{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:14:19Z","timestamp":1777436059318,"version":"3.51.4"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012704","name":"Universitetet i Agder","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Disappointingly few efficacious health interventions are successfully scaled up and implemented in real world settings. This represents an evidence-to-practice gap, with loss of opportunity to improve practice. Aiming to improve nutrition in the first 1000 days of life, we have combined four efficacious dietary interventions into a single adapted digital resource (Nutrition Now) for implementation in a Norwegian community setting. Nutrition Now targets pregnant women and parents of 0\u20132-year-olds with messages focusing on healthy dietary behaviours. Early childhood education and care (ECEC) staff are provided with pedagogical tools addressing healthy food exposure and child food acceptance. Objectives: a) evaluate the effectiveness of provision of the Nutrition Now resource on child diet and diet-related outcomes, with special attention to the influence of socio-economic position, b) gather information on the effectiveness of the implementation process to inform forthcoming scale-up and c) perform trial- and model-based economic evaluations. This is a hybrid type 1 implementation study, focusing on evaluation of effectiveness. A quasi-experimental design with pre- and post-tests, where one municipality gets access to the resource (n~800), while a matched non-equivalent control municipality (n~800) does not, will be used. Effectiveness will be assessed by examining e.g., diet outcomes, developmental outcomes, and feeding practices. The resource will be implemented in ECEC settings and made available to pregnant women and parents through the Norwegian system of maternal and child health (MCH) care. The implementation process includes iterative adjustments and implementation strategies from the implementation framework Expert Recommendations for Implementing Change (ERIC) informed by dialogues with stakeholders. Implementation outcomes (e.g., acceptability and adoption) will be assessed through questionnaires and interviews with parents, ECEC and MCH staff, with particular attention to ethnic diverse groups. Both within-trial and modelling-based economic evaluation will be performed. Nutrition Now will bridge the existing evidence-to-practice gap through rigorous scientific effectiveness evaluation of municipal scale up and inform subsequent county scale up. The study is the first to implement efficacious nutrition interventions in early life with potential for health improvement using technology to maximise the reach and impact of both parental and MCH dietary guidance and ECEC practice.<\/jats:p><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:uri>https:\/\/www.isrctn.com\/<\/jats:uri>, identified ISRCTN10694967.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.1071489","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T20:58:41Z","timestamp":1673384321000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluating the effectiveness and implementation of evidence-based early-life nutrition interventions in a community setting a hybrid type 1 non-randomized trial \u2013 the Nutrition Now project protocol"],"prefix":"10.3389","volume":"13","author":[{"given":"Nina Cecilie","family":"\u00d8verby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet Rudjord","family":"Hillesund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sissel Heidi","family":"Helland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Helle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew Keith","family":"Wills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Admassu Nadew","family":"Lamu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie Garzon","family":"Osorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torunn Iveland","family":"Ersfjord","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Van Daele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tormod","family":"Bj\u00f8rkkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlend Nuland","family":"Valen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mekdes Kebede","family":"Gebremariam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Grasaas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Kiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrica von Thiele","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne Hope","family":"Abel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Love","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Elizabeth","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00f8ydis Nordg\u00e5rd","family":"Vik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anine Christine","family":"Medin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"s7","DOI":"10.1017\/S1368980019004415","article-title":"Developing a conceptual framework for implementation science to evaluate a nutrition intervention scaled-up in a real-world setting","volume":"24","author":"Sarma","year":"2021","journal-title":"Public Health Nutr"},{"key":"B2","volume-title":"Dissemination and implementation research in health","author":"Brownson","year":"2018"},{"key":"B3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13643-016-0229-1","article-title":"Supporting successful implementation of public health interventions: protocol for a realist synthesis","volume":"5","author":"MacDonald","year":"2016","journal-title":"Syst Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-3716","article-title":"Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health","volume":"141","author":"Schwarzenberg","year":"2018","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bpobgyn.2014.06.007","article-title":"Developmental origins of health and disease\u2013global public health implications","volume":"29","author":"Hanson","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(15)30034-5","article-title":"The international federation of gynecology and obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: \"Think nutrition first\"","author":"Hanson","year":"2015","journal-title":"Int J Gynaecol Obstet."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1159\/000499698","article-title":"Impact of micronutrient status during pregnancy on early nutrition programming","volume":"74","author":"Cetin","year":"2019","journal-title":"Ann Nutr Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.069047","article-title":"Learning to eat: birth to age 2 y","volume":"99","author":"Birch","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"B10","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4324\/9780203079751","volume-title":"Food and culture","author":"Counihan","year":"2012"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248429","article-title":"Early childhood investments substantially boost adult health","volume":"343","author":"Campbell","year":"2014","journal-title":"Science"},{"key":"B12","first-page":"107","volume-title":"The life-course approach: from theory to practice","year":"2018"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2003584","article-title":"A life course approach to diet, nutrition and the prevention of chronic diseases","volume":"7","author":"Darnton-Hill","year":"2004","journal-title":"Public Health Nutr"},{"key":"B14","volume-title":"National action plan for improved diet (2017-2020)","year":"2017"},{"key":"B15","volume-title":"Mid-evaluation of the national action plan on improved diet (2017-2020)","year":"2020"},{"key":"B16","volume-title":"SPEDKOST 3 national dietary survey among infants in Norway, 6 months","author":"Myhre","year":"2020"},{"key":"B17","volume-title":"National dietary survey among infants in Norway, 12 months","year":"2020"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40348-019-0089-6","article-title":"Complementary foods in baby food pouches: position statement from the nutrition commission of the German society for pediatrics and adolescent medicine (DGKJ, e.V.)","volume":"6","author":"Koletzko","year":"2019","journal-title":"Mol Cell Pediatr"},{"key":"B19","volume-title":"Content and labelling of fruit purees for infants and toddlers (In Norwegian)","year":"2020"},{"key":"B20","volume-title":"Meals, physical activity and health care in kindergarten- a survey among kindergarten staff","year":"2012"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980017003925","article-title":"Socio-economic status and maternal BMI are associated with duration of breast-feeding of Norwegian infants","volume":"21","author":"Bj\u00f8rset","year":"2018","journal-title":"Public Health Nutr"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13016","article-title":"Mediators of socioeconomic inequalities in dietary behaviours among youth: A systematic review","volume":"21","author":"Mekonnen","year":"2020","journal-title":"Obes Rev"},{"key":"B23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12884-016-0856-5","article-title":"Internet Use by pregnant women seeking pregnancy-related information: a systematic review","volume":"16","author":"Sayakhot","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"B24","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.midw.2017.03.005","article-title":"The internet as a source of information used by women after childbirth to meet their need for information: A web-based survey","volume":"48","author":"Slomian","year":"2017","journal-title":"Midwifery"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.717468","article-title":"Protocol for an effectiveness-implementation hybrid trial to evaluate scale up of an evidence-based intervention addressing lifestyle behaviours from the start of life: INFANT","volume":"12","author":"Laws","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B26","unstructured":"Kindergartens2022"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17103712","article-title":"Knowledge, attitudes and practices of Australian trainee childcare educators regarding their role in the feeding behaviours of young children","volume":"17","author":"Love","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174416000258","article-title":"Effect of a diet intervention during pregnancy on dietary behavior in the randomized controlled Norwegian fit for delivery study","volume":"7","author":"Hillesund","year":"2016","journal-title":"J Dev Orig Health Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12966-018-0763-4","article-title":"Evaluation of an eHealth intervention aiming to promote healthy food habits from infancy -the Norwegian randomized controlled trial early food for future health","volume":"16","author":"Helle","year":"2019","journal-title":"Int J Behav Nutr Phys Act."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v65.7679","article-title":"Effectiveness of a kindergarten-based intervention to increase vegetable intake and reduce food neophobia amongst 1-year-old children: a cluster randomised controlled trial","volume":"65","author":"Blomkvist","year":"2021","journal-title":"Food Nutr Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"105581","DOI":"10.1016\/j.appet.2021.105581","article-title":"Wow! they really like celeriac! kindergarten teachers' experiences of an intervention to increase 1-year-olds' acceptance of vegetables","volume":"166","author":"Helland","year":"2021","journal-title":"Appetite"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2196\/18311.","article-title":"Effect of a parent-focused eHealth intervention on children's fruit, vegetable, and discretionary food intake (Food4toddlers): Randomized controlled trial","volume":"23","author":"R\u00f8ed","year":"2021","journal-title":"J Med Internet Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.psych.52.1.1","article-title":"Social cognitive theory: An agentic perspective","volume":"52","author":"Bandura","year":"2001","journal-title":"Annu Rev Psychol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s11121-015-0555-x","article-title":"Standards of evidence for efficacy, effectiveness, and scale-up research in prevention science: Next generation","volume":"16","author":"Gottfredson","year":"2015","journal-title":"Prev Sci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182408812","article-title":"Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact","volume":"50","author":"Curran","year":"2012","journal-title":"Med Care"},{"key":"B36","doi-asserted-by":"publisher","first-page":"112513","DOI":"10.1016\/j.psychres.2019.112513","article-title":"An introduction to effectiveness-implementation hybrid designs","volume":"280","author":"Landes","year":"2019","journal-title":"Psychiatry Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"19","DOI":"10.5539\/jedp.v5n1p19","article-title":"Development of \"The child eating-enjoyment scale\"","volume":"5","author":"Ito","year":"2015","journal-title":"J Educ Dev Psychol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11136-010-9730-5","article-title":"The PedsQL\u2122 infant scales: feasibility, internal consistency reliability, and validity in healthy and ill infants","volume":"20","author":"Varni","year":"2011","journal-title":"Qual Life Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/22.3.313","article-title":"Revision of a parent-completed development screening tool: Ages and stages questionnaires","volume":"22","author":"Squires","year":"1997","journal-title":"J Pediatr Psychol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa4901_13","article-title":"The satisfaction with life scale","volume":"49","author":"Diener","year":"1985","journal-title":"J Pers Assess"},{"key":"B41","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13012-017-0635-3","article-title":"Psychometric assessment of three newly developed implementation outcome measures","volume":"12","author":"Weiner","year":"2017","journal-title":"Implement Sci"},{"key":"B42","unstructured":"Assessing implementation2022"},{"key":"B43","volume-title":"Assessing maintenance","year":"2022"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00064","article-title":"RE-AIM planning and evaluation framework: Adapting to new science and practice with a 20-year review","volume":"7","author":"Glasgow","year":"2019","journal-title":"Front Public Health"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.89.9.1322","article-title":"Evaluating the public health impact of health promotion interventions: the RE-AIM framework","volume":"89","author":"Glasgow","year":"1999","journal-title":"Am J Public Health"},{"key":"B46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s10488-010-0319-7","article-title":"Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda","volume":"38","author":"Proctor","year":"2011","journal-title":"Adm Policy Ment Health"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2390","article-title":"Improving the reporting of pragmatic trials: an extension of the CONSORT statement","volume":"337","author":"Zwarenstein","year":"2008","journal-title":"Bmj"},{"key":"B48","unstructured":"NorwayS\n          Municipality data (In Norwegian: Kommunefakta)2022"},{"key":"B49","unstructured":"NorwayS\n          StatBank Norway from statistics Norway2022"},{"key":"B50","volume-title":"Public health profiles for municipalities and counties from NIPH","year":"2022"},{"key":"B51","unstructured":"Municipality a. arendal municipality2022"},{"key":"B52","unstructured":"Municipality l. larvik municipality2022"},{"key":"B53","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/1471-2458-13-132","article-title":"Study protocol: fit for delivery - can a lifestyle intervention in pregnancy result in measurable health benefits for mothers and newborns? a randomized controlled trial","volume":"13","author":"Sagedal","year":"2013","journal-title":"BMC Public Health"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/smi.2701","article-title":"The dynamic integrated evaluation model (DIEM): Achieving sustainability in organizational intervention through a participatory evaluation approach","volume":"32","author":"von Thiele Schwarz","year":"2016","journal-title":"Stress Health"},{"key":"B55","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13012-015-0295-0","article-title":"Use of concept mapping to characterize relationships among implementation strategies and assess their feasibility and importance: results from the expert recommendations for implementing change (ERIC) study","volume":"10","author":"Waltz","year":"2015","journal-title":"Implement Sci"},{"key":"B56","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/1748-5908-8-139","article-title":"Implementation strategies: recommendations for specifying and reporting","volume":"8","author":"Proctor","year":"2013","journal-title":"Implement Sci"},{"key":"B57","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13012-015-0209-1","article-title":"A refined compilation of implementation strategies: results from the expert recommendations for implementing change (ERIC) project","volume":"10","author":"Powell","year":"2015","journal-title":"Implement Sci"},{"key":"B58","volume-title":"Applied methods of cost-effectiveness analysis in health care","author":"Gray","year":"2011"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0207-x","article-title":"Estimands: improving inference in randomized controlled trials in clinical nutrition in the presence of missing values","volume":"72","author":"Ritz","year":"2018","journal-title":"Eur J Clin Nutr"},{"key":"B60","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1186\/s13063-021-05644-4","article-title":"Estimands in published protocols of randomised trials: urgent improvement needed","volume":"22","author":"Kahan","year":"2021","journal-title":"Trials"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw314","article-title":"Triangulation in aetiological epidemiology","volume":"45","author":"Lawlor","year":"2016","journal-title":"Int J Epidemiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1748-5908-4-50","article-title":"Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science","volume":"4","author":"Damschroder","year":"2009","journal-title":"Implement Sci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00246.x","article-title":"A validation study of the Norwegian version of the ages and stages questionnaires","volume":"96","author":"Richter","year":"2007","journal-title":"Acta Paediatr"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw029","article-title":"Cohort profile update: The Norwegian mother and child cohort study (MoBa)","volume":"45","author":"Magnus","year":"2016","journal-title":"Int J Epidemiol"},{"key":"B65","unstructured":"Create a nettskjema for collecting sensitive data to TSD2022"},{"key":"B66","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1748-5908-8-117","article-title":"The dynamic sustainability framework: addressing the paradox of sustainment amid ongoing change","volume":"8","author":"Chambers","year":"2013","journal-title":"Implement Sci"},{"key":"B67","volume-title":"WHO health evidence network synthesis reports. what quantitative and qualitative methods have been developed to measure the implementation of a life-course approach in public health policies at the national level?","author":"Jacob","year":"2019"},{"key":"B68","volume-title":"Societal returns following Norwegian dietary guidelines","year":"2015"},{"key":"B69","unstructured":"Lovdata. lov om folkehelsearbeid (folkehelseloven)2011"},{"key":"B70","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1186\/s12889-019-6915-x","article-title":"The Food4toddlers study - study protocol for a web-based intervention to promote healthy diets for toddlers: a randomized controlled trial","volume":"19","author":"R\u00f8ed","year":"2019","journal-title":"BMC Public Health"},{"key":"B71","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1186\/s12889-017-4731-8","article-title":"Early food for future health: a randomized controlled trial evaluating the effect of an eHealth intervention aiming to promote healthy food habits from early childhood","volume":"17","author":"Helle","year":"2017","journal-title":"BMC Public Health"},{"key":"B72","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12887-018-1206-8","article-title":"A cluster randomized web-based intervention trial to reduce food neophobia and promote healthy diets among one-year-old children in kindergarten: study protocol","volume":"18","author":"Blomkvist","year":"2018","journal-title":"BMC Pediatr"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1071489\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T20:59:08Z","timestamp":1673384348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1071489\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":72,"alternative-id":["10.3389\/fendo.2022.1071489"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1071489","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"article-number":"1071489"}}