{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T11:26:50Z","timestamp":1772278010967,"version":"3.50.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Central compartment lymph node metastasis (CLNM) is a manifestation of tumor aggressiveness and an indicator of tumor prognosis. The purpose of this study was to construct a nomogram for evaluating CLNM patterns in papillary thyroid carcinoma (PTC) in different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 907 patients diagnosed with PTC from August 2014 to December 2018 were enrolled. A nomogram illustrating CLNM was generated using the results of multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the best Youden index, we set the cut-off age at 45 years. Multivariate logistic regression analysis showed that in patients aged &amp;lt;45 years, large tumor size (P&amp;lt;0.05), extra-thyroid extension (P&amp;lt;0.05) and thyroglobulin level &amp;gt;40 ng\/ml (OR=2.985, 95% CI 1.379-6.462; P&amp;lt;0.05) were independent risk factors; meanwhile, Hashimoto\u2019s thyroiditis (OR=0.532, 95% CI 0.324-0.874; P&amp;lt;0.05) was a protective factor of CLNM. In the subgroup with age \u226545 years, large tumor size (P&amp;lt;0.05), extra-thyroid extension (P&amp;lt;0.05), unclear margin (OR=1.604, 95% CI 1.065-2.416; P&amp;lt;0.05), male gender (OR=2.009, 95% CI 1.257-3.212; P&amp;lt;0.05) were independent risk factors for CLNM. In the subgroup with age &amp;lt;45 years, an area under the curve (AUC) of 0.729 (95% CI 0.680-0.777); P&amp;lt;0.05) was obtained. In the \u226545 years subgroup, the AUC was 0.668 (95% CI 0.619-0.716; P&amp;lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CLNM of PTC in different age groups may have distinct patterns. Based on the potential risk factors for CLNM in patients with different age stratification, a user-friendly predictive model was established.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.807431","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T10:59:45Z","timestamp":1645095585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Central Compartment Lymph Nodes Have Distinct Metastatic Patterns in Different Age 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