{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:53:01Z","timestamp":1773107581262,"version":"3.50.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This was a non-blinded randomized controlled study to evaluate whether endometrial irrigation <jats:italic>via<\/jats:italic> office hysteroscopy during the early follicular phase would lead to a higher level of live birth rates compared to no irrigation in the fresh embryo transfer cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was conducted in Tehran university of medical sciences from June 2015 to June 2016. women under the age of 40 with primary infertility without history of previous IVF\/ICSI or hysteroscopic examination, were included. Controlled ovarian hyperstimulation was done. Hysteroscopy was performed in the early mid-follicular phase of a stimulation cycle (day 5-7) with a vaginoscopy approach and saline irrigation in hysteroscopy group. Embryo-transfer was done in the same cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>228 patients completed their participation in the study. In the fresh cycle, clinical pregnancy rate was 46% in the hysteroscopy group and 40.43% in the control group. (<jats:italic>p-value= 0.326, RR= 1.16 [95%CI: 0.862 to 1.56]<\/jats:italic>). Live birth rate was 41.28% in the hysteroscopic group and 31.93% in the control group (<jats:italic>p-value=0.143, RR= 1.293 [95%CI: 0.916 to 1.825]<\/jats:italic>). For those patients having surplus cryopreserved embryos, after 2 months, a second embryo transfer was performed. The cumulative LBR was 44.05% in the hysteroscopic group and 32.25% in the control group (<jats:italic>p-value=0.029, RR= 1.368 [95%CI: 1.031 to 1.815], RD= 11.9% [95%CI: 1.2% to 22.3%] and NNT= 8 [95%CI: 4 to 85]<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study clearly demonstrated a significantly higher cumulative live birth rate in the intervention group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>[<jats:uri>https:\/\/www.irct.ir\/trial\/19586<\/jats:uri>], identifier IRCT2016011022795N2.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.778988","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T12:42:23Z","timestamp":1644410543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Uterine Cavity Irrigation With Office Hysteroscopy During Ovarian Stimulation for IVF: A Randomized Controlled Trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Marzieh","family":"Ghasemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Aleyasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Human M.","family":"Fatemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Ghaemdoust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Shahrakipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.rbmo.2017.06.015","article-title":"The Vienna Consensus: Report of an Expert Meeting on the Development of ART Laboratory Performance Indicators","volume":"35","year":"2017","journal-title":"Reprod BioMed Online"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2000.0121","article-title":"Paracrine Regulators of Implantation","volume":"14","author":"Sim\u00f3n","year":"2000","journal-title":"Baillieres Best Pract Res Clin Obstet Gynaecol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.06.012","article-title":"Local Endometrial Injury and IVF Outcome: A Systematic Review and Meta-Analysis","volume":"25","author":"El-Toukhy","year":"2012","journal-title":"Reprod BioMed Online"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey334","article-title":"Decrease in Pregnancy Rate After Endometrial Scratch in Women Undergoing a First or Second In Vitro Fertilization. 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