{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:04:26Z","timestamp":1792793066485,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of thyroid carcinoma (TC) and Hashimoto\u2019s thyroiditis (HT) has been increasing dramatically over the past decades. We investigated the relationship between HT and TC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines for carrying out and reporting this meta-analysis. The literature from January 1, 2010 to December 31, 2020, regardless of region and publication type, was searched comprehensively in PubMed, Embase, Web of Science, and Cochrane Library databases. After careful selection and data extraction, the pooled odds ratio of various clinical characteristics in 39 studies were calculated. Publication bias was analyzed using funnel plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meta-analysis of 39 original research articles showed HT to be a risk factor of TC (pooled odds ratio = 1.71; 95% confidence interval, 1.57\u20131.80;\n                      <jats:italic>p &amp;lt;<\/jats:italic>\n                      0.00001) and papillary thyroid carcinoma (1.67, 1.51\u20131.85, &amp;lt;0.00001). Patients with papillary thyroid carcinoma (PTC) combined with HT were more likely to have multifocal carcinomas. The prevalence of an extrathyroidal extension, metastasis, BRAF\n                      <jats:sup>V600E<\/jats:sup>\n                      mutation, and recurrence was significantly lower in patients with PTC combined with HT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HT is a \u201cdouble-edged sword\u201d in TC patients. HT increases the risk of TC and PTC but is a protective factor against PTC progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2022.801925","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T23:31:23Z","timestamp":1645659083000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":81,"title":["Hashimoto\u2019s Thyroiditis: A \u201cDouble-Edged Sword\u201d in Thyroid Carcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Jiangyue","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangsheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"American Thyroid Association Management Guidelines for Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/thy.2014.0294","article-title":"Papillary Thyroid Carcinoma in Denmark, 1996-2008: Outcome and Evaluation of Established Prognostic Scoring Systems in a Prospective National Cohort","volume":"25","author":"Londero","year":"2015","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27497","article-title":"Thyroid Cancer in Denmark 1943-2008, Before and After Iodine Supplementation","volume":"131","author":"Blomberg","year":"2012","journal-title":"Int J Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2010.06.006","article-title":"Increased Annual Frequency of Hashimoto's Thyroiditis Between Years 1988 and 2007 at a Cytological Unit of Sicily","volume":"71","author":"Rizzo","year":"2010","journal-title":"Ann Endocrinol (Paris)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune Thyroid Disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto Thyroiditis: Clinical and Diagnostic Criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e55450","DOI":"10.1371\/journal.pone.0055450","article-title":"Hashimoto's Thyroiditis: Similar and Dissimilar Characteristics in Neighboring Areas. 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