{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:24:23Z","timestamp":1781886263280,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the hypothesis that obese primiparous women with an unfavorable cervix in delayed pregnancy may experience a worse induction of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>In total, 467 primiparas with poor cervical condition and delayed pregnancy (gestational age [GA]: &amp;gt;40weeks) were divided into an obese primiparas group (body mass index [BMI] &amp;gt;30kg\/m<jats:sup>2<\/jats:sup>; n=166) and a non-obese primiparas group (BMI &amp;lt; 30kg\/m<jats:sup>2<\/jats:sup>; (n=301). Labor was induced by various methods, double balloon, dinoprostone inserts, and amniotomy combined with oxytocin depending on the Bishop score. Experimental data were analyzed by Statistical Product Service Solutions (SPSS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BMI in the obese primiparas group was higher than in the non-obese group (33.91 \u00b1 2.67 versus 24.09 \u00b1 5.78, p&amp;lt;0.001), and there were significant differences in uterine tone and duration of contractions between the two groups in the second stage of labour (p=0.041, p=0.026, respectively).The rate of cesarean section (CS) was significantly higher in the primiparas group (23.49% versus 12.29%; P=0.002). There was a significant difference between the two groups in terms of the duration of time to vaginal delivery (VD) (18h versus 8h; P &amp;lt;0.001) while the duration until VD in the obese primiparas group within 12 hours and 24 hours was significantly longer (P &amp;lt;0.001). After adjusting for possible confounders, caesarean section rates remained high in the obese primiparas women (OR: 2.564;95%CI1.919,3.864;P&amp;lt;0.001). Similarly, after adjusting for the same confounding factors, obese primiparas women increased the duration until VD within 24\u00a0h by 3.598 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obese primiparas with an unfavorable cervix in delayed pregnancy have a significantly higher risk of CS and a longer duration until VD than non-obese primiparas during labor induction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.1055098","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:50:31Z","timestamp":1673416231000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of labor induction in obesity with delayed pregnancy: A retrospective study based on Chinese obese 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