{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:28:49Z","timestamp":1787668129382,"version":"build-2736575974"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis was performed to evaluate the effectiveness and safety of prophylactic central neck dissection (PCND) in patients with clinically node-negative (cN0) papillary thyroid carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A meta-analysis of the literature was performed using the key words \u201cpapillary thyroid carcinomas\u201d and \u201clymph node ecisions\u201d for searches of electronic databases. Complications such as transient hypocalcemia, permanent hypocalcemia, transient and permanent hypoparathyroidism, transient and permanent vocal cord paralysis, transient recurrent and permanent recurrent laryngeal nerve injury, and local recurrence were pooled by meta-analysis. Stata17.0 was used to carry out the meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data were extracted from 15 studies. In the present review, the group of patients who had total thyroidectomy (TT) with PCND had a lower local recurrence than the group with TT alone (OR 0.22, 95% CI 0.10-0.45, P = 0.000), whereas the incidence of permanent hypocalcemia (OR 4.24, 95% CI 1.05-17.22, P = 0.043) and transient hypoparathyroidism (OR 2.14, 95% CI 1.34-3.42, P =0.001) were higher. No significant differences were recorded in the incidence of other complications: transient hypocalcemia (OR 2.24, 95% CI 0.77-6.51, P = 0.138), permanent hypoparathyroidism (OR 1.70, 95% CI 0.89-3.27, P = 0.111), transient vocal cord paralysis (OR 1.48, 95% CI 0.78-2.83, P = 0.231), permanent vocal cord paralysis (OR 1.44, 95% CI 0.53-3.94, P = 0.477), transient recurrent laryngeal nerve injury (OR 1.47, 95% CI 0.93-2.32, P = 0.102) and permanent recurrent laryngeal nerve injury (OR 1.24, 95% CI 0.56-2.74, P = 0.587) between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with TT alone, TT with PCND was more effective in reducing local recurrence without increasing the risk of recurrent laryngeal nerve, thyroid and vocal cord, except for hypocalcemia and transient hypoparathyroidism. Therefore, we believe that TT with PCND should be recommended for patients with cN0 PTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:uri>\n                      , identifier CRD4202 2355078.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.1094012","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T23:39:48Z","timestamp":1673912388000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["The effectiveness and safety of prophylactic central neck dissection in clinically node-negative papillary thyroid carcinoma patients: A meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Yao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kainan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29251","article-title":"Thyroid cancer mortality and incidence: A global overview","volume":"136","author":"La Vecchia","year":"2015","journal-title":"Int J Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.09.019","article-title":"Commentary on: Occult lymph node metastasis and risk of regional recurrence in papillary thyroid cancer after bilateral prophylactic central neck dissection: A multi-institutional study","volume":"161","author":"Wang","year":"2017","journal-title":"Surgery"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2018.1464910","article-title":"Surgical options for thyroid cancer and post-surgical management","volume":"13","author":"Doubleday","year":"2018","journal-title":"Expert Rev Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003580","article-title":"The American association of endocrine surgeons guidelines for the definitive surgical management of thyroid disease in adults","volume":"271","author":"Patel","year":"2020","journal-title":"Ann Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"American Thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2015","journal-title":"Thyroid"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.906695","article-title":"A narrative review of preventive central lymph node dissection in patients with papillary thyroid cancer-a necessity or an excess","author":"Dolidze","year":"2022","journal-title":"Front Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8985","article-title":"Prophylactic central neck dissection for papillary thyroid cancer","volume":"100","author":"Barczy\u0144ski","year":"2013","journal-title":"Br J Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1135-9","article-title":"Nodal recurrence in the lateral neck after total thyroidectomy with prophylactic central neck dissection for papillary thyroid cancer","volume":"399","author":"Barczy\u0144ski","year":"2013","journal-title":"Langenbeck's Arch Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12957-016-0879-4","article-title":"Role of prophylactic central compartment lymph node dissection in clinically N0 differentiated thyroid cancer patients: Analysis of risk factors and review of modern trends","volume":"14","author":"Conzo","year":"2016","journal-title":"World J Surg Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3825","article-title":"Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: Clinical implications derived from the first prospective randomized controlled single institution study","volume":"100","author":"Viola","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1995-6","article-title":"Impact of combined prophylactic unilateral central neck dissection and hemithyroidectomy in patients with papillary thyroid microcarcinoma","volume":"19","author":"Hyun","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05830-1","article-title":"Effect of prophylactic central neck dissection on the surgical outcomes in papillary thyroid cancer: experience in a single center","volume":"277","author":"Yaz\u0131c\u0131","year":"2020","journal-title":"Eur Arch oto-rhino-laryngol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.03.071","article-title":"A prospective randomized controlled trial to assess the efficacy and safety of prophylactic central compartment lymph node dissection in papillary thyroid carcinoma","volume":"171","author":"Ahn","year":"2022","journal-title":"Surgery"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.02.004","article-title":"Prophylactic central lymph node dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complications","volume":"151","author":"So","year":"2012","journal-title":"Surgery"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05702-3","article-title":"Randomized trial of prophylactic ipsilateral central lymph node dissection in patients with clinically node negative papillary thyroid microcarcinoma","volume":"277","author":"Kim","year":"2020","journal-title":"Eur Arch oto-rhino-laryngol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000250451.59685.67","article-title":"Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients: pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone","volume":"245","author":"Roh","year":"2007","journal-title":"Ann Surg"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-013-2089-3","article-title":"Influence of prophylactic neck dissection on rate of retreatment for papillary thyroid carcinoma","volume":"37","author":"Hartl","year":"2013","journal-title":"World J Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/j.ijsu.2017.01.113","article-title":"Rationality in prophylactic central neck dissection in clinically node-negative (cN0) papillary thyroid carcinoma: Is there anything more to say? a decade experience in a single-center","author":"Dobrinja","year":"2017","journal-title":"Int J Surg (Lond Engl)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0418-3","article-title":"Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma","volume":"34","author":"Moo","year":"2010","journal-title":"World J Surg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05744-7","article-title":"Efficacy of prophylactic central neck dissection in hemithyroidectomy for papillary thyroid carcinoma","volume":"277","author":"Jin","year":"2020","journal-title":"Eur Arch oto-rhino-laryngol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.09.017","article-title":"Total thyroidectomy alone versus ipsilateral versus bilateral prophylactic central neck dissection in clinically node-negative differentiated thyroid carcinoma. a retrospective multicenter study","volume":"43","author":"Cal\u00f2","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-017-1556-y","article-title":"The need of prophylactic central lymph node dissection is controversial in terms of postoperative thyroglobulin follow-up of patients with cN0 papillary thyroid cancer","volume":"402","author":"Korkmaz","year":"2017","journal-title":"Langenbeck's Arch Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6060(03)00424-0","article-title":"Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer","volume":"134","author":"Kouvaraki","year":"2003","journal-title":"Surgery"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0113-y","article-title":"Clinical significance of metastasis to the central compartment from papillary microcarcinoma of the thyroid","volume":"30","author":"Ito","year":"2006","journal-title":"World J Surg"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.06.027","article-title":"Children are at a high risk of hypocalcaemia and hypoparathyroidism after total thyroidectomy","volume":"55","author":"de Jong","year":"2020","journal-title":"J Pediatr Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-6903-1","article-title":"Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years","volume":"28","author":"Rosato","year":"2004","journal-title":"World J Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"030006052199691","DOI":"10.1177\/0300060521996911","article-title":"Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis","volume":"49","author":"Chen","year":"2021","journal-title":"J Int Med Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.717769","article-title":"Complications after thyroidectomy in children: Lymph node dissection is a risk factor for permanent hypocalcemia","volume":"12","author":"van Rooijen","year":"2021","journal-title":"Front Endocrinol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199605000-00003","article-title":"Parathyroid autotransplantation during thyroidectomy. results of long-term follow-up","volume":"223","author":"Olson","year":"1996","journal-title":"Ann Surg"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26733","article-title":"Intraoperative near-infrared autofluorescence imaging for hypocalcemia risk reduction after total thyroidectomy: Evidence from a meta-analysis","volume":"43","author":"Weng","year":"2021","journal-title":"Head Neck"},{"key":"B33","article-title":"Application of central lymph node dissection to surgical operation for clinical stage n0 papillary thyroid carcinoma]","volume":"27","author":"Hu","year":"2008","journal-title":"Ai zheng"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0251-9","article-title":"The role of surgery in the current management of differentiated thyroid cancer","volume":"47","author":"Conzo","year":"2014","journal-title":"Endocrine"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26733","article-title":"Advancement of thyroid surgery video recording: A comparison between two full HD head mounted video cameras","volume":"41","author":"Ortensi","year":"2017","journal-title":"Int J Surg"},{"key":"B36","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12893-018-0447-7","article-title":"May predictors of difficulty in thyroid surgery increase the incidence of complications? prospective study with the proposal of a preoperative score","volume":"18","author":"D\u2019Orazi","year":"2019","journal-title":"BMC Surg"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.11138\/gchir\/2016.37.3.101","article-title":"Use of loupes magnification and microsurgical technique in thyroid surgery: ten years experience in a single center","volume":"37","author":"D'Orazi","year":"2016","journal-title":"G Chir"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-012-1036-3","article-title":"Can intraoperative frozen section influence the extension of central neck dissection in cN0 papillary thyroid carcinoma","volume":"398","author":"Raffaelli","year":"2013","journal-title":"Langenbecks Arch Surg"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4383-9","article-title":"Ipsilateral central neck dissection plus frozen section examination versus prophylactic bilateral central neck dissection in cN0 papillary thyroid carcinoma","volume":"22","author":"Raffaelli","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.053","article-title":"Prospective evaluation of total thyroidectomy versus ipsilateral versus bilateral central neck dissection in patients with clinically node\u2013negative papillary thyroid carcinoma","volume":"152","author":"Raffaelli","year":"2012","journal-title":"Surgery"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1094012\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T23:39:51Z","timestamp":1673912391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.1094012\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":40,"alternative-id":["10.3389\/fendo.2022.1094012"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.1094012","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"article-number":"1094012"}}