{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:08:25Z","timestamp":1793898505730,"version":"4.8.0"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971433, 81701500"],"award-info":[{"award-number":["81971433, 81701500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (\n                    <jats:italic>BMAL1<\/jats:italic>\n                    ), a core component of circadian oscillation, is involved in many physiological activities. Increasing evidence has demonstrated the essential role of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    in reproductive physiology. For instance,\n                    <jats:italic>BMAL1<\/jats:italic>\n                    -knockout (KO) mice were infertile, with impaired reproductive organs and gametes. Additionally, in\n                    <jats:italic>BMAL1<\/jats:italic>\n                    -KO mice, hormone secretion and signaling of hypothalamus-pituitary-gonadal (H-P-G) hormones were also disrupted, indicating that H-P-G axis was impaired in\n                    <jats:italic>BMAL1<\/jats:italic>\n                    -KO mice. Moreover, both\n                    <jats:italic>BMAL1<\/jats:italic>\n                    -KO mice and BMAL1-knockdown by small interfering RNA (siRNA)\n                    <jats:italic>in vitro<\/jats:italic>\n                    cultured steroidogenic cells showed that\n                    <jats:italic>BMAL1<\/jats:italic>\n                    was associated with gonadal steroidogenesis and expression of related genes. Importantly,\n                    <jats:italic>BMAL1<\/jats:italic>\n                    also participates in pathogenesis of human reproductive diseases. In this review, we elaborate on the impaired reproduction of BMAL1-KO mice including the reproductive organs, reproductive endocrine hormones, and reproductive processes, highlighting the vital role of\n                    <jats:italic>BMAL1<\/jats:italic>\n                    in fertility and reproductive endocrinology.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2022.818272","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T02:56:12Z","timestamp":1646189772000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility"],"prefix":"10.3389","volume":"13","author":[{"given":"Yin","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiechao","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308709101","article-title":"PERIOD2::LUCIFERASE 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