{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:31:37Z","timestamp":1793809897619,"version":"4.6.1"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Wound healing is a programmed process of continuous events which is impaired in the case of diabetic patients. This impaired process of healing in diabetics leads to amputation, longer hospitalisation, immobilisation, low self-esteem, and mortality in some patients. This problem has paved the way for several innovative strategies like the use of nanotechnology for the treatment of wounds in diabetic patients. The use of biomaterials, nanomaterials have advanced approaches in tissue engineering by designing multi-functional nanocomposite scaffolds. Stimuli-responsive scaffolds that interact with the wound microenvironment and controlled release of bioactive molecules have helped in overcoming barriers in healing. The use of different types of nanocomposite scaffolds for faster healing of diabetic wounds is constantly being studied. Nanocomposites have helped in addressing specific issues with respect to healing and improving angiogenesis. Method: A literature search was followed to retrieve the articles on strategies for wound healing in diabetes across several databases like PubMed, EMBASE, Scopus and Cochrane database. The search was performed in May 2022 by two researchers independently. They keywords used were \u201cdiabetic wounds, nanotechnology, nanocomposites, nanoparticles, chronic diabetic wounds, diabetic foot ulcer, hydrogel\u201d. Exclusion criteria included insulin resistance, burn wound, dressing material.<\/jats:p>","DOI":"10.3389\/fendo.2022.1074568","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:18:42Z","timestamp":1673414322000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Diverse nanocomposites as a potential dressing for diabetic wound healing"],"prefix":"10.3389","volume":"13","author":[{"given":"Remya Rajan","family":"Renuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeline","family":"Julius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman Thodhal","family":"Yoganandham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhamodharan","family":"Umapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Ramadoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony V.","family":"Samrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danis D.","family":"Vijay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.09.005","article-title":"Charge-reversal biodegradable MSNs for tumor synergetic chemo\/photothermal and visualized therapy","volume":"338","author":"Li","year":"2021","journal-title":"J Control Release"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125","article-title":"Factors affecting wound healing","volume":"89","author":"Guo","year":"2010","journal-title":"J Dent Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jccw.2014.03.001","article-title":"Factors that impair wound healing","volume":"4","author":"Anderson","year":"2012","journal-title":"J Am Coll Clin Wound Spec"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00264-3","article-title":"Newer antidiabetic agents: At what price will they be cost effective","volume":"9","author":"Unnikrishnan","year":"2021","journal-title":"The Lancet Diabetes & Endocrinology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569","article-title":"Update on management of diabetic foot ulcers","volume":"1411","author":"Everett","year":"2018","journal-title":"Ann N Y Acad Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2017.0477","article-title":"A universal classification system of skin substitutes inspired by factorial design","volume":"24","author":"Davison-Kotler","year":"2018","journal-title":"Tissue Eng Part B Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2013.03.014","article-title":"Topical and biologic therapies for diabetic foot ulcers","volume":"97","author":"Richmond","year":"2013","journal-title":"Med Clin"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.82","article-title":"Nanomaterials for wound healing: Scope and advancement","volume":"10","author":"Kalashnikova","year":"2015","journal-title":"Nanomedicine"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b00291","article-title":"Engineered nanomaterials for infection control and healing acute and chronic wounds","volume":"8","author":"Parani","year":"2016","journal-title":"ACS Appl Mater Interfaces"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2217\/dmt.15.28","article-title":"Nanotechnology as an innovative approach for accelerating wound healing in diabetes","volume":"5","author":"Mordorski","year":"2015","journal-title":"Diabetes Manag"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1659338","article-title":"Recent progress in development of dressings used for diabetic wounds with special emphasis on scaffolds","author":"Awasthi","year":"2022","journal-title":"BioMed Res Int"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.07.006","article-title":"Nanosilver as a new generation of nanoproduct in biomedical applications","volume":"28","author":"Chaloupka","year":"2010","journal-title":"Trends Biotechnol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/NSA.S133415","article-title":"Antibacterial effect of silver nanoparticles in pseudomonas aeruginosa","volume":"10","author":"Salomoni","year":"2017","journal-title":"Nanotechnol Sci Appl"},{"key":"B14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2323\/jgam.2016.07.004","article-title":"Silver nanoparticles as an antimicrobial agent: A case study on staphylococcus aureus and escherichia coli as models for gram-positive and gram-negative bacteria","volume":"63","author":"Gomaa","year":"2017","journal-title":"J Gen Appl Microbiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4929","DOI":"10.7150\/thno.41839","article-title":"Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-5034-4_21","article-title":"Application of nanomedicine in wound healing","volume-title":"Nanotechnology in dermatology","author":"Liu","year":"2013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.08.018","article-title":"Topical treatment with anti-oxidants and au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products","volume":"47","author":"Chen","year":"2012","journal-title":"Eur J Pharm Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.03.011","article-title":"Preparation of copper-containing bioactive glass\/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing","volume":"36","author":"Li","year":"2016","journal-title":"Acta Biomater"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.09.008","article-title":"Silicate bioceramics induce angiogenesis during bone regeneration","volume":"8","author":"Zhai","year":"2012","journal-title":"Acta Biomater"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b06521","article-title":"Binary doping of strontium and copper enhancing osteogenesis and angiogenesis of bioactive glass nanofibers while suppressing osteoclast activity","volume":"9","author":"Weng","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00573.x","article-title":"Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings","volume":"18","author":"Borkow","year":"2010","journal-title":"Wound Repair Regener"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00417","article-title":"Copper sulfide nanoparticles-incorporated hyaluronic acid injectable hydrogel with enhanced angiogenesis to promote wound healing","volume":"8","author":"Zhou","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.08.032","article-title":"Antibacterial performance and in vivo diabetic wound healing of curcumin loaded gum tragacanth\/poly (\u03f5-caprolactone) electrospun nanofibers","volume":"69","author":"Ranjbar-Mohammadi","year":"2016","journal-title":"Mater Sci Eng C"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.02.003","article-title":"A novel in situ silver\/hyaluronan bio-nanocomposite fabrics for wound and chronic ulcer dressing: In vitro and in vivo evaluations","volume":"520","author":"Abdel-Mohsen","year":"2017","journal-title":"Int J Pharm"},{"key":"B25","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/21691401.2018.1460372","article-title":"Neurotensin-loaded PLGA\/CNC composite nanofiber membranes accelerate diabetic wound healing","volume":"46","author":"Zheng","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201501018","article-title":"Upregulating hif-1\u03b1 by hydrogel nanofibrous scaffolds for rapidly recruiting angiogenesis relative cells in diabetic wound","volume":"5","author":"Chen","year":"2016","journal-title":"Adv Healthc Mater"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra02450h","article-title":"Electrospun polycaprolactone membranes incorporated with ZnO nanoparticles as skin substitutes with enhanced fibroblast proliferation and wound healing","volume":"4","author":"Augustine","year":"2014","journal-title":"Rsc Adv"},{"key":"B28","doi-asserted-by":"publisher","first-page":"102483","DOI":"10.1016\/j.nano.2021.102483","article-title":"Cerium oxide nanoparticle conjugation to microRNA-146a mechanism of correction for impaired diabetic wound healing","volume":"40","author":"Dewberry","year":"2022","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181ae9d45","article-title":"Poly-n-acetyl glucosamine nanofibers: A new bioactive material to enhance diabetic wound healing by cell migration and angiogenesis","volume":"250","author":"Scherer","year":"2009","journal-title":"Ann Surg"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318225583c","article-title":"Poly-n-acetyl glucosamine fibers are synergistic with vacuum-assisted closure in augmenting the healing response of diabetic mice","volume":"71","author":"Erba","year":"2011","journal-title":"J Trauma Acute Care Surg"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c24569","article-title":"Thermosensitive hydrogel incorporating Prussian blue nanoparticles promotes diabetic wound healing via ROS scavenging and mitochondrial function restoration","volume":"14","author":"Xu","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b03656","article-title":"Efficient angiogenesis-based diabetic wound healing\/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11040","article-title":"pH\/glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing","volume":"16","author":"Liang","year":"2022","journal-title":"ACS Nano"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c09889","article-title":"Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-inflammatory behavior for chronically infected diabetic wound treatment","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00662","article-title":"Infant skin friendly adhesive hydrogel patch activated at body temperature for bioelectronics securing and diabetic wound healing","volume":"16","author":"Jiang","year":"2022","journal-title":"ACS Nano"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2018.5312","article-title":"Development of nanotechnology for advancement and application in wound healing: A review","volume":"13","author":"Bhattacharya","year":"2019","journal-title":"IET Nanobiotechnol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.010","article-title":"Incorporation of ZnO nanoparticles into heparinised polyvinyl alcohol\/chitosan hydrogels for wound dressing application","volume":"114","author":"Khorasani","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.04.019","article-title":"Coumestrol\/hydroxypropyl-\u03b2-cyclodextrin association incorporated in hydroxypropyl methylcellulose hydrogel exhibits wound healing effect: In vitro and in vivo study","volume":"119","author":"Bianchi","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34118","article-title":"The potential of the stem cells composite hydrogel wound dressings for promoting wound healing and skin regeneration: in vitro and in vivo evaluation","volume":"107","author":"Hsu","year":"2019","journal-title":"J BioMed Mater Res Part B Appl Biomater"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/biom9010004","article-title":"Nitric oxide release from antimicrobial peptide hydrogels for wound healing","volume":"9","author":"Dur\u00e3o","year":"2018","journal-title":"Biomolecules"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2018.12.021","article-title":"Design and optimization of process parameters of polyvinyl (alcohol)\/chitosan\/nano zinc oxide hydrogels as wound healing materials","volume":"207","author":"Khorasani","year":"2019","journal-title":"Carbohydr Polym"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-017-1956-y","article-title":"Novel enzymatic crosslinked hydrogels that mimic extracellular matrix for skin wound healing","volume":"53","author":"Zhu","year":"2018","journal-title":"J Mater Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9536","article-title":"Diabetes: Advances in diagnosis and treatment","volume":"314","author":"Nathan","year":"2015","journal-title":"Jama"},{"key":"B44","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/iwj.12230","article-title":"Recent accomplishments in wound healing","volume":"12","author":"Mudge","year":"2015","journal-title":"Int Wound J"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201503565","article-title":"Self-assembled wound dressings silence MMP-9 and improve diabetic wound healing in vivo","volume":"28","author":"Castleberry","year":"2016","journal-title":"Adv Mater"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346","article-title":"Prevention and treatment of diabetic foot ulcers","volume":"110","author":"Lim","year":"2017","journal-title":"J R Soc Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/term.2443","article-title":"Innovations in gene and growth factor delivery systems for diabetic wound healing","volume":"12","author":"Laiva","year":"2018","journal-title":"J Tissue Eng Regener Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/term.2564","article-title":"Acellular dermal matrix scaffolds coated with connective tissue growth factor accelerate diabetic wound healing by increasing fibronectin through PKC signalling pathway","volume":"12","author":"Yan","year":"2018","journal-title":"J Tissue Eng Regener Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01152","article-title":"Biomimetic elastomeric polypeptide-based nanofibrous matrix for overcoming multidrug-resistant bacteria and enhancing full-thickness wound healing\/skin regeneration","volume":"12","author":"Xi","year":"2018","journal-title":"ACS Nano"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40204-018-0083-4","article-title":"Synthetic polymeric biomaterials for wound healing: A review","volume":"7","author":"Mir","year":"2018","journal-title":"Prog Biomater"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07173","article-title":"Bioactive anti-inflammatory, antibacterial, antioxidative silicon-based nanofibrous dressing enables cutaneous tumor photothermo-chemo therapy and infection-induced wound healing","volume":"14","author":"Xi","year":"2020","journal-title":"ACS Nano"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1806883","DOI":"10.1002\/adfm.201806883","article-title":"Injectable self-healing antibacterial bioactive polypeptide-based hybrid nanosystems for efficiently treating multidrug resistant infection, skin-tumor therapy, and enhancing wound healing","volume":"29","author":"Zhou","year":"2019","journal-title":"Adv Funct Mater"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/504693","article-title":"Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats","author":"Lee","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b05314","article-title":"Mussel-inspired tissue-adhesive hydrogel based on the polydopamine\u2013chondroitin sulfate complex for growth-factor-free cartilage regeneration","volume":"10","author":"Han","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.068","article-title":"Extracellular matrix hydrogels from decellularized tissues: Structure and function","volume":"49","author":"Saldin","year":"2017","journal-title":"Acta Biomater"},{"key":"B56","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.actbio.2016.11.017","article-title":"Cell infiltrative hydrogel fibrous scaffolds for accelerated wound healing","volume":"49","author":"Zhao","year":"2017","journal-title":"Acta Biomater"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.05.006","article-title":"Biocompatibility of hydrogel-based scaffolds for tissue engineering applications","volume":"35","author":"Naahidi","year":"2017","journal-title":"Biotechnol Adv"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3627","article-title":"Advances in engineering hydrogels","volume":"356","author":"Zhang","year":"2017","journal-title":"Science"},{"key":"B59","doi-asserted-by":"publisher","first-page":"110837","DOI":"10.1016\/j.msec.2020.110837","article-title":"A multifunctional nanocomposite spray dressing of kappa-carrageenan-polydopamine modified ZnO\/L-glutamic acid for diabetic wounds","volume":"111","author":"Tavakoli","year":"2020","journal-title":"Mater Sci Eng C"},{"key":"B60","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/gels7020059","article-title":"Nanoclay\/Polymer-based hydrogels and enzyme-loaded nanostructures for wound healing applications","volume":"7","author":"Villalba-Rodr\u00edguez","year":"2021","journal-title":"Gels"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB00302H","article-title":"Zwitterionic nanocomposite hydrogels as effective wound dressings","volume":"4","author":"Huang","year":"2016","journal-title":"J Mater Chem B"},{"key":"B62","doi-asserted-by":"publisher","first-page":"109569","DOI":"10.1016\/j.compositesb.2021.109569","article-title":"Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2+ for diabetic wounds","volume":"231","author":"Zhu","year":"2022","journal-title":"Compos Part B Eng"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB00343K","article-title":"Bio-fabricated nanocomposite hydrogel with ROS scavenging and local oxygenation accelerates diabetic wound healing","volume":"10","author":"Pu","year":"2022","journal-title":"J Mater Chem B"},{"key":"B64","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3390\/md17050285","article-title":"Edaravone-loaded alginate-based nanocomposite hydrogel accelerated chronic wound healing in diabetic mice","volume":"17","author":"Fan","year":"2019","journal-title":"Mar Drugs"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.53350\/pjmhs211561571","article-title":"Quantitative evaluation of diabetic foot wound healing using hydrogel nanosilver based dressing vs. traditional dressing: A prospective randomized control study","volume":"15","author":"Yahia","year":"2021","journal-title":"Pak J Med Heal Sci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1089\/wound.2019.0982","article-title":"Clinical study of nanofibrillar cellulose hydrogel dressing for skin graft donor site treatment","volume":"9","author":"Koivuniemi","year":"2020","journal-title":"Adv Wound Care"},{"key":"B67","doi-asserted-by":"publisher","first-page":"29","DOI":"10.4103\/0976-0105.145776","article-title":"Healing of burn wounds by topical treatment: A randomized controlled comparison between silver sulfadiazine and nano-crystalline silver","volume":"6","author":"Adhya","year":"2014","journal-title":"J Basic Clin Pharm"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31821c495d","article-title":"The use of silver nylon in preventing surgical site infections following colon and rectal surgery","volume":"54","author":"Krieger","year":"2011","journal-title":"Dis Colon Rectum"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0B013E318148C9E4","article-title":"A silver-coated antimicrobial barrier dressing used postoperatively on meshed autografts: A dressing comparison study","volume":"28","author":"Silver","year":"2007","journal-title":"J Burn Care Res"},{"key":"B70","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1524-4725.2009.01387.x","article-title":"Evaluation of 60 patients with pilonidal sinus treated with laser epilation after surgery","volume":"36","author":"Oram","year":"2010","journal-title":"Dermatol Surg"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00603.x","article-title":"A randomized-controlled trial comparing cadexomer iodine and nanocrystalline silver on the healing of leg ulcers","volume":"18","author":"Miller","year":"2010","journal-title":"Wound Repair Regener"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.06.035","article-title":"Application of Chitosan\/PVA nano fiber as a potential wound dressing for streptozotocin-induced diabetic rats","volume":"92","author":"Majd","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"rbab009","DOI":"10.1093\/rb\/rbab009","article-title":"Therapeutic effects of EGF-modified curcumin\/chitosan nano-spray on wound healing","volume":"8","author":"Li","year":"2021","journal-title":"Regener Biomater"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-020-00737-9","article-title":"Preparation of PLA\/chitosan nanoscaffolds containing cod liver oil and experimental diabetic wound healing in male rats study","volume":"18","author":"Khazaeli","year":"2020","journal-title":"J Nanobiotechnol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.027","article-title":"Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats","volume":"162","author":"Correa","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.09.011","article-title":"Chitosan\u2013hyaluronic acid\/nano silver composite sponges for drug resistant bacteria infected diabetic wounds","volume":"62","author":"Anisha","year":"2013","journal-title":"Int J Biol Macromol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2017.1390383","article-title":"Wound healing properties of PVA\/starch\/chitosan hydrogel membranes with nano zinc oxide as antibacterial wound dressing material","volume":"28","author":"Baghaie","year":"2017","journal-title":"J Biomater Sci Polym Ed"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.08.001","article-title":"In situ injectable nano-composite hydrogel composed of curcumin, n, O-carboxymethyl chitosan and oxidized alginate for wound healing application","volume":"437","author":"Li","year":"2012","journal-title":"Int J Pharm"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2200010","DOI":"10.1002\/anbr.202200010","article-title":"Perspectives on the technological aspects and biomedical applications of virus-like Particles\/Nanoparticles in reproductive biology: Insights on the medicinal and toxicological outlook","author":"Chandrasekar","year":"2022","journal-title":"Adv NanoBiomed Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00087","article-title":"Emerging application of nanorobotics and artificial intelligence to cross the BBB: Advances in design, controlled maneuvering, and targeting of the barriers","volume":"12","author":"Singh","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"B81","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.3390\/cells11182801","article-title":"Micropatterned neurovascular interface to mimic the blood\u2013brain barrier\u2019s neurophysiology and micromechanical function: A BBB-on-CHIP model","volume":"11","author":"Singh","year":"2022","journal-title":"Cells"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1901862","DOI":"10.1002\/adhm.201901862","article-title":"Artificial intelligence and machine learning in computational nanotoxicology: Unlocking and empowering nanomedicine","volume":"9","author":"Singh","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c18470","article-title":"Machine-learning-based approach to decode the influence of nanomaterial properties on their interaction with cells","volume":"13","author":"Singh","year":"2020","journal-title":"ACS Appl Mater Interfaces"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1074568\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:18:45Z","timestamp":1673414325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1074568\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":83,"alternative-id":["10.3389\/fendo.2022.1074568"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1074568","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]},"article-number":"1074568"}}