{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:42:17Z","timestamp":1784133737374,"version":"3.55.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present study was to evaluate the prevalence of polycystic ovary syndrome (PCOS), its phenotypical and cardio-metabolic features in a community sample of the Iranian population in comparison to healthy eumenorrheic, non-hirsute women without polycystic ovaries. The second aim was to assess the cardio-metabolic characteristics of women who suffered from one criteria of PCOS compared to those healthy eumenorrheic, non-hirsute women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross-sectional population-based study, a total of 1,960 eligible women, aged (18\u201345 years) were recruited from the Tehran-Lipid and Glucose-Study participants and were classified as the three groups of (i) women with PCOS by the Rotterdam criteria, (ii) non-PCOS women with one criteria of PCOS and (iii) healthy eumenorrheic, non-hirsute women without polycystic ovaries morphology (PCOM) as the control group. Further PCOS women were extended to four phenotypes of hyperandrogenism, oligo-anovulation, polycystic ovaries (phenotype A), hyperandrogenism, oligo\/anovulation (phenotype B), hyperandrogenism, polycystic ovaries (phenotype C) and oligo-anovulation, polycystic ovaries (phenotype D). Cardio-metabolic profiles and the prevalence of comorbidities of metabolic syndrome (MetS) and lipid abnormalities were compared among these groups linear, and the median regression models adjusted for age and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of PCOS according to the diagnostic criteria of the NIH, Rotterdam and AE-PCOS Society were 13.6, 19.4, and 17.8, respectively. Among those who met the Rotterdam criteria, 23.9, 46.3, 21.6, and 8.2% had phenotypes A, B, C, and D, respectively. Among the remaining 1,580 women who did not fulfil the PCOS criteria, 108 (6.8%) suffered from only oligo\/anovulation, 332 (21%) only hyperandrogenism\/hyperandrogenemia, 159 (16.2%) only PCOM in ultrasound and 981 (62%) were healthy eumenorrheic, non-hirsute women without PCOM. The study revealed that some adiposity indices and lipid abnormalities in PCOS phenotypes with hyperandrogenism (A, B, and C) were worse than in healthy women. By contrast, women with phenotype D did not differ from the healthy ones in terms of adiposity and lipid abnormalities. However, the respective values for other cardio-metabolic profiles and MetS rates in different phenotypes of PCOS were similar to the healthy women. Only the prevalence of MetS in phenotype A was significantly higher than in the healthy women. There were no statistically significant differences between participants with one criteria of PCOS and healthy counterparts in terms of most adiposity indexes, cardio-metabolic factors, and comorbidity of MetS and its components. However, women with hyperandrogenism had a significantly higher level of the waist to height ratio (WHtR) and hypertriglyceridemia than their healthy counterparts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCOS, mainly classical phenotypes A and B, are common among Iranian women of reproductive age. Women with PCOS who had androgen excess exhibited the worst lipid profile, and those who had full three criteria of the syndrome exhibited the higher rate of MetS. However, women with only ovulatory dysfunction and only PCOM had similar cardio-metabolic characteristics, compared to healthy subjects. These data suggest that routine screening for metabolic disturbances may be needed in the prevention of cardio-metabolic disorders in patients with more serious phenotypes of PCOS.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2022.825528","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T04:39:15Z","timestamp":1646109555000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":56,"title":["The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Mahbanoo","family":"Farhadi-Azar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Behboudi-Gandevani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Rahmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mahboobifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensi","family":"Khalili Pouya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Ramezani Tehrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereidoun","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/humupd\/dmy022","article-title":"Understanding Variation in Prevalence Estimates of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"24","author":"Skiba","year":"2018","journal-title":"Hum Reprod Update"},{"key":"B2","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1080\/09513590.2020.1859474","article-title":"Prevalence of Acne Vulgaris Among Women With Polycystic Ovary Syndrome: A Systemic Review and Meta-Analysis","volume":"37","author":"Ramezani Tehrani","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00516","article-title":"Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions","volume":"11","author":"Aversa","year":"2020","journal-title":"Front Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1117069","article-title":"Insulin Resistance in Obesity and Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis of Observational Studies","volume":"32","author":"Behboudi-Gandevani","year":"2016","journal-title":"Gynecol Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.667422","article-title":"Central Regulation of PCOS: Abnormal Neuronal-Reproductive-Metabolic Circuits in PCOS Pathophysiology","volume":"12","author":"Liao","year":"2021","journal-title":"Front Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"759835","DOI":"10.1093\/humrep\/deaa371","article-title":"Metabolic Features of Women With Polycystic Ovary Syndrome in Latin America: A Systematic Review","volume":"12","author":"Marchesan","year":"2021","journal-title":"Front Endocrinol"},{"key":"B7","first-page":"377","volume-title":"Diagnostic Criteria for Polycystic Ovary Syndrome: Towards a More Rational Approach. PCOS","author":"Zawadzki","year":"1992"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098","article-title":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"B9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-9-39","article-title":"The Prevalence of Polycystic Ovary Syndrome in a Community Sample of Iranian Population: Iranian PCOS Prevalence Study","volume":"9","author":"Tehrani","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"key":"B12","volume-title":"National Institutes of Health Evidence Based Methodology Workshop on Polycystic Ovary Syndrome (Executive Summary)","author":"Johnson","year":"2012"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1016\/j.fertnstert.2017.04.011","article-title":"Gaps in Knowledge Among Physicians Regarding Diagnostic Criteria and Management of Polycystic Ovary Syndrome","volume":"107","author":"Dokras","year":"2017","journal-title":"Fertil Steril"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-153","article-title":"Metabolic Profiles Characterizing Different Phenotypes of Polycystic Ovary Syndrome: Plasma Metabolomics Analysis","volume":"10","author":"Zhao","year":"2012","journal-title":"BMC Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13477","article-title":"The Risk of Metabolic Syndrome in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"88","author":"Behboudi-Gandevani","year":"2018","journal-title":"Clin Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.08.046","article-title":"Cardiometabolic Risks in Polycystic Ovary Syndrome: Long-Term Population-Based Follow-Up Study","volume":"110","author":"Behboudi-Gandevani","year":"2018","journal-title":"Fertil Steril"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.09.004","article-title":"Polycystic Ovary Syndrome is a Risk Factor for Diabetes and Prediabetes in Middle-Aged But Not Elderly Women: A Long-Term Population-Based Follow-Up Study","volume":"108","author":"Kazemi Jaliseh","year":"2017","journal-title":"Fertil Steril"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa029","article-title":"Long-Term Cardiometabolic Disease Risk in Women With PCOS: A Systematic Review and Meta-Analysis","volume":"26","author":"Wekker","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew218","article-title":"The Prevalence and Phenotypic Features of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"key":"B20","doi-asserted-by":"publisher","first-page":"493.e1","DOI":"10.1016\/j.ajog.2017.01.003","article-title":"Racial and Ethnic Differences in the Polycystic Ovary Syndrome Metabolic Phenotype","volume":"216","author":"Engmann","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09078.x","article-title":"Is There a Role for Insulin Resistance in Nonobese Patients With Idiopathic Hirsutism","volume":"160","author":"Fattah","year":"2009","journal-title":"Br J Dermatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ11-0101","article-title":"Evaluation of Various Insulin Sensitivity Indices in Lean Idiopathic Hirsutism Patients","volume":"59","author":"Ucak","year":"2012","journal-title":"Endocr J"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/09513590312331290278","article-title":"Insulin Resistance and Lipid Profile in Women With Polycystic Appearing Ovaries: Implications With Regard to Polycystic Ovary Syndrome","volume":"17","author":"Sayin","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031600","article-title":"Polycystic Ovarian Morphology With Regular Ovulatory Cycles: Insights Into the Pathophysiology of Polycystic Ovarian Syndrome","volume":"89","author":"Adams","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.797399","article-title":"The Lack of Association Between Idiopathic Hirsutism and Metabolic Disturbances: Iranian PCOS Prevalence Study","volume":"29","author":"Sadat Hosseini","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew071","article-title":"Does the Risk of Metabolic Disorders Increase Among Women With Polycystic Ovary Morphology? A Population-Based Study","volume":"31","author":"Bahri Khomami","year":"2016","journal-title":"Hum Reprod"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-5","article-title":"Prevention of Non-Communicable Disease in a Population in Nutrition Transition: Tehran Lipid and Glucose Study Phase II","volume":"10","author":"Azizi","year":"2009","journal-title":"Trials"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.84786","article-title":"Reproductive Assessment: Findings From 20 Years of the Tehran Lipid and Glucose Study","volume":"16","author":"Ramezani Tehrani","year":"2018","journal-title":"Int J Endocrinol Metab"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-9-52","article-title":"A Modified Formula for Calculating Low-Density Lipoprotein Cholesterol Values","volume":"9","author":"Chen","year":"2010","journal-title":"Lipids Health Dis"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu249","article-title":"Lipid Profiles and Ovarian Reserve Status: A Longitudinal Study","volume":"29","author":"Tehrani","year":"2014","journal-title":"Hum Reprod"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: Implications, Etiology, and Management. am","volume":"140","author":"Hatch","year":"1981","journal-title":"J Obstet Gynecol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijwd.2017.10.006","article-title":"Paller as. A Review of Diagnosis and Treatment of Acne in Adult Female Patients","volume":"4","author":"Tan","year":"2017","journal-title":"Int J Womens Dermatol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.09.029","article-title":"Normal Cut-Off Values for Hyperandrogenaemia in Iranian Women of Reproductive Age","volume":"172","author":"Hashemi","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-6-5","article-title":"the\u201d Lipid Accumulation Product\u201d Performs Better Than the Body Mass Index for Recognizing Cardiovascular Risk: A Population-Based Comparison","volume":"5","author":"Kahn","year":"2005","journal-title":"BMC Cardiovasc Disord"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.08.011","article-title":"Gynecology","volume":"205","author":"Behboudi-Gandevani","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143","article-title":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn137","article-title":"A Simple Screening Approach for Assessing Community Prevalence and Phenotype of Polycystic Ovary Syndrome in a Semi-Urban Population in Sri Lanka","volume":"168","author":"Kumarapeli","year":"2008","journal-title":"Am J Epidemiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.131162","article-title":"Vaidya R. A Cross-Sectional Study of Polycystic Ovarian Syndrome Among Adolescent and Young Girls in Mumbai, India","volume":"18","author":"Joshi","year":"2014","journal-title":"Indian J Endocrinol Metab"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.12891\/ceog16282014","article-title":"Epidemiologic Investigation of Polycystic Ovarian Syndrome (PCOS) in Han Ethnic Women of Reproductive Age in Liaoning Province, China","volume":"41","author":"Jiao","year":"2014","journal-title":"Clin Exp Obstet Gynecol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-96","article-title":"Polycystic Ovary Syndrome in Salvador, Brazil: A Prevalence Study in Primary Healthcare","volume":"10","author":"Gabrielli","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.12.018","article-title":"To What Extent Does the Use of the Rotterdam Criteria Affect the Prevalence of Polycystic Ovary Syndrome? A Community-Based Study From the Southwest of Iran","volume":"174","author":"Rashidi","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B43","first-page":"591","article-title":"Prevalence of Polycystic Ovary Syndrome and its Associated Complications in Iranian Women: A Meta-Analysis","volume":"13","author":"Jalilian","year":"2015","journal-title":"Iran J Reprod Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19180","article-title":"The Prevalence of Polycystic Ovary Syndrome in Reproductive-Aged Women of Different Ethnicity: A Systematic Review and Meta-Analysis","volume":"8","author":"Ding","year":"2017","journal-title":"Oncotarget"},{"key":"B45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/jrms.JRMS_804_16","article-title":"The Glucose Metabolism Disorder and Dyslipidemia Among Girls With Different Phenotype Polycystic Ovary Syndrome","volume":"24","author":"Akbarzadeh","year":"2019","journal-title":"J Res Med Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00948-2","article-title":"Prevalence and Predictors of Dyslipidemia in Women With Polycystic Ovary Syndrome","volume":"111","author":"Legro","year":"2001","journal-title":"Am J Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep121","article-title":"Milder Forms of Atherogenic Dyslipidemia in Ovulatory Versus Anovulatory Polycystic Ovary Syndrome Phenotype","volume":"24","author":"Rizzo","year":"2009","journal-title":"Hum Reprod"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-016-0898-7","article-title":"Endocrine and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome","volume":"66","author":"Pikee","year":"2016","journal-title":"J Obstet Gynaecol India"},{"key":"B49","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.numecd.2009.01.007","article-title":"Prominent Role of Low HDL-Cholesterol in Explaining the High Prevalence of the Metabolic Syndrome in Polycystic Ovary Syndrome","volume":"19","author":"Gambineri","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2013.56.3.137","article-title":"Dyslipidemia in Women With Polycystic Ovary Syndrome","volume":"56","author":"Kim","year":"2013","journal-title":"Obstet Gynecol Sci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2279","article-title":"Phenotypic Variation in Hyperandrogenic Women Influences the Findings of Abnormal Metabolic and Cardiovascular Risk Parameters","volume":"90","author":"Carmina","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.fertnstert.2010.12.027","article-title":"Lipid Levels in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis","volume":"95","author":"Wild","year":"2011","journal-title":"Fertil Steril"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.07.004","article-title":"Pathophysiology and Types of Dyslipidemia in PCOS","volume":"18","author":"Diamanti-Kandarakis","year":"2007","journal-title":"Trends Endocrinol Metab"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.04.008","article-title":"Understanding Androgen Action in Adipose Tissue","volume":"143","author":"O\u2019Reilly","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1658215","article-title":"Lipidomics Biomarkers in Women With Polycystic Ovary Syndrome (PCOS) Using Ultra-High Performance Liquid Chromatography-Quadrupole Time of Flight Electrospray in a Positive Ionization Mode Mass Spectrometry","volume":"79","author":"Vonica","year":"2019","journal-title":"Scand J Clin Lab Invest"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-011-0184-0","article-title":"Metabolic Syndrome, Androgens, and Hypertension","volume":"13","author":"Moulana","year":"2011","journal-title":"Curr Hypertens Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2020.100086","article-title":"Targeting Hypertriglyceridemia to Mitigate Cardiovascular Risk: A Review","volume":"3","author":"Toth","year":"2020","journal-title":"Am J Prev Cardiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.114.000600","article-title":"Bet Al. Human Plasma Lipidome is Pleiotropically Associated With Cardiovascular Risk Factors and Death","volume":"7","author":"Bellis","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2013.15853","article-title":"[Turkish Adult Risk Factor Study Survey 2012: Overall and Coronary Mortality and Trends in the Prevalence of Metabolic Syndrome]","volume":"41","author":"Onat","year":"2013","journal-title":"Turk Kardiyol Dern Ars"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12985","article-title":"Metabolic Syndrome and Metabolic Risk Profile According to Polycystic Ovary Syndrome Phenotype","volume":"42","author":"Bil","year":"2016","journal-title":"J Obstet Gynaecol Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"56","DOI":"10.15171\/jcvtr.2018.10","article-title":"Metabolic Syndrome and its Components Among Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"10","author":"Hallajzadeh","year":"2018","journal-title":"J Cardiovasc Thorac Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-89","article-title":"The Prevalence of Metabolic Disorders in Various Phenotypes of Polycystic Ovary Syndrome: A Community Based Study in Southwest of Iran","volume":"12","author":"Tehrani","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/569862","article-title":"Phenotype and Metabolic Disorders in Polycystic Ovary Syndrome","volume":"2012","author":"G\u0142uszak","year":"2012","journal-title":"ISRN Endocrinol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v13i4.6888","article-title":"Prevalence of Metabolic Syndrome in Four Phenotypes of PCOS and its Relationship With Androgenic Components Among Iranian Women: A Cross-Sectional Study","volume":"18","author":"Zaeemzadeh","year":"2020","journal-title":"Int J Reprod BioMed"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137609","article-title":"Trend of Cardio-Metabolic Risk Factors in Polycystic Ovary Syndrome: A Population-Based Prospective Cohort Study","volume":"10","author":"Ramezani Tehrani","year":"2015","journal-title":"PloS One"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168402","article-title":"Menstrual Cycle Irregularity and Metabolic Disorders: A Population-Based Prospective Study","volume":"11","author":"Rostami Dovom","year":"2016","journal-title":"PloS One"},{"key":"B67","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1210\/jcem.85.3.6452","article-title":"Normal Ovulatory Women With Polycystic Ovaries Have Hyperandrogenic Pituitary-Ovarian Responses to Gonadotropin-Releasing Hormone-Agonist Testing","volume":"85","author":"Chang","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.614679","article-title":"Impact of Increased Oxidative Stress on Cardiovascular Diseases in Women With Polycystic Ovary Syndrome","volume":"12","author":"Duic\u0103","year":"2021","journal-title":"Front Endocrinol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2017.1318840","article-title":"Metabolic Effect of Obesity on Polycystic Ovary Syndrome in Adolescents: A Meta-Analysis","volume":"37","author":"Li","year":"2017","journal-title":"J Obstet Gynaecol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.5804","article-title":"Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study","volume":"2","author":"Lyall","year":"2017","journal-title":"JAMA Cardiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12902-019-0348-5","article-title":"Trend of Various Adiposity Indices in Women With and Without History of Gestational Diabetes: A Population-Based Cohort Study","volume":"19","author":"Behboudi-Gandevani","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.453","article-title":"The Lipid Accumulation Product and All-Cause Mortality in Patients at High Cardiovascular Risk: A Precis Database Study","volume":"18","author":"Ioachimescu","year":"2010","journal-title":"Obesity"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.181","article-title":"Visceral Adiposity Index, Hypertriglyceridemic Waist and Risk of Diabetes: The China Health and Nutrition Survey 2009","volume":"38","author":"Du","year":"2014","journal-title":"Int J Obes"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.jhrs_12_21","article-title":"Visceral Adiposity Index and Lipid Accumulation Product as Diagnostic Markers of Metabolic Syndrome in South Indians With Polycystic Ovary Syndrome","volume":"14","author":"Naghshband","year":"2021","journal-title":"J Hum Reprod Sci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1519794","article-title":"The Impact of Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) on Clinical, Hormonal and Metabolic Parameters in Lean Women With Polycystic Ovary Syndrome","volume":"35","author":"Anik Ilhan","year":"2019","journal-title":"Gynecol Endocrinol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-113463","article-title":"Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women With Polycystic Ovary Syndrome","volume":"49","author":"Abruzzese","year":"2017","journal-title":"Horm Metab Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt061","article-title":"Definition and Significance of Polycystic Ovarian Morphology: A Task Force Report From the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum Reprod Update"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00516","article-title":"Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions","volume":"11","author":"Aversa","year":"2020","journal-title":"Front Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.825528\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T04:39:21Z","timestamp":1646109561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2022.825528\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":78,"alternative-id":["10.3389\/fendo.2022.825528"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2022.825528","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]},"article-number":"825528"}}