{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:14:31Z","timestamp":1767093271578,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013779","name":"Sabzevar University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the efficacy and safety of inactivated SARS-CoV-2 vaccine (BBIBP-CorV) in patients with breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multi- institutional cohort study, a total of 160 breast cancer patients (mean age of 50.01 \u00b1 11.5 years old) were assessed for the SARS-CoV-2 Anti-Spike IgG and SARS-CoV2 Anti RBD IgG by ELISA after two doses of 0.5 mL inactivated, COVID-19 vaccine (BBIBP-CorV). All patients were followed up for three months for clinical COVID-19 infection based on either PCR results or imaging findings. Common Terminology Criteria for Adverse Events were used to assess the side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The presence of SARS-CoV-2 anti-spike IgG, SARS-CoV2 anti-RBD IgG, or either of these antibodies was 85.7%, 87.4%, and 93.3%. The prevalence of COVID-19 infection after vaccination was 0.7%, 0% and 0% for the first, second and third months of the follow-up period. The most common local and systemic side-effects were injection site pain and fever which were presented in 22.3% and 24.3% of patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The inactivated SARS-CoV-2 vaccine (BBIBP-CorV) is a tolerable and effective method to prevent COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.798975","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:36:20Z","timestamp":1646112980000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["A Cohort Study on the Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients With Breast Cancer; Does Trastuzumab Interfere With the Outcome?"],"prefix":"10.3389","volume":"13","author":[{"given":"Maryam","family":"Joudi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Moradi Binabaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pejman","family":"Porouhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"PeyroShabany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Tabasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danial","family":"Fazilat-Panah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab","family":"Khajeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezoo","family":"Mehrabian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansoureh","family":"Dehghani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batol","family":"Keykhosravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Akbari Yazdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Ariamanesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Ferns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Alireza","family":"Javadinia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32880","article-title":"NCCN Resource-Stratified and Harmonized Guidelines: A Paradigm for Optimizing Global Cancer Care","volume":"126","author":"Koh","year":"2020","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: Cancer J Clin"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An Interactive Web-Based Dashboard to Track COVID-19 in Real Time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2021.106585","article-title":"The Impact of the Covid-19 Pandemic on Breast Cancer Early Detection and Screening","volume":"151","author":"Figueroa","year":"2021","journal-title":"Prev Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.5812\/ijcm.103283","article-title":"The COVID-19 Outbreak and Oncology Centers in Iran","volume":"13","author":"Soroosh","year":"2020","journal-title":"Int J Cancer Manag"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06362-w","article-title":"Medical Care Disruptions During the First Six-Months of the COVID19 Pandemic: The Experience of Older Breast Cancer Survivors","volume":"190","author":"Dilawari","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-10639-1","article-title":"Analysis of the Impact of the COVID-19 Pandemic on the Multidisciplinary Management of Breast Cancer: Review From the American Society of Breast Surgeons COVID-19 and Mastery Registries","volume":"28","author":"Wilke","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"PS14","DOI":"10.1158\/1538-7445.SABCS20-PS14-06","article-title":"Abstract PS14-06: Changes in Management of Breast Cancer Patients During First Wave of COVID19, Throughout the Area of Kent, United Kingdom. An Audit of ESMO Guideline Implementation","volume":"81","author":"Rodney","year":"2021","journal-title":"Cancer Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0574","article-title":"Implementation of Breast Cancer Continuum of Care in Low- and Middle-Income Countries During the COVID-19 Pandemic","volume":"16","author":"Elghazawy","year":"2020","journal-title":"Future Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1378","article-title":"COVID-19 in Cancer Patients May Be Presented by Atypical Symptoms and Higher Mortality Rate, a Case-Controlled Study From Iran","volume":"4","author":"Shahidsales","year":"2021","journal-title":"Cancer Rep (Hoboken)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5812\/ijcm.110907","article-title":"COVID-19 in Cancer and Non-Cancer Patients","volume":"14","author":"Taghizadeh-Hesary","year":"2021","journal-title":"Int J Cancer Manag"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e13527","article-title":"Impact of COVID19 Pandemic on the Hospitalization Burden of Cancer Patients: Results of a Quasi-Experimental Study","volume":"39","author":"Sanchez","year":"2021","journal-title":"J Clin Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.6178","article-title":"Analyses of Risk, Racial Disparity, and Outcomes Among US Patients With Cancer and COVID-19 Infection","volume":"7","author":"Wang","year":"2021","journal-title":"JAMA Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.3390\/cancers12092421","article-title":"The Potential Role of Immune Alteration in the Cancer\u2013Covid19 Equation\u2014a Prospective Longitudinal Study","volume":"12","author":"Goshen-Lago","year":"2020","journal-title":"Cancers"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01085","article-title":"A Protracted Course of COVID19 Infection in a Metastatic Breast Cancer Patient During CDK4\/6 Inhibitor Therapy","volume":"10","author":"Grinshpun","year":"2020","journal-title":"Front Oncol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-021-01046-w","article-title":"COVID-19 Vaccines for Patients With Cancer: Benefits Likely Outweigh Risks","volume":"14","author":"Hwang","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06293-6","article-title":"COVID-19 Vaccination and Breast Cancer Surgery Timing","volume":"188","author":"Ko","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"B18","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/07357907.2021.1992420","article-title":"Immunogenicity and Safety of the Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV) in Patients With Malignancy","volume":"40","author":"Ariamanesh","year":"2022","journal-title":"Cancer Invest"},{"key":"B19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1473-3099(20)30831-8","article-title":"Safety and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine, BBIBP-CorV: A Randomised, Double-Blind, Placebo-Controlled, Phase 1\/2 Trial","volume":"21","author":"Xia","year":"2021","journal-title":"Lancet Infect Dis"},{"volume-title":"Sample Size Calculator for Evaluation of COVID-19 Vaccine Effectiveness","year":"2021","key":"B20"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2021.1995742","article-title":"Multicenter Study of Antibody Seroprevalence Against COVID-19 in Patients Presenting to Iranian Cancer Centers After One Year of the COVID-19 Pandemic. Cancer Invest","volume":"40","author":"Javadinia","year":"2022"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052306","article-title":"Trastuzumab After Adjuvant Chemotherapy in HER2-Positive Breast Cancer","volume":"353","author":"Piccart-Gebhart","year":"2005","journal-title":"N Engl J Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.5437","article-title":"Phase III Study of Doxorubicin\/Cyclophosphamide With Concomitant Versus Sequential Docetaxel as Adjuvant Treatment in Patients With Human Epidermal Growth Factor Receptor 2-Normal, Node-Positive Breast Cancer: BCIRG-005 Trial","volume":"29","author":"Eiermann","year":"2011","journal-title":"J Clin Oncol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.bcp.2019.03.031","article-title":"Therapeutic Potential of Pharmacological TGF-\u03b2 Signaling Pathway Inhibitors in the Pathogenesis of Breast Cancer","volume":"164","author":"Khoshakhlagh","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338","article-title":"Cancer Statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA: Cancer J Clin"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30096-6","article-title":"Cancer Patients in SARS-CoV-2 Infection: A Nationwide Analysis in China","volume":"21","author":"Liang","year":"2020","journal-title":"Lancet Oncol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0422","article-title":"Patients With Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study During the COVID-19 Outbreak","volume":"10","author":"Dai","year":"2020","journal-title":"Cancer Discov"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13349","article-title":"Development of a High-Sensitivity ELISA Detecting IgG, IgA and IgM Antibodies to the SARS-CoV-2 Spike Glycoprotein in Serum and Saliva","volume":"164","author":"Faustini","year":"2021","journal-title":"Immunology"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05644-z","article-title":"Recommendations for Prioritization, Treatment, and Triage of Breast Cancer Patients During the COVID-19 Pandemic. The COVID-19 Pandemic Breast Cancer Consortium","volume":"181","author":"Dietz","year":"2020","journal-title":"Breast Cancer Res Treat"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab097","article-title":"Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling","volume":"113","author":"Alagoz","year":"2021","journal-title":"JNCI J Natl Cancer Institute"},{"key":"B31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.34172\/ipp.2021.31","article-title":"Efficacy and Side Effects of","volume":"7","author":"Ghiasi","year":"2021","journal-title":"Immunopathol Persa"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.08.013","article-title":"Side Effects and Perceptions Following Sinopharm COVID-19 Vaccination","volume":"111","author":"Saeed","year":"2021","journal-title":"Int J Infect Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00155-8","article-title":"Short-Term Safety of the BNT162b2 mRNA COVID-19 Vaccine in Patients With Cancer Treated With Immune Checkpoint Inhibitors","volume":"22","author":"Waissengrin","year":"2021","journal-title":"Lancet Oncol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.2155","article-title":"Evaluation of Seropositivity Following BNT162b2 Messenger RNA Vaccination for SARS-CoV-2 in Patients Undergoing Treatment for Cancer","volume":"7","author":"Massarweh","year":"2021","journal-title":"JAMA Oncol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13058-015-0669-x","article-title":"Lymphocyte Depletion and Repopulation After Chemotherapy for Primary Breast Cancer","volume":"18","author":"Verma","year":"2016","journal-title":"Breast Cancer Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.2159","article-title":"Difference in SARS-CoV-2 Antibody Status Between Patients With Cancer and Health Care Workers During the COVID-19 Pandemic in Japan","volume":"7","author":"Yazaki","year":"2021","journal-title":"JAMA Oncol"},{"key":"B37","article-title":"Influence of Adjuvant Hormone Therapy and Chemotherapy on the Immune System Analysed in the Bone Marrow of Patients With Breast Cancer","volume":"9","author":"Solomayer","year":"2003","journal-title":"Clin Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e2020014","DOI":"10.4084\/mjhid.2020.014","article-title":"The Impact of Chemotherapy After Pediatric Malignancy on Humoral Immunity to Vaccine-Preventable Diseases","volume":"12","author":"Garonzi","year":"2020","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70477-7","article-title":"The Immune System and Response to HER2-Targeted Treatment in Breast Cancer","volume":"15","author":"Bianchini","year":"2014","journal-title":"Lancet Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00213-8","article-title":"Safety and Immunogenicity of One Versus Two Doses of the COVID-19 Vaccine BNT162b2 for Patients With Cancer: Interim Analysis of a Prospective Observational Study","volume":"22","author":"Monin","year":"2021","journal-title":"Lancet Oncol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-021-00191-y","article-title":"Patterns of Seroconversion for SARS-CoV-2 IgG in Patients With Malignant Disease and Association With Anticancer Therapy","volume":"2","author":"Thakkar","year":"2021","journal-title":"Nat Cancer"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2021.06.002","article-title":"Serological Response to COVID-19 Vaccination in Patients With Cancer Older Than 80 Years","volume":"12","author":"Iacono","year":"2021","journal-title":"J Geriatric Oncol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jcv.2009.02.011","article-title":"Examination of Seroprevalence of Coronavirus HKU1 Infection With S Protein-Based ELISA and Neutralization Assay Against Viral Spike Pseudotyped Virus","volume":"45","author":"Chan","year":"2009","journal-title":"J Clin Virol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00278-10","article-title":"Prevalence of Antibodies to Four Human Coronaviruses Is Lower in Nasal Secretions Than in Serum","volume":"17","author":"Gorse","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"752","DOI":"10.3390\/pathogens10060752","article-title":"Relative COVID-19 Viral Persistence and Antibody Kinetics","volume":"10","author":"Huang","year":"2021","journal-title":"Pathogens"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1731266","article-title":"Hypoxia-Induced Acetylation of PAK1 Enhances Autophagy and Promotes Brain Tumorigenesis via Phosphorylating ATG5","volume":"17","author":"Feng","year":"2021","journal-title":"Autophagy"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1016\/j.jinf.2020.07.018","article-title":"Prevalence and Clinical Characterization of Cancer Patients With Asymptomatic SARS-CoV-2 Infection History","volume":"81","author":"Bi","year":"2020","journal-title":"J Infect"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.08.014","article-title":"Effects of the COVID-19 Pandemic on Breast Cancer Screening in Taiwan","volume":"54","author":"Tsai","year":"2020","journal-title":"Breast"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.798975\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T05:36:23Z","timestamp":1646112983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.798975\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":48,"alternative-id":["10.3389\/fendo.2022.798975"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.798975","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"article-number":"798975"}}