{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:36:01Z","timestamp":1789011361335,"version":"build-2803163510"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700400"],"award-info":[{"award-number":["2021YFC2700400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Genome-wide association studies (GWAS) have identified <jats:italic>THADA<\/jats:italic> as one of the susceptibility genes for polycystic ovary syndrome (PCOS). Single nucleotide polymorphisms (SNPs) in the <jats:italic>THADA<\/jats:italic> gene showed significant over-transmission in PCOS and strong correlations with testosterone level. However, there was insufficient evidence to verify the effect of <jats:italic>THADA in vivo<\/jats:italic> on female reproductive system. In this study, we investigated the impacts of <jats:italic>Thada<\/jats:italic> ablation on ovarian function and reproductive outcomes with knockout (KO) mice. The results showed that the <jats:italic>Thada<\/jats:italic> deletion was insufficient to affect ovarian folliculogenesis, steroidogenesis, and female fertility. Additionally, we stressed the mice with high-fat-high-sugar diet (HFHS). In this case, the KO mice still merely had a negligible impact on ovarian function. These findings indicated that <jats:italic>Thada<\/jats:italic> deficiency was dispensable for female fertility in mice, which enriched our knowledge about <jats:italic>in vivo<\/jats:italic> functions of PCOS susceptibility genes.<\/jats:p>","DOI":"10.3389\/fendo.2022.787733","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T10:54:28Z","timestamp":1649674468000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Thada Is Dispensable for Female Fertility in Mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Shan","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.coemr.2020.02.011","article-title":"The Contribution of Rare Genetic Variants to the Pathogenesis of Polycystic Ovary Syndrome","volume":"12","author":"Dapas","year":"2020","journal-title":"Curr Opin Endocr Metab Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0666-1","article-title":"Prenatal Androgen Exposure and Transgenerational Susceptibility to Polycystic Ovary Syndrome","volume":"25","author":"Risal","year":"2019","journal-title":"Nat Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1007813","DOI":"10.1371\/journal.pgen.1007813","article-title":"Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria","volume":"14","author":"Day","year":"2018","journal-title":"PloS Genet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ng.732","article-title":"Genome-Wide Association Study Identifies Susceptibility Loci for Polycystic Ovary Syndrome on Chromosome 2p16.3, 2p21 and 9q33.3","volume":"43","author":"Chen","year":"2011","journal-title":"Nat Genet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100427","article-title":"Replication of Association Ofdennd1a and THADA Variants With Polycystic Ovary Syndrome in European Cohorts","volume":"49","author":"Goodarzi","year":"2012","journal-title":"J Med Genet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des424","article-title":"Genotype-Phenotype Correlations of PCOS Susceptibility Snps Identified by GWAS in a Large Cohort of Han Chinese Women","volume":"28","author":"Cui","year":"2013","journal-title":"Hum Reprod"},{"key":"B7","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1055\/a-0969-1872","article-title":"THADA_Rs13429458 Minor Allele Increases the Risk of Polycystic Ovary Syndrome in Asian, But Not in Caucasian Women: A Systematic Review and Meta-Analysis","volume":"51","author":"Park","year":"2019","journal-title":"Horm. 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