{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:51:51Z","timestamp":1775742711369,"version":"3.50.1"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Oxytocin (OT) is a nonapeptide mainly produced in the supraoptic and paraventricular nuclei. OT in the brain and blood has extensive functions in both mental and physical activities. These functions are mediated by OT receptors (OTRs) that are distributed in a broad spectrum of tissues with dramatic sexual dimorphism. In both sexes, OT generally facilitates social cognition and behaviors, facilitates parental behavior and sexual activity and inhibits feeding and pain perception. However, there are significant differences in OT levels and distribution of OTRs in men from women. Thus, many OT functions in men are different from women, particularly in the reproduction. In men, the reproductive functions are relatively simple. In women, the reproductive functions involve menstrual cycle, pregnancy, parturition, lactation, and menopause. These functions make OT regulation of women\u2019s health and disease a unique topic of physiological and pathological studies. In menstruation, pre-ovulatory increase in OT secretion in the hypothalamus and the ovary can promote the secretion of gonadotropin-releasing hormone and facilitate ovulation. During pregnancy, increased OT synthesis and preterm release endow OT system the ability to promote maternal behavior and lactation. In parturition, cervix expansion-elicited pulse OT secretion and uterine OT release accelerate the expelling of fetus and reduce postpartum hemorrhage. During lactation, intermittent pulsatile OT secretion is necessary for the milk-ejection reflex and maternal behavior. Disorders in OT secretion can account for maternal depression and hypogalactia. In menopause, the reduction of OT secretion accounts for many menopausal symptoms and diseases. These issues are reviewed in this work.<\/jats:p>","DOI":"10.3389\/fendo.2022.786271","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T13:06:11Z","timestamp":1644930371000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Oxytocin in Women\u2019s Health and Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Ning","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haipeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"179272","DOI":"10.1155\/2013\/179272","article-title":"Nonsocial Functions of Hypothalamic Oxytocin","volume":"2013","author":"Yang","year":"2013","journal-title":"ISRN Neurosci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.neuron.2020.10.032","article-title":"Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain","volume":"109","author":"Zhang","year":"2021","journal-title":"Neuron"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.041","article-title":"A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing","volume":"89","author":"Eliava","year":"2016","journal-title":"Neuron"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The Oxytocin Receptor System: Structure, Function, and Regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol Rev"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01317","article-title":"Oxytocin Inhibition of Metastatic Colorectal Cancer by Suppressing the Expression of Fibroblast Activation Protein-Alpha","volume":"13","author":"Ma","year":"2019","journal-title":"Front Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuroscience.2021.05.034","article-title":"Distribution of Vasopressin and Oxytocin Neurons in the Basal Forebrain and Midbrain of Spiny Mice (Acomys Cahirinus)","volume":"468","author":"Kelly","year":"2021","journal-title":"Neuroscience"},{"key":"B7","article-title":"Synthesis and Metabolism of Oxytocin in Late Gestation in Human Decidua","volume":"395","author":"Mitchell","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.80.2.7852522","article-title":"Estrogen Stimulates Oxytocin Gene Expression in Human Chorio-Decidua","volume":"80","author":"Chibbar","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90214-S","article-title":"Synthesis of Oxytocin in Amnion, Chorion and Decidua: A Potential Paracrine Role for Oxytocin in the Onset of Human Parturition","volume":"45","author":"Miller","year":"1993","journal-title":"Regul Pept"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116169","article-title":"Synthesis of Oxytocin in Amnion, Chorion, and Decidua may Influence the Timing of Human Parturition","volume":"91","author":"Chibbar","year":"1993","journal-title":"J Clin Invest"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nature00822","article-title":"Intracellular Calcium Stores Regulate Activity-Dependent Neuropeptide Release From Dendrites","volume":"418","author":"Ludwig","year":"2002","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e12569","DOI":"10.1111\/jne.12569","article-title":"Integrative Neuro-Humoral Regulation of Oxytocin Neuron Activity in Pregnancy and Lactation","author":"Augustine","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neuroscience.2020.10.016","article-title":"Key Roles of Cyclooxygenase 2-Protein Kinase A-Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 Pathway in the Regulation of Oxytocin Neuronal Activity in Lactating Rats With Intermittent Pup-Deprivation","volume":"452","author":"Li","year":"2021","journal-title":"Neuroscience"},{"key":"B14","doi-asserted-by":"publisher","first-page":"17590914211014731","DOI":"10.1177\/17590914211014731","article-title":"Oxytocin Modulation of Maternal Behavior and Its Association With Immunological Activity in Rats With Cesarean Delivery","volume":"13","author":"Li","year":"2021","journal-title":"ASN Neuro"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e12963","DOI":"10.1111\/jne.12963","article-title":"Transport of Oxytocin to the Brain After Peripheral Administration by Membrane-Bound or Soluble Forms of Receptors for Advanced Glycation End-Products","volume":"33","author":"Munesue","year":"2021","journal-title":"J Neuroendocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5346-06.2007","article-title":"Dominant Role of Betagamma Subunits of G-Proteins in Oxytocin-Evoked Burst Firing","volume":"27","author":"Wang","year":"2007","journal-title":"J Neurosci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e14047","DOI":"10.14814\/phy2.14047","article-title":"Lactation Induces Increased IPSC Bursting in Oxytocinergic Neurons","volume":"7","author":"Popescu","year":"2019","journal-title":"Physiol Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1759091419843762","DOI":"10.1177\/1759091419843762","article-title":"Role of Connexin 36 in Autoregulation of Oxytocin Neuronal Activity in Rat Supraoptic Nucleus","volume":"11","author":"Wang","year":"2019","journal-title":"ASN Neuro"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4669-08.2009","article-title":"Astrocytic Plasticity and Patterned Oxytocin Neuronal Activity: Dynamic Interactions","volume":"29","author":"Wang","year":"2009","journal-title":"J Neurosci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00262","article-title":"Oxytocin Rapidly Changes Astrocytic GFAP Plasticity by Differentially Modulating the Expressions of pERK 1\/2 and Protein Kinase A","volume":"10","author":"Wang","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01267.2005","article-title":"Mechanisms Underlying Oxytocin-Induced Excitation of Supraoptic Neurons: Prostaglandin Mediation of Actin Polymerization","volume":"95","author":"Wang","year":"2006","journal-title":"J Neurophysiol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4119-07.2007","article-title":"Interaction of Extracellular Signal-Regulated Protein Kinase 1\/2 With Actin Cytoskeleton in Supraoptic Oxytocin Neurons and Astrocytes: Role in Burst Firing","volume":"27","author":"Wang","year":"2007","journal-title":"J Neurosci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1759091420944658","DOI":"10.1177\/1759091420944658","article-title":"Involvement of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 3 in Oxytocin Neuronal Activity in Lactating Rats With Pup Deprivation","volume":"12","author":"Li","year":"2020","journal-title":"ASN Neuro"},{"key":"B24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.neulet.2004.10.033","article-title":"Neuromedin U Receptor-2 mRNA and HCN Channels mRNA Expression in NMU-Sensitive Neurons in Rat Hypothalamic Paraventricular Nucleus","volume":"374","author":"Qiu","year":"2005","journal-title":"Neurosci Lett"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1588-16.2016","article-title":"Nitric Oxide Modulates HCN Channels in Magnocellular Neurons of the Supraoptic Nucleus of Rats by an S-Nitrosylation-Dependent Mechanism","volume":"36","author":"Pires Da Silva","year":"2016","journal-title":"J Neurosci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.jlr.2021.100059","article-title":"The Ligand-Bound State of a G Protein-Coupled Receptor Stabilizes the Interaction of Functional Cholesterol Molecules","volume":"62","author":"Lemel","year":"2021","journal-title":"J Lipid Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0300109","article-title":"Molecular Regulation of the Oxytocin Receptor in Peripheral Organs","volume":"30","author":"Kimura","year":"2003","journal-title":"J Mol Endocrinol"},{"key":"B28","first-page":"97","article-title":"Oxytocin\u2013anatomy and Functional Assignments: A Minireview","volume":"39","author":"Kiss","year":"2005","journal-title":"Endocr Regul"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01914-9","article-title":"Vasopressin-Induced Contraction of Uterus is Mediated Solely by the Oxytocin Receptor in Mice, But Not in Humans","volume":"472","author":"Kawamata","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5593-08.2009","article-title":"Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice","volume":"29","author":"Yoshida","year":"2009","journal-title":"J Neurosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah039","article-title":"Oxytocin Receptor Gene Expression of Estrogen-Stimulated Human Myometrium in Extracorporeally Perfused Non-Pregnant Uteri","volume":"10","author":"Richter","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5144","DOI":"10.3390\/ijms21145144","article-title":"The New Frontier in Oxytocin Physiology: The Oxytonic Contraction","volume":"21","author":"Camerino","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B33","article-title":"Myometrial Oxytocin Receptor Expression and Intracellular Pathways","volume":"66","author":"Yulia","year":"2014","journal-title":"Minerva Ginecol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00766.2005","article-title":"Oxytocin Receptor Binding in the Hypothalamus During Gestation in Rats","volume":"291","author":"Bealer","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0615","article-title":"Dynamic Changes in Oxytocin Receptor Expression and Activation at Parturition in the Rat Brain","volume":"148","author":"Meddle","year":"2007","journal-title":"Endocrinology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4149\/gpb_2016022","article-title":"The Response of Rat and Human Uterus to Oxytocin From Different Gestational Stages In Vitro","volume":"36","author":"Alotaibi","year":"2017","journal-title":"Gen Physiol Biophys"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1113\/JP276806","article-title":"Oxytocin can Regulate Myometrial Smooth Muscle Excitability by Inhibiting the Na(+) -Activated K(+) Channel, Slo2.1","volume":"597","author":"Ferreira","year":"2019","journal-title":"J Physiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00499","article-title":"Functional Hierarchy of Uterotonics Required for Successful Parturition in Mice","volume":"160","author":"Yoshida","year":"2019","journal-title":"Endocrinology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"110211","DOI":"10.1016\/j.cellsig.2021.110211","article-title":"The MAP Kinase ERK5\/MAPK7 is a Downstream Effector of Oxytocin Signaling in Myometrial Cells","volume":"90","author":"Devost","year":"2021","journal-title":"Cell Signal"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.04.001","article-title":"Oxytocin: The Great Facilitator of Life","volume":"88","author":"Lee","year":"2009","journal-title":"Prog Neurobiol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.005","article-title":"The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior","volume":"65","author":"Insel","year":"2010","journal-title":"Neuron"},{"key":"B42","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.physbeh.2010.05.004","article-title":"Oxytocin-Messages via the Cerebrospinal Fluid: Behavioral Effects; a Review","volume":"101","author":"Veening","year":"2010","journal-title":"Physiol Behav"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00185.x","article-title":"REVIEW: Oxytocin: Crossing the Bridge Between Basic Science and Pharmacotherapy","volume":"16","author":"Viero","year":"2010","journal-title":"CNS Neurosci Ther"},{"key":"B44","doi-asserted-by":"publisher","first-page":"211","DOI":"10.4172\/2167-0501.1000211","article-title":"Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study","volume":"5","author":"Hou","year":"2016","journal-title":"Biochem Pharmacol (Los Angel)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00693","article-title":"Approaches Mediating Oxytocin Regulation of the Immune System","volume":"7","author":"Li","year":"2016","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00454","article-title":"Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways","volume":"13","author":"Wang","year":"2019","journal-title":"Front Neurosci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12868-021-00631-6","article-title":"Oxytocin Ameliorates Impaired Social Behavior in a Chd8 Haploinsufficiency Mouse Model of Autism","volume":"22","author":"Cherepanov","year":"2021","journal-title":"BMC Neurosci"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0061-21.2021","article-title":"Intranasal Administration of Oxytocin Attenuates Social Recognition Deficits and Increases Prefrontal Cortex Inhibitory Postsynaptic Currents Following Traumatic Brain Injury","volume":"8","author":"Runyan","year":"2021","journal-title":"eNeuro"},{"key":"B49","doi-asserted-by":"publisher","first-page":"105247","DOI":"10.1016\/j.psyneuen.2021.105247","article-title":"Experiences Affect Social Behaviors via Altering Neuronal Morphology and Oxytocin System","volume":"129","author":"Wei","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"100737","DOI":"10.1016\/j.yfrne.2019.02.001","article-title":"Comparing Vasopressin and Oxytocin Fiber and Receptor Density Patterns in the Social Behavior Neural Network: Implications for Cross-System Signaling","volume":"53","author":"Smith","year":"2019","journal-title":"Front Neuroendocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e12641","DOI":"10.1111\/jne.12641","article-title":"Factors Promoting Vulnerability to Dysregulated Stress Reactivity and Stress-Related Disease","volume":"30","author":"Russell","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1530\/EC-21-0043","article-title":"Oxytocin Signal Contributes to the Adaptative Growth of Islets During Gestation","volume":"10","author":"Gu","year":"2021","journal-title":"Endocr Connect"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.11.001","article-title":"Oxytocin-Secreting System: A Major Part of the Neuroendocrine Center Regulating Immunologic Activity","volume":"289","author":"Wang","year":"2015","journal-title":"J Neuroimmunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"119130","DOI":"10.1016\/j.lfs.2021.119130","article-title":"Cardiovascular Protective Properties of Oxytocin Against COVID-19","volume":"270","author":"Wang","year":"2021","journal-title":"Life Sci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.1.278","article-title":"Atrial Natriuretic Peptide and Oxytocin Induce Natriuresis by Release of cGMP","volume":"96","author":"Soares","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00444.2014","article-title":"A Comparison of Physiological and Transcriptome Responses to Water Deprivation and Salt Loading in the Rat Supraoptic Nucleus","volume":"308","author":"Greenwood","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000505997","article-title":"Physiological and Transcriptomic Changes in the Hypothalamic-Neurohypophysial System After 24 H of Furosemide-Induced Sodium Depletion","volume":"111","author":"Dutra","year":"2021","journal-title":"Neuroendocrinology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00800.2010","article-title":"Estradiol Potentiates Hypothalamic Vasopressin and Oxytocin Neuron Activation and Hormonal Secretion Induced by Hypovolemic Shock","volume":"301","author":"Mecawi","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02133.x","article-title":"Oestradiol Potentiates Hormone Secretion and Neuronal Activation in Response to Hypertonic Extracellular Volume Expansion in Ovariectomised Rats","volume":"23","author":"Vilhena-Franco","year":"2011","journal-title":"J Neuroendocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1177\/0891988720915526","article-title":"Serum Oxytocin Levels and Logical Memory in Older People in Rural Japan","volume":"34","author":"Kunitake","year":"2021","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00071-y","article-title":"Low Serum Oxytocin Concentrations Are Associated With Painful Menstruation","volume":"27","author":"Oladosu","year":"2020","journal-title":"Reprod Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150205","article-title":"Why is Depression More Prevalent in Women","volume":"40","author":"Albert","year":"2015","journal-title":"J Psychiatry Neurosci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.025","article-title":"Sexually Dimorphic Expression of Oxytocin Binding Sites in Forebrain and Spinal Cord of the Rat","volume":"135","author":"Uhl-Bronner","year":"2005","journal-title":"Neuroscience"},{"key":"B64","doi-asserted-by":"publisher","first-page":"102096","DOI":"10.1016\/j.npep.2020.102096","article-title":"Estradiol and the Feeding State Modulate the Interaction Between Leptin and the Nitrergic System in Female Rats","volume":"84","author":"Oliveira","year":"2020","journal-title":"Neuropeptides"},{"key":"B65","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1744-8069-4-19","article-title":"Oxytocin-Induced Antinociception in the Spinal Cord is Mediated by a Subpopulation of Glutamatergic Neurons in Lamina I-II Which Amplify GABAergic Inhibition","volume":"4","author":"Breton","year":"2008","journal-title":"Mol Pain"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.06.043","article-title":"Region-Specific Associations Between Sex, Social Status, and Oxytocin Receptor Density in the Brains of Eusocial Rodents","volume":"303","author":"Mooney","year":"2015","journal-title":"Neuroscience"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2018_55","article-title":"Neural Regulation of Paternal Behavior in Mammals: Sensory, Neuroendocrine, and Experiential Influences on the Paternal Brain","volume":"43","author":"Horrell","year":"2019","journal-title":"Curr Top Behav Neurosci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e12594","DOI":"10.1111\/jne.12594","article-title":"Role of Oxytocin in Parental Behaviour","volume":"30","author":"Olazabal","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S192951","article-title":"Sexual Dimorphism of Oxytocin and Vasopressin in Social Cognition and Behavior","volume":"12","author":"Lu","year":"2019","journal-title":"Psychol Res Behav Manag"},{"key":"B70","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/aur.1270","article-title":"Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms","volume":"6","author":"Miller","year":"2013","journal-title":"Autism Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"7672","DOI":"10.1038\/s41598-018-26020-4","article-title":"Endogenous Testosterone and Exogenous Oxytocin Influence the Response to Baby Schema in the Female Brain","volume":"8","author":"Holtfrerich","year":"2018","journal-title":"Sci Rep"},{"key":"B72","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.yhbeh.2017.08.003","article-title":"Cryptic Sexual Dimorphism in Spatial Memory and Hippocampal Oxytocin Receptors in Prairie Voles (Microtus Ochrogaster)","volume":"95","author":"Rice","year":"2017","journal-title":"Horm Behav"},{"key":"B73","doi-asserted-by":"publisher","first-page":"100313","DOI":"10.1016\/j.ynstr.2021.100313","article-title":"Intranasal Oxytocin Compensates for Estrus Cycle-Specific Reduction of Conditioned Safety Memory in Rats: Implications for Psychiatric Disorders","volume":"14","author":"Kreutzmann","year":"2021","journal-title":"Neurobiol Stress"},{"key":"B74","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuroscience.2017.11.037","article-title":"Chronic Intranasal Oxytocin has Dose-Dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus Ochrogaster)","volume":"369","author":"Guoynes","year":"2018","journal-title":"Neuroscience"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz014","article-title":"Sex Differences in Gene Expression in Response to Ischemia in the Human Left Ventricular Myocardium","volume":"28","author":"Stone","year":"2019","journal-title":"Hum Mol Genet"},{"key":"B76","doi-asserted-by":"publisher","first-page":"8551","DOI":"10.3390\/ijms22168551","article-title":"Oxytocin and Bone: Review and Perspectives","volume":"22","author":"Breuil","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e12945","DOI":"10.1111\/adb.12945","article-title":"No Changes in the Oxytocin System in Alcohol-Dependent Female Rodents and Humans: Towards a Sex-Specific Psychopharmacology in Alcoholism","volume":"26","author":"Hansson","year":"2021","journal-title":"Addict Biol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1080\/00224499.2020.1856316","article-title":"VR Porn as \"Empathy Machine\"? Perception of Self and Others in Virtual Reality Pornography","volume":"58","author":"Dekker","year":"2021","journal-title":"J Sex Res"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05721.x","article-title":"Oxytocin Injected Into the Ventral Tegmental Area Induces Penile Erection and Increases Extracellular Dopamine in the Nucleus Accumbens and Paraventricular Nucleus of the Hypothalamus of Male Rats","volume":"26","author":"Melis","year":"2007","journal-title":"Eur J Neurosci"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24116","article-title":"Oxytocin Receptors are Expressed on Dopamine and Glutamate Neurons in the Mouse Ventral Tegmental Area That Project to Nucleus Accumbens and Other Mesolimbic Targets","volume":"525","author":"Peris","year":"2017","journal-title":"J Comp Neurol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.84851","article-title":"The Orgasmic History of Oxytocin: Love, Lust, and Labor","volume":"15","author":"Magon","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.08.033","article-title":"Normal Male Sexual Function: Emphasis on Orgasm and Ejaculation","volume":"104","author":"Alwaal","year":"2015","journal-title":"Fertil Steril"},{"key":"B83","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/dneu.22431","article-title":"Oxytocin and Behavior: Lessons From Knockout Mice","volume":"77","author":"Caldwell","year":"2017","journal-title":"Dev Neurobiol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1242\/bio.022616","article-title":"Vasotocin Receptor Blockade Disrupts Maternal Care of Offspring in a Viviparous Snake, Sistrurus Miliarius","volume":"6","author":"Lind","year":"2017","journal-title":"Biol Open"},{"key":"B85","doi-asserted-by":"publisher","first-page":"e0244033","DOI":"10.1371\/journal.pone.0244033","article-title":"An Acute Dose of Intranasal Oxytocin Rapidly Increases Maternal Communication and Maintains Maternal Care in Primiparous Postpartum California Mice","volume":"16","author":"Guoynes","year":"2021","journal-title":"PLoS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1262\/jrd.2015-046","article-title":"Puerperal and Parental Experiences Alter Rat Preferences for Pup Odors via Changes in the Oxytocin System","volume":"62","author":"Munetomo","year":"2016","journal-title":"J Reprod Dev"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnss.2019.09.009","article-title":"Oxytocin and Early Parent-Infant Interactions: A Systematic Review","volume":"6","author":"Scatliffe","year":"2019","journal-title":"Int J Nurs Sci"},{"key":"B88","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/7854_2017_18","article-title":"Oxytocin and Human Evolution","volume":"35","author":"Sue Carter","year":"2018","journal-title":"Curr Top Behav Neurosci"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/da.22599","article-title":"Association of Peripartum Synthetic Oxytocin Administration and Depressive and Anxiety Disorders Within the First Postpartum Year","volume":"34","author":"Kroll-Desrosiers","year":"2017","journal-title":"Depress Anxiety"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00725.2005","article-title":"Autofeedback Effects of Progressively Rising Oxytocin Concentrations on Supraoptic Oxytocin Neuronal Activity in Slices From Lactating Rats","volume":"290","author":"Wang","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0311-6","article-title":"Oxytocin Modulates Hippocampal Perfusion in People at Clinical High Risk for Psychosis","volume":"44","author":"Davies","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/B978-0-12-820107-7.00006-9","article-title":"Oxytocin, Eating Behavior, and Metabolism in Humans","volume":"180","author":"Kerem","year":"2021","journal-title":"Handb Clin Neurol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s41419-021-03849-8","article-title":"Oxytocin Receptor Induces Mammary Tumorigenesis Through Prolactin\/P-STAT5 Pathway","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"B94","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.3390\/ijms22042146","article-title":"Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment","volume":"22","author":"Goh","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03129-5","article-title":"Astrocytic Modulation of Supraoptic Oxytocin Neuronal Activity in Rat Dams With Pup-Deprivation at Different Stages of Lactation","volume":"46","author":"Li","year":"2021","journal-title":"Neurochem Res"},{"key":"B96","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1515\/revneuro-2021-0038","article-title":"The Influence of Rs53576 Polymorphism in the Oxytocin Receptor (OXTR) Gene on Empathy in Healthy Adults by Subtype and Ethnicity: A Systematic Review and Meta-Analysis","volume":"33","author":"Chander","year":"2021","journal-title":"Rev Neurosci"},{"key":"B97","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/7854_2017_6","article-title":"Molecular Basis of Oxytocin Receptor Signalling in the Brain: What We Know and What We Need to Know","volume":"35","author":"Busnelli","year":"2018","journal-title":"Curr Top Behav Neurosci"},{"key":"B98","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/erv.2703","article-title":"Methylation of the OXTR Gene in Women With Anorexia Nervosa: Relationship to Social Behavior","volume":"28","author":"Thaler","year":"2020","journal-title":"Eur Eat Disord Rev"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.05.043","article-title":"OXTR Moderates Adverse Childhood Experiences on Depressive Symptoms Among Incarcerated Males","volume":"140","author":"Zhang","year":"2021","journal-title":"J Psychiatr Res"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04792-x","article-title":"DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders","volume":"51","author":"Siu","year":"2021","journal-title":"J Autism Dev Disord"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2004.01235.x","article-title":"Interaction Between Norepinephrine, Oxytocin, and Nitric Oxide in the Stimulation of Gonadotropin-Releasing Hormone Release From Proestrous Rat Basal Hypothalamus Explants","volume":"16","author":"Selvage","year":"2004","journal-title":"J Neuroendocrinol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02818.x","article-title":"Oxytocin is Not Important for the Control of Gonadotrophin Secretion in the Late Follicular Phase of the Cycle","volume":"66","author":"Vanakara","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg291","article-title":"Evidence That Oxytocin is a Physiological Component of LH Regulation in Non-Pregnant Women","volume":"18","author":"Evans","year":"2003","journal-title":"Hum Reprod"},{"key":"B104","article-title":"Expression of Glial Fibrillary Acidic Protein in Astrocytes of Rat Supraoptic Nucleus Throughout Estrous Cycle","volume":"37","author":"Liu","year":"2016","journal-title":"Neuro Endocrinol Lett"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03172-2","article-title":"Astroglial Regulation of Magnocellular Neuroendocrine Cell Activities in the Supraoptic Nucleus","volume":"46","author":"Wang","year":"2021","journal-title":"Neurochem Res"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14001","article-title":"Effect of Exogenous Administration of Oxytocin on Postpartum Follicular Dynamics, Oestrous Rate and Ovulation in Nili-Ravi Buffaloes","volume":"56","author":"Murtaza","year":"2021","journal-title":"Reprod Domest Anim"},{"key":"B107","doi-asserted-by":"crossref","DOI":"10.55782\/ane-1996-1187","article-title":"The Central Oxytocin Pulse Generator: A Pacemaker for the Ovarian Cycle","volume":"56","author":"Mccracken","year":"1996","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"B108","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1365-2826.2012.02295.x","article-title":"Allopregnanolone and Induction of Endogenous Opioid Inhibition of Oxytocin Responses to Immune Stress in Pregnant Rats","volume":"24","author":"Brunton","year":"2012","journal-title":"J Neuroendocrinol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopsycho.2015.04.003","article-title":"The Influence of Early Life Sexual Abuse on Oxytocin Concentrations and Premenstrual Symptomatology in Women With a Menstrually Related Mood Disorder","volume":"109","author":"Crowley","year":"2015","journal-title":"Biol Psychol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/nature15378","article-title":"A Sexually Dimorphic Hypothalamic Circuit Controls Maternal Care and Oxytocin Secretion","volume":"525","author":"Scott","year":"2015","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13441","article-title":"Intranasal Oxytocin as a Treatment for Chronic Pelvic Pain: A Randomized Controlled Feasibility Study","volume":"152","author":"Flynn","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"key":"B112","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.psyneuen.2017.10.014","article-title":"Intranasal Oxytocin in the Treatment of Anorexia Nervosa: Randomized Controlled Trial During Re-Feeding","volume":"87","author":"Russell","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01052.x","article-title":"Central Blockade of Oxytocin Receptors During Late Gestation Disrupts Systemic Release of Oxytocin During Suckling in Rats","volume":"15","author":"Lipschitz","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10016","article-title":"Role of the Supraoptic Nucleus in Regulation of Parturition and Milk Ejection Revisited","volume":"56","author":"Higuchi","year":"2002","journal-title":"Microsc Res Tech"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14042","article-title":"Dosage of Oxytocin for Augmentation of Labor and Women's Childbirth Experiences: A Randomized Controlled Trial","volume":"100","author":"Selin","year":"2021","journal-title":"Acta Obstet Gynecol Scand"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2020.1768268","article-title":"Carbetocin Versus Oxytocin for Prevention of Postpartum Hemorrhage in Hypertensive Women Undergoing Elective Cesarean Section","volume":"39","author":"Ibrahim","year":"2020","journal-title":"Hypertens Pregnancy"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-73-4-804","article-title":"Comparison of Plasma Oxytocin and Catecholamine Concentrations With Uterine Activity in Pregnant Rhesus Monkeys","volume":"73","author":"Hirst","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90099-5","article-title":"Plasma Oxytocin and Nocturnal Uterine Activity: Maternal But Not Fetal Concentrations Increase Progressively During Late Pregnancy and Delivery in Rhesus Monkeys","volume":"169","author":"Hirst","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1054\/npep.2002.0909","article-title":"The Social Deficits of the Oxytocin Knockout Mouse","volume":"36","author":"Winslow","year":"2002","journal-title":"Neuropeptides"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1037\/a0020799","article-title":"3rd, and Caldwell, H.K","volume":"124","author":"Macbeth","year":"2010","journal-title":"Behav Neurosci"},{"key":"B121","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/B978-0-444-64239-4.00002-3","article-title":"Neurophysiological and Cognitive Changes in Pregnancy","volume":"171","author":"Grattan","year":"2020","journal-title":"Handb Clin Neurol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e0235806","DOI":"10.1371\/journal.pone.0235806","article-title":"Maternal Plasma Levels of Oxytocin During Breastfeeding-A Systematic Review","volume":"15","author":"Uvnas Moberg","year":"2020","journal-title":"PloS One"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1440463","article-title":"Effects of Hemitransection of the Midbrain on Milk-Ejection Burst of Oxytocin Neurones in Lactating Rat","volume":"144","author":"Wang","year":"1995","journal-title":"J Endocrinol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.1996.04703.x","article-title":"Milk Ejection Bursts of Supraoptic Oxytocin Neurones During Bilateral and Unilateral Suckling in the Rat","volume":"8","author":"Wang","year":"1996","journal-title":"J Neuroendocrinol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0304-3940(97)00300-5","article-title":"Effect of Interhemispheric Sections of the Hypothalamus on Milk-Ejection Bursts of Supraoptic Oxytocin Neurones During Bilateral and Unilateral Suckling in the Rat","volume":"227","author":"Wang","year":"1997","journal-title":"Neurosci Lett"},{"key":"B126","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-2826.2012.02368.x","article-title":"Lesions of Hypothalamic Mammillary Body Desynchronise Milk-Ejection Bursts of Rat Bilateral Supraoptic Oxytocin Neurones","volume":"25","author":"Wang","year":"2013","journal-title":"J Neuroendocrinol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03218-5","article-title":"Involvement of Protein Kinase A in Oxytocin Neuronal Activity in Rat Dams With Pup Deprivation","volume":"46","author":"Li","year":"2021","journal-title":"Neurochem Res"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e12826","DOI":"10.1111\/jne.12826","article-title":"Advances in the Neurophysiology of Magnocellular Neuroendocrine Cells","volume":"32","author":"Tasker","year":"2020","journal-title":"J Neuroendocrinol"},{"key":"B129","first-page":"002","article-title":"Pulsatile But Not Tonic Secretion of Oxytocin Plays the Role of Anti-Precancerous Lesions of the Mammary Glands in Rat Dams Separated From the Pups During Lactation","volume":"1","author":"Liu","year":"2016","journal-title":"Mathews J Neurol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.peptides.2018.07.007","article-title":"Oxytocin Effects on the Inhibition of the NF-Kappab\/Mir195 Pathway in Mice Breast Cancer","volume":"107","author":"Khori","year":"2018","journal-title":"Peptides"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1159\/000492001","article-title":"Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship With Obesity, Body Composition and Metabolic Variables","volume":"11","author":"Maestrini","year":"2018","journal-title":"Obes Facts"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1258\/mi.2011.011030","article-title":"Topical Oxytocin Reverses Vaginal Atrophy in Postmenopausal Women: A Double-Blind Randomized Pilot Study","volume":"17","author":"Jonasson","year":"2011","journal-title":"Menopause Int"},{"key":"B133","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12905-020-00935-5","article-title":"The Effect of Oxytocin Vaginal Gel on Vaginal Atrophy in Postmenopausal Women: A Randomized Controlled Trial","volume":"20","author":"Zohrabi","year":"2020","journal-title":"BMC Womens Health"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0127","article-title":"Oxytocin Controls Differentiation of Human Mesenchymal Stem Cells and Reverses Osteoporosis","volume":"26","author":"Elabd","year":"2008","journal-title":"Stem Cells"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1688","article-title":"Oxytocin Reverses Ovariectomy-Induced Osteopenia and Body Fat Gain","volume":"155","author":"Beranger","year":"2014","journal-title":"Endocrinology"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2577","article-title":"Oxytocin Levels are Lower in Premenopausal Women With Type 1 Diabetes Mellitus Compared With Matched Controls","volume":"31","author":"Kujath","year":"2015","journal-title":"Diabetes Metab Res Rev"},{"key":"B137","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1507\/endocrj.EJ19-0586","article-title":"Effects of Peripheral Oxytocin Administration on Body Weight, Food Intake, Adipocytes, and Biochemical Parameters in Peri- and Postmenopausal Female Rats","volume":"68","author":"Erdenebayar","year":"2021","journal-title":"Endocr J"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00461","article-title":"Ovarian Hormone Deprivation Reduces Oxytocin Expression in Paraventricular Nucleus Preautonomic Neurons and Correlates With Baroreflex Impairment in Rats","volume":"7","author":"De Melo","year":"2016","journal-title":"Front Physiol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.786271\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T16:29:07Z","timestamp":1726676947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.786271\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":138,"alternative-id":["10.3389\/fendo.2022.786271"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.786271","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]},"article-number":"786271"}}