2006","journal-title":"Anat Rec A Discovery Mol Cell Evol Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.06.003","article-title":"The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult","volume":"2","author":"Zhang","year":"2012","journal-title":"Cell Rep"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.206854","article-title":"Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution","volume":"130","author":"Fei","year":"2017","journal-title":"J Cell Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.tig.2011.05.006","article-title":"Biogenesis and function of nuclear bodies","volume":"27","author":"Mao","year":"2011","journal-title":"Trends Genet"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003368","article-title":"Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor b-MYB","volume":"9","author":"Tripathi","year":"2013","journal-title":"PloS Genet"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903808116","article-title":"Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization","volume":"116","author":"Wang","year":"2019","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/srep36572","article-title":"A comprehensive characterization of the function of LincRNAs in transcriptional regulation through long-range chromatin interactions","volume":"6","author":"Cai","year":"2016","journal-title":"Sci Rep"},{"key":"B20","article-title":"Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer","volume":"9","author":"Li","year":"2019","journal-title":"Am J Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7281","article-title":"MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10","volume":"7","author":"Qi","year":"2016","journal-title":"Oncotarget"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5728","article-title":"LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3968","article-title":"GRID-seq reveals the global RNA-chromatin interactome","volume":"35","author":"Li","year":"2017","journal-title":"Nat Biotechnol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.01.011","article-title":"Systematic mapping of RNA-chromatin interactions In vivo","volume":"27","author":"Sridhar","year":"2017","journal-title":"Curr Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.2147\/ott.S136878","article-title":"Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, oncomine, and TCGA databases","volume":"10","author":"Xie","year":"2017","journal-title":"Onco Targets Ther"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.086","article-title":"Long non-coding RNA MALAT1 interacts with transcription factor Foxo1 to regulate SIRT1 transcription in high glucose-induced HK-2 cells injury","volume":"503","author":"Zhou","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.05.009","article-title":"Silencing of lncRNA MALAT1 prevents inflammatory injury after lung transplant ischemia-reperfusion by downregulation of IL-8 via p300","volume":"18","author":"Wei","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0067-3","article-title":"Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity","volume":"32","author":"Amodio","year":"2018","journal-title":"Leukemia"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx600","article-title":"Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation","volume":"45","author":"Chen","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14006","article-title":"Multiple function of lncRNA MALAT1 in cancer occurrence and progression","author":"Malakoti","year":"2021","journal-title":"Chem Biol Drug Des"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8098001","article-title":"lncRNA MALAT1 promotes diabetic nephropathy progression via miR-15b-5p\/TLR4 signaling axis","volume":"2022","author":"Yang","year":"2022","journal-title":"J Immunol Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.858558","article-title":"LncRNA MALAT1 promotes PPAR\u03b1\/CD36-mediated hepatic lipogenesis in nonalcoholic fatty liver disease by modulating miR-206\/ARNT axis","volume":"10","author":"Xiang","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2022.3426","article-title":"MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a\/HMGB2 pathway","volume":"66","author":"Chen","year":"2022","journal-title":"Eur J Histochem"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.807419","article-title":"Long noncoding RNA GAS5: A new factor involved in bone diseases","volume":"9","author":"Zhou","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0074-2","article-title":"Functions and mechanisms of epigenetic inheritance in animals","volume":"19","author":"Skvortsova","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29223","article-title":"Differential expression of lncRNA\/miRNA\/mRNA and their related functional networks during the osteogenic\/odontogenic differentiation of dental pulp stem cells","volume":"235","author":"Liu","year":"2020","journal-title":"J Cell Physiol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29132","article-title":"Identification of functional lncRNAs based on competing endogenous RNA network in osteoblast differentiation","volume":"235","author":"Hong","year":"2020","journal-title":"J Cell Physiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3409","article-title":"lncRNA MALAT1 promotes osteogenic differentiation through the miR-217\/AKT3 axis: A possible strategy to alleviate osteoporosis","volume":"24","author":"Song","year":"2022","journal-title":"J Gene Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26907","article-title":"Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells","volume":"119","author":"Gao","year":"2018","journal-title":"J Cell Biochem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2963-2","article-title":"LncRNA MALAT1 sponges miR-30 to promote osteoblast differentiation of adipose-derived mesenchymal stem cells by promotion of Runx2 expression","volume":"376","author":"Yi","year":"2019","journal-title":"Cell Tissue Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0000000000008092","article-title":"Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes the osteoblast differentiation of human bone marrow-derived mesenchymal stem cells by targeting the microRNA-96\/Osterix axis","volume":"33","author":"Zang","year":"2022","journal-title":"J Craniofac Surg"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102264","article-title":"LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis","volume":"11","author":"Yang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07136-3","article-title":"lncRNAs MALAT1 and LINC00657 upstream to miR-214-3p\/BMP2 regulate osteogenic differentiation of human mesenchymal stem cells","volume":"49","author":"Li","year":"2022","journal-title":"Mol Biol Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.05.037","article-title":"LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4","volume":"243","author":"Xiao","year":"2017","journal-title":"Int J Cardiol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101619","article-title":"MALAT1 regulates osteogenic differentiation of human periodontal ligament stem cells through mediating miR-155-5p\/ETS1 axis","volume":"73","author":"Hua","year":"2021","journal-title":"Tissue Cell"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201906_18038","article-title":"LncRNA MALAT1 inhibits osteogenic differentiation of mesenchymal stem cells in osteoporosis rats through MAPK signaling pathway","volume":"23","author":"Zheng","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102032","article-title":"The p38\u03b1 MAPK function in osteoprecursors is required for bone formation and bone homeostasis in adult mice","volume":"9","author":"Rodr\u00edguez-Carballo","year":"2014","journal-title":"PloS One"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.561","article-title":"Interactions between extracellular signal-regulated kinase 1\/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity","volume":"27","author":"Ge","year":"2012","journal-title":"J Bone Miner Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2022.111724","article-title":"The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells","volume":"207","author":"Lu","year":"2022","journal-title":"Mech Ageing Dev"},{"key":"B50","first-page":"7","article-title":"RANKL inhibits cell proliferation by regulating MALAT1 expression in a human osteoblastic cell line hFOB 1.19","volume":"61","author":"Che","year":"2015","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3363","article-title":"MALAT1 enhanced the proliferation of human osteoblasts treated with ultra\u2212high molecular weight polyethylene by targeting VEGF via miR\u221222\u22125p","volume":"41","author":"Yang","year":"2018","journal-title":"Int J Mol Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1186\/s12864-022-08646-x","article-title":"Comprehensive analysis of lncRNA-miRNA-mRNA networks during osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"23","author":"Liu","year":"2022","journal-title":"BMC Genomics"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8273648","article-title":"An overview of long noncoding RNAs involved in bone regeneration from mesenchymal stem cells","volume":"2018","author":"Peng","year":"2018","journal-title":"Stem Cells Int"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111942","article-title":"Contribution of miRNAs and lncRNAs in osteogenesis and related disorders","volume":"142","author":"Ghafouri-Fard","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153985","article-title":"Expression profile analysis of lncRNA in bone marrow mesenchymal stem cells exosomes of postmenopausal osteoporosis patients through microarray and bioinformatics analyses","volume":"236","author":"Wang","year":"2022","journal-title":"Pathol Res Pract"},{"key":"B56","doi-asserted-by":"publisher","first-page":"9127","DOI":"10.1038\/s41598-018-27501-2","article-title":"LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2019.108533","article-title":"LncRNA-MALAT1 promotes osteogenic differentiation through regulating ATF4 by sponging miR-214: Implication of steroid-induced avascular necrosis of the femoral head","volume":"154","author":"Huang","year":"2020","journal-title":"Steroids"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21811","article-title":"Neobavaisoflavone protects osteoblasts from dexamethasone-induced oxidative stress by upregulating the CRNDE-mediated Nrf2\/HO-1 signaling pathway","volume":"82","author":"Zhu","year":"2021","journal-title":"Drug Dev Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000495159","article-title":"Long non-coding RNA MALAT1 protects human osteoblasts from dexamethasone-induced injury via activation of PPM1E-AMPK signaling","volume":"51","author":"Fan","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2590055","article-title":"Expression of lncRNA MALAT1 through miR-144-3p in osteoporotic tibial fracture rats and its effect on osteogenic differentiation of BMSC under traction","volume":"2022","author":"Ling","year":"2022","journal-title":"Evid Based Complement Alternat Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14228","article-title":"EPC-derived exosomes promote osteoclastogenesis through LncRNA-MALAT1","volume":"23","author":"Cui","year":"2019","journal-title":"J Cell Mol Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2020.03.17","article-title":"Denosumab inhibits MCF-7 cell line-induced spontaneous osteoclastogenesis via the RANKL\/MALAT1\/miR-124 axis","volume":"9","author":"Feng","year":"2020","journal-title":"Transl Cancer Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.248.27","article-title":"Antiresorptive agents and anti-angiogenesis drugs in the development of osteonecrosis of the jaw","volume":"248","author":"Allegra","year":"2019","journal-title":"Tohoku J Exp Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9879876","article-title":"Altered long noncoding RNA expression profile in multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw","volume":"2020","author":"Allegra","year":"2020","journal-title":"BioMed Res Int"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00649-8","article-title":"Long non-coding RNA MALAT1 enhances angiogenesis during bone regeneration by regulating the miR-494\/SP1 axis","volume":"101","author":"Ding","year":"2021","journal-title":"Lab Invest"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103214","article-title":"The role of long noncoding RNA in major human disease","volume":"92","author":"Zhang","year":"2019","journal-title":"Bioorg Chem"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.12.001","article-title":"Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients","volume":"23","author":"Fu","year":"2015","journal-title":"Osteoarthr Cartilage"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/art.39520","article-title":"Long intergenic noncoding RNAs mediate the human chondrocyte inflammatory response and are differentially expressed in osteoarthritis cartilage","volume":"68","author":"Pearson","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18-0053","article-title":"Umbilical cord-derived mesenchymal stromal cells (MSCs) for knee osteoarthritis: Repeated MSC dosing is superior to a single MSC dose and to hyaluronic acid in a controlled randomized phase I\/II trial","volume":"8","author":"Matas","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.772002","article-title":"LncRNA malat-1 from MSCs-derived extracellular vesicles suppresses inflammation and cartilage degradation in osteoarthritis","volume":"9","author":"Pan","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116801","article-title":"LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K\/Akt\/mTOR axis","volume":"254","author":"Li","year":"2020","journal-title":"Life Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.11.1081","article-title":"LncRNA MALAT1\/MiR-145 adjusts IL-1\u03b2-Induced chondrocytes viability and cartilage matrix degradation by regulating ADAMTS5 in human osteoarthritis","volume":"60","author":"Liu","year":"2019","journal-title":"Yonsei Med J"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8471","article-title":"Therapeutic effect of resveratrol in the treatment of osteoarthritis via the MALAT1\/miR-9\/NF-\u03baB signaling pathway","volume":"19","author":"Zhang","year":"2020","journal-title":"Exp Ther Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13578-019-0302-2","article-title":"LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p\/AKT3 axis","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26200","article-title":"MALAT1\/miR-127-5p regulates osteopontin (OPN)-mediated proliferation of human chondrocytes through PI3K\/Akt pathway","volume":"119","author":"Liang","year":"2018","journal-title":"J Cell Biochem"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28977","article-title":"Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1\u03b2-induced inflammation in articular chondrocytes via the JNK signaling pathway","volume":"120","author":"Gao","year":"2019","journal-title":"J Cell Biochem"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.09.011","article-title":"Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis","volume":"43","author":"Quasnichka","year":"2006","journal-title":"Biorheology"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040786","article-title":"The expression and function of metastases associated lung adenocarcinoma transcript-1 long non-coding RNA in subchondral bone and osteoblasts from patients with osteoarthritis","volume":"10","author":"Alnajjar","year":"2021","journal-title":"Cells"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370327","article-title":"Synovial inflammation in patients with early osteoarthritis of the knee","volume":"17","author":"Myers","year":"1990","journal-title":"J Rheumatol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/art.41158","article-title":"Regulation of the inflammatory synovial fibroblast phenotype by metastasis-associated lung adenocarcinoma transcript 1 long noncoding RNA in obese patients with osteoarthritis","volume":"72","author":"Nanus","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520907665","article-title":"Current treatment options for intervertebral disc pathologies","volume":"11","author":"Eisenstein","year":"2020","journal-title":"Cartilage"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-014-0465-5","article-title":"Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study","volume":"16","author":"Wan","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"B83","article-title":"The role of lncRNA MALAT1 in intervertebral degenerative disc disease","volume":"10","author":"Zhang","year":"2017","journal-title":"Int J Clin Exp Pathol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12860-020-00265-2","article-title":"LncRNA MALAT1 exhibits positive effects on nucleus pulposus cell biology in vivo and in vitro by sponging miR-503","volume":"21","author":"Zheng","year":"2020","journal-title":"BMC Mol Cell Biol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24016","article-title":"High glucose-induced excessive reactive oxygen species promote apoptosis through mitochondrial damage in rat cartilage endplate cells","volume":"36","author":"Jiang","year":"2018","journal-title":"J Orthop Res"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11009","article-title":"Long non\u2212coding RNA MALAT1 promotes high glucose\u2212induced rat cartilage endplate cell apoptosis via the p38\/MAPK signalling pathway","volume":"21","author":"Jiang","year":"2020","journal-title":"Mol Med Rep"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2017-135441","article-title":"Association of interleukin-10 gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population","volume":"94","author":"Zhang","year":"2018","journal-title":"Postgrad Med J"},{"key":"B88","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2478\/jtim-2019-0002","article-title":"LncRNA: An all-rounder in rheumatoid arthritis","volume":"7","author":"Liang","year":"2019","journal-title":"J Transl Int Med"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-015-9477-2","article-title":"The pathogenic role of angiogenesis in rheumatoid arthritis","volume":"18","author":"Elshabrawy","year":"2015","journal-title":"Angiogenesis"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/cells7120223","article-title":"Defective T-cell apoptosis and T-regulatory cell dysfunction in rheumatoid arthritis","volume":"7","author":"Malemud","year":"2018","journal-title":"Cells"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2020-0009","article-title":"Increase in MEG3, MALAT1, NEAT1 significantly predicts the clinical parameters in patients with rheumatoid arthritis","volume":"17","author":"Chatterjee","year":"2020","journal-title":"Per Med"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2755","article-title":"Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1","volume":"38","author":"Pan","year":"2016","journal-title":"Int J Mol Med"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108878","article-title":"Efficacy of DMARDs and methylprednisolone treatment on the gene expression levels of HSPA5, MMD, and non-coding RNAs MALAT1, H19, miR-199a-5p, and miR-1-3p, in patients with rheumatoid arthritis","volume":"108","author":"Mahmoudi","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02529","article-title":"Long non-coding RNAs genes polymorphisms and their expression levels in patients with rheumatoid arthritis","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180168","article-title":"Toward new classification criteria for juvenile idiopathic arthritis: First steps, pediatric rheumatology international trials organization international consensus","volume":"46","author":"Martini","year":"2019","journal-title":"J Rheumatol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.909118","article-title":"Value of literature review to inform development and use of biologics in juvenile idiopathic arthritis","volume":"10","author":"Golhen","year":"2022","journal-title":"Front Pediatr"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4618","article-title":"Long non\u2212coding RNA RP11\u2212340F14.6 promotes a shift in the Th17\/Treg ratio by binding with P2X7R in juvenile idiopathic arthritis","volume":"46","author":"Huang","year":"2020","journal-title":"Int J Mol Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155397","article-title":"Suppression of lncRNA MALAT1 reduces pro-inflammatory cytokines production by regulating miR-150-5p\/ZBTB4 axis through JAK\/STAT signal pathway in systemic juvenile idiopathic arthritis","volume":"138","author":"Jiang","year":"2021","journal-title":"Cytokine"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14956.1","article-title":"Recent advances in ankylosing spondylitis: understanding the disease and management","volume":"7","author":"Garcia-Montoya","year":"2018","journal-title":"F1000Res"},{"key":"B100","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41413-019-0057-8","article-title":"Ankylosing spondylitis: etiology, pathogenesis, and treatments","volume":"7","author":"Zhu","year":"2019","journal-title":"Bone Res"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.790924","article-title":"Emerging roles of long non-coding RNAs in ankylosing spondylitis","volume":"13","author":"Sun","year":"2022","journal-title":"Front Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2022.2081","article-title":"The molecular mechanism of long non-coding RNA MALAT1-mediated regulation of chondrocyte pyroptosis in ankylosing spondylitis","volume":"45","author":"Chen","year":"2022","journal-title":"Mol Cells"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23816","article-title":"Prevalence and factors associated with bone erosion in patients with gout","volume":"71","author":"Wu","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2022.04.013","article-title":"A review on benefits of quercetin in hyperuricemia and gouty arthritis","volume":"30","author":"Nutmakul","year":"2022","journal-title":"Saudi Pharm J"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa165","article-title":"The role of noncoding RNAs in gout","volume":"161","author":"Li","year":"2020","journal-title":"Endocrinology"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7816","article-title":"Aberrant expression of long non-coding RNAs in peripheral blood mononuclear cells isolated from patients with gouty arthritis","volume":"18","author":"Zhong","year":"2019","journal-title":"Exp Ther Med"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111413","article-title":"Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1\/miR-876-5p\/NLRP3 signaling cascade in gouty arthritis","volume":"138","author":"Meng","year":"2021","journal-title":"BioMed Pharmacother"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1054827\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T05:13:26Z","timestamp":1668402806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1054827\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":107,"alternative-id":["10.3389\/fendo.2022.1054827"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1054827","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,14]]},"article-number":"1054827"}}